Wendell Yarbrough, MD, MMHC, FACS

Professor of Surgery (Otolaryngology) and of Pathology; Section Chief, Otolaryngology; Co-Director Molecular Virology Research Program; Director, Head & Neck Cancer Program, Smilow Cancer Hospital

Physician Biography

My practice focuses on surgery for head and neck cancers including those of the mouth, throat, voicebox, nasal cavity, salivary glands neck, and thyroid glands. We provide multi-specialty care, since patients with head and neck cancers do better when treated by teams of doctors to offer personalized therapy plans. I perform minimally invasive procedures using robots and lasers, as well as more traditional surgeries. Our team is able to provide all aspects of care including reconstructive surgery designed to provide the best cosmetic and functional outcomes. Our team also provides radiation and chemotherapy that can be used after surgery for high risk patients or as a definitive treatment to avoid surgery.

Clinical Interests

  • Clinical Trials as Topic
  • Ear Neoplasms
  • Head and Neck Neoplasms
  • Laryngeal Neoplasms
  • Mouth Neoplasms
  • Neoplasms
  • Neoplasms, Glandular and Epithelial
  • Neoplasms, Unknown Primary
  • Otolaryngology
  • Otorhinolaryngologic Neoplasms
  • Parathyroid Neoplasms
  • Pharyngeal Neoplasms
  • Sarcoma
  • Skin Neoplasms
  • Thyroid Neoplasms
  • Tracheal Neoplasms
  • Early Detection of Cancer
  • Vocal Cord Dysfunction

Patient Care

Accepts new patients? Yes
Patient Type: Adult; Adolescent; Child; Geriatric
Referrals: From patients or physicians

Patient Care Organizations

Surgery: Otolaryngology Surgery: Head & Neck Cancer Surgery Program


Yale Cancer Center: Head & Neck Cancers Program

Yale Medicine

Board Certifications

  • Otolaryngology AB of Otolaryngology (1995)

Clinical Trials

Conditions Study Title
Larynx, Lip, Oral Cavity and Pharynx A Phase 3 Randomized, Open-Label Clinical Study to Evaluate the Efficacy and Safety of Pembrolizumab Plus Epacadostat, Pembrolizumab Monotherapy, and the EXTREME Regimen as First Line Treatment for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-669/ECHO-304)
Other Skin A Phase 2, Open-Label, Single Arm Study to Evaluate the Safety and Efficacy of Pembrolizumab in Participants With Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma (R/M cSCC)
Larynx, Lip, Oral Cavity and Pharynx A Randomized Phase III Study of Pembrolizumab Given Concomitantly With Chemoradiation and as Maintenance Therapy Versus Chemoradiation Alone in Subjects With Locally Advanced Head and Neck Squamous Cell Carcinoma (KEYNOTE-412)
Phase I An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Lip, Oral Cavity and Pharynx, Soft Tissue A Phase II Study of Enzalutamide (NSC# 766085) for Patients With Androgen Receptor Positive Salivary Cancers
Larynx, Lip, Oral Cavity and Pharynx Single-Arm Phase II Trial of Dual Inhibition of EGFR With Afatinib and Cetuximab With Correlative Studies in the Second-Line Treatment of Recurrent or Metastatic Squamous Cell Cancers of the Head and Neck
Thyroid A Phase 2 Study of Efatutazone, an Oral PPAR Agonist, In Combination With Paclitaxel in Patients With Advanced Anaplastic Thyroid Cancer
Lip, Oral Cavity and Pharynx A Two-arm, Open-label, Randomized Phase II Study of Pembrolizumab (MK-3475) Monotherapy Versus Standard Chemotherapy in Platinum Pre-treated, Recurrent or Metastatic Nasopharyngeal Cancer (NPC) (Keynote-122)
Larynx, Lip, Oral Cavity and Pharynx, Ill-Defined Sites A Phase II Study of Pembrolizumab for Patients With Head and Neck Squamous Cell Carcinoma With Residual Disease Following Definitive Chemoradiation
Lip, Oral Cavity and Pharynx Window Trial 5-aza in HNSCC, T-tare
Lip, Oral Cavity and Pharynx Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA

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Contact Info

Wendell Yarbrough, MD, MMHC, FACS
Patient Care Locations
Head & Neck Cancer ProgramSmilow Cancer Hospital at Yale New Haven
35 Park Street

New Haven, CT 06511
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Park Avenue Medical CenterPark Avenue Medical Center
5520 Park Avenue

Trumbull, CT 06611
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Mailing Address
Otolaryngology SurgeryPO Box 208062
New Haven, CT 06520-8062

Curriculum Vitae

Yarbrough Laboratory for Head and Neck Oncology