Nikhil Joshi, PhD

My laboratory uses intricate tumor models and advanced approaches to investigate immune cell interactions with developing tumors. My goal is to determine mechanistically why these interactions do not lead to more potent anti-tumor responses and to identify entry points for modulating these interactions through genetic manipulation and therapeutic intervention. My previous studies have focused on using established complex mouse models to investigate how subtypes of T cells in the tumor microenvironment impact tumor development. My laboratory will combine advanced genetic modeling of mice and immunologic techniques to address fundamental questions in tumor immunology.