2023
Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
McCafferty C, Gruenbaum B, Tung R, Li J, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu J, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson E, Vitkovskiy P, Sampognaro J, Freedman I, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli B, Herman P, Hyder F, Blumenfeld H. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 2023, 14: 117. PMID: 36627270, PMCID: PMC9832004, DOI: 10.1038/s41467-022-35535-4.Peer-Reviewed Original ResearchConceptsThalamic neuronsAbsence seizuresSeizure onsetNeuronal firingConsciousness-impairing seizuresFemale rat modelLow-frequency electroencephalographic activityFunctional magnetic resonanceBehavioral arrestRat modelRhythmic firingTransient initial peakFiring increasesSeizuresNeuronal mechanismsElectroencephalographic activityNeuronsBrain state changesBrief episodesFiring decreasesInitial peakFiringMagnetic resonanceDistinct patternsOnset
2022
Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing
Ramirez V, Litvinov B, Gunawardane NA, Zhao CW, Yotter C, Quraishi IH, Blumenfeld H. Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing. Epileptic Disorders 2022, 24: 899-905. PMID: 35904040, PMCID: PMC10042123, DOI: 10.1684/epd.2022.1472.Peer-Reviewed Original ResearchConceptsFocal seizuresResponsiveness testingCurrent International LeagueClinical practice settingEEG-video monitoringEpilepsy monitoring unitImportant clinical settingsEpilepsy guidelinesPatient groupFocal epilepsyIctal eventsClinical careInternational LeagueSeizuresPatientsClinical settingPractice settingsClassification guidelinesFurther studiesEpilepsyResponsivenessRecall of experiencesPreliminary findingsRecall testingSettingA machine‐learning approach for predicting impaired consciousness in absence epilepsy
Springer M, Khalaf A, Vincent P, Ryu JH, Abukhadra Y, Beniczky S, Glauser T, Krestel H, Blumenfeld H. A machine‐learning approach for predicting impaired consciousness in absence epilepsy. Annals Of Clinical And Translational Neurology 2022, 9: 1538-1550. PMID: 36114696, PMCID: PMC9539371, DOI: 10.1002/acn3.51647.Peer-Reviewed Original Research
2019
Up and Down States of Cortical Neurons in Focal Limbic Seizures
Yue Z, Freedman IG, Vincent P, Andrews JP, Micek C, Aksen M, Martin R, Zuckerman D, Perrenoud Q, Neske GT, Sieu LA, Bo X, Cardin JA, Blumenfeld H. Up and Down States of Cortical Neurons in Focal Limbic Seizures. Cerebral Cortex 2019, 30: 3074-3086. PMID: 31800015, PMCID: PMC7197089, DOI: 10.1093/cercor/bhz295.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresDeep anesthesiaLimbic seizuresCortical neuronsVivo whole-cell recordingsDepressed cortical functionInput resistanceNeocortical slow wavesSubcortical arousal systemsLoss of consciousnessWhole-cell recordingsCortical-subcortical networksSeizure propagationMembrane potentialRat modelCortical functionTemporal lobeSeizuresCortical arousalExtracellular recordingsElectrophysiological propertiesCortical electrophysiologyFiring rateAnesthesiaArousal systemRealistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study
Cohen E, Antwi P, Banz BC, Vincent P, Saha R, Arencibia CA, Ryu JH, Atac E, Saleem N, Tomatsu S, Swift K, Hu C, Krestel H, Farooque P, Levy S, Wu J, Crowley M, Vaca FE, Blumenfeld H. Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study. Epilepsia 2019, 61: 19-28. PMID: 31646628, PMCID: PMC7424790, DOI: 10.1111/epi.16356.Peer-Reviewed Original ResearchConceptsEpileptiform dischargesGeneralized epileptiform dischargesEEG amplitudeClinical seizuresElectroencephalographic featuresGeneralized epilepsyLarger sample sizeDriving impairmentClinical accompanimentBaseline testingPilot studyMotor vehicle safetyLonger durationSimultaneous EEGSeizuresVisual stimuliEEGSubjectsStimuliRiskSafetyDurationSample sizeResponseEpilepsy
2017
Functional MRI in Basic Epilepsy Research☆
Englot D, Blumenfeld H. Functional MRI in Basic Epilepsy Research☆. 2017 DOI: 10.1016/b978-0-12-809324-5.00092-4.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingInvasive electrophysiological techniquesPathophysiology of seizuresMagnetic resonance imagingWidespread brain networksUse of anestheticsBasic epilepsy researchConvulsive seizuresAnimal fMRI studiesSeizure onsetResonance imagingElectrophysiological techniquesFunctional MRIEpilepsy researchBrain functionSeizuresFMRI studyBrain networksEpilepsyFMRI investigationSignal changesPathophysiologyAnestheticsMRI
2016
Chapter 16 Epilepsy and Consciousness
Blumenfeld H. Chapter 16 Epilepsy and Consciousness. 2016, 255-270. DOI: 10.1016/b978-0-12-800948-2.00016-9.Peer-Reviewed Original ResearchSeizure typesImpaired consciousnessNormal consciousnessDiverse seizure typesTemporal lobe seizuresTonic-clonic seizuresParietal association cortexMedial thalamusUpper brainstemAbsence seizuresNeuronal activityPatient injuryBehavioral testingAssociation cortexEpileptic seizuresSeizuresInterhemispheric regionSynchronous dischargesLateral frontalNeuroimaging signalsAbnormal increaseAnatomical regionsEpilepsySpecific anatomical structuresConsciousness system
2015
Decreased Subcortical Cholinergic Arousal in Focal Seizures
Motelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H. Decreased Subcortical Cholinergic Arousal in Focal Seizures. Neuron 2015, 85: 561-572. PMID: 25654258, PMCID: PMC4319118, DOI: 10.1016/j.neuron.2014.12.058.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresFocal temporal lobe seizuresReduced cholinergic neurotransmissionBilateral temporal lobesLoss of consciousnessPedunculopontine tegmental nucleusQuality of lifeBrainstem arousal systemsFunctional magnetic resonanceSeizure spreadCholinergic neuronsImpaired consciousnessFocal seizuresBasal forebrainAnterior hypothalamusCholinergic neurotransmissionTegmental nucleusLateral septumCortical functionRodent modelsTemporal lobeSubcortical regionsSeizuresImpair consciousnessSubcortical arousal
2013
Temporal Lobe Seizures
Furman M, Blumenfeld H. Temporal Lobe Seizures. 2013, 51-62. DOI: 10.1007/978-3-642-37580-4_4.Peer-Reviewed Original ResearchTemporal lobe seizuresTemporal epilepsyTemporal lobeFocal temporal lobe seizuresNetwork inhibition hypothesisSlow electroencephalogram activityLoss of consciousnessParietal association cortexImpaired consciousnessCortical dysfunctionSide effectsAnimal modelsNovel treatmentsAssociation cortexDeep anesthesiaAwake stateHuman patientsElectrophysiological techniquesMemory lossSeizuresElectroencephalogram (EEG) activityElectrophysiological dataEpilepsyCortexLobe
2012
Impaired consciousness in epilepsy
Blumenfeld H. Impaired consciousness in epilepsy. The Lancet Neurology 2012, 11: 814-826. PMID: 22898735, PMCID: PMC3732214, DOI: 10.1016/s1474-4422(12)70188-6.Peer-Reviewed Original ResearchConceptsConsciousness systemQuality of lifeImpaired consciousnessEmotional healthDiverse seizure typesNormal human lifeComplex partial seizuresImpairment of consciousnessImproved treatment strategiesBehavioral testingBrain dysfunctionPartial seizuresSeizure typesTreatment strategiesEpileptic seizuresConsciousnessEpilepsySeizuresHuge consequencesNeuroimagingAlertnessAnatomical structuresSame setImpairmentLife
2011
The Default Mode Network and Altered Consciousness in Epilepsy
Danielson N, Guo J, Blumenfeld H. The Default Mode Network and Altered Consciousness in Epilepsy. Behavioural Neurology 2011, 24: 55-65. DOI: 10.1155/2011/912720.Peer-Reviewed Original ResearchLoss of consciousnessDefault mode networkDefault mode network activitySeizure typesMode networkArousal systemNetwork inhibition hypothesisTypes of seizuresSubcortical arousal systemsCertain cortical regionsPrecuneus/posterior cingulateLateral parietal cortexNetwork activityActive inhibitionAltered consciousnessAbsence seizuresCortical deactivationCortical areasEpileptic seizuresAwake statePosterior cingulateParietal cortexSeizuresCortical regionsElectrophysiological modalities
2009
Brain imaging and electroconvulsive therapy
Peng K, Blumenfeld H. Brain imaging and electroconvulsive therapy. 2009, 94-108. DOI: 10.1017/cbo9780511576393.006.Peer-Reviewed Original ResearchElectroconvulsive therapyClinical practiceBrain stimulation therapyMedication therapyTreatment modalitiesAntipsychotic drugsStimulation therapyNeuromodulation therapiesPsychiatric treatmentTherapyBrain imagingBody healthClinical proceduresDrugsModalitiesElectroconvulsiveRecent refinementsSeizuresCliniciansBrainIMAGING | Functional MRI in Basic Epilepsy Research
Englot D, Blumenfeld H. IMAGING | Functional MRI in Basic Epilepsy Research. 2009, 539-544. DOI: 10.1016/b978-012373961-2.00023-0.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingInvasive electrophysiological techniquesPathophysiology of seizuresMagnetic resonance imagingWidespread brain networksUse of anestheticsBasic epilepsy researchConvulsive seizuresAnimal fMRI studiesSeizure onsetResonance imagingElectrophysiological techniquesFunctional MRIEpilepsy researchBrain functionSeizuresFMRI studyBrain networksEpilepsyFMRI investigationSignal changesImagingPathophysiologyAnestheticsMRI
2005
High resolution measurements of neuronal activity, cerebral blood flow, and fMRI during spike-wave seizures in WAG/Rij rats
Blumenfeld H, Nersesyan H, Khubchandani M, Schridde U, Berman R, Rothman D, Hyder F. High resolution measurements of neuronal activity, cerebral blood flow, and fMRI during spike-wave seizures in WAG/Rij rats. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s409-s409. DOI: 10.1038/sj.jcbfm.9591524.0409.Peer-Reviewed Original Research