Key Discoveries and Contributions
The Chen Lab works to understand the molecular, biochemical, and functional aspects of cell surface molecular pathways, including both costimulatory and coinhibitory molecules, in the control and modulation of immune responses. We are also interested in translating these laboratory findings into the development of new treatment options for cancer, autoimmune diseases, viral infections, transplantation rejection, and inflammation.
- Characterizing Co-Signaling Molecules
- Identifying New Co-signaling Molecules
Characterizing New Co-Signaling Molecules and their Roles in the Regulation of an Immune Response
- Chen L, Ashe S, Brady WA, Hellström I, Hellström KE, Ledbetter JA, McGowan P, Linsley PS. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell. 1992 Dec 24;71(7):1093-102. PubMed PMID: 1335364.
- Chen L, Linsley PS, Hellström KE. Costimulation of T cells for tumor immunity. Immunol Today. 1993 Oct;14(10):483-6. PubMed PMID: 7506034.
- Li Y, Hellstrom KE, Newby SA, Chen L. Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors. J Exp Med. 1996 Feb 1;183(2):639-44. PubMed PMID: 8627175; PubMed Central PMCID: PMC2192440.
- Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol. 2013 Apr;13(4):227-42. PubMed PMID: 23470321; PubMed Central PMCID: PMC3786574.