Choukri Ben Mamoun, PhD

Associate Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis

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Dr. Ben Mamoun’s laboratory studies the pathogenesis of human malaria and babesiosis. The primary objectives of his research program are to identify new targets for development of potent and selective new therapies to treat these diseases and to develop a new diagnostic test for early detection of Babesia infection to prevent transfusion transmitted babesiosis. His laboratory has discovered several genes that play a critical function in Plasmodium falciparum and Babesia microti development and differentiation and used a combination of biochemical, structural and pharmacological analyses to identify specific inhibitors with potent activity against these parasites. One available project in the lab focuses the characterization of transporters and enzymes involved in the biosynthesis of co-enzyme A and understanding the metabolic, biochemical and structural bases of inhibition of this pathway by a highly potent class of inhibitors. Other available projects include the development of a humanized mouse model for falciparum and vivax malaria, and development of new tools for genetic manipulation of B. microti.