Skip to Main Content

The George M. O’Brien Kidney Center at Yale

D

The George M. O'Brien Kidney Center at Yale was established to facilitate translational and clinical research that will advance the prevention and treatment of kidney diseases.

A critically important benefit of the center is to provide renal investigators both at Yale and across the country with access to highly specialized services not otherwise routinely available to support their research. To this end, three research cores have been established.

Leadership

  • Peter S. Aronson

    Director

    C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology

    Dr. Aronson received his undergraduate education at the University of Rochester and his medical education at New York University. He was an internal medicine resident at the University of North Carolina and a research fellow at the National Institutes of Health before coming to Yale as a renal fellow in 1974. He was Chief of the Section of Nephrology at Yale from 1987-2002. Dr. Aronson has published articles and book chapters on the mechanisms regulating sodium, acid-base, and oxalate excretion by the kidney, particularly as related to the formation of kidney stones. He has received a number of awards for his research work, including the Young Investigator Award of the American Society of Nephrology (ASN) and American Heart Association in 1985, the Homer W. Smith Award of the ASN in 1994, election to the American Academy of Arts and Sciences in 2009, the Robert W. Berliner Award of the American Physiological Society (APS) in 2016, and the Walter B. Cannon Award of the APS in 2019. He served as President of the American Society of Nephrology in 2008. Dr. Aronson actively participates in the teaching of undergraduate, graduate and medical students, as well as residents and fellows. He was a co-recipient of the Charles W. Bohmfalk Teaching Prize in the Basic Sciences in 2005. Dr. Aronson is an Associate Director of the Yale M.D.-Ph.D. Program.

  • Stefan Somlo

    Associate Director

    C. N. H. Long Professor of Medicine (Nephrology) and Professor of Genetics; Chief, Section of Nephrology

The Animal Physiology and Phenotyping Core provides specialized services and training for assessing renal function in small animals at the level of single tubules in vitro and in vivo (e.g. micropuncture, microperfusion, and tubule-specific microdissection), the whole kidney (e.g. clearance studies in anesthetized animals, perfusion fixation for histology studies), and the intact organism (e.g. balance studies in metabolic cages, acute and chronic BP measurements).

The Disease Models and Mechanisms Core provides services to generate unique in vivo mouse models and kidney specific cell lines.

The Human Genetics and Clinical Research Core provides services to enhance translational studies in kidney disease, particularly in the area of human genetics.

This core provides infrastructure support for several key steps in translational research, including development of HIC protocols, patient recruitment, patient DNA extraction and archiving, tools for high throughput SNP genotyping and DNA sequencing, and analysis of genetic linkage and linkage disequilibrium.

Training

The Center also includes a Research Training Program to enhance the training of college students, graduate students, medical students, and postdoctoral fellows in kidney disease research in general, and in the specialized methods provided by the Research Cores in particular.

This Center is supported by Award P30DK079310 from the National Institute of Diabetes and Digestive and Kidney Diseases, within the National Institutes of Health.