Research & Publications
Maor Sauler has been a member of the Pulmonary & Critical Care faculty since 2014. Dr. Sauler specializes in adult critical care including acute lung injury and sepsis. He also sees patients in the outpatient setting with pulmonary diseases such as Chronic Obstructive Pulmonary Disease (COPD). Dr. Sauler is board-certified in internal medicine, pulmonary medicine, and critical care medicine.
Dr. Sauler earned his undergraduate degree from Princeton University and received his MD from Rutgers-New Jersey Medical School. Dr. Sauler then completed both an internship and residency in internal medicine at Yale-New Haven Hospital. He went on to complete fellowship training in pulmonary and critical care medicine at Yale-School of Medicine.
The overall goal of Dr. Sauler's research program is to study biologic mechanisms that maintain lung "resilience" in response to oxidative stress and DNA damage. His research focuses on understanding cellular stress responses that change with age or with COPD, and then try to identify mechanisms through which these aberrant cellular stress responses contribute to susceptibility to injury, excessive inflammation, or abnormal lung repair. To do this, his lab integrates lung- and cell-targeted genetic mouse models, cell-based assays, novel imaging techniques, and multiple high-throughput genomic approaches. His work has focused on the role of Macrophage Migration Inhibitory Factor (MIF), a canonical innate immune cytokine that is secreted in response to oxidative stress, DNA damage, and infection. Dr. Sauler's lab has identified mechanisms through which this cytokine can mitigate oxidative stress, cellular senescence, and apoptosis, and promote tissue repair. His research has also demonstrated that expression of DNA repair enzymes are decreased in COPD and he has identified a dysregulated miR-24-3p/BRCA1 signaling network that may contribute to COPD pathogenesis.
Education & Training
- FellowYale School of Medicine (2014)
- ResidentYale-New Haven Hospital (2009)
- InternYale-New Haven Hospital (2007)
- MDRutgers New Jersey Medical School (2006)
- BAPrinceton University (2001)
Honors & Recognition
|K08 Career Development Award||National Institute of Health, NHLBI||2017|
|Young Clinical Scientist Award||Flight Attendant Medical Research Institute||2015|
|Abstract Scholarship Award||American Thoracic Society||2015|
|Parker B. Francis Fellowship||Francis Ford Foundation||2015|
|Distinction in Scholarship||American Physiology Society||2014|
|Senior Research Training Fellowship||American Lung Association||2013|
|Respiratory DIsease Young Investigators' Forum, Top Presentation Award||2013|