Christine Miller, DO
she/her/hers
Clinical FellowDownloadHi-Res Photo
About
Titles
Clinical Fellow
Appointments
Pediatric Infectious Diseases
Clinical FellowPrimaryPediatric Infectious Diseases
InstructorSecondary
Other Departments & Organizations
Education & Training
- Infectious Disease Fellow
- Yale School of Medicine (2024)
- Pediatric Resident
- University of Massachusetts Chan Medical School (2021)
- DO
- Touro College of Osteopathic Medicine (2018)
- BS
- Bucknell University, Biology (2008)
Board Certifications
General Pediatrics
- Certification Organization
- American Academy of Pediatrics
- Original Certification Date
- 2021
Research
Overview
Post-acute infection syndromes (PAIS) are a poorly understood area of medicine that occur after a patient experiences an infection and either fails to recover, or temporarily recovers followed by a recurrence of their symptoms. PAIS affect both children and adults and can result in significant debilitation and poor quality of life. Symptoms of PAIS are often heterogenous and subsequently difficulty to diagnose and treat. The goal of my research is to identify specific biomarkers for PAIS for more accurate diagnoses and targeted therapy.
Medical Research Interests
Epstein-Barr Virus Infections; Gammaherpesvirinae; Herpesviridae Infections; Pediatrics; SARS-CoV-2
ORCID
0000-0003-0486-5047
Research at a Glance
Yale Co-Authors
Frequent collaborators of Christine Miller's published research.
Publications Timeline
A big-picture view of Christine Miller's research output by year.
Research Interests
Research topics Christine Miller is interested in exploring.
Carlos R Oliveira, MD, PhD
Akiko Iwasaki, PhD
Camila Aparicio, MD
Cynthia Brandt, MD, MPH
Elijah Paintsil, FAAP, MD
Emma Taylor-Salmon, MD
19Publications
3,423Citations
SARS-CoV-2
Pediatrics
Publications
2024
Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review
Miller C, Borre C, Green A, Funaro M, Oliveira C, Iwasaki A. Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review. American Journal Of Medicine Open 2024, 12: 100078. PMID: 39639960, PMCID: PMC11617896, DOI: 10.1016/j.ajmo.2024.100078.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical epidemiologyPost-acute sequelae of COVID-19High risk of biasLack of standardized definitionsPost-acute sequelaeRisk of biasSequelae of COVID-19United StatesScoping reviewComprehensive literature searchUS childrenShort follow-up durationFollow-up durationInclusion criteriaFemale sexOlder ageRisk factorsSARS-CoV-2 infectionLiterature searchChest painHigh riskOptimal preventionPediatric patientsPersistent symptomsCOVID-19Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis
Aparicio C, Willis Z, Nakamura M, Wolf J, Little C, Maron G, Sue P, Anosike B, Miller C, Bio L, Singh P, James S, Oliveira C. Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis. Journal Of The Pediatric Infectious Diseases Society 2024, 13: 352-362. PMID: 38780125, PMCID: PMC11519042, DOI: 10.1093/jpids/piae052.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOdds ratioCritical COVID-19Absolute riskMeta-analysisSystematic reviewRisk stratificationConfidence intervalsInvasive mechanical ventilation requirementRisk factorsEstimate pooled odds ratiosSignificant ORsKey risk factorsPooled odds ratioCritical diseaseIntensive care unit admissionStatistically significant ORsMechanical ventilation requirementRandom-effects modelRisk of critical diseaseChronic pulmonary conditionsHealth conditionsIndependent reviewersPooled ORInclusion criteriaCOVID-19Guidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce
Willis Z, Oliveira C, Abzug M, Anosike B, Ardura M, Bio L, Boguniewicz J, Chiotos K, Downes K, Grapentine S, Hersh A, Heston S, Hijano D, Huskins W, James S, Jones S, Lockowitz C, Lloyd E, MacBrayne C, Maron G, McDonough M, Miller C, Morton T, Olivero R, Orscheln R, Schwenk H, Singh P, Soma V, Sue P, Vora S, Nakamura M, Wolf J. Guidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce. Journal Of The Pediatric Infectious Diseases Society 2024, 13: 159-185. PMID: 38339996, PMCID: PMC11494238, DOI: 10.1093/jpids/piad116.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRisk factorsRisk stratificationPediatric intensive care medicineEffects of therapyNon-hospitalized childrenPediatric infectious diseasesSevere COVID-19Cases of infectionMeta-analysis of dataIntensive care medicineClinical characteristicsPreventive therapyPediatric populationManagement of COVID-19Fatal infectionConsensus statementSevere illnessTherapyMeta-analysisTherapeutic interventionsSARS-CoV-2Expert consensusCare medicineRe-convenedGuidance statements
2023
Progressive shingles in a toddler due to reactivation of Varicella Zoster vaccine virus four days after infection with SARS-CoV-2; a case report
Miller C, Taylor-Salmon E, Emuren L, Landry M, Gershon A, Miller G. Progressive shingles in a toddler due to reactivation of Varicella Zoster vaccine virus four days after infection with SARS-CoV-2; a case report. BMC Infectious Diseases 2023, 23: 854. PMID: 38057696, PMCID: PMC10698951, DOI: 10.1186/s12879-023-08809-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVaricella-zoster virusVZV reactivationVaccine-strain varicella-zoster virusSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Latent varicella zoster virusSymptomatic COVID-19 infectionRespiratory syndrome coronavirus 2SARS-CoV2 infectionSyndrome coronavirus 2COVID-19 infectionVaccine-type strainsSARS-CoV-2Vesicular rashPediatric patientsSignificant morbidityClinical syndromeCoronavirus 2Single doseCase reportGeneral populationMechanical traumaDisease processHZ casesPhysiologic stressSeizure as Presenting Symptom of Multisystem Inflammatory Syndrome in Children
D’Ambrosio E, Gauguet S, Miller C, McMahon E, Driscoll C, Mohanty M, Guggina T. Seizure as Presenting Symptom of Multisystem Inflammatory Syndrome in Children. Case Reports In Infectious Diseases 2023, 2023: 3581310. PMID: 37456213, PMCID: PMC10349669, DOI: 10.1155/2023/3581310.Peer-Reviewed Original ResearchConceptsMIS-CMultisystem inflammatory syndromeNew-onset seizuresPresenting symptomsInflammatory syndromeDiagnosis of multisystem inflammatory syndromeSevere cardiac dysfunctionCoronary artery dilationCardiac dysfunctionClinical entityCase reportNeurological involvementArtery dilationCOVID-19 infectionClinical pictureFebrile seizuresMedical literatureSeizuresSARS-CoV-2Disease processSyndromeFeverDiagnosisChildhood illnessesSymptoms
2022
Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data
Fashina T, Miller C, Paintsil E, Niccolai L, Brandt C, Oliveira C. Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data. Journal Of The Pediatric Infectious Diseases Society 2022, 12: 113-116. PMID: 36548966, PMCID: PMC9969330, DOI: 10.1093/jpids/piac132.Peer-Reviewed Original ResearchCitationsAltmetric
2016
The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury
Song L, Papaioannou G, Zhao H, Luderer H, Miller C, Dall’Osso C, Nazarian R, Wagers A, Demay M. The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology 2016, 157: 4066-4075. PMID: 27526034, PMCID: PMC5045513, DOI: 10.1210/en.2016-1474.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVDR KO miceVitamin D receptorWild-type miceKO miceResident macrophagesM-CSFM-CSF gene expressionVitamin D receptor ablationM-CSF-induced proliferationVitamin D receptor knockoutVitamin D receptor statusInflammatory response to injuryMacrophage colony-stimulating factorColony-stimulating factorPeritoneal resident macrophagesRecruitment of macrophagesTissue resident macrophagesRegulation of innateLigand-dependent actionsLiganded vitamin D receptorResponse to injuryCyclin D1 expressionMacrophage self-renewalParabiosis studiesMacrophage defectEGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
Olenchock B, Moslehi J, Baik A, Davidson S, Williams J, Gibson W, Chakraborty A, Pierce K, Miller C, Hanse E, Kelekar A, Sullivan L, Wagers A, Clish C, Vander Heiden M, Kaelin W. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell 2016, 165: 497. PMID: 27058668, DOI: 10.1016/j.cell.2016.03.037.Peer-Reviewed Original ResearchCitationsAltmetricEGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
Olenchock B, Moslehi J, Baik A, Davidson S, Williams J, Gibson W, Chakraborty A, Pierce K, Miller C, Hanse E, Kelekar A, Sullivan L, Wagers A, Clish C, Vander Heiden M, Kaelin W. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell 2016, 164: 884-895. PMID: 26919427, PMCID: PMC4819986, DOI: 10.1016/j.cell.2016.02.006.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRemote ischemic preconditioningIschemic preconditioningHypoxia-inducible factorKynurenic acidIschemic protectionMyocardial ischemia-reperfusion (I/R) injuryIschemia-reperfusion (I/R) injuryParabiosis experimentsPeriod of sublethal ischemiaMouse modelIschemic insultSecreted factorsPharmacological inhibitorsHepatic productionOther organsGene deletionSublethal ischemiaIschemiaMiceEGLN1Inhibition
2015
Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses
Kim M, Miller C, Shadrach J, Wagers A, Serwold T. Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses. The Journal Of Immunology 2015, 194: 4784-4795. PMID: 25870244, PMCID: PMC4481326, DOI: 10.4049/jimmunol.1403158.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsThymic epithelial cellsAge-related thymic involutionMolecular processesColony-forming assayAged thymusCell-intrinsic changesThymic growthProliferative capacityEpithelial cellsIn vitro colony-forming assayIncreased T cell productionT-cell recoveryT-cell lymphopeniaBone marrow transplantationT cell production
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Pediatric Infectious Diseases
464 Congress Ave
New Haven, Connecticut 06519
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