Acute Kidney Injury in Marathon Runners
Participation in marathons has gained popularity in the United States with up to 1,100 marathons and 507, 600 finishers. We have shown that the majority of runners develop transient acute kidney injury (AKI) with urine sediments and novel kidney injury biomarkers which reveal intrinsic tubular damage. The mechanism behind runner AKI has yet to be investigated.Currently, we have an enrollment of 45 runners who have participated in the Hartford, Connecticut marathon in years 2015 and 2017. We collected blood, urine, and sweat samples to measure both conventional and novel markers involved in injury, repair and regulatory responses, in order to better understand the mechanism behind the transient, yet severe, AKI in runners. We also collected extensive training histories, as well as detailed intake/output histories through questionnaires given to runners before and after the races.