Erol Fikrig

Erol Fikrig

MD
Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis; Investigator, Howard Hughes Medical Institute; Section Chief, Infectious Diseases

Contact Information

Erol Fikrig, MD

Patient Care Location

Office Location

Mailing Address

  • Infectious Diseases

    PO Box 208031, 300 Cedar Street

    New Haven, CT, 06520-8056

    United States

Erol Fikrig

Appointments

Biography

My laboratory investigates vector-borne diseases. Studies are directed toward understanding Lyme disease, Human granulocytic ehrlichiosis, and West Nile virus. Efforts on Lyme disease include exploring immunity to Borrelia burgdorferi, selective B. burgdorferi gene expression in vivo, and the immunobiology of Lyme arthritis. Human granulocytic ehrlichiosis is caused by a newly described pathogen, transmitted by Ixodes scapularis ticks, that persists within neutrophils. We are investigating the molecular strategies that this pathogen uses to survive in polymorphonuclear leukocytes. West Nile virus can cause fatal encephalitis, and we seek to understand the pathogenesis of this emerging disease. Finally, we are also developing molecular approaches to prevent ticks from feeding on a mammalian host, thereby interfering with pathogen transmission.

Education & Training

  • MD
    Cornell University (1985)
  • BA
    Cornell University (1981)
  • Resident
    Vanderbilt University Hospital
  • Fellow
    Yale University School of Medicine
  • Board Certification
    AB of Internal Medicine, Internal Medicine (1988)

Activities

  • West-Nile Virus Protein
    Canada 2010
    Yale and McGill University scientists have identified a protein that is critical in fighting mosquito-borne West Nile Virus in mice. This finding could have therapeutic implications for controlling the potentially deadly virus in humans. The study appears in the Advance Online Publication of Nature Immunology.
  • Pathogenesis of Lyme Disease
    Netherlands 2007
    The goal of this project is to determine how specific components of the Lyme disease agent, Borrelia burgdorferi, and its arthropod vector, Ixodes ticks, contribute to the pathogenesis of Lyme disease in Europe.
  • Pathogenesis of Lyme Disease
    Netherlands 2007
    The goal of this project is to determine how specific components of the Lyme disease agent, Borrelia burgdorferi, and its arthropod vector, Ixodes ticks, contribute to the pathogenesis of Lyme disease in Europe.

Departments & Organizations