A note from YCCMD Director Karl L. Insogna, M.D.
The YCCMD facility was established through a shared instrument grant from NIH. Using these funds we were able to purchase a state-of-the-art ScanCo MicroCT 35 machine, which is currently housed in TAC S-138. I am acting as the Director of the facility, which is managed by Dr. Ben-hua Sun in Endocrinology.
Our machine has extremely high resolution with the capacity to resolve structures down to 3.5 microns. We have the ability to provide fine structural images at the level of individual trabeculae.
All specimens should be submitted using the YCCMD MicroCT Submission Form. Samples can be sent to:
Benhua Sun, MD
Internal Medicine Endocrinology
One Gilbert Street, Room TAC S-130
New Haven, CT 06519
I am available on a consultative basis to help interpret your data if needed. In order to maintain this facility, and cover the expense of the service contract, we charge $60/bone; $120 for whole calvaria. Costs for other special imaging modalities can be arranged on an individual basis, depending on the amount of machine time required.
We can analyze a variety of soft and hard tissues with our instrument, including rat and mouse bones, and segments of larger bones if need be, since we have a variety of sized holders that can be placed in the machine. Since the majority of you, we imagine, will be using the machine for either rat or mouse bones, we devised the template reports to reflect that, anticipating that the majority of you will be analyzing either vertebral bones or femurs. In the femur, we will analyze distal femur for trabecular and cortical bone. Our general report will include images at 7 microns that include a cross section of the whole bone to allow investigators to get some sense of the size and shape of their bones and the relative amount of cortex and trabecular bone present. An abstracted summary of the critical parameters, both cortical and trabecular, are included in the report, as well as a graphic summary of those changes that were most significantly different. The third tab on the report form will include all of the parameters acquired by the instrument.
It is vitally important that appropriate charging instructions be included with the samples. We will not be able to process samples without this information.
We rely on you for input and guidance, and we would welcome your comments and feedback.