Vector Parasite/Symbiont Interactions Publications

Gloria-Soria A, Dunn WA, Yu X, Vigneron A, Lee KY, Li M, Weiss BL, Zhao H, Aksoy S, Caccone A. Uncovering Genomic Regions Associated with Trypanosoma Infections in Wild Populations of the Tsetse Fly Glossina fuscipes. G3 (Bethesda). 2018 Jan 17. pii: g3.300493.2017. doi: 10.1534/g3.117.300493. [Epub ahead of print] PubMed PMID: 29343494.

Bateta R, Wang J, Wu Y, Weiss BL, Warren WC, Murilla GA, Aksoy S, Mireji PO. Tsetse fly (Glossina pallidipes) midgut responses to Trypanosoma brucei challenge. Parasit Vectors. 2017 Dec 19;10(1):614. doi: 10.1186/s13071-017-2569-7. PubMed PMID: 29258576; PubMed Central PMCID: PMC5738168.

Benoit JB, Vigneron A, Broderick NA, Wu Y, Sun JS, Carlson JR, Aksoy S, Weiss BL. Symbiont-induced odorant binding proteins mediate insect host hematopoiesis. Elife. 2017 Jan 12;6. pii: e19535. doi: 10.7554/eLife.19535. PubMed PMID: 28079523; PubMed Central PMCID: PMC5231409.

Savage AF, Kolev NG, Franklin JB, Vigneron A, Aksoy S, Tschudi C. Transcriptome Profiling of Trypanosoma brucei Development in the Tsetse Fly Vector Glossina morsitans. PLoS One. 2016 Dec 21;11(12):e0168877. doi: 10.1371/journal.pone.0168877. eCollection 2016. PubMed PMID: 28002435; PubMed Central PMCID: PMC5176191.

Aksoy E, Vigneron A, Bing X, Zhao X, O'Neill M, Wu YN, Bangs JD, Weiss BL, Aksoy S. Mammalian African trypanosome VSG coat enhances tsetse's vector competence. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6961-6. doi: 10.1073/pnas.1600304113. Epub 2016 May 16. PubMed PMID: 27185908; PubMed Central PMCID: PMC4922192.

Gilbert JA, Medlock J, Townsend JP, Aksoy S, Ndeffo Mbah M, Galvani AP. Determinants of Human African Trypanosomiasis Elimination via Paratransgenesis. PLoS Negl Trop Dis. 2016 Mar 8;10(3):e0004465. doi: 10.1371/journal.pntd.0004465. eCollection 2016 Mar. PubMed PMID: 26954675; PubMed Central PMCID: PMC4783105.

Hrusa G, Farmer W, Weiss BL, Applebaum T, Roma JS, Szeto L, Aksoy S, Runyen-Janecky LJ. TonB-dependent heme iron acquisition in the tsetse fly symbiont Sodalis glossinidius. Appl Environ Microbiol. 2015 Apr;81(8):2900-9. doi: 10.1128/AEM.04166-14. Epub 2015 Feb 13. PubMed PMID: 25681181; PubMed Central PMCID: PMC4375324.

Aksoy S, Weiss BL, Attardo GM. Trypanosome Transmission Dynamics in Tsetse. Curr Opin Insect Sci. 2014 Sep;3:43-49. PubMed PMID: 25580379; PubMed Central PMCID: PMC4286356.

Weiss BL, Savage AF, Griffith BC, Wu Y, Aksoy S. The peritrophic matrix mediates differential infection outcomes in the tsetse fly gut following challenge with commensal, pathogenic, and parasitic microbes. Journal of immunology. 2014;193(2):773-82. doi: 10.4049/jimmunol.1400163. PubMed PMID: 24913976; PMCID: 4107339.

Michalkova V, Benoit JB, Weiss BL, Attardo GM, Aksoy S. Vitamin B6 generated by obligate symbionts is critical for maintaining proline homeostasis and fecundity in tsetse flies. Applied and environmental microbiology. 2014;80(18):5844-53. doi: 10.1128/AEM.01150-14. PubMed PMID: 25038091; PMCID: 4178588.

Brelsfoard C, Tsiamis G, Falchetto M, Gomulski LM, Telleria E, Alam U, Doudoumis V, Scolari F, Benoit JB, Swain M, Takac P, Malacrida AR, Bourtzis K, Aksoy S. Presence of extensive Wolbachia symbiont insertions discovered in the genome of its host Glossina morsitans morsitans. PLoS neglected tropical diseases. 2014;8(4):e2728. doi: 10.1371/journal.pntd.0002728. PubMed PMID: 24763283; PMCID: 3998919.

Aksoy S, Weiss BL, Attardo GM. Trypanosome Transmission Dynamics in Tsetse. Current opinion in insect science. 2014;3:43-9. doi: 10.1016/j.cois.2014.07.003. PubMed PMID: 25580379; PMCID: 4286356.

Aksoy E, Telleria EL, Echodu R, Wu Y, Okedi LM, Weiss BL, Aksoy S, Caccone A. Analysis of multiple tsetse fly populations in Uganda reveals limited diversity and species-specific gut microbiota. Applied and environmental microbiology. 2014;80(14):4301-12. doi: 10.1128/AEM.00079-14. PubMed PMID: 24814785; PMCID: 4068677.

Weiss BL, Wang J, Maltz MA, Wu Y, Aksoy S. Trypanosome infection establishment in the tsetse fly gut is influenced by microbiome-regulated host immune barriers. PLoS pathogens. 2013;9(4):e1003318. doi: 10.1371/journal.ppat.1003318. PubMed PMID: 23637607; PMCID: 3630092.

Wang J, Weiss BL, Aksoy S. Tsetse fly microbiota: form and function. Frontiers in cellular and infection microbiology. 2013;3:69. doi: 10.3389/fcimb.2013.00069. PubMed PMID: 24195062; PMCID: 3810596.

Wang J, Brelsfoard C, Wu Y, Aksoy S. Intercommunity effects on microbiome and GpSGHV density regulation in tsetse flies. Journal of invertebrate pathology. 2013;112 Suppl:S32-9. doi: 10.1016/j.jip.2012.03.028. PubMed PMID: 22874746; PMCID: 3772524.

Wamwiri FN, Alam U, Thande PC, Aksoy E, Ngure RM, Aksoy S, Ouma JO, Murilla GA. Wolbachia, Sodalis and trypanosome co-infections in natural populations of Glossina austeni and Glossina pallidipes. Parasites & vectors. 2013;6(1):232. doi: 10.1186/1756-3305-6-232. PubMed PMID: 23924682; PMCID: 3751944.

Symula RE, Alam U, Brelsfoard C, Wu Y, Echodu R, Okedi LM, Aksoy S, Caccone A. Wolbachia association with the tsetse fly, Glossina fuscipes fuscipes, reveals high levels of genetic diversity and complex evolutionary dynamics. BMC evolutionary biology. 2013;13:31. doi: 10.1186/1471-2148-13-31. PubMed PMID: 23384159; PMCID: 3574847.

Smith CL, Weiss BL, Aksoy S, Runyen-Janecky LJ. Characterization of the achromobactin iron acquisition operon in Sodalis glossinidius. Applied and environmental microbiology. 2013;79(9):2872-81. doi: 10.1128/AEM.03959-12. PubMed PMID: 23435882; PMCID: 3623160.

Medlock J, Atkins KE, Thomas DN, Aksoy S, Galvani AP. Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. PLoS neglected tropical diseases. 2013;7(8):e2374. doi: 10.1371/journal.pntd.0002374. PubMed PMID: 23967363; PMCID: 3744416.

Echodu R, Sistrom M, Hyseni C, Enyaru J, Okedi L, Aksoy S, Caccone A. Genetically distinct Glossina fuscipes fuscipes populations in the Lake Kyoga region of Uganda and its relevance for human African trypanosomiasis. BioMed research international. 2013;2013:614721. doi: 10.1155/2013/614721. PubMed PMID: 24199195; PMCID: 3807537.

Doudoumis V, Alam U, Aksoy E, Abd-Alla AM, Tsiamis G, Brelsfoard C, Aksoy S, Bourtzis K. Tsetse-Wolbachia symbiosis: comes of age and has great potential for pest and disease control. Journal of invertebrate pathology. 2013;112 Suppl:S94-103. doi: 10.1016/j.jip.2012.05.010. PubMed PMID: 22835476; PMCID: 3772542.

Balmand S, Lohs C, Aksoy S, Heddi A. Tissue distribution and transmission routes for the tsetse fly endosymbionts. Journal of invertebrate pathology. 2013;112 Suppl:S116-22. doi: 10.1016/j.jip.2012.04.002. PubMed PMID: 22537833; PMCID: 3772537.

Abd-Alla AM, Bergoin M, Parker AG, Maniania NK, Vlak JM, Bourtzis K, Boucias DG, Aksoy S. Improving Sterile Insect Technique (SIT) for tsetse flies through research on their symbionts and pathogens. Journal of invertebrate pathology. 2013;112 Suppl:S2-10. doi: 10.1016/j.jip.2012.07.009. PubMed PMID: 22841636; PMCID: 4242710.

Weiss BL, Maltz M, Aksoy S. Obligate symbionts activate immune system development in the tsetse fly. J Immunol. 2012 Apr 1;188(7):3395-403. Epub 2012 Feb 24. PubMed PMID: 22368278; PubMed Central PMCID: PMC3311772.

Wang J, Aksoy S. PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse's offspring. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(26):10552-7. doi: 10.1073/pnas.1116431109. PubMed PMID: 22689989; PMCID: 3387098.

Savage AF, Cerqueira GC, Regmi S, Wu Y, El Sayed NM, Aksoy S. Transcript expression analysis of putative Trypanosoma brucei GPI-anchored surface proteins during development in the tsetse and mammalian hosts. PLoS neglected tropical diseases. 2012;6(6):e1708. doi: 10.1371/journal.pntd.0001708. PubMed PMID: 22724039; PMCID: 3378594.

Rio RV, Symula RE, Wang J, Lohs C, Wu YN, Snyder AK, Bjornson RD, Oshima K, Biehl BS, Perna NT, Hattori M, Aksoy S. Insight into the transmission biology and species-specific functional capabilities of tsetse (Diptera: glossinidae) obligate symbiont wigglesworthia. MBio. 2012 Feb 14;3(1). pii: e00240-11. doi: 10.1128/mBio.00240-11. Print 2012. PubMed PMID: 22334516; PubMed Central PMCID: PMC3280448.

Maltz MA, Weiss BL, O'Neill M, Wu Y, Aksoy S. OmpA-mediated biofilm formation is essential for the commensal bacterium Sodalis glossinidius to colonize the tsetse fly gut. Applied and environmental microbiology. 2012;78(21):7760-8. doi: 10.1128/AEM.01858-12. PubMed PMID: 22941073; PMCID: 3485708.

Doudoumis V, Tsiamis G, Wamwiri F, Brelsfoard C, Alam U, Aksoy E, Dalaperas S, Abd-Alla A, Ouma J, Takac P, Aksoy S, Bourtzis K. Detection and characterization of Wolbachia infections in laboratory and natural populations of different species of tsetse flies (genus Glossina). BMC Microbiol. 2012 Jan 18;12 Suppl 1:S3. [Epub ahead of print] PubMed PMID: 22376025; PubMed Central PMCID: PMC3287514.

Alam U, Hyseni C, Symula RE, Brelsfoard C, Wu Y, Kruglov O, Wang J, Echodu R, Alioni V, Okedi LM, Caccone A, Aksoy S. Implications of microfauna-host interactions for trypanosome transmission dynamics in Glossina fuscipesfuscipes in Uganda. Applied and environmental microbiology. 2012;78(13):4627-37. doi: 10.1128/AEM.00806-12. PubMed PMID: 22544247; PMCID: 3370491.

Weiss BL, Wang J, Aksoy S. Tsetse immune system maturation requires the presence of obligate symbionts in larvae. PLoS biology. 2011;9(5):e1000619. doi: 10.1371/journal.pbio.1000619. PubMed PMID: 21655301; PMCID: 3104962.

Weiss B, Aksoy S. Microbiome influences on insect host vector competence. Trends in parasitology. 2011;27(11):514-22. doi: 10.1016/j.pt.2011.05.001. PubMed PMID: 21697014; PMCID: 3179784.

Symula RE, Marpuri I, Bjornson RD, Okedi L, Beadell J, Alam U, Aksoy S, Caccone A. Influence of host phylogeographic patterns and incomplete lineage sorting on within-species genetic variability in Wigglesworthia species, obligate symbionts of tsetse flies. Appl Environ Microbiol. 2011 Dec;77(23):8400-8. Epub 2011 Sep 23. PubMed PMID: 21948847; PubMed Central PMCID: PMC3233068.

Alam U, Medlock J, Brelsfoard C, Pais R, Lohs C, Balmand S, Carnogursky J, Heddi A, Takac P, Galvani A, Aksoy S. Wolbachia symbiont infections induce strong cytoplasmic incompatibility in the tsetse fly Glossina morsitans. PLoS Pathog. 2011 Dec;7(12):e1002415. Epub 2011 Dec 8. PubMed PMID: 22174680; PubMed Central PMCID: PMC3234226.

Weiss B, Aksoy S. Microbiome influences on insect host vector competence. Trends Parasitol. 2011 Nov;27(11):514-22. Epub 2011 Jun 21. Review. PubMed PMID: 21697014; PubMed Central PMCID: PMC3179784.

Weiss BL, Wang J, Aksoy S. Tsetse immune system maturation requires the presence of obligate symbionts in larvae. PLoS Biol. 2011 May;9(5):e1000619. Epub 2011 May 31. PubMed PMID: 21655301; PubMed Central PMCID: PMC3104962.

Wang J, Wu Y, Yang G, Aksoy S. Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12133-8. Epub 2009 Jul 8. PubMed PMID: 19587241; PubMed Central PMCID: PMC2715537.

Pais R, Lohs C, Wu Y, Wang J, Aksoy S. The obligate mutualist Wigglesworthia glossinidia influences reproduction, digestion, and immunity processes of its host, the tsetse fly. Appl Environ Microbiol. 2008 Oct;74(19):5965-74. Epub 2008 Aug 8. PubMed PMID: 18689507; PubMed Central PMCID: PMC2565960.

Weiss BL, Wu Y, Schwank JJ, Tolwinski NS, Aksoy S. An insect symbiosis is influenced by bacterium-specific polymorphisms in outer-membrane protein A. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15088-93. Epub 2008 Sep 24. PubMed PMID: 18815366; PubMed Central PMCID: PMC2567497.

Savage AF, Cerqueira GC, Regmi S, Wu Y, El Sayed NM, Aksoy S. Transcript Expression Analysis of Putative Trypanosoma brucei GPI-Anchored Surface Proteins during Development in the Tsetse and Mammalian Hosts. PLoS Negl Trop Dis. 2012 Jun;6(6):e1708. Epub 2012 Jun 19. PubMed PMID: 22724039.

Wang J, Hu C, Wu Y, Stuart A, Amemiya C, Berriman M, Toyoda A, Hattori M, Aksoy S. Characterization of the antimicrobial peptide attacin loci from Glossina morsitans. Insect Mol Biol. 2008 Jun;17(3):293-302. PubMed PMID: 18477243; PubMed Central PMCID: PMC2656931.

Aksoy S, Weiss B, Attardo G. Paratransgenesis applied for control of tsetse transmitted sleeping sickness. Adv Exp Med Biol. 2008;627:35-48. Review. PubMed PMID: 18510012.

Nayduch D, Aksoy S. Refractoriness in tsetse flies (Diptera: Glossinidae) may be a matter of timing. J Med Entomol. 2007 Jul;44(4):660-5. PubMed PMID: 17695022.

Dasgupta R, Free HM, Zietlow SL, Paskewitz SM, Aksoy S, Shi L, Fuchs J, Hu C, Christensen BM. Replication of flock house virus in three genera of medically important insects. J Med Entomol. 2007 Jan;44(1):102-10. PubMed PMID: 17294927.

Weiss BL, Mouchotte R, Rio RV, Wu YN, Wu Z, Heddi A, Aksoy S. Interspecific transfer of bacterial endosymbionts between tsetse fly species: infection establishment and effect on host fitness. Appl Environ Microbiol. 2006 Nov;72(11):7013-21. Epub 2006 Sep 1. PubMed PMID: 16950907; PubMed Central PMCID: PMC1636136.

Hu C, Aksoy S. Innate immune responses regulate trypanosome parasite infection of the tsetse fly Glossina morsitans morsitans. Mol Microbiol. 2006 Jun;60(5):1194-204. PubMed PMID: 16689795.

Rio RV, Wu YN, Filardo G, Aksoy S. Dynamics of multiple symbiont density regulation during host development: tsetse fly and its microbial flora. Proc Biol Sci. 2006 Apr 7;273(1588):805-14. PubMed PMID: 16618673; PubMed Central PMCID: PMC1560226.

Toh H, Weiss BL, Perkin SA, Yamashita A, Oshima K, Hattori M, Aksoy S. Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host. Genome Res. 2006 Feb;16(2):149-56. Epub 2005 Dec 19. PubMed PMID: 16365377; PubMed Central PMCID: PMC1361709.

Aksoy S, Rio RV. Interactions among multiple genomes: tsetse, its symbionts and trypanosomes. Insect Biochem Mol Biol. 2005 Jul;35(7):691-8. Epub 2005 Mar 28. Review. Erratum in: Insect Biochem Mol Biol. 2008 Nov;38(11):1033. PubMed PMID: 15894186.

Hu Y, Aksoy S. An antimicrobial peptide with trypanocidal activity characterized from Glossina morsitans morsitans. Insect Biochem Mol Biol. 2005 Feb;35(2):105-15. PubMed PMID: 15681221.

Lehane MJ, Aksoy S, Levashina E. Immune responses and parasite transmission in blood-feeding insects. Trends Parasitol. 2004 Sep;20(9):433-9. Review. PubMed PMID: 15324734.

Rio RV, Hu Y, Aksoy S. Strategies of the home-team: symbioses exploited for vector-borne disease control. Trends Microbiol. 2004 Jul;12(7):325-36. Review. PubMed PMID: 15223060.

Hao Z, Kasumba I, Aksoy S. Proventriculus (cardia) plays a crucial role in immunity in tsetse fly (Diptera: Glossinidiae). Insect Biochem Mol Biol. 2003 Nov;33(11):1155-64. PubMed PMID: 14563366.

Aksoy S. Control of tsetse flies and trypanosomes using molecular genetics. Vet Parasitol. 2003 Jul 25;115(2):125-45. Review. PubMed PMID: 12878419.

Aksoy S, Gibson WC, Lehane MJ. Interactions between tsetse and trypanosomes with implications for the control of trypanosomiasis. Adv Parasitol. 2003;53:1-83. Review. PubMed PMID: 14587696.

Haines LR, Haddow JD, Aksoy S, Gooding RH, Pearson TW. The major protein in the midgut of teneral Glossina morsitans morsitans is a molecular chaperone from the endosymbiotic bacterium Wigglesworthia glossinidia. Insect Biochem Mol Biol. 2002 Nov;32(11):1429-38. PubMed PMID: 12530210.

Aksoy S, Hao Z, Strickler PM. What can we hope to gain for trypanosomiasis control from molecular studies on tsetse biology? Kinetoplastid Biol Dis. 2002 Jun 6;1(1):4. PubMed PMID: 12234385; PubMed Central PMCID: PMC119325.

Hao Z, Kasumba I, Lehane MJ, Gibson WC, Kwon J, Aksoy S. Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12648-53. Epub 2001 Oct 9. PubMed PMID: 11592981; PubMed Central PMCID: PMC60108.

Akman L, Aksoy S. A novel application of gene arrays: Escherichia coli array provides insight into the biology of the obligate endosymbiont of tsetse flies. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7546-51. Epub 2001 Jun 12. PubMed PMID: 11404467; PubMed Central PMCID: PMC34705.

Aksoy S, Maudlin I, Dale C, Robinson AS, O'Neill SL. Prospects for control of African trypanosomiasis by tsetse vector manipulation. Trends Parasitol. 2001 Jan;17(1):29-35. PubMed PMID: 11137738.

Cheng Q, Ruel TD, Zhou W, Moloo SK, Majiwa P, O'Neill SL, Aksoy S. Tissue distribution and prevalence of Wolbachia infections in tsetse flies, Glossina spp. Med Vet Entomol. 2000 Mar;14(1):44-50. PubMed PMID: 10759311.

Aksoy S. Tsetse--A haven for microorganisms. Parasitol Today. 2000 Mar;16(3):114-8. Review. PubMed PMID: 10689331.

Cheng Q, Aksoy S. Tissue tropism, transmission and expression of foreign genes in vivo in midgut symbionts of tsetse flies. Insect Mol Biol. 1999 Feb;8(1):125-32. PubMed PMID: 9927181.

Chen X, Li S, Aksoy S. Concordant evolution of a symbiont with its host insect species: molecular phylogeny of genus Glossina and its bacteriome-associated endosymbiont, Wigglesworthia glossinidia. J Mol Evol. 1999 Jan;48(1):49-58. PubMed PMID: 9873076.

Aksoy S, Chen X, Hypsa V. Phylogeny and potential transmission routes of midgut-associated endosymbionts of tsetse (Diptera:Glossinidae). Insect Mol Biol. 1997 May;6(2):183-90. PubMed PMID: 9099582.

Aksoy S. Wigglesworthia gen. nov. and Wigglesworthia glossinidia sp. nov., taxa consisting of the mycetocyte-associated, primary endosymbionts of tsetse flies. Int J Syst Bacteriol. 1995 Oct;45(4):848-51. PubMed PMID: 7547309.

Aksoy S, Pourhosseini AA, Chow A. Mycetome endosymbionts of tsetse flies constitute a distinct lineage related to Enterobacteriaceae. Insect Mol Biol. 1995 Feb;4(1):15-22. PubMed PMID: 7742973.

Aksoy S. Molecular analysis of the endosymbionts of tsetse flies: 16S rDNA locus and over-expression of a chaperonin. Insect Mol Biol. 1995 Feb;4(1):23-9. PubMed PMID: 7538012.

O'Neill SL, Gooding RH, Aksoy S. Phylogenetically distant symbiotic microorganisms reside in Glossina midgut and ovary tissues. Med Vet Entomol. 1993 Oct;7(4):377-83. PubMed PMID: 8268495.

Beard CB, O'Neill SL, Mason P, Mandelco L, Woese CR, Tesh RB, Richards FF, Aksoy S. Genetic transformation and phylogeny of bacterial symbionts from tsetse. Insect Mol Biol. 1993;1(3):123-31. PubMed PMID: 8269090.