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Experimental Models

  • Bleomycin induced lung fibrosis
  • TGF-beta 1 over expression induced lung fibrosis
  • Bioengineering based approaches using decellularized rodent or human lung culture and stimulation of primary human cells
  • Hyperoxia
  • Cecal ligation
  • Cigarette smoke
  • Transgenic overexpression of cytokines
  • Inhaled Poly (I:C)
  • Thioacetamide, CCl4 and steatohepatitis induced liver fibrosis.
  • Bile duct ligation induced fibrosis.
  • Culture of primary hepatocytes, stellate cells, Kupffer cells and cell lines to test for responses to anti-fibrotics.
  • Unilateral ureteral obstruction induced renal fibrosis
  • Oxalate diet induced renal failure
  • Ischemia/Reperfusion
  • Bleomycin induced skin fibrosis
  • Foreign body reaction