COPD Program

Chronic obstructive pulmonary disease (COPD) is a major focus of both scientific and clinical interest in the Section of Pulmonary, Critical Care and Sleep Medicine. Drs. Patty Lee, Naftali KaminskiCharles Dela Cruz, and Min-Jong Kang have recently identified novel mechanisms that likely contribute to the pathogenesis of pulmonary emphysema using transgenic and other mouse models of emphysema and airways inflammation.

Numerous members of PCCSM are currently collaborating in translational studies that are testing the applicability of these findings to human disease, investigating the molecular mechanisms underlying clinical heterogeneity in this disorder and the factors that affect the rate of decline in lung function among COPD patients. Clinical faculty members with particular expertise and interest in COPD include Dr. Carolyn Rochester (Winchester Clinic and VA) and Dr. Hilary Cain (VA). A broad base of patients with COPD, ranging from those with mild disease to those in need of rehabilitation, assisted ventilation or under consideration for Lung Volume Reduction Surgery or Lung Transplantation are seen at the Winchester Chest Clinic COPD Center and the two campuses (West Haven and Newington) of the VA-CT Medical Center.

An outpatient Pulmonary Rehabilitation Program was developed at the West Haven VA to improve the functional capacity, exercise tolerance and symptoms of patients with COPD and other forms of chronic respiratory disease. Drs. Rochester and Cain are also participating in a multi-center, randomized, placebo-controlled trial investigating the effects of the long acting anticholinergic, Tiotropium, on lung function in COPD (based at the West Haven VAMC).

COPD Work Team

Bio Profile

Carolyn Rochester, MD

Professor

Medical Director, Pulmonary Rehabilitation Program

Medical Director, Yale COPD Center

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Publications

Spruit MA, Singh SJ, Rochester CL, Greening NJ, Franssen FME, Pitta F, Troosters T, Nolan C, Vogiatzis I, Clini EM, Man WD, Burtin C, Goldstein RS, Vanfleteren LEGW, Kenn K, Nici L, Janssen DJA, Casaburi R, Shioya T, Garvey C, Carlin BW, ZuWallack RL, Steiner M, Wouters EFM, Puhan MA: Pulmonary rehabilitation for patients with COPD during and after an exacerbation-related hospitalisation: back to the future? Eur Respir J. 2018 Jan; 2018 Jan 11. PMID: 29326328

Korde A, Jin L, Zhang JG, Ramaswamy A, Hu B, Kolahian S, Guardela BJ, Herazo-Maya J, Siegfried JM, Stabile L, Pisani MA, Herbst RS, Kaminski N, Elias JA, Puchalski JT, Takyar SS: Lung Endothelial MicroRNA-1 Regulates Tumor Growth and Angiogenesis. Am J Respir Crit Care Med. 2017 Dec 1. PMID: 28853613

Rochester CL, Spruit MA: Maintaining the Benefits of Pulmonary Rehabilitation. The Holy Grail. Am J Respir Crit Care Med. 2017 Mar 1. PMID: 28248138

Vogiatzis I, Rochester CL, Spruit MA, Troosters T, Clini EM, American Thoracic Society/European Respiratory Society Task Force on Policy in Pulmonary Rehabilitation.: Increasing implementation and delivery of pulmonary rehabilitation: key messages from the new ATS/ERS policy statement. Eur Respir J. 2016 May. PMID: 27132269

Takyar S, Zhang Y, Haslip M, Jin L, Shan P, Zhang X, Lee PJ: An endothelial TLR4-VEGFR2 pathway mediates lung protection against oxidant-induced injury. FASEB J. 2016 Mar; 2015 Dec 11. PMID: 26655705

Pimienta G, Fok V, Haslip M, Nagy M, Takyar S, Steitz JA: Proteomics and Transcriptomics of BJAB Cells Expressing the Epstein-Barr Virus Noncoding RNAs EBER1 and EBER2. PLoS One. 2015; 2015 Jun 29. PMID: 26121143

Ahangari F, Sood A, Ma B, Takyar S, Schuyler M, Qualls C, Dela Cruz CS, Chupp GL, Lee CG, Elias JA: Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation. Am J Respir Crit Care Med. 2015 Apr 1. PMID: 25629580

Rochester CL, Fairburn C, Crouch RH: Pulmonary rehabilitation for respiratory disorders other than chronic obstructive pulmonary disease. Clin Chest Med. 2014 Jun. PMID: 24874132

Rochester CL, Spanevello A: Heterogeneity of pulmonary rehabilitation: like apples and oranges - both healthy fruit. Eur Respir J. 2014 May. PMID: 24789943

Franssen FM, Rochester CL: Comorbidities in patients with COPD and pulmonary rehabilitation: do they matter? Eur Respir Rev. 2014 Mar 1. PMID: 24591670

Takyar S, Vasavada H, Zhang JG, Ahangari F, Niu N, Liu Q, Lee CG, Cohn L, Elias JA: VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis. J Exp Med. 2013 Sep 23; 2013 Sep 16. PMID: 24043765

Lee CG, Ma B, Takyar S, Ahangari F, Delacruz C, He CH, Elias JA: Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2011 Nov. PMID: 22052929

Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA: RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. Am J Respir Crit Care Med. 2011 May 15; 2011 Jan 28. PMID: 21278304

Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA: Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol. 2011. PMID: 21054166

Vaz Fragoso CA, Concato J, McAvay G, Van Ness PH, Rochester CL, Yaggi HK, Gill TM: Chronic obstructive pulmonary disease in older persons: A comparison of two spirometric definitions. Respir Med. 2010 Aug; 2010 Mar 3. PMID: 20199857

Vaz Fragoso CA, Concato J, McAvay G, Van Ness PH, Rochester CL, Yaggi HK, Gill TM: The ratio of FEV1 to FVC as a basis for establishing chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010 Mar 1; 2009 Dec 17. PMID: 20019341

Rochester CL: Rehabilitation in the intensive care unit. Semin Respir Crit Care Med. 2009 Dec; 2009 Nov 25. PMID: 19941223

Vaz Fragoso CA, Concato J, McAvay G, Van Ness PH, Rochester CL, Yaggi HK, Gill TM: Defining chronic obstructive pulmonary disease in older persons. Respir Med. 2009 Oct; 2009 May 21. PMID: 19464159

Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA: IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J Immunol. 2007 Feb 1. PMID: 17237446

Rochester CL: Exercise training in chronic obstructive pulmonary disease. J Rehabil Res Dev. 2003 Sep-Oct. PMID: 15074454

Rochester CL, Mohsenin V: Respiratory complications of stroke. Semin Respir Crit Care Med. 2002 Jun. PMID: 16088617

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