Biomarkers for Diagnosis of Acute Interstitial Nephritis

Clinical diagnosis of acute interstitial nephritis (AIN) is challenging as there are no reliable, non-invasive biomarkers and its diagnosis currently requires a kidney biopsy. We are creating a cohort of participants with biopsy-confirmed AIN and controls. Since 2015, we have enrolled over 400 participants who underwent a kidney biopsy at Yale for evaluation of unexplained loss of kidney function.  This includes cases with AIN, as well as controls with other common kidney diseases.  The participants have donated plasma, urine and biopsy tissue for research.  

Information from this cohort has also helped us evaluate patient perspectives towards participation in biopsy-based studies in kidney diseases, as well as evaluate risks of kidney biopsies.

Contact Information

For more information, or if you are interested in collaborating on this study, please contact Dr. Dennis Moledina

Project Funding

Funding for this project comes, in part, from the following grants:


K23 DK117065 (NIH/NIDDK)
Career Development Award

18CDA34060118 (American Heart Association)
Career Development Award

E.  Leet and Clara Guthrie Patterson Trust
Mentored Clinical Research Award