John Rose, PhD

Professor Emeritus of Pathology and Senior Research Scientist; Director, Molecular Virology Program

Departments & Organizations

Pathology: Experimental Pathology Graduate Program | Pathology Research | Rose Lab

Molecular Virology: Virology Laboratories

Yale Cancer Center: Virus and Other Infection-associated Cancers

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development

Office of Cooperative Research


Dr. Rose earned his Ph.D. at Stanford University in 1973 in the laboratory of Dr. Charles Yanofsky. His thesis research focused on regulation of the tryptophan operon of E. coli. He then did postdoctoral research at MIT in the laboratories of Drs. David Baltimore and Harvey Lodish, where he began work on eucaryotic RNA viruses. In 1978, Dr. Rose took a faculty position at the Salk Institute, where he continued work on RNA virus transcription, as well as structure, function, and transport of the vesicular stomatitis virus (VSV) glycoprotein. In 1986, he moved to become Professor of Pathology and Cell Biology at Yale University School of Medicine. In 1994, his laboratory developed a system for recovering non-segmented, negative-strand RNA viruses from DNA plasmids. His work at Yale during the past fifteen years has focused largely on new approaches to vaccine development using vectors based on recombinant VSV and other viral replicons. This work has led to development of robust vaccine platforms that can protect animals against numerous viral and bacterial pathogens, typically after a single dose. A VSV-based HIV vaccine advanced from the Rose laboratory has recently completed a successful Phase I clinical trial.

Education & Training

PhD Stanford University (1973)
BS Brandeis University (1969)
Fellow Massachusetts Institute of Technology

Honors & Recognition

  • National Institutes of Health MERIT award, 2003-2012 NIH

  • National Institutes of Health MERIT award, 1986-1996NIH

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Contact Info

John Rose, PhD
Office Location
Department of PathologyLauder Hall
310 Cedar Street, Ste LH 315C

New Haven, CT 06510
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Mailing Address
Pathology310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Rose Lab