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The Department of Internal Medicine is made up of 11 academic sections, each with their own research sections found below.
The broad research efforts of Cardiovascular Medicine are divided into five separate (and often interactive) domains: the Yale Cardiovascular Research Center (YCVRC), the Center for Outcomes Research (CORE), Clinical Studies, including the Yale Cardiovascular Research Group (YCVRG), the Yale Translational Imaging Center (YTRIC), and VA Connecticut Healthcare System Cardiology Research Group
Yale Digestive Diseases Section has had an enduring and continuing impact on fundamental and clinical investigation in digestive and liver disorders.
Home to a rich tapestry of basic, clinical and translational research activities, enhanced by 4 different interdepartmental research centers led by members of our Section.
Our research programs focus on core issues in general internal medicine including the epidemiology and outcomes in common chronic diseases (cardio-vascular disease, stroke, HIV disease, substance abuse and cancer), health policy, medical education and the humanities.
The Yale Geriatrics Faculty perform on-site research through the Yale Program on Aging and Pepper Center.
We offer comprehensive clinical care and research programs in both non-malignant and malignant hematologic diseases.
Focus of Research programs within the Infectious Diseases Section includes, Vector-borne diseases e.g. Lyme disease, Zika, West Nile, Malaria), Immunology of Aging, Infections in Older Adults, Microbial pathogenesis (bacterial, fungal and protozoal) relationship of allowed immunity to infection, pneumonia, HIV disease: Coinfection with Hepatitis C, HIV/HCV in the criminal justice system: US and internationally, nosocomial infections
We are committed to advancing the science and practice of medical oncology by understanding the molecular basis of the disease, and translating these advances to our clinics through innovative clinical trials.
Current areas of research focus include studies of the mechanisms of acute kidney injury and repair, molecular genetics of polycystic kidney disease and other cilia related disorders, renal tubular electrolyte transport and acid base regulation, renal epithelial cell biology and morphogenesis, and biomarkers in acute kidney injury and other kidney diseases.
The section has a wide and varied research portfolio that extends from basic bench-focused studies of disease pathogenesis and target gene validation to human-based studies of clinical issues such as cognitive impairment in the MICU.

Research encompasses a wide range of allergic and immunological diseases in pediatric and adult populations since our section is uniquely fully combined adult and pediatric in all aspects and extends considerably beyond typical IgE mediated wheal and flare allergic diseases to molecular genetic DNA analysis and therapeutic applications of nanovesicle exosomes.