Carlo Spirli, PhD

Associate Professor of Internal Medicine (Digestive Diseases)

Research Interests

Biliary Tract Diseases; Cystic Fibrosis; Digestive System Diseases; Liver Diseases; Alagille Syndrome

Research Organizations

Internal Medicine: Digestive Diseases | Liver Center

Faculty Research

Office of Cooperative Research

Research Summary

The main focus of my research is the pathophysiology and therapy of diseases of the biliary tree (also called cholangiopathies). This is a large group of chronic liver diseases, congenital or acquired, that causes significant morbility and mortality in both the adult and pediatric population. The pathogenesis of biliary tree diseases is still elusive and, contrary to other areas of hepatology, effective treatment is still lacking. Previous work of our laboratory has contributed to the understanding of the normal physiology of biliary cells and to the identification of prototypic mechanisms for biliary damage for which a model human cholangiopathy exists. Among them, the lab is now addressing the pathophysiology and treatment of Cystic Fibrosis cholangiopathy, polycystic liver disease and Alagille syndrome.

Selected Publications

Full List of PubMed Publications

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Contact Info

Carlo Spirli, PhD
Lab Location
The Anlyan Center
300 Cedar Street, Ste S-220

New Haven, CT 06519
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Office Location
The Anlyan Center
300 Cedar Street, Ste Suite S227 B

New Haven, CT 06519
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Mailing Address
Internal MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056

Curriculum Vitae