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Jeffrey Wickersham, PhD

Assistant Professor of Medicine (AIDS); Affiliated Faculty, Yale Institute for Global Health



Jeffrey Wickersham is Assistant Professor of Medicine in the section of infectious diseases. His research is focused on improving HIV treatment and prevention outcomes among sexual and gender minorities, including transgender women, gay men, and bisexual men. Dr. Wickersham's research has focused on development of biomedical and behavioral interventions, including peer/patient navigation, implementation of pre-exposure prophylaxis (PrEP) for HIV prevention, development of artificial intelligence-based "chatbot" technology to improve uptake of HIV testing, and adaptation of mHealth applications for transgender women to scale-up HIV testing and linkage to PrEP services. Most of this research is being conducted in Southeast Asia, primarily at sites in Malaysia and Thailand.

Active Research

  • Developing an Artificial Intelligence Chatbot to Promote HIV Testing
    • Grant No: R21AI152927
    • This NIAID-funded R21 focuses on the development and evaluation of an artificial intelligence-based "chatbot" application to improve uptake of HIV testing among men who have sex with men (MSM), including gay and bisexual men, in Malaysia. The project will leverage machine learning technology to create an adaptive and resourceful tool that links and retains vulnerable, high-risk MSM in routine HIV testing and prevention services.
  • Improving HIV testing and PrEP for transgender women through mHealth
    • Grant No: R21AI157857
    • This multiple PI award (Yale: Jeffrey Wickersham; UConn: Roman Shrestha) aims to adapt and evaluate the feasibility and acceptability of a mHealth smartphone application to improve HIV testing uptake and retention, as well as facilitate linkage to PrEP, for transgender women in Malaysia. The selected application will include a clinician's portal that can empower smaller, community-based health care providers to engage with transgender patients and facilitate continuity of care.

Education & Training

  • Postdoctoral Associate
    Yale School of Medicine (2012)
  • PhD
    University of Connecticut (2010)
  • MA
    University of Maine (2005)
  • BA
    Southwestern University (2000)


  • Perspectives on Ethical Issues Around the Use of Smartphone Apps for HIV Prevention in Malaysia: Focus Group Study With Men Who Have Sex With Men
    Mansfield, United States 2022
  • Developing an Artificial Intelligence Chatbot to Promote HIV Testing
    Kuala Lumpur, Malaysia (2020-2022)
    This NIH-funded R21 grant aims to develop an artificial intelligence "chatbot" to improve the uptake of HIV testing among men who have sex with men in Malaysia. The project will utilize new technology in machine learning to generate a flexible new mHealth tool that can help link and retain MSM to routine HIV testing.
  • HIV Testing and Prevention among Thai Transgender Women and MSM
    Bangkok, Thailand 2018
    Research collaboration with Mahidol University examining innovations around HIV testing service delivery, including online HIV testing and at-home HIV testing, among Thai transgender women and men who have sex with men (MSM).
  • Pre-exposure Prophylaxis (PrEP) for HIV Prevention among Transgender Women Sex Workers in Malaysia
    Kuala Lumpur, Malaysia (2014-2019)
    Evaluation of behavioral and biomedical interventions for HIV and substance abuse prevention among female and transgender women sex workers in Malaysia.
  • HIV & Substance Dependence
    Kiev, Ukraine 2011
    Development and evaluation of medication-assisted treatment programs for opioid dependence among individuals reentering the community from correctional settings.
  • HIV and Drug Abuse in Malaysia
    Kuala Lumpur, Malaysia (2010-2015)
    Intervention of HIV, Drug Use and the Criminal Justice System in Malaysia

Departments & Organizations