Serena Spudich, MD, MA

Professor of Neurology; Division Chief, Neurological Infections & Global Neurology; Co-director, Center for Neuroepidemiology and Clinical Neurological Research

Research Interests

Acquired Immunodeficiency Syndrome; Antiviral Agents; Cerebrospinal Fluid; Dementia; HIV; Nervous System; Neurology; Magnetic Resonance Spectroscopy; Biomarkers, Pharmacological

Public Health Interests

Antivirals; Biomarkers; Dementia; Disease transmission; HIV/AIDS; Immune functions; Infectious Disease; Viruses

Research Organizations


Center for Neuroepidemiology and Clinical Neurological Research

Faculty Research

Stem Cell Center, Yale

Office of Cooperative Research

Yale Institute for Global Health

Research Summary

Our group’s clinical and translational research focuses on characterization of the central nervous system in HIV-infected patients in an effort to understand and treat the processes underlying damage to the nervous system by HIV, as well as establishment and reduction of potential central nervous system reservoirs for infection.

Our current program employs a multidisciplinary approach to patient-oriented research in neuro-HIV, through active collaborations with researchers in immunology, radiology, neuropsychology, virology, and molecular biomarkers. We apply these methods to novel studies of patients that may inform about neuroprotection and neuropathogenesis in HIV, including individuals with acute or early HIV infection, patients at different stages of treatment with antiretroviral therapy, and individuals with cerebrospinal fluid HIV escape (detected HIV in the central nervous system despite effective treatment in the blood). We are also performing clinical studies aimed to examine and/or reduce early establishment of central nervous system reservoirs for HIV infection.

Our studies focus on subjects recruited in urban centers in the US and international sites including Bangkok, Thailand. Broader involvement with the design and implementation of multicenter studies relevant to neuro-HIV is facilitated by Dr. Spudich’s position within the international AIDS Clinical Trials Group (ACTG), facilitated by an affiliation with the Cornell AIDS Clinical Trials Unit.

Specialized Terms: HIV; AIDS; Central nervous system inflammation; Viral compartmentalization; Acute infection; HIV reservoirs; Magnetic resonance spectroscopy; Diffusion tensor imaging; Neural markers; Cerebrospinal fluid biomarkers

Selected Publications

Full List of PubMed Publications

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Contact Info

Serena Spudich, MD, MA
Patient Care Locations
Yale AIDS Care Program135 College Street
New Haven, CT 06510
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Yale NeurologyLaboratory for Medicine and Pediatrics (LMP)
15 York Street

New Haven, CT 06510
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Mailing Address
NeurologyPO Box 208018
New Haven, CT 06520

Spudich Lab