Richard E Carson, PhD
Professor of Radiology and Biomedical Imaging and of Biomedical Engineering; Director, Yale PET Center; Director of Graduate Studies, Biomedical Engineering
Research Interests
Biomedical Engineering; Nuclear Medicine; Physiology; Radiology; Positron-Emission Tomography
Research Organizations
Radiology & Biomedical Imaging: Bioimaging Sciences: Positron Emission Tomography (PET)
Neuroscience Research Training Program (NRTP)
Stress & Addiction Clinical Research Program
Research Summary
Dr. Richard Carson's research uses Positron Emission Tomography (PET) as a tool to noninvasively measure a wide range of in vivo physiology in human beings and laboratory animals. His focus is on the development and applications of new tracer kinetic modeling methods and algorithms and on research in PET image reconstruction and image quantification. These quantitative techniques are then applied in clinical populations and preclinical models of disease. Application areas include neuropsychiatric populations, diabetes, cardiology, and oncology. A primary focus of his more biological applications is the measurement of synaptic density in a wide range of neuropsychiatric disorders.
Specialized Terms: Positron emission tomography (PET) modeling and physics; Tracer kinetic modeling methods and parametric imaging techniques for PET tracers; Application of receptors ligands to assess neurotransmitter dynamic; 3D and 4D PET image reconstruction; Medical imaging
Extensive Research Description
Following administration of a positron-emitting radiopharmaceutical (tracer), PET permits the direct measurement of the four-dimensional radioactivity profile throughout a 3D object over time. Depending on the characteristics of the tracer, physiological parameters can be estimated, such as blood flow, metabolism, and receptor concentration. These measurements can be made with subjects in different states (e.g., stimulus or drug activation), used to compare patient groups to controls, or to assess the efficacy of drug treatment.
Tracer Kinetic Modeling
The goal of PET tracer kinetic modeling is to devise a biologically validated, quantitatively reliable, and logistically practical method for use in human PET studies. Animal studies are typically performed to characterize the tracers, followed by initially complex human studies, typically leading to the development of simplified methods, e.g., using continuous tracer infusion. These techniques are also applied on a pixel-by-pixel level to produce images of PET physiological and pharmacological parameters, such as blood flow and receptor binding. Mathematical methodology includes linear and non-linear differential equations, statistical estimation theory, methods to avoid the needs for arterial blood measurements (the input function) such as blind deconvolution, plus the development of novel rapid computational algorithms.
PET Physics and Reconstruction.
Proper characterization of the PET image data is essential for modeling studies. This requires accurate and carefully characterized corrections for the physics and electronics of coincident event acquisition. Studies of these effects are performed with phantom measurements made on the scanner.
A critical component in the application to real data is the correction for subject motion, particularly as the resolution of modern machines has improved (better than 3-mm in human brain machines). Both hardware and software approaches are employed to address these issues. To produce accurate images with minimum noise, a statistically-based iterative reconstruction algorithm is necessary. Developments in this area include the mathematical aspects of algorithm development, the computer science issues associated with a large cluster-based algorithm, the incorporation of the physics and motion correction, the use of prior information provided from MR images, and the tuning and characterization necessary for practical application for biological studies. The ultimate goal is the combination of the tracer kinetic modeling and image reconstruction to directly process a 4D dataset into parametric images of the physiological parameters of interest. When applied in the thorax, respiratory and cardiac motion must be included, raising the problem to 5D and 6D analysis.
PET Applications
PET studies are performed in human subjects and preclinical models of a wide variety of diseases. Examples of interest include:
- Synaptic density imaging in the living human brain (See Science Translational Medicine, 2016)
- Measuring beta cells in the pancreas for diabetes with novel tracers including ligands for the vesicular monoamine transporter
- Using PET to measure drug delivery in cancer
- Neuroreceptor studies have focused on determining changes in receptor concentration as a function of disease or measurement of receptor occupancy by drugs. Such changes have been successfully demonstrated in the dopaminergic, muscarinic, and serotonergic systems.
- Measurement of the relationship between dopamine receptors and impulsivity
- New methods for quantification of myocardial blood flow
- Hypoxia assessment in tumors before and after radiation treatment
- Differentiation of radiation necrosis vs. tumor recurrence
- 4D/5D Image reconstruction for PET
- Mathematical model development for novel radiopharmaceuticals
- Imaging of beta cells in the pancreas
- Neuroinflammation imaging in a wide variety of disorders
- Novel preclinical and clinical applications in oncology
Selected Publications
- Kinetic evaluation of 11C UCB-J, a novel radioligand for PET imaging of synaptic vesicle glycoprotein 2A in humans Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J. Huang Y, Carson RE, J Cereb Blood Flow Metabol, epub, 2017
- Estradiol modulates neural response to conspecific and heterospecific song in female house sparrows: an in vivo positron emission tomography stu Lattin CR, Stabile F, Carson RE, dy, PLOS One, 12:e0182875, 2017
- Direct Reconstruction of Parametric Images for Brain PET with Event-by-Event Motion Correction: Evaluation in Two Tracers Across Count Levels Germino M, Gallezot JD, Yan J, Carson RE, , Phys Med Biol, 62:5344-5364, 2017
- Data-driven event-by-event respiratory motion correction using TOF PET list-mode centroid of distribution Ren S, Jin X, Chan C, Jian Y, Mulnix T, Liu C, Carson RE, , Phys Med Biol, 62:4741-4755, 2017
- Regional and source-based of 11C (+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorder 256. Worhunsky PD, Matuskey D, Gallezot JD, Gaiser EC, Nabulsi N, Angarita GA, Calhoun VD, Malison RT, Potenza MN, Carson RE, Neuroimage, 148:343-351, 2017
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Imaging synaptic density in the living human brain,
Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE, Imaging synaptic density in the living human brain, Sci Transl Med, 8:348ra96, 2016 (cover).
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Synthesis and preclinical evaluation of 11C‑UCB‑J as a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the brain
Nabulsi N, Mercier J, Holden D, Carre S, Najafzadeh S, Vandergeten MC, Lin SF, Deo A, Price N, Lara-Jaine T, Montel F, Laruelle M, Carson RE, Hannestad J, Huang Y, Synthesis and preclinical evaluation of 11C‑UCB‑J as a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the brain, J Nucl Med, 57:777-784, 2016
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OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5‑HT1B receptor binding
Pittenger C, Adams TG, Gallezot JD, Crowley MJ, Nabulsi N, Ropchan J, Gao H, Kichuk SA, Simpson R, Billingslea E, Bloch M, Mayes L, Bhagwagar Z, Carson RE, OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5‑HT1B receptor binding, J Aff Dis, 196:87-96, 2016.
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Receptor occupancy of the kappa opioid antagonist LY2456302 using the novel PET radiotracer 11C‑LY2795050
Naganawa M, Dickinson G, Zheng MQ, Henry S, Vandenhende F, Witcher J, Bell R, Nabulsi N, Lin SF, Ropchan J, Neumeister A, Ranganathan M, Tauscher J, Huang Y, Carson RE, Receptor occupancy of the kappa opioid antagonist LY2456302 using the novel PET radiotracer 11C‑LY2795050, J Phar Exp Ther, 356:260-266 2016.
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Measurement of Bmax and Kd with the glycine transporter 1 radiotracer 18F MK6577 using a novel multi-infusion paradigm
Xia Y, Zheng M-Q, Holden D, Lin S-F, Kapinos M, Ropchan J, Gallezot J-D, Huang Y, Carson RE, Measurement of Bmax and Kd with the glycine transporter 1 radiotracer 18F MK6577 using a novel multi-infusion paradigm, J Cereb Blood Flow Metabol, 35:2001-2009, 2015.
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Test/retest reproducibility of the metabotropic glutamate receptor ligand [18F]FPEB with bolus plus constant infusion in human
Park E, Sullivan J, Planeta P, Gallezot J-D, Lim K-P, Lin S-F, Ropchan J, McCarthy T, Ding Y-S, Morris ED, Williams WA, Huang Y, Carson RE, Test/retest reproducibility of the metabotropic glutamate receptor ligand [18F]FPEB with bolus plus constant infusion in human, Eur J Nuc Med Mol Imag, 42:570-577, 2015.
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11C PBR28 imaging in multiple sclerosis patients and healthy controls: Test-retest reproducibility and visualization of focal activation
Park E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O’Connor K, Lim K, Lee J-Y, Chastre A, Chen, MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D, 11C PBR28 imaging in multiple sclerosis patients and healthy controls: Test-retest reproducibility and visualization of focal activation, Eur J Nucl Med Mol Imag, 42:1081-1092, 2015.
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In vivo ketamine-induced changes in [11C]ABP688 binding to brain mGluR5 receptors in humans
DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Man JJ, Krystal J, Parsey RV, Carson RE, Esterlis I, In vivo ketamine-induced changes in [11C]ABP688 binding to brain mGluR5 receptors in humans, Biol Psych, 77:266-275, 2015.
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Application of line-of-response probability density function resolution models in list mode reconstruction for PET
Jian Y, Yao R, Mulnix T, Jin X, Carson RE, Application of line-of-response probability density function resolution models in list mode reconstruction for PET, Phys Med Biol, 60:253-278, 2015.
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Kinetic modeling of 11C-LY2795050, a novel antagonist radiotracer for PET imaging of the kappa opioid receptor in humans
Naganawa M, Zheng M-Q, Nabulsi N, Tomasi G, Henry S, Lin S-F, Ropchan J, Labaree D, Tauscher J, Neumeister A, Carson RE, Huang Y, Kinetic modeling of 11C-LY2795050, a novel antagonist radiotracer for PET imaging of the kappa opioid receptor in humans, J Cereb Blood Flow Metab, 34:1818-1825, 2014.
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Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptors in humans: kinetic model selection, test-retest reproducibility, and receptor occupancy by the antagonist PF-04455242
Naganawa M, Jacobsen LK, Zheng M-Q, Lin S-F, Banerjee A, Byon W, Weinzimmer D, Tomasi G, Grimwood S, Badura LL, Carson RE, McCarthy TJ, Huang Y, Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptors in humans: kinetic model selection, test-retest reproducibility, and receptor occupancy by the antagonist PF-04455242, Neuroimage, 99:69-79, 2014.
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Parametric imaging and test-retest variability of [11C]-(+)-PHNO binding to D2/D3 dopamine receptors in humans on the HRRT PET scanner
Gallezot J-D, Zheng M-Q, Lim K, Lin SF, Labaree D, Matuskey D, Huang Y, Ding Y-S, Carson RE, Malison RT, Parametric imaging and test-retest variability of [11C]-(+)-PHNO binding to D2/D3 dopamine receptors in humans on the HRRT PET scanner, J Nucl Med, 14:960-966, 2014.
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Dopamine D3 Receptor Alterations in Cocaine-Dependent Humans Imaged with the PET Ligand [11C](+)PHNO
Matuskey D, Gallezot J-D, Pittman B, Williams W, Wanyiri J, Gaiser E, Lee DE, Lim K, Zheng M-Q, Lin S-F, Labaree D, Potenza M, Carson RE, Malison RT, Ding Y-S, Dopamine D3 Receptor Alterations in Cocaine-Dependent Humans Imaged with the PET Ligand [11C](+)PHNO, Drug Alc Dep, 139:100-105, 2014.
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Decreased norepinephrine transporter availability in obesity: PET imaging with [11C]MRB
Li CR, Potenza MM, Lee DE, Planeta B, Gallezot J-D, Labaree D, Henry S, Nabulsi N, Sinha R, Ding, Y-S, Carson RE, Neumeister A, Decreased norepinephrine transporter availability in obesity: PET imaging with [11C]MRB, Neuroimage, 86:306-310, 2014
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Evaluation of motion correction methods in human brain PET imaging - a simulation study based on human motion data
Jin X, Mulnix T, Gallezot J-D, Carson RE, Evaluation of motion correction methods in human brain PET imaging - a simulation study based on human motion data, Med Phys, 40:102503, 2013.
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Reductions in Brain 5-HT1B Receptor Availability in Primarily Cocaine-Dependent Humans
Matuskey D, Bhagwagar Z, Planeta B, Pittman B, Gallezot J-D, Chen J, Wanyiri J, Geha P, Potenza MN, Neumeister A, Carson RE, Malison RT, Reductions in Brain 5-HT1B Receptor Availability in Primarily Cocaine-Dependent Humans, Biol Psych, 76:816-822,2014
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Awake nonhuman primate brain PET imaging with minimal head restraint: Evaluation of GABAA, benzodiazepine binding with [11C]flumazenil in awake and anesthetized animals
Sandiego CM, Jin X, Mulnix T, Fowles K, Wells L, Labaree D, Ropchan J, Huang Y, Rabiner EA, Cosgrove K, Castner SA, Williams GV, Carson RE, Awake nonhuman primate brain PET imaging with minimal head restraint: Evaluation of GABAA, benzodiazepine binding with [11C]flumazenil in awake and anesthetized animals, J Nucl Med, 54:1962-1968, 2013.
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A non-invasive imaging technique for measuring the distribution of drugs and polymers after direct delivery to the brain
Sirianni RW, Zheng M-Q, Schafbauer T, Patel T, Zhou J, Saltzman WM, Huang Y, Carson RE, A non-invasive imaging technique for measuring the distribution of drugs and polymers after direct delivery to the brain, Mol Imag Biol, 15:596-605, 2013.
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The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [11C]PBR28 PET study
Hannestad J, DellaGioia N, Gallezot J-D, Lim K, Nabulsi N, Esterlis I, Pittman B, Lee J-Y, O’Connor KC, Pelletier D, Carson RE, The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [11C]PBR28 PET study, Brain Beh Immun, 33:131-138, 2013.
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List mode reconstruction for the Biograph mCT with probabilistic LOR positioning and event-by-event motion correction
Jin X, Chan C, Mulnix T, Panin V, Casey ME, Liu C, Carson RE, List mode reconstruction for the Biograph mCT with probabilistic LOR positioning and event-by-event motion correction, Phys Med Biol, 58:5567-5591, 2013
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Cerebral blood flow with [15O]water PET using image-derived input functions and MR-defined carotid centerlines
Fung EK, Carson RE, Cerebral blood flow with [15O]water PET using image-derived input functions and MR-defined carotid centerlines, Phys Med Biol, 58:1903-1923, PMC3626495, 2013
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Direct 4D PET list mode parametric reconstruction with a novel EM algorithm
Yan J, Planeta-Wilson B, Carson RE, Direct 4D PET list mode parametric reconstruction with a novel EM algorithm, IEEE Trans Med Imag, 31:2213-2223, PMC3660152, 2012
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In vivo imaging of endogenous pancreatic ß cell mass in healthy and type 1 diabetic subjects using [18F](+)-FP-DTBZ and PET
Normandin M, Petersen KF, Ding, Y-S, Lin, S-F, Naik S, Skrovonsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL, Cline GW, In vivo imaging of endogenous pancreatic ß cell mass in healthy and type 1 diabetic subjects using [18F](+)-FP-DTBZ and PET, J Nucl Med, 53: 908-916, 2012.
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Assessing the sensitivity of [11C]P943, a novel 5 HT1B PET radioligand, to endogenous serotonin release
Cosgrove KP, Kloczynski T, Nabulsi N, Weinzimmer D, Lin S-F, Staley JK, Bhagwagar Z, Carson RE, Assessing the sensitivity of [11C]P943, a novel 5 HT1B PET radioligand, to endogenous serotonin release, Synapse, 65:1113-1117, 2011
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Kinetic modeling of the serotonin 5 HT1B receptor radioligand [11C]P943 in humans
Gallezot J-D, Nabulsi N, Neumeister A, Planeta-Wilson B, Williams WA, Singhal T, Kim S, Maguire RP, McCarthy T, Frost JJ, Huang Y, Ding Y-S, Carson RE, Kinetic modeling of the serotonin 5 HT1B receptor radioligand [11C]P943 in humans, J Cereb Blood Flow Metab, 30: 196-210, 2010
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Consensus nomenclature for in vivo imaging of reversibly binding radioligands
Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, Holden J, Houle S, Huang SC, Ichise M, Iida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, and Carson RE, Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab, 2007. 27(9): p. 1533-9 PMCID 17519979.
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Quantification of amphetamine-induced changes in [11C]-raclopride binding with continuous infusion
Carson RE, Breier A, de Bartolomeis A, Saunders RC, Su TP, Schmall B, Der MG, Pickar D, Eckelman WC, Quantification of amphetamine-induced changes in [11C]-raclopride binding with continuous infusion, J Cereb Blood Flow Metab, 17:437-447, 1997
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Comparison of bolus and infusion methods for receptor quantitation: Application to [18F]-cyclofoxy and positron emission tomography
Carson RE, Channing MA, Blasberg RG, Dunn BB, Cohen RM, Rice KC, Herscovitch P, Comparison of bolus and infusion methods for receptor quantitation: Application to [18F]-cyclofoxy and positron emission tomography, J Cereb Blood Flow Metab, 13:24-42, 1993.
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EM reconstruction algorithms for emission and transmission tomography
Lange K, Carson RE, EM reconstruction algorithms for emission and transmission tomography, J Comput Assist Tomogr, 8:306-316, 1984
Full List of PubMed Publications
- Radhakrishnan R, Nabulsi N, Gaiser E, Gallezot JD, Henry S, Planeta B, Lin SF, Ropchan J, Williams W, Morris E, D'Souza DC, Huang Y, Carson RE, Matuskey D: Age-related change in 5-HT6 receptor availability in healthy male volunteers measured with 11C-GSK215083 PET. J Nucl Med. 2018 Apr 6; 2018 Apr 6. PMID: 29626125
- Belfort-DeAguiar RD, Gallezot JD, Hwang JJ, Elshafie A, Yeckel CW, Chan O, Carson RE, Ding YS, Sherwin RS: Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia. J Clin Endocrinol Metab. 2018 Mar 23; 2018 Mar 23. PMID: 29590401
- Bhatt S, Hillmer AT, Nabulsi N, Matuskey D, Lim K, Lin SF, Esterlis I, Carson RE, Huang Y, Cosgrove KP: Evaluation of (-)-[18 F]Flubatine-specific binding: Implications for reference region approaches. Synapse. 2018 Mar; 2017 Nov 17. PMID: 29105121
- Wu J, Gallezot JD, Lu Y, Ye Q, Liu H, Esserman DA, Kyriakides TC, Thorn S, Hashemi Zonouz T, Liu YH, Lampert R, Sinusas AJ, Carson RE, Liu C: Simplified Quantification and Acquisition Protocol of 123I-mIBG Dynamic SPECT. J Nucl Med. 2018 Feb 23; 2018 Feb 23. PMID: 29476001
- Naganawa M, Lim K, Nabulsi NB, Lin SF, Labaree D, Ropchan J, Herold KC, Huang Y, Harris P, Ichise M, Cline GW, Carson RE: Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes. Mol Imaging Biol. 2018 Feb 21; 2018 Feb 21. PMID: 29468404
- Lu Y, Fontaine K, Mulnix T, Onofrey JA, Ren S, Panin V, Jones J, Casey ME, Barnett R, Kench P, Fulton R, Carson RE, Liu C: Respiratory Motion Compensation for PET/CT with Motion Information Derived from Matched Attenuation Corrected Gated PET Data. J Nucl Med. 2018 Feb 9; 2018 Feb 9. PMID: 29439015
- Gallezot JD, Nabulsi NB, Holden D, Lin SF, Labaree D, Ropchan J, Najafzadeh S, Donnelly DJ, Cao K, Bonacorsi S, Seiders J, Roppe J, Hayes W, Huang Y, Du S, Carson RE: Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11C-BMT-136088 for Lung Imaging in Rhesus Monkeys. J Nucl Med. 2018 Feb; 2017 Sep 1. PMID: 28864634
- Germino M, Carson RE: Cardiac-gated parametric images from 82 Rb PET from dynamic frames and direct 4D reconstruction. Med Phys. 2018 Feb; 2017 Dec 30. PMID: 29205378
- D'Souza DC, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH, Yale GlyT1 Study Group.: Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects. Biol Psychiatry. 2018 Jan 31; 2018 Jan 31. PMID: 29499855
- Bini J, Naganawa M, Nabulsi NB, Huang YH, Ropchan J, Lim K, Najafzadeh S, Herold KC, Cline GW, Carson RE: Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of 11C-PHNO. J Nucl Med. 2018 Jan 25; 2018 Jan 25. PMID: 29371405
- Lattin CR, Emerson MA, Gallezot JD, Mulnix T, Brown JE, Carson RE: A 3D-printed modular device for imaging the brain of small birds. J Neurosci Methods. 2018 Jan 1; 2017 Oct 6. PMID: 28988856
- Mecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, Nadelmann J, Benincasa AL, Ropchan J, Huang Y, Gelernter J, Van Ness PH, Carson RE, van Dyck CH: Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease. Neurobiol Aging. 2018 Jan; 2017 Oct 6. PMID: 29111487
- Naganawa M, Gallezot JD, Rossano S, Carson RE: Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy. Bull Math Biol. 2017 Dec 11; 2017 Dec 11. PMID: 29230702
- Hillmer AT, Holden D, Fowles K, Nabulsi N, West BL, Carson RE, Cosgrove KP: Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates. EJNMMI Res. 2017 Dec; 2017 Jul 24. PMID: 28741281
- Kelada OJ, Rockwell S, Zheng MQ, Huang Y, Liu Y, Booth CJ, Decker RH, Oelfke U, Carson RE, Carlson DJ: Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements. Mol Imaging Biol. 2017 Dec. PMID: 28409339
- Lattin CR, Stabile FA, Carson RE: Estradiol modulates neural response to conspecific and heterospecific song in female house sparrows: An in vivo positron emission tomography study. PLoS One. 2017; 2017 Aug 23. PMID: 28832614
- DeLorenzo C, Gallezot JD, Gardus J, Yang J, Planeta B, Nabulsi N, Ogden RT, Labaree DC, Huang YH, Mann JJ, Gasparini F, Lin X, Javitch JA, Parsey RV, Carson RE, Esterlis I: In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB. J Cereb Blood Flow Metab. 2017 Aug; 2016 Jan 1. PMID: 27742888
- Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I, Traumatic Stress Brain Study Group.: Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proc Natl Acad Sci U S A. 2017 Aug 1; 2017 Jul 17. PMID: 28716937
- Germino M, Gallezot JD, Yan J, Carson RE: Direct reconstruction of parametric images for brain PET with event-by-event motion correction: evaluation in two tracers across count levels. Phys Med Biol. 2017 Jul 7; 2017 May 15. PMID: 28504644
- Abdallah CG, Hannestad J, Mason GF, Holmes SE, DellaGioia N, Sanacora G, Jiang L, Matuskey D, Satodiya R, Gasparini F, Lin X, Javitch J, Planeta B, Nabulsi N, Carson RE, Esterlis I: Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Jul; 2017 Apr 6. PMID: 28993818
- Bao W, Jia H, Finnema S, Cai Z, Carson RE, Huang YH: PET Imaging for Early Detection of Alzheimer's Disease: From Pathologic to Physiologic Biomarkers. PET Clin. 2017 Jul; 2017 May 2. PMID: 28576171
- Ren S, Jin X, Chan C, Jian Y, Mulnix T, Liu C, Carson RE: Data-driven event-by-event respiratory motion correction using TOF PET list-mode centroid of distribution. Phys Med Biol. 2017 Jun 21; 2017 May 18. PMID: 28520558
- Hillmer AT, Li S, Zheng MQ, Scheunemann M, Lin SF, Nabulsi N, Holden D, Pracitto R, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Esterlis I, Cosgrove KP, Brust P, Carson RE, Huang Y: PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humans. Eur J Nucl Med Mol Imaging. 2017 Jun; 2017 Jan 24. PMID: 28120003
- Lattin CR, Pechenenko AV, Carson RE: Experimentally reducing corticosterone mitigates rapid captivity effects on behavior, but not body composition, in a wild bird. Horm Behav. 2017 Mar; 2017 Jan 5. PMID: 28065712
- Gallezot JD, Planeta B, Nabulsi N, Palumbo D, Li X, Liu J, Rowinski C, Chidsey K, Labaree D, Ropchan J, Lin SF, Sawant-Basak A, McCarthy TJ, Schmidt AW, Huang Y, Carson RE: Determination of receptor occupancy in the presence of mass dose: [11C]GSK189254 PET imaging of histamine H3 receptor occupancy by PF-03654746. J Cereb Blood Flow Metab. 2017 Mar; 2016 Jul 20. PMID: 27207170
- Worhunsky PD, Matuskey D, Gallezot JD, Gaiser EC, Nabulsi N, Angarita GA, Calhoun VD, Malison RT, Potenza MN, Carson RE: Regional and source-based patterns of [11C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorder. Neuroimage. 2017 Mar 1; 2017 Jan 19. PMID: 28110088
- Sawant-Basak A, Chen L, Shaffer CL, Palumbo D, Schmidt A, Tseng E, Spracklin DK, Gallezot JD, Labaree D, Nabulsi N, Huang Y, Carson RE, McCarthy T: Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy. Xenobiotica. 2017 Feb; 2016 Jun 29. PMID: 27353353
- Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE: Kinetic evaluation and test-retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans. J Cereb Blood Flow Metab. 2017 Jan 1; 2017 Jan 1. PMID: 28792356
- Lin SF, Bois F, Holden D, Nabulsi N, Pracitto R, Gao H, Kapinos M, Teng JK, Shirali A, Ropchan J, Carson RE, Elmore CS, Vasdev N, Huang Y: The Search for a Subtype-Selective PET Imaging Agent for the GABAA Receptor Complex: Evaluation of the Radiotracer [11C]ADO in Nonhuman Primates. Mol Imaging. 2017 Jan-Dec. PMID: 28929924
- Germino M, Ropchan J, Mulnix T, Fontaine K, Nabulsi N, Ackah E, Feringa H, Sinusas AJ, Liu C, Carson RE: Quantification of myocardial blood flow with (82)Rb: Validation with (15)O-water using time-of-flight and point-spread-function modeling. EJNMMI Res. 2016 Dec; 2016 Aug 1. PMID: 27650280
- Gaiser EC, Gallezot JD, Worhunsky PD, Jastreboff AM, Pittman B, Kantrovitz L, Angarita GA, Cosgrove KP, Potenza MN, Malison RT, Carson RE, Matuskey D: Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO. Neuropsychopharmacology. 2016 Dec; 2016 Jul 4. PMID: 27374277
- Naganawa M, Lin SF, Lim K, Labaree D, Ropchan J, Harris P, Huang Y, Ichise M, Carson RE, Cline GW: Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons. Nucl Med Biol. 2016 Dec; 2016 Sep 2. PMID: 27673755
- Girgis RR, Slifstein M, D'Souza D, Lee Y, Periclou A, Ghahramani P, Laszlovszky I, Durgam S, Adham N, Nabulsi N, Huang Y, Carson RE, Kiss B, Kapás M, Abi-Dargham A, Rakhit A: Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [(11)C]-(+)-PHNO. Psychopharmacology (Berl). 2016 Oct; 2016 Aug 15. PMID: 27525990
- Chen L, Nabulsi N, Naganawa M, Zasadny K, Skaddan MB, Zhang L, Najafzadeh S, Lin SF, Helal CJ, Boyden TL, Chang C, Ropchan J, Carson RE, Villalobos A, Huang Y: Preclinical Evaluation of 18F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme. J Nucl Med. 2016 Sep; 2016 May 19. PMID: 27199356
- Naganawa M, Waterhouse RN, Nabulsi N, Lin SF, Labaree D, Ropchan J, Tarabar S, DeMartinis N, Ogden A, Banerjee A, Huang Y, Carson RE: First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430. J Nucl Med. 2016 Sep; 2016 Apr 21. PMID: 27103022
- Wu J, Lin SF, Gallezot JD, Chan C, Prasad R, Thorn SL, Stacy MR, Huang Y, Zonouz TH, Liu YH, Lampert RJ, Carson RE, Sinusas AJ, Liu C: Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method. J Nucl Med. 2016 Aug; 2016 Apr 14. PMID: 27081169
- Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE: Imaging synaptic density in the living human brain. Sci Transl Med. 2016 Jul 20. PMID: 27440727
- Yu Y, Chan C, Ma T, Liu Y, Gallezot JD, Naganawa M, Kelada OJ, Germino M, Sinusas AJ, Carson RE, Liu C: Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging. J Nucl Med. 2016 Jul; 2016 Feb 23. PMID: 26912437
- Ranganathan M, Cortes-Briones J, Radhakrishnan R, Thurnauer H, Planeta B, Skosnik P, Gao H, Labaree D, Neumeister A, Pittman B, Surti T, Huang Y, Carson RE, D'Souza DC: Reduced Brain Cannabinoid Receptor Availability in Schizophrenia. Biol Psychiatry. 2016 Jun 15; 2015 Aug 29. PMID: 26432420
- Pittenger C, Adams TG Jr, Gallezot JD, Crowley MJ, Nabulsi N, James Ropchan, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE: OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. J Affect Disord. 2016 May 15; 2016 Feb 9. PMID: 26919057
- Nabulsi NB, Mercier J, Holden D, Carré S, Najafzadeh S, Vandergeten MC, Lin SF, Deo A, Price N, Wood M, Lara-Jaime T, Montel F, Laruelle M, Carson RE, Hannestad J, Huang Y: Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. J Nucl Med. 2016 May; 2016 Feb 4. PMID: 26848175
- Han L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J: Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging. ACS Nano. 2016 Apr 26; 2016 Mar 16. PMID: 26967254
- Matuskey D, Worhunksy P, Correa E, Pittman B, Gallezot JD, Nabulsi N, Ropchan J, Sreeram V, Gudepu R, Gaiser E, Cosgrove K, Ding YS, Potenza MN, Huang Y, Malison RT, Carson RE: Age-related changes in binding of the D2/3 receptor radioligand [(11)C](+)PHNO in healthy volunteers. Neuroimage. 2016 Apr 15; 2016 Feb 11. PMID: 26876475
- Hillmer AT, Kloczynski T, Sandiego CM, Pittman B, Anderson JM, Labaree D, Gao H, Huang Y, Deluliis G, O'Malley SS, Carson RE, Cosgrove KP: Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence. Alcohol Clin Exp Res. 2016 Apr; 2016 Mar 12. PMID: 26971694
- Hillmer AT, Zheng MQ, Li S, Scheunemann M, Lin SF, Holden D, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Carson RE, Brust P, Huang Y: PET imaging evaluation of [(18)F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates. Eur J Nucl Med Mol Imaging. 2016 Mar; 2015 Oct 12. PMID: 26455500
- Zheng MQ, Lin SF, Holden D, Naganawa M, Ropchan JR, Najafzaden S, Kapinos M, Tabriz M, Carson RE, Hamill TG, Huang Y: Comparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK-6577 in baboons. Synapse. 2016 Mar; 2016 Jan 6. PMID: 26671330
- Nicolas JM, Hannestad J, Holden D, Kervyn S, Nabulsi N, Tytgat D, Huang Y, Chanteux H, Staelens L, Matagne A, Mathy FX, Mercier J, Stockis A, Carson RE, Klitgaard H: Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action. Epilepsia. 2016 Feb; 2015 Dec 10. PMID: 26663401
- Naganawa M, Dickinson GL, Zheng MQ, Henry S, Vandenhende F, Witcher J, Bell R, Nabulsi N, Lin SF, Ropchan J, Neumeister A, Ranganathan M, Tauscher J, Huang Y, Carson RE: Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050. J Pharmacol Exp Ther. 2016 Feb; 2015 Dec 1. PMID: 26628406
- D'Souza DC, Cortes-Briones JA, Ranganathan M, Thurnauer H, Creatura G, Surti T, Planeta B, Neumeister A, Pittman B, Normandin M, Kapinos M, Ropchan J, Huang Y, Carson RE, Skosnik PD: Rapid Changes in CB1 Receptor Availability in Cannabis Dependent Males after Abstinence from Cannabis. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jan 1. PMID: 26858993
- D'Souza DC, Cortes-Briones JA, Ranganathan M, Thurnauer H, Creatura G, Surti T, Planeta B, Neumeister A, Pittman B, Normandin MD, Kapinos M, Ropchan J, Huang Y, Carson RE, Skosnik PD: Rapid Changes in Cannabinoid 1 Receptor Availability in Cannabis-Dependent Male Subjects After Abstinence From Cannabis. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jan; 2015 Oct 22. PMID: 29560896
- Xia Y, Zheng MQ, Holden D, Lin SF, Kapinos M, Ropchan J, Gallezot JD, Huang Y, Carson RE: Measurement of Bmax and Kd with the glycine transporter 1 radiotracer ¹⁸F-MK6577 using a novel multi-infusion paradigm. J Cereb Blood Flow Metab. 2015 Dec; 2015 Jul 22. PMID: 26198176
- Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O'Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP: Imaging robust microglial activation after lipopolysaccharide administration in humans with PET. Proc Natl Acad Sci U S A. 2015 Oct 6; 2015 Sep 18. PMID: 26385967
- Matuskey D, Gaiser EC, Gallezot JD, Angarita GA, Pittman B, Nabulsi N, Ropchan J, MaCleod P, Cosgrove KP, Ding YS, Potenza MN, Carson RE, Malison RT: A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO. Drug Alcohol Depend. 2015 Sep 1; 2015 Jun 30. PMID: 26164205
- Park E, Sullivan JM, Planeta B, Gallezot JD, Lim K, Lin SF, Ropchan J, McCarthy TJ, Ding YS, Morris ED, Williams WA, Huang Y, Carson RE: Test-retest reproducibility of the metabotropic glutamate receptor 5 ligand [¹⁸F]FPEB with bolus plus constant infusion in humans. Eur J Nucl Med Mol Imaging. 2015 Sep; 2015 Jun 5. PMID: 26044120
- Normandin MD, Zheng MQ, Lin KS, Mason NS, Lin SF, Ropchan J, Labaree D, Henry S, Williams WA, Carson RE, Neumeister A, Huang Y: Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: assessment of kinetic analysis methods, test-retest reproducibility, and gender differences. J Cereb Blood Flow Metab. 2015 Aug; 2015 Apr 1. PMID: 25833345
- Park E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O'Connor KC, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D: (11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas. Eur J Nucl Med Mol Imaging. 2015 Jun; 2015 Apr 2. PMID: 25833352
- Hwang JJ, Yeckel CW, Gallezot JD, Aguiar RB, Ersahin D, Gao H, Kapinos M, Nabulsi N, Huang Y, Cheng D, Carson RE, Sherwin R, Ding YS: Imaging human brown adipose tissue under room temperature conditions with (11)C-MRB, a selective norepinephrine transporter PET ligand. Metabolism. 2015 Jun; 2015 Mar 5. PMID: 25798999
- Bois F, Gallezot JD, Zheng MQ, Lin SF, Esterlis I, Cosgrove KP, Carson RE, Huang Y: Evaluation of [(18)F]-(-)-norchlorofluorohomoepibatidine ([(18)F]-(-)-NCFHEB) as a PET radioligand to image the nicotinic acetylcholine receptors in non-human primates. Nucl Med Biol. 2015 Jun; 2014 Aug 8. PMID: 25858513
- Slifstein M, van de Giessen E, Van Snellenberg J, Thompson JL, Narendran R, Gil R, Hackett E, Girgis R, Ojeil N, Moore H, D'Souza D, Malison RT, Huang Y, Lim K, Nabulsi N, Carson RE, Lieberman JA, Abi-Dargham A: Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study. JAMA Psychiatry. 2015 Apr. PMID: 25651194
- Saricicek A, Chen J, Planeta B, Ruf B, Subramanyam K, Maloney K, Matuskey D, Labaree D, Deserno L, Neumeister A, Krystal JH, Gallezot JD, Huang Y, Carson RE, Bhagwagar Z: Test-retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943. Eur J Nucl Med Mol Imaging. 2015 Mar; 2014 Nov 27. PMID: 25427881
- DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Yang J, Wen R, Mann JJ, Krystal JH, Parsey RV, Carson RE, Esterlis I: In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5. Biol Psychiatry. 2015 Feb 1; 2014 Jul 10. PMID: 25156701
- Naganawa M, Zheng MQ, Henry S, Nabulsi N, Lin SF, Ropchan J, Labaree D, Najafzadeh S, Kapinos M, Tauscher J, Neumeister A, Carson RE, Huang Y: Test-retest reproducibility of binding parameters in humans with 11C-LY2795050, an antagonist PET radiotracer for the κ opioid receptor. J Nucl Med. 2015 Feb; 2015 Jan 15. PMID: 25593119
- Lin SF, Labaree D, Chen MK, Holden D, Gallezot JD, Kapinos M, Teng JK, Najafzadeh S, Plisson C, Rabiner EA, Gunn RN, Carson RE, Huang Y: Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis. Synapse. 2015 Feb; 2014 Dec 11. PMID: 25450608
- Sirianni RW, Zheng MQ, Patel TR, Shafbauer T, Zhou J, Saltzman WM, Carson RE, Huang Y: Radiolabeling of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with biotinylated F-18 prosthetic groups and imaging of their delivery to the brain with positron emission tomography. Bioconjug Chem. 2014 Dec 17; 2014 Dec 1. PMID: 25322194
- Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O'Malley S, Carson RE, Krystal JH: Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proc Natl Acad Sci U S A. 2014 Dec 16; 2014 Dec 1. PMID: 25453062
- Matuskey D, Bhagwagar Z, Planeta B, Pittman B, Gallezot JD, Chen J, Wanyiri J, Najafzadeh S, Ropchan J, Geha P, Huang Y, Potenza MN, Neumeister A, Carson RE, Malison RT: Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans. Biol Psychiatry. 2014 Nov 15; 2013 Nov 28. PMID: 24433854
- Naganawa M, Zheng MQ, Nabulsi N, Tomasi G, Henry S, Lin SF, Ropchan J, Labaree D, Tauscher J, Neumeister A, Carson RE, Huang Y: Kinetic modeling of (11)C-LY2795050, a novel antagonist radiotracer for PET imaging of the kappa opioid receptor in humans. J Cereb Blood Flow Metab. 2014 Nov; 2014 Sep 3. PMID: 25182664
- Pietrzak RH, Naganawa M, Huang Y, Corsi-Travali S, Zheng MQ, Stein MB, Henry S, Lim K, Ropchan J, Lin SF, Carson RE, Neumeister A: Association of in vivo κ-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology. JAMA Psychiatry. 2014 Nov. PMID: 25229257
- Gallezot JD, Esterlis I, Bois F, Zheng MQ, Lin SF, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE, Cosgrove KP: Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys. Synapse. 2014 Nov; 2014 Jul 28. PMID: 25043426
- Naganawa M, Jacobsen LK, Zheng MQ, Lin SF, Banerjee A, Byon W, Weinzimmer D, Tomasi G, Nabulsi N, Grimwood S, Badura LL, Carson RE, McCarthy TJ, Huang Y: Evaluation of the agonist PET radioligand [¹¹C]GR103545 to image kappa opioid receptor in humans: kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242. Neuroimage. 2014 Oct 1; 2014 May 17. PMID: 24844744
- Pietrzak RH, Huang Y, Corsi-Travali S, Zheng MQ, Lin SF, Henry S, Potenza MN, Piomelli D, Carson RE, Neumeister A: Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. Neuropsychopharmacology. 2014 Oct; 2014 May 12. PMID: 24820537
- Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV: Biodistribution and radiation dosimetry of LMI1195: first-in-human study of a novel 18F-labeled tracer for imaging myocardial innervation. J Nucl Med. 2014 Sep; 2014 Jul 3. PMID: 24994931
- Zheng MQ, Kim SJ, Holden D, Lin SF, Need A, Rash K, Barth V, Mitch C, Navarro A, Kapinos M, Maloney K, Ropchan J, Carson RE, Huang Y: An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of (11)C-LY2459989. J Nucl Med. 2014 Jul; 2014 May 22. PMID: 24854795
- Matuskey D, Gallezot JD, Pittman B, Williams W, Wanyiri J, Gaiser E, Lee DE, Hannestad J, Lim K, Zheng MQ, Lin SF, Labaree D, Potenza MN, Carson RE, Malison RT, Ding YS: Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO. Drug Alcohol Depend. 2014 Jun 1; 2014 Mar 20. PMID: 24717909
- Gallezot JD, Zheng MQ, Lim K, Lin SF, Labaree D, Matuskey D, Huang Y, Ding YS, Carson RE, Malison RT: Parametric Imaging and Test-Retest Variability of ¹¹C-(+)-PHNO Binding to D₂/D₃ Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner. J Nucl Med. 2014 Jun; 2014 Apr 14. PMID: 24732151
- Gallezot JD, Kloczynski T, Weinzimmer D, Labaree D, Zheng MQ, Lim K, Rabiner EA, Ridler K, Pittman B, Huang Y, Carson RE, Morris ED, Cosgrove KP: Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET. Neuropsychopharmacology. 2014 Mar; 2013 Oct 15. PMID: 24220025
- Jin X, Mulnix T, Sandiego CM, Carson RE: Evaluation of frame-based and event-by-event motion-correction methods for awake monkey brain PET imaging. J Nucl Med. 2014 Feb; 2014 Jan 16. PMID: 24434295
- Li CS, Potenza MN, Lee DE, Planeta B, Gallezot JD, Labaree D, Henry S, Nabulsi N, Sinha R, Ding YS, Carson RE, Neumeister A: Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[(11)C]O-methylreboxetine. Neuroimage. 2014 Feb 1; 2013 Oct 10. PMID: 24121204
- Martinez D, Slifstein M, Nabulsi N, Grassetti A, Urban NB, Perez A, Liu F, Lin SF, Ropchan J, Mao X, Kegeles LS, Shungu DC, Carson RE, Huang Y: Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy. Biol Psychiatry. 2014 Jan 15; 2013 Sep 12. PMID: 24035345
- Naganawa M, Nabulsi N, Planeta B, Gallezot JD, Lin SF, Najafzadeh S, Williams W, Ropchan J, Labaree D, Neumeister A, Huang Y, Carson RE: Tracer kinetic modeling of [(11)C]AFM, a new PET imaging agent for the serotonin transporter. J Cereb Blood Flow Metab. 2013 Dec; 2013 Aug 7. PMID: 23921898
- Sandiego CM, Jin X, Mulnix T, Fowles K, Labaree D, Ropchan J, Huang Y, Cosgrove K, Castner SA, Williams GV, Wells L, Rabiner EA, Carson RE: Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals. J Nucl Med. 2013 Nov; 2013 Oct 10. PMID: 24115528
- Pietrzak RH, Gallezot JD, Ding YS, Henry S, Potenza MN, Southwick SM, Krystal JH, Carson RE, Neumeister A: Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus. JAMA Psychiatry. 2013 Nov. PMID: 24048210
- Chan C, Jin X, Fung EK, Naganawa M, Mulnix T, Carson RE, Liu C: Event-by-event respiratory motion correction for PET with 3D internal-1D external motion correlation. Med Phys. 2013 Nov. PMID: 24320466
- Hannestad J, DellaGioia N, Gallezot JD, Lim K, Nabulsi N, Esterlis I, Pittman B, Lee JY, O'Connor KC, Pelletier D, Carson RE: The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study. Brain Behav Immun. 2013 Oct; 2013 Jul 9. PMID: 23850810
- Jin X, Mulnix T, Gallezot JD, Carson RE: Evaluation of motion correction methods in human brain PET imaging--a simulation study based on human motion data. Med Phys. 2013 Oct. PMID: 24089924
- Sirianni RW, Zheng MQ, Saltzman WM, Huang Y, Carson RE: Direct, quantitative, and noninvasive imaging of the transport of active agents through intact brain with positron emission tomography. Mol Imaging Biol. 2013 Oct. PMID: 23624949
- Kim SJ, Zheng MQ, Nabulsi N, Labaree D, Ropchan J, Najafzadeh S, Carson RE, Huang Y, Morris ED: Determination of the in vivo selectivity of a new κ-opioid receptor antagonist PET tracer 11C-LY2795050 in the rhesus monkey. J Nucl Med. 2013 Sep; 2013 Aug 5. PMID: 23918735
- Jin X, Chan C, Mulnix T, Panin V, Casey ME, Liu C, Carson RE: List-mode reconstruction for the Biograph mCT with physics modeling and event-by-event motion correction. Phys Med Biol. 2013 Aug 21; 2013 Jul 29. PMID: 23892635
- Sandiego CM, Nabulsi N, Lin SF, Labaree D, Najafzadeh S, Huang Y, Cosgrove K, Carson RE: Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys. Synapse. 2013 Aug; 2013 Mar 27. PMID: 23424090
- Zhou J, Patel TR, Sirianni RW, Strohbehn G, Zheng MQ, Duong N, Schafbauer T, Huttner AJ, Huang Y, Carson RE, Zhang Y, Sullivan DJ Jr, Piepmeier JM, Saltzman WM: Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma. Proc Natl Acad Sci U S A. 2013 Jul 16; 2013 Jul 1. PMID: 23818631
- Sullivan JM, Lim K, Labaree D, Lin SF, McCarthy TJ, Seibyl JP, Tamagnan G, Huang Y, Carson RE, Ding YS, Morris ED: Kinetic analysis of the metabotropic glutamate subtype 5 tracer [(18)F]FPEB in bolus and bolus-plus-constant-infusion studies in humans. J Cereb Blood Flow Metab. 2013 Apr; 2012 Dec 19. PMID: 23250105
- Tomasi G, Nabulsi N, Zheng MQ, Weinzimmer D, Ropchan J, Blumberg L, Brown-Proctor C, Ding YS, Carson RE, Huang Y: Determination of in vivo Bmax and Kd for 11C-GR103545, an agonist PET tracer for κ-opioid receptors: a study in nonhuman primates. J Nucl Med. 2013 Apr; 2013 Feb 19. PMID: 23424192
- Fung EK, Carson RE: Cerebral blood flow with [15O]water PET studies using an image-derived input function and MR-defined carotid centerlines. Phys Med Biol. 2013 Mar 21; 2013 Feb 27. PMID: 23442733
- Zheng MQ, Nabulsi N, Kim SJ, Tomasi G, Lin SF, Mitch C, Quimby S, Barth V, Rash K, Masters J, Navarro A, Seest E, Morris ED, Carson RE, Huang Y: Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imaging. J Nucl Med. 2013 Mar; 2013 Jan 25. PMID: 23353688
- Lee DE, Gallezot JD, Zheng MQ, Lim K, Ding YS, Huang Y, Carson RE, Morris ED, Cosgrove KP: Test-retest reproducibility of [11C]-(+)-propyl-hexahydro-naphtho-oxazin positron emission tomography using the bolus plus constant infusion paradigm. Mol Imaging. 2013 Mar-Apr. PMID: 23415395
- Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE, Cosgrove KP: Imaging changes in synaptic acetylcholine availability in living human subjects. J Nucl Med. 2013 Jan; 2012 Nov 15. PMID: 23160789
- Sandiego CM, Weinzimmer D, Carson RE: Optimization of PET-MR registrations for nonhuman primates using mutual information measures: a Multi-Transform Method (MTM). Neuroimage. 2013 Jan 1; 2012 Aug 25. PMID: 22926293
- Yan J, Planeta-Wilson B, Carson RE: Direct 4-D PET list mode parametric reconstruction with a novel EM algorithm. IEEE Trans Med Imaging. 2012 Dec; 2012 Aug 23. PMID: 22929383
- Hannestad J, Gallezot JD, Schafbauer T, Lim K, Kloczynski T, Morris ED, Carson RE, Ding YS, Cosgrove KP: Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates. Neuroimage. 2012 Oct 15; 2012 Jul 6. PMID: 22776451
- Lin SF, Fan X, Yeckel CW, Weinzimmer D, Mulnix T, Gallezot JD, Carson RE, Sherwin RS, Ding YS: Ex vivo and in vivo evaluation of the norepinephrine transporter ligand [11C]MRB for brown adipose tissue imaging. Nucl Med Biol. 2012 Oct; 2012 May 16. PMID: 22595487
- Matuskey D, Pittman B, Planeta-Wilson B, Walderhaug E, Henry S, Gallezot JD, Nabulsi N, Ding YS, Bhagwagar Z, Malison R, Carson RE, Neumeister A: Age effects on serotonin receptor 1B as assessed by PET. J Nucl Med. 2012 Sep; 2012 Jul 31. PMID: 22851636
- Normandin MD, Petersen KF, Ding YS, Lin SF, Naik S, Fowles K, Skovronsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL, Cline GW: In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET. J Nucl Med. 2012 Jun; 2012 May 9. PMID: 22573821
- Gallezot JD, Beaver JD, Gunn RN, Nabulsi N, Weinzimmer D, Singhal T, Slifstein M, Fowles K, Ding YS, Huang Y, Laruelle M, Carson RE, Rabiner EA: Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo. Synapse. 2012 Jun; 2012 Feb 24. PMID: 22213512
- Hannestad J, Subramanyam K, Dellagioia N, Planeta-Wilson B, Weinzimmer D, Pittman B, Carson RE: Glucose metabolism in the insula and cingulate is affected by systemic inflammation in humans. J Nucl Med. 2012 Apr; 2012 Mar 13. PMID: 22414635
- Wang X, Duffy P, McGee AW, Hasan O, Gould G, Tu N, Harel NY, Huang Y, Carson RE, Weinzimmer D, Ropchan J, Benowitz LI, Cafferty WB, Strittmatter SM: Recovery from chronic spinal cord contusion after Nogo receptor intervention. Ann Neurol. 2011 Nov. PMID: 22162062
- Singhal T, Ding YS, Weinzimmer D, Normandin MD, Labaree D, Ropchan J, Nabulsi N, Lin SF, Skaddan MB, Soeller WC, Huang Y, Carson RE, Treadway JL, Cline GW: Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes. Mol Imaging Biol. 2011 Oct; 2010 Sep 8. PMID: 20824509
- Cosgrove KP, Kloczynski T, Nabulsi N, Weinzimmer D, Lin SF, Staley JK, Bhagwagar Z, Carson RE: Assessing the sensitivity of [¹¹C]p943, a novel 5-HT1B radioligand, to endogenous serotonin release. Synapse. 2011 Oct; 2011 May 3. PMID: 21484884
- Gallezot JD, Weinzimmer D, Nabulsi N, Lin SF, Fowles K, Sandiego C, McCarthy TJ, Maguire RP, Carson RE, Ding YS: Evaluation of [(11)C]MRB for assessment of occupancy of norepinephrine transporters: Studies with atomoxetine in non-human primates. Neuroimage. 2011 May 1; 2010 Sep 30. PMID: 20869448
- Hannestad J, Gallezot JD, Planeta-Wilson B, Lin SF, Williams WA, van Dyck CH, Malison RT, Carson RE, Ding YS: Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo. Biol Psychiatry. 2010 Nov 1; 2010 Aug 5. PMID: 20691429
- Esterlis I, Cosgrove KP, Batis JC, Bois F, Stiklus SM, Perkins E, Seibyl JP, Carson RE, Staley JK: Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding. J Nucl Med. 2010 Aug; 2010 Jul 21. PMID: 20660383
- Qiu M, Paul Maguire R, Arora J, Planeta-Wilson B, Weinzimmer D, Wang J, Wang Y, Kim H, Rajeevan N, Huang Y, Carson RE, Constable RT: Arterial transit time effects in pulsed arterial spin labeling CBF mapping: insight from a PET and MR study in normal human subjects. Magn Reson Med. 2010 Feb. PMID: 19953506
- Nabulsi N, Huang Y, Weinzimmer D, Ropchan J, Frost JJ, McCarthy T, Carson RE, Ding YS: High-resolution imaging of brain 5-HT 1B receptors in the rhesus monkey using [11C]P943. Nucl Med Biol. 2010 Feb; 2009 Dec 1. PMID: 20152720
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