Joseph Brennan, MD, BS

Associate Professor of Medicine (Cardiology); Director, Interventional Cardiology Fellowship Program, Internal Medicine; Medical Director, Coronary Intensive Care Unit, Yale-New Haven Hospital, Yale Medicine; Director, Inpatient Cardiology Services, Yale Medicine

Departments & Organizations

Internal Medicine: Cardiovascular Medicine: Cardiac Inpatient Services; Cardiomyopathy & Inherited Cardiovascular Disease Program; Interventional Cardiology Program

Yale Medicine

Office of Cooperative Research


I have been a member of the Section of Cardiovascular Medicine since completion of Cardiology fellowship in 1989. My primary interest has been clinical cardiology particularly in the areas of both Intensive Care Cardiology (serving as Medical Director of the CICU) as well as Interventional cardiology (serving as the Fellowship Director of the Interventional Cardiology Fellowship for the past 20 yrs). I have been the recipient of innumerable teaching awards both within the Yale Medical School as ell as the Department of Medicine/Section of Cardiology.

Education & Training

MD Medical College of Virginia, Richmond, Virginia (1983)
BS College of William and Mary, Biology (1978)
Fellow Yale New Haven Hospital
Chief Resident Yale New Haven Hospital
Resident Yale New Haven Hospital
Board Certification AB of Internal Medicine, Internal Medicine (1987)
Board Certification AB of Internal Medicine, Cardiovascular Disease (1989)
Board Certification AB of Internal Medicine, Interventional Cardiology (2001, recertified: 2012)

Honors & Recognition

  • Tow Humanism Award (2017)

  • Teacher of the Year Yale Primary Care Residency (2015)

  • Master Clinician Yale Primary Care Residency (2015)

  • Consultant of the Year Given by ED Residents (2013)

  • Teacher of the Year Cardiology Section (2012)

  • Nurses Choice Award (2012)

  • Teacher of the Year Yale Traditional Internal Medicine Residency (2011)

  • "Top Docs"Connecticut Magazine (2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019)

  • Fellow, Society of Coronary Angiography and interventions (2005)

  • Connecticut State Medical Society (CSMS) (2005)

  • Inaugaral Faculty Award for Clinical Care- Dept. of Internal Medicine (2004)

  • Society of Distinguished Teachers- Yale University School of MedicineYale University (2000)

  • Outstanding House Staff Award- Given by Graduating Medical School Class (YSM) (1987)

  • Alpha Omega Alpha- Medical Honor SocietyVCU/MCV (1982)

  • Phi Beta KappaThe College of William and Mary (1976)

Professional Service

  • Department of Internal Medicine (2019 - Present) Facilitator/participant in Department of Internal Medicine Medical Error Disclosure Panel.

  • Department of Internal Medicine-RISE Faculty (2018 - Present) Discussant/Presenter/Facilitator at Workshops for new "hires" in Department of Internal Medicine at New Faculty Orientation.

  • Clinical Events Committee- LAAO Registry. Identifier: NCT02699957 (2018 - Present) Chair of committee to adjudicate events The Left Atrial Appendage Occlusion Registry (LAAO Registry™) is designed to assess the prevalence, demographics, management, and outcomes of patients undergoing percutaneous and epicardial based left atrial appendage occlusion procedures to reduce the risk of stroke. Patient-level data will be submitted by participating hospitals on a quarterly basis to the American College of Cardiology Foundation's National Cardiovascular Data Registry (NCDR). The primary aims of the LAAO Registry are to optimize the outcomes and management of patients through the implementation of evidence-based guideline recommendations in clinical practice, facilitate efforts to improve the quality and safety for patients undergoing percutaneous and epicardial based left atrial appendage procedures, investigate novel quality improvement methods and provide risk-adjusted assessment of patients for comparison with nationwide NCDR data.

  • Clinical Event Committee-REFLECT Trial. Identifier: NCT02536196 (2018 - 2019) Serving as member of Clinical Event Committee (CEC) for REFLECT Trial, adjudicating all outcome events for this large trial.The Keystone Heart TriGuard™ HDH is an aortic embolism deflection device intended to reduce the amount of embolic material that may enter the carotid, subclavian, and vertebral arteries during transcatheter heart valve implantation. The objective of the study is to assess the safety and efficacy of the TriGuard™ HDH embolic deflection device in patients undergoing transcatheter aortic valve implantation (TAVI), in comparison with an active control group of patients undergoing unprotected TAVI.

  • Clinical Events Committee-5. BIOHELIX I. Bare Metal Stent Study. Sponsor: Biotronik. Identifier: NCT01612767 (2017 - 2018) Adjudicated end point and clinical events for the investigational BIOTRONIK PRO-Kinetic Energy stent in subjects with atherosclerotic disease of native coronary arteries

  • Hearts Around the World (2016) Served as physician liasion in Havana, Cuba

  • WTNH New Haven Channel 8 (2016) Presenter/Speaker

  • Clinical Events Committee-6. SHOCKWAVE Coronary Rx Lithoplasty Study. Sponsor: Shockwave Medical Inc, Identifier: NCT02650128 (2016 - 2018) Adjudicated end point and clinical events for Prospective, multi-center, single arm study designed to evaluate the safety and performance of the Shockwave Coronary Rx Lithoplasty® System to treat calcified lesions in the coronary arteries for the purpose of enhancing the placement of stents and reducing the ultimate residual stenosis.

  • Clinical Events Committee-4. FANTOM II Trial: FANTOM Sirolimus-Eluting Bioresorbable Coronary Scaffold. Sponsor: REVA Medical. Identifier: NCT02539966 (2015 - 2017) Adjudicated end point and clinical events for Fantom Bioresorbable Coronary Scaffold in native coronary arteries

  • Yale New Haven Hospital-ICU Leadership Committee (2015 - Present) ICU leadership Committee

  • Clinical Event Committee-2. Chair, ABLATE Trial (Atherectomy by Laser Ablation With Turbo-Elite (ABLATE) Sponsor: Spectranetics Corporation. Identifier: NCT02307370 (2014 - 2017) Chair of Clinical events Committee for trial employing Spectranetics Laser treatment of infra-inguinal arteries

  • Hearts Around the World (2014) Served as physician liasion in Dalian, China

  • Clinical Events Committee-1. DEFLECT II: A Study to Evaluate the Safety and Performance of the (2014 - 2015) Served as member of committee to adjudicate clinical events related to a neuro-protective device for TAVRs.

  • Clinical Events Committee-3. SALUS. Transcatheter Aortic Valve Replacement System Pivotal trial. Sponsor: Direct Flow. Identifier: NCT02163850. (2013 - 2016) Adjudicated clinical events for a new Transcatheter Aortic valve (Direct Flow)

  • Yale New Haven Hospital-YNHH Hospitalist Advisory Committee (2013 - Present) Member of YNHH Hospitalist Advisory Committee

  • Yale New Haven Hospital-YNHH Medical Directors Leadership Committee (2013 - Present) Member of YNHH Medical Directors Leadership Committee

  • YNHH-HVC Patient Experience Forum (2013 - Present) Co-Chair HVC Paytient Experience Forum

  • YNHH-HVC Operations Committee (2013 - Present) HVC Operations Council

  • Yale University School of Medicine-YSM Cardiology Electives (2011 - Present) Served as Director of YSM Student Electives in Section of Cardiovascular Medicine

  • YNHH-Therapeutic Hypothermia Committee (2010 - Present) Member, Therapeutic Hypothermia Committee-YNHH

  • YNHH-Chest Pain Reaccreditation Committee (2010 - Present) Member, Chest Pain Center Reaccreditaion Committee

  • YNHH-D2B Committee (2008 - Present) Member, YNHH D2B Committee

  • Hearts Around the World (2005) Served as Physician liasion in St. Petersburg, Russia


  • CRT Washington, United States (2019 - 2019)

    Speaker- Fellowship Directors Symposium

  • Physician Education Havana, Cuba; Saint Petersburg, Russia; Dalian, China; Moschi, Tanzania; Dechapelle, Haiti (1985 - 2016)

    Have served in multiple areas around the world both during medical residency as well as a faculty member

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Contact Info

Joseph Brennan, MD, BS
Patient Care Locations
Yale CardiologyYale New Haven Hospital
20 York Street

New Haven, CT 06510
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Yale Heart and Vascular Outpatient Services
84 North Main Street

Branford, CT 06405
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Yale CardiologyYale Physicians Building
800 Howard Avenue

New Haven, CT 06519
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Cardiovascular Services of Greenwich, PCGreenwich Hospital
55 Holly Hill Lane, Ste Suite 240

Greenwich, CT 06830
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Yale CardiologyLaboratory for Medicine and Pediatrics (LMP)
15 York Street

New Haven, CT 06510
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Mailing Address
Cardiovascular MedicinePO Box 208056
New Haven, CT 06520-8056