Brian B. Koo, MD

Associate Professor; Director, Sleep Medicine Program at Connecticut Veterans Affairs Healthcare System; Director, Yale Center for Restless Legs Syndrome

Research Interests

Neurology; Restless Legs Syndrome; Sleep; Veterans; Sleep Apnea, Obstructive; Stroke

Research Organizations


Center for Neuroepidemiology and Clinical Neurological Research

Faculty Research

Pulmonary, Critical Care & Sleep Medicine

Research Summary

My main research interests lie in the intersection between neurology and sleep medicine. My current area of focus is on the restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) and their association with cardiovascular disease. We have compiled epidemiologic evidence that PLMS is associated with the development of cardiovascular disease such as myocardial infarction, peripheral vascular disease and stroke. We are learning from additional studies that hypertension may play a role in this association. I am currently interested in taking a closer look at the sleep physiology in individuals with RLS and PLMS, inspecting specific time domain elements of these limb movements as well as heart rate and breathing. In addition to this vein of research, I have completed work on an animal model of RLS and am currently investigating the human genetics related to this troubling disorder.

Specialized Terms: Restless Legs Syndrome; Periodic Limb Movements During Sleep; Obstructive Sleep Apnea and Stroke

Selected Publications

Full List of PubMed Publications

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Contact Info

Brian B. Koo, MD
Patient Care Locations
Yale NeurologyYale Physicians Building
800 Howard Avenue, Ste Lower Level

New Haven, CT 06519
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Yale Center for Sleep Medicine1291 Boston Post Road, Ste Suite 202
Madison, CT 06443
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Yale Pulmonary & Critical Care MedicineClinic Building
789 Howard Avenue, Ste Winchester Chest Clinic

New Haven, CT 06519
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Yale Center for Sleep Medicine8 Devine Street
North Haven, CT 06473
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Mailing Address
NeurologyPO Box 208018
New Haven, CT 06520-8018