Completed Pilot Projects

2017-2018


Recipient Project Title
Bhat, Neha, PhD (Cardiovascular Research Center) Characterizing the pathophysiology of metabolic syndrome upon genetic manipulation of Dyrk1b in the liver
Iwakiri, Yasuko, PhD (Digestive Diseases) Lymphangiogenesis in the liver
Joshi, Nikhil, PhD (Immunobiology) Understanding mechanisms of hepatocyte-induced T cell immunologic tolerance
Kulkarni, Supriya, PhD (Digestive Diseases) Identification and characterization of OSTα/β inhibitors for drug therapy in cholestasis
Soroka, Carol, PhD (Digestive Diseases) Isolation of Organoids from Bile of Patients with Primary Sclerosing Cholangitis Provides a Unique Opportunity to Study Extrahepatic Biliary Cells Throughout the Progression of the Disease

2016-2017


Recipient Project Title
Soroka, Carol, PhD (Digestive Diseases) Use of Human Organoids in the Study of Liver Disease: A Model for Maintaining PSC Patient Progenitor Cells in Long-term Culture with the Potential Ability to Screen for the Efficacy of Drug Therapies
Mani, Arya, MD (Cardiovascular Genetics) Investigation of liver disease in mice with impaired TCF7L2 function
Arterbery, Adam, PhD (Pediatrics) The role of Inflammasome activity and the induction of the Unfolded Protein Response in the immune pathogenesis of T cells in de novo autoimmune hepatitis (DAIH) following liver transplantation”
Peters, Dana, PhD (Radiology and Biomedical Imaging) Magnetic Resonance biomarkers of Acidosis in Liver Tumor Microenvironment”
Fiorotto, Romina, PhD (Digestive Diseases) CFTR-defective biliary cells from human induced pluripotent-stem cells (iPSC) as a model to study the role of innate immunity in cystic fibrosis liver disease

2015-2016

Recipient Project Title
Chen, Ying, PhD (Public Health) Redox-based regulatory role of glutathione in the pathogenesis of fatty liver disease
Vilarinho, Silvia, MD (Digestive Diseases) Genomic Architecture of Biliary Atresia
Fiorotto, Romina, PhD (Digestive Diseases) CFTR-defective biliary cells from human induced pluripotent-stem cells (iPSC) as a model to study the role of innate immunity in cystic fibrosis liver disease
Ben Mamoun, Choukri, PhD (Infectious Diseases) Elucidating the role of the solute transporter OSTα/SCL51A In malaria infection

2014-2015

Recipient Project Title
Koff, Jonathan, MD (Pulmonary, Critical Care, and Sleep Medicine) Hepatitis C virus activates EGFR to suppress antiviral immunity
Lomakin, Ivan, PhD (Molecular Biophysics and Biochemistry) The structural characterization of the HCV IRES with the ribosome
Ruan, Hai-Bin, PhD (Biology and Physiology) CaMKII signaling regulates liver autophagy through Ulk1 O-G1cNAcylation
Kibbey, Richard, MD, PhD (Endocrionology, Cellular and Molecular Physiology) Direct measurement of hepatic PEPCK-M-Dependent Transmitochondrial Fluxes
Finberg, Karin, MD (Pathology) Effect of Vitamin D on Hepatic Regulation of Systemic Iron Balance

2013-2014

Recipient Project Title
Ouyang, Xinshou, PhD (Digestive Diseases) Downregulation of HIF-1α to limit inflammasome mediated acute liver injury
Robek, Michael, PhD (Pathology) A new humanized mouse model of chronic hepatitis B
Lee, Hochang, MD (Psychiatry) Flumazenil treatment of HE and Changes in cortical GABA levels
Ekong, Udeme, MD, PhD (Pediatrics) The role of pathogenic Th17 cells in de novo autoimmune hepatitis