Jonathan Koff, MD

Associate Professor Term; Director, Adult Cystic Fibrosis Program

Research Interests

Asthma; Bronchiectasis; Cystic Fibrosis; Influenza, Human; Lung; Viruses; Respiratory Mucosa

Research Organizations

Internal Medicine: CPIRT - Pulmonary Infection Research and Treatment | Koff Laboratory | Liver Center

Office of Cooperative Research

Research Summary

The airways are continuously exposed to pathogens, allergens, toxins, and environmental contaminants. In addition to its role as a physical barrier, the airway epithelial surface represents a “battleground,” where the host intercepts signals from pathogens (e.g., viruses) and activates epithelial defenses to prevent infection. The defensive roles of the airway epithelium are crucial; the epithelium activates innate defense mechanisms and recruits inflammatory and immune cells to activate innate immune responses and to amplify adaptive immunity. Our research program focuses on elucidating airway epithelial inflammatory responses to viral infection. Utilizing both in vitro and ex vivo airway epithelial cell cultures and murine models, we have found novel signaling pathways which regulate viral infection. Currently, there are only limited therapies available to treat viral exacerbations of chronic airway diseases (e.g., asthma, COPD, and cystic fibrosis); therefore investigating novel viral mechanisms may provide targets for novel therapies.

Selected Publications

Full List of PubMed Publications

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Contact Info

Jonathan Koff, MD
Patient Care Locations
Winchester Chest ClinicFitkin Memorial Pavilion
789 Howard Avenue, Ste 2nd Floor

New Haven, CT 06519
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Yale Pulmonary & Critical Care MedicineYale New Haven Hospital
20 York Street

New Haven, CT 06510
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Lab Location
The Anlyan Center
300 Cedar Street, Ste S430

New Haven, CT 06519
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Office Location
The Anlyan Center
300 Cedar Street, Ste S455C

New Haven, CT 06519
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Mailing Address
PO Box 208057
300 Cedar Street

New Haven, CT 06520-8057

Koff Laboratory