Local variations in circuitry are key to brain’s power
Yale researchers studying how the human cortex performs its remarkable feats have shown that regional variations in brain local circuitry — not just long-distance connections between regions — help determine how well we think, perceive, and analyze the world around us.
Marriage of imaging and genetics opens new view of brain function
Neuroimaging has revolutionized the study of the brain, but can provide no information about what is actually happening at molecular level in humans. Scientists at Yale have developed new approaches to link gene expression patterns to brain signals captured by imaging.
New study reveals shift in global brain signals in schizophrenia
Schizophrenia (SCZ) is a disabling neuropsychiatric disease associated with disruptions across distributed neural systems. Resting-state functional magnetic resonance imaging has identified extensive abnormalities in the blood-oxygen level-dependent signal in SCZ patients, including alterations in the average signal over the brain—i.e. the “global” signal (GS). It remains unknown, however, if these “global” alterations occur pervasively or follow a spatially preferential pattern. This study presents the first network-by-network quantification of GS topography in healthy subjects and SCZ patients.
Anticevic Lab collaborates on neuroimaging study examining treatment in major depression.
Capitalizing on recent advances in resting state functional connectivity magnetic resonance imaging (rs-fcMRI) and the distinctive paradigm of rapid mood normalization following ketamine treatment, the current study investigated intrinsic brain networks in major depressive disorder (MDD) during a depressive episode and following treatment with ketamine.
Beyond behavior: Frontiers of neuroscience research
Driven by scientific curiosity and humanitarian concern, clinical neuroscientist Alan Anticevic, PhD and other Yale researchers are trying to understand the mechanisms of the brain in a deeper, more systematic way for the benefit of people with mental health problems.
New research division within Department of Psychiatry will focus on neurocognition, neurocomputation, and neurogenetics
Yale Department of Psychiatry is pleased to announce the creation of a new research division that will focus on systems neuroscience in psychiatry, combining cognitive, computational and genetic approaches. This new division, named Neurocognition, Neurocomputation, and Neurogenetics (N3), will be co-directed by David Glahn, PhD, professor of psychiatry, and Alan Anticevic, PhD, assistant professor of psychiatry and of psychology.
Too much of a bad thing: Schizophrenia onset linked to elevated neural links
In its chronic stage, schizophrenia is typically marked by a dearth of links between brain cells in the prefrontal cortex, the region of the brain responsible for higher-order thinking. However, a new study by Yale and Chinese researchers shows that the onset of the disease — usually in the early 20s — is marked by an abnormal spike in neural connections.
NIMH highlights Yale research in a sampling of summer science
Thomas Insel, MD, director of the National Institute of Mental Health, touts Yale-led research as offering "real promise for understanding how cortical function becomes dysregulated in people prone to psychosis" and as an important step towards detecting risk for schizophrenia.
Shared brain disruption illustrates similarities between mental illnesses
A specific brain disruption is present both in individuals diagnosed with schizophrenia and those with bipolar disorder, adding to evidence that many mental illnesses have biological similarities. The brain activity patterns identified by Yale University researchers and reported online July 3 in the journal Cerebral Cortex may serve as important biomarkers for diagnostic classification of complex psychiatric illnesses.
Anticevic receives Young Investigator Award at 14th International Congress on Schizophrenia Research
Alan Anticevic, PhD, associate research scientist in psychiatry at Yale School of Medicine, is the recipient of a Young Investigator Award at the 14th International Congress on Schizophrenia Research (ICOSR). ICOSR is a biennial meeting where scientists involved with discovery in schizophrenia gather to exchange data, techniques, and ideas.
Young investigator is first Yale recipient of NIH Early Independence Award
Alan Anticevic, PhD, associate research scientist in psychiatry at Yale School of Medicine, is one of fourteen recipients of the NIH Director's Early Independence Award. The award recognizes talented junior scientists and accelerates their transition to independent research. Anticevic is the first Yale investigator to receive the honor.
Research team uses pharmacological neuroimaging and computational modeling to provide clues about large-scale brain systems
A team led by Yale researchers has used pharmacological neuroimaging and computational modeling to examine large-scale functional organization in the human brain. Their novel approach has yielded important insights about how disruption of a specific molecular signaling mechanism within neural systems may contribute to symptoms of schizophrenia. The results are reported online ahead of print in the Proceedings of the National Academy of Sciences.