Mark Joseph Mamula, PhD

Professor of Medicine (Rheumatology)

Departments & Organizations

Internal Medicine: Rheumatology: Rheumatic Diseases Research Core

Faculty Research

Immunology and Immunotherapy

Skin Diseases Research Center, Yale

Yale Cancer Center: Cancer Immunology

Office of Cooperative Research

Biography

Dr. Mamula’s received degrees from UCLA, the University of Notre Dame and the University of Oklahoma.  Dr. Mamula’s central research interests are in investigating the early events involved with breaking immune tolerance to self proteins, both in autoimmune disease and in tumor biology.  Overall, it is the goal of Dr. Mamula's laboratory to understand the mechanisms that may shift this balance toward the initiation of anti-self immune responses.  Seminal work from the Mamula lab elucidated the biochemical forms of autoantigens capable of breaking immunologic tolerance to intracellular autoantigens in systemic lupus erythematosus (SLE), and type 1 diabetes (T1D).  Simply put, Dr. Mamula examines posttranslational protein modifications that alter cellular biology and immunity.  These studies have now been applied to the development of novel therapeutic approaches in developing anti-tumor vaccines in breast cancer and colon cancer.  In addition, studies from the Mamula laboratory first demonstrated the ability of B cells to present autoantigens in the triggering of T cell autoimmunity and in the phenomenon of epitope spreading in lupus autoimmunity.  This work preceded more recent studies illustrating the how B cells transfer autoantigens to other antigen presenting cells, including dendritic cells and macrophages. 

Education & Training

PhD University of Oklahoma (1986)
MS University of Notre Dame (1982)
BA University of California at Los Angeles (1979)

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Contact Info

Mark Joseph Mamula, PhD
Mailing Address
PO Box 208031
333 Cedar Street

New Haven, CT 06520-8031