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Yale/NIDA Neuroproteomics Center Pilot Research Project Grants

The goals of the Pilot Research Projects Program of the Yale/NIDA Neuroproteomics Center are to encourage young investigators working in our Center’s laboratories to embark on careers in substance abuse research, disseminate the Center’s core technologies to researchers investigating the neurobiology of addiction who are not yet using neuroproteomics technologies, and to expand the technical abilities of the Center. Pilot Research Projects Grants provide short term funding to obtain preliminary data so that applicants can apply to funding agencies for longer term grant support. These awards provide free access to all of the Center's Cores and Technologies as well as a small amount of funding (up to $7,500 Direct Costs together with the associated Indirect Costs to non-Yale universities) to help pay for the cost of preparing and analyzing proteomic samples in the Center’s Cores:

Applications will be accepted from: 1) Center investigators and 2) their Graduate Students, Postdoctoral Fellows, and higher level research staff who will need mentoring from their own PI’s, as well as extensive training from Center Core staff; 3) non-Center investigators expert in substance abuse with interests in initiating research in neuroproteomics who also will need proteomics training and 4) non-Center investigators with expertise in cellular and molecular aspects of neuronal signaling with interests in initiating neuroproteomics research who can learn from Center PIs and Core staff about how to apply their molecular expertise to problems related to drugs of abuse.

Awards will be for one year for research that is directly related to the Center’s theme of the “Proteomics of Altered Signaling in Addiction":

and that proposes either to apply existing technologies available from the Cores or to develop new technologies. Awards to non-Center investigators will be accompanied by Center membership for at least the term of the award. Awardees must agree to provide a short progress report to support the Centers’ annual grant applications and to give a seminar at one of the Center’s Research in Progress Meetings. Priority will be given to new projects that are directly related to our Center’s theme, to collaborative projects involving multiple investigators, and to Technology Development projects. The receipt deadline for the next round of Pilot Research Project grant applications for Grant Year 15 is June 5, 2019.

Applications should follow PHS398 format except the Research Plan (items #2-5 below) is limited to 3 pages or less:

  1. Title Page and Project Summary: the first page of the application should contain the name/title of the PI, institution, and a 500 or less word Project Summary
  2. Specific Aims (including the title of the proposed research project)
  3. Significance
  4. Innovation
  5. Approach (must address the review criteria outlined below and include Preliminary Results if applicable)
  6. Literature Cited (this section is not included in the 3 page limit)
  7. Budget: for the purpose of the application this section only needs a 1-2 sentence general description of the proposed use of the funds. Successful applicants will need to submit a detailed NIH-style budget prior to award.
  8. NIH-style Biographical Sketch of the proposed PI

Criteria for review will include:

  1. Scientific merit as judged by the significance and innovation of the proposed research.
  2. Relevance to the Center’s theme of "Proteomics of Altered Signaling in Addiction"
  3. Does the proposal use one or more of the Center’s cores effectively or does it propose to develop a new or improve an existing technology that is likely to benefit the Center?
  4. Is the application from an investigator who qualifies under one of the four applicant categories?
  5. Will the proposal develop biotechnology, bioinformatics, or biostatistics resources or tools that may directly benefit the research programs of multiple Center investigators?
  6. In addition, higher priority is given to applications that: a) are from young investigators as one of the goals of the pilot projects grant program is to enable promising young researchers to obtain sufficient preliminary data to support NIH and other grant applications that we hope will help to launch successful careers in substance abuse research, b) originate from new projects/directions or from Center investigators who have not yet used the Center’s cores, and c) involve collaborative research by investigators from multiple Center laboratories.

With a short application, the opportunity of getting technical advice from Center leaders before submitting and after review, and fast review cycles; Pilot Project grant applications provide a wonderful opportunity for young investigators to gain valuable grant writing experience and for more established investigators to obtain the funding and access to the core technologies needed to obtain the preliminary data that is essential for embarking on new research directions. In addition, Pilot Project grantees who successfully complete their projects and who are not Center investigators are considered for full membership in the Center.

Applications should be submitted by 6/5/19 as pdf email attachments to the Director of the Pilot Research Projects Core: