Proteomes Journal Special Issue "Neuroproteomics"
As described in more detail in the accompanying Editorial, the articles in the Neuroproteomics Special Issue, which soon will be published as a book, provide an overview of the unique challenges that must be addressed to carry out meaningful MS/proteomics analyses on neural tissues and the tools and technologies that are available to meet these challenges. The several articles that cover drug addiction, as well as Alzheimer’s Disease, and schizophrenia illustrate how MS/proteomics technologies can be used to help improve our ability to diagnose and understand the molecular basis for neurological diseases. We believe that several of the articles in this Special Issue also will be of interest to investigators beyond the field of neurological disorders. In particular, the review by Carlyle et al (2018), “Proteomic Approaches for the Discovery of Biofluid Biomarkers of Neurodegenerative Dementias”, may be of interest to investigators searching for blood and CSF biomarkers for virtually any disease. Similarly, the review by Natividad et al (2018), “From Synapse to Function, A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction”, provides a general overview of the utility of MS/proteomics approaches for addressing critical questions in addiction neuroscience that should be equally applicable to investigators involved in virtually any area of biomedical research. Likewise, the article by Wilson et al (2019), “Development of Targeted Mass Spectrometry-Based Approaches for Quantitation of Proteins Enriched in the Postsynaptic Density”, may be useful for any investigator who wishes to design and validate DIA and/or PRM assays for virtually any proteins. Finally, the peroxidase-mediated proximity labeling technology described in the article by Cijsouw et al (2018), “Mapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins”, may be of interest to investigators interested in mapping many other spatially restricted proteomes.
Dr. Kenneth R. Williams