Charles Dela Cruz, MD, PhD

Associate Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) and of Microbial Pathogenesis; Director, Center for Pulmonary Infection Research and Treatment (CPIRT)

Research Interests

Respiratory Tract Infections; Pulmonary Disease, Chronic Obstructive

Research Organizations

Internal Medicine: Pulmonary, Critical Care & Sleep Medicine: CPIRT - Pulmonary Infection Research and Treatment; Dela Cruz Lab; The Center for Precision Pulmonary Medicine (P2MED)

Microbial Pathogenesis

Virology Laboratories

Yale Stem Cell Center

Office of Cooperative Research

Research Summary

Our group is committed to innovative and cutting-edge basic, translational and clinical research that will further our understanding of pulmonary infections and lead to effective diagnosis and treatment. Current therapies for pulmonary infections have largely focused on the use of antibiotics and have led to the rapid emergence of drug resistance and hypervirulent strains. We will address current priorities in novel strategies in studying the host and the pathogen for both acute and chronic pulmonary infections. The research endeavors are aimed at delineating the basic mechanisms by which pulmonary pathogens cause disease as well as applying scientific advances to promote patient diagnosis and treatment

Our work is focused in both explorative and targeted research relevant to pulmonary infection and immunity in 3 specific areas:

(1) To explore the basic science of key host-microbe molecular and cellular interactions in the lung;

(2) To investigate and define the mechanisms of infections which either cause or exacerbate acute / chronic lung diseases using both basic and translational approaches;

(3) To utilize and develop novel technologies that will make it possible to better diagnose and treat pernicious lung infections.

Selected Publications

Full List of PubMed Publications

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Contact Info

Charles Dela Cruz, MD, PhD
Patient Care Locations
VA Connecticut Healthcare
950 Campbell Avenue

West Haven, CT 06516
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Winchester Chest ClinicFitkin Memorial Pavilion
789 Howard Avenue

New Haven, CT 06519
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Yale Pulmonary & Critical Care MedicineYale New Haven Hospital
20 York Street

New Haven, CT 06510
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Office Location
The Anlyan Center
300 Cedar Street, Ste S441

New Haven, CT 06519
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Mailing Address
Pulmonary, Critical Care & Sleep MedicinePO Box 208057
300 Cedar Street

New Haven, CT 06520-8057

Dela Cruz Lab