Yale takes home top honor at 2021 Ivy+ Three-Minute Thesis Competition
Matthew Ellis, a Yale Ph.D. student in the Department of Cellular and Molecular Physiology, took top honors for his presentation on “Using Stem Cells to Model and Treat Cardiovascular Disease.” The prize comes with a $1,000 award.
Collective Efforts to Increase Diversity, Equity, and Inclusion in the Genetics Department Make Steady Progress
Every two weeks, members of the Yale Genetics Diversity Advisory Committee (DAC) come together to discuss ways to address equity and inclusion across all underrepresented memberships within the department.
New Work from Doug! Treating A Deadly Lung Disease With A Little Help From Amoebas
Douglas Robinson (Cooley Lab Alum) is featured in new Scientific American article! The original research article can be found in the Journal of Cell Science here: https://doi.org/10.1242/jcs.257162Source: Scientific American
Tiffany Wong presented her Senior Thesis yesterday: "Investigating the Tissue Specificity and Efficiency of Translational Stop Codon Readthrough in Drosophila". This presentation and poster are the culmination of a ton of hard work she did in the Cooley Lab over the last few years. Congratulations Tiffany!
PNAS paper from the Cooley and Atkins labs!
Translational stop codon readthrough occurs in organisms ranging from viruses to mammals and is especially prevalent in decoding Drosophila and viral mRNAs. We characterize major efficiency differences in a variety of cell types. Reporters of readthrough demonstrated greater than 30% readthrough in adult brains, in neurons but not glia. The extent of readthrough stimulatory sequences flanking the readthrough stop codon was assessed in transgenic Drosophila and in human tissue culture cells where inefficient readthrough occurs. A 99-nucleotide sequence with potential to form an mRNA stem-loop 3′ of the readthrough stop codon stimulated readthrough efficiency.Source: Tissue-specific dynamic codon redefinition in Drosophila (PNAS)
In collaboration with the Atkins Lab, a new Cooley Lab paper accepted to PNAS! (publication date pending- here it is on BioRxiv)
Tissue-specific dynamic codon redefinition in Drosophila. We show that high-effficiency readthrough in the CNS is common in Drosophila, raising the possibility that the neuronal proteome includes many proteins with conserved C-terminal extensions. This work provides new evidence for a remarkable degree of tissue- and cell-specific dynamic stop codon redefinition in Drosophila.Source: bioRxiv