Biomarkers for Diagnosis of Acute Interstitial Nephritis

Clinical diagnosis of acute interstitial nephritis (AIN) is challenging as there are no reliable, non-invasive biomarkers and its diagnosis currently requires a kidney biopsy. We are creating a cohort of participants with biopsy-confirmed AIN and controls. Since 2015, we have enrolled over 400 participants who underwent a kidney biopsy at Yale for evaluation of unexplained loss of kidney function.  This includes cases with AIN, as well as controls with other common kidney diseases.  The participants have donated plasma, urine and biopsy tissue for research.  

Information from this cohort has also helped us evaluate patient perspectives towards participation in biopsy-based studies in kidney diseases, as well as evaluate risks of kidney biopsies.

Bio Profile

Dennis Moledina, MBBS

Instructor

Investigative Medicine Program (PhD Candidate)

Attending Physician, Yale Medicine

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Michael Kashgarian
Professor of Pathology, Yale University

Michael Kuperman, MD
Nephropathologist, Arkana Laboratories

Gilbert Moeckel, MD, PhD
Professor of Pathology, Yale University

Chirag R. Parikh, MD, PhD
Adjunct Professor of Medicine, Nephrology, Yale University

Mark A. Perazella, MD
Professor of Medicine, Nephrology, Yale University

F. Perry Wilson, MD, MSCE
Assistant Professor of Medicine, Nephrology, Yale University


Publications

Contact Information

For more information, or if you are interested in collaborating on this study, please contact Dr. Dennis Moledina

Project Funding

Funding for this project comes, in part, from the following grants:


K23 DK117065 (NIH/NIDDK)
Career Development Award

18CDA34060118 (American Heart Association)
Career Development Award

E.  Leet and Clara Guthrie Patterson Trust
Mentored Clinical Research Award