Overview of Projects

The Program of Applied Translational Research (PATR) currently has thirteen projects under way. Below you will find information regarding each of them. If you are interested in learning more about them, you can explore their individual pages or contact us.

Biomarkers for Diagnosis of Acute Interstitial Nephritis

Clinical diagnosis of acute interstitial nephritis (AIN) is challenging as there are no reliable non-invasive biomarkers and its diagnosis currently requires a kidney biopsy.

Identification of Subclinical Acute Interstitial Nephritis

Acute interstitial nephritis (AIN) is a common condition characterized by minimal clinical features and slowly worsening kidney function.

Evaluation of the Prevalence and Outcomes of Acute Kidney Disease

Acute kidney disease (AKD) is a condition characterized by sub-acute loss of kidney function.

Kidney Precision Medicine Program at Yale AKI Site

In the hopes of discovering therapeutic targets for acute kidney injury, which currently has no specific therapy, the NIH/NIDDK has created the Kidney Precision Medicine Program consortium.

Phenotyping Deceased Donor Acute Kidney Injury to Predict Recipient Outcomes (Ancillary Study Using DDS)

There are over 100,000 patients awaiting a kidney transplant, but only 20% will receive one.

The Role of Adaptive and Maladaptive Repair Biomarkers in Predicting Cardiac and Renal Outcomes after an Episode of AKI (Ancillary Study using ASSESS-AKI)

Acute kidney injury (AKI) is a risk factor for chronic kidney disease (CKD) and cardiovascular disease (CVD) with several biological processes orchestrating either recovery or progression to poor long-term outcomes after the initial insult of AKI.

Chronic Kidney Disease in Children

Progression of chronic kidney disease (CKD) in children leads to end stage renal disease (ESRD), which is associated with mortality rates 30-150 times higher than the general pediatric population.

Acute Kidney Injury in Marathon Runners

Participation in marathons has gained popularity in the United States with up to 1100 marathons and 507, 600 finishers.

Electronic Alerts for Acute Kidney Injury Amelioration (ELAIA-1)

Acute kidney injury (AKI) affects up to 20% of hospitalized patients and increases the risk of dying in the hospital by a factor of 10.

Drug Targeted Alerts for Acute Kidney Injury Amelioration (ELAIA-2)

This trial will randomize patients with acute kidney injury (AKI) who are receiving a kidney-toxic medication to alerts (highlighting the particular medication) versus usual care.

Learning Alerts for Acute Kidney Injury (ELAIA-3)

This trial will use an advanced machine-learning technique known as uplift modeling to target AKI alerts to a subset of patients who are most likely to be benefited by reducing alert fatigue and improving overall effectiveness.

Predicting Imminent AKI (AKI Tomorrow)

While AKI carries substantial risk, there remains no therapeutic intervention that can alter the course of AKI once it develops, beyond optimizing usual care.

Targeting Histone Deacetylase in Focal Segmental Glomerulosclerosis: From Mice to Patients

Our prior research in a mouse model of proteinuric kidney disease revealed upregulation of a protein called histone deacetylase (HDAC).