Transformative R01 FOA Released


  • LOIs: due December 29, 2008
  • Applications: due January 29, 2009
  • Earliest start date: September 1, 2009

A major goal of the NIH is to foster bold and creative investigator-initiated research. The NIH has created the Transformative Research Projects Program (T-R01) to enhance submission and support of exceptionally innovative, high risk, original and/or unconventional research that has the potential to create new or challenge existing scientific paradigms. The T-R01 program will be piloting novel approaches to peer review and program management to facilitate identification and support of groundbreaking advances, unproven concepts and truly transformative ideas.

The NIH encourages T-R01 applications from scientists representing all disciplines relevant to the NIH mission, including the biological, behavioral, clinical, social, physical, chemical, computational, engineering, and mathematical sciences.

Areas of highlighted need in RFA-RM-08-029 that have been identified through an NIH strategic planning process include:

  • Understanding and facilitating behavior change
  • Formulation of novel protein capture reagents
  • Functional variation in mitochondria in disease
  • Complex 3-Dimensional tissue models
  • Transitions from acute to chronic pain
  • Providing an evidence base for pharmacogenomics

Additional information about the Transformative R01 Program and a link to the current FOA is available at the NIH Roadmap for Medical Research.

The NIH Roadmap for Medical Research, launched in 2004, is a series of initiatives designed to address fundamental knowledge gaps, develop transformative tools and technologies, and/or foster innovative approaches to complex problems. Funded through the NIH Common Fund, these programs cut across the missions of individual NIH Institutes and Centers (ICs) and are intended to accelerate the translation of research to improvements in public health. OPASI, in collaboration with all NIH ICs, oversees programs funded by the Common Fund. Additional information about the NIH Roadmap and Common Fund can be found at

The National Institutes of Health (NIH) –“The Nation's Medical Research Agency” – includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit the NIH.