Digestive Diseases Publications

Clara Abraham, MD

2023

IL-12 and IL-23 pathway inhibition in inflammatory bowel disease.Verstockt B, Salas A, Sands BE, Abraham C, Leibovitzh H, Neurath MF, Vande Casteele N. Nat Rev Gastroenterol Hepatol. 2023 Apr 17; 2023 Apr 17. PMID: 37069321.

2019

LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.Huang C, Hedl M, Ranjan K, Abraham C. Cell Rep. 2019 Dec 24. PMID: 31875558.
STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes.Hedl M, Sun R, Huang C, Abraham C. J Immunol. 2019 Dec 15; 2019 Nov 15. PMID: 31732533.
Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets.Gettler K, Giri M, Kenigsberg E, Martin J, Chuang LS, Hsu NY, Denson LA, Hyams JS, Griffiths A, Noe JD, Crandall WV, Mack DR, Kellermayer R, Abraham C, Hoffman G, Kugathasan S, Cho JH. Genes Immun. 2019 Sep; 2019 Jan 29. PMID: 30692607.
Correction to: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens.Pandey SP, Yan J, Turner JR, Abraham C. Mucosal Immunol. 2019 Jul. PMID: 31182816.
Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens.Pandey SP, Yan J, Turner JR, Abraham C. Mucosal Immunol. 2019 Jul; 2019 May 3. PMID: 31053739.
Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters.Sun R, Hedl M, Abraham C. J Immunol. 2019 Jun 1; 2019 Apr 26. PMID: 31028123.
Challenges in IBD Research: Precision Medicine.Denson LA, Curran M, McGovern DPB, Koltun WA, Duerr RH, Kim SC, Sartor RB, Sylvester FA, Abraham C, de Zoeten EF, Siegel CA, Burns RM, Dobes AM, Shtraizent N, Honig G, Heller CA, Hurtado-Lorenzo A, Cho JH. Inflamm Bowel Dis. 2019 May 16. PMID: 31095701.
IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome.Hedl M, Yan J, Witt H, Abraham C. J Immunol. 2019 Feb 1; 2018 Dec 28. PMID: 30593537.

2018

INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. Elife. 2018 Oct 25; 2018 Oct 25. PMID: 30355448.

2017

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nature. 2017 Jun 29; 2017 Jun 21. PMID: 28636595.
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B. Nat Commun. 2017 Jun 28; 2017 Jun 28. PMID: 28656966.
Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes.Lahiri A, Hedl M, Yan J, Abraham C. Nat Commun. 2017 Jun 8; 2017 Jun 8. PMID: 28593945.
ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. Cell Death Dis. 2017 Feb 23; 2017 Feb 23. PMID: 28230865.
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases.Abraham C, Dulai PS, Vermeire S, Sandborn WJ. Gastroenterology. 2017 Feb; 2016 Oct 22. PMID: 27780712.

2016

JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages.Hedl M, Proctor DD, Abraham C. J Immunol. 2016 Nov 1; 2016 Sep 23. PMID: 27664279.
A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion.Hedl M, Abraham C. Gut. 2016 Nov; 2015 Jul 27. PMID: 26215868.
A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Evelyn Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D, Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R, Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S, Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K, Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe'er I, Kugathasan S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH. Gastroenterology. 2016 Oct; 2016 Jul 1. PMID: 27377463.
IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation.Hedl M, Yan J, Abraham C. Cell Rep. 2016 Aug 30; 2016 Aug 18. PMID: 27545875.

2015

MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.Lahiri A, Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2015 Aug 18; 2015 Aug 3. PMID: 26240347.
Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators.Zheng S, Hedl M, Abraham C. J Immunol. 2015 Jul 1; 2015 May 27. PMID: 26019273.
T cell-extrinsic CD18 attenuates antigen-dependent CD4+ T cell activation in vivo.Wu X, Lahiri A, Sarin R, Abraham C. J Immunol. 2015 May 1; 2015 Mar 23. PMID: 25801431.
TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages.Zheng S, Hedl M, Abraham C. J Immunol. 2015 Feb 15; 2015 Jan 7. PMID: 25567680.

2014

Activation of pattern recognition receptors up-regulates metallothioneins, thereby increasing intracellular accumulation of zinc, autophagy, and bacterial clearance by macrophages.Lahiri A, Abraham C. Gastroenterology. 2014 Oct; 2014 Jun 21. PMID: 24960189.
A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2014 Sep 16; 2014 Sep 2. PMID: 25197060.
The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.Hedl M, Zheng S, Abraham C. J Immunol. 2014 Jun 15; 2014 May 19. PMID: 24842757.
Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.Hedl M, Lahiri A, Ning K, Cho JH, Abraham C. Immunity. 2014 May 15. PMID: 24837102.
NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury.Wu X, Lahiri A, Haines GK 3rd, Flavell RA, Abraham C. J Immunol. 2014 Apr 1; 2014 Mar 3. PMID: 24591373.

2013

NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms.Zheng S, Abraham C. Mol Cell Biol. 2013 Dec; 2013 Oct 7. PMID: 24100018.
The influence of depression on quality of life in patients with inflammatory bowel disease.Zhang CK, Hewett J, Hemming J, Grant T, Zhao H, Abraham C, Oikonomou I, Kanakia M, Cho JH, Proctor DD. Inflamm Bowel Dis. 2013 Jul. PMID: 23669400.
NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation.Hedl M, Abraham C. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15; 2013 Jan 3. PMID: 23287275.
Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells.Shen H, Zhang W, Abraham C, Cho JH. PLoS One. 2013; 2013 Mar 1. PMID: 23469228.

2012

Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines.Hedl M, Abraham C. Gastroenterology. 2012 Dec; 2012 Sep 8. PMID: 22967725.
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA. Nature. 2012 Nov 8; 2012 Oct 17. PMID: 23075849.
CD18 is required for optimal lymphopenia-induced proliferation of mouse T cells.Sarin R, Abraham C. Am J Physiol Gastrointest Liver Physiol. 2012 Oct; 2012 Jul 19. PMID: 22821945.
IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells.Hedl M, Abraham C. J Immunol. 2012 Jun 1; 2012 Apr 27. PMID: 22544929.
Effector CD4+ T cell expression signatures and immune-mediated disease associated genes.Zhang W, Ferguson J, Ng SM, Hui K, Goh G, Lin A, Esplugues E, Flavell RA, Abraham C, Zhao H, Cho JH. PLoS One. 2012; 2012 Jun 8. PMID: 22715389.

2011

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.Menard L, Saadoun D, Isnardi I, Ng YS, Meyers G, Massad C, Price C, Abraham C, Motaghedi R, Buckner JH, Gregersen PK, Meffre E. J Clin Invest. 2011 Sep; 2011 Aug 1. PMID: 21804190.
Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages.Hedl M, Abraham C. J Biol Chem. 2011 Jul 29; 2011 Jun 9. PMID: 21659536.
Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses.Sarin R, Wu X, Abraham C. Proc Natl Acad Sci U S A. 2011 Jun 7; 2011 May 23. PMID: 21606346.
Interactions between the host innate immune system and microbes in inflammatory bowel disease.Abraham C, Medzhitov R. Gastroenterology. 2011 May. PMID: 21530739.
Secretory mediators regulate Nod2-induced tolerance in human macrophages.Hedl M, Abraham C. Gastroenterology. 2011 Jan; 2010 Sep 18. PMID: 20854823.

2010

Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.Capurso NA, Look M, Jeanbart L, Nowyhed H, Abraham C, Craft J, Fahmy TM. Self Nonself. 2010 Oct. PMID: 21487509.
Unraveling the genetics of autoimmunity.Zenewicz LA, Abraham C, Flavell RA, Cho JH. Cell. 2010 Mar 19. PMID: 20303870.

2009

Inflammatory bowel disease.Abraham C, Cho JH. N Engl J Med. 2009 Nov 19. PMID: 19923578.
Interleukin-23/Th17 pathways and inflammatory bowel disease.Abraham C, Cho J. Inflamm Bowel Dis. 2009 Jul. PMID: 19253307.
IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease.Abraham C, Cho JH. Annu Rev Med. 2009. PMID: 18976050.

2008

A case of indometacin-induced acute hepatitis developing into chronic autoimmune hepatitis.Abraham C, Hart J, Locke SM, Baker AL. Nat Clin Pract Gastroenterol Hepatol. 2008 Mar; 2008 Jan 29. PMID: 18227818.

2007

Inflammatory bowel disease genetics: Nod2.Cho JH, Abraham C. Annu Rev Med. 2007. PMID: 16987083.

Harry Aslanian, MD

2022

Endoscopic Removal of Ingested Wire Bristle from the Pancreas.Lerner BA, Aslanian HR, Muniraj T. Clin Gastroenterol Hepatol. 2022 Apr; 2021 Feb 17. PMID: 33609785.
Evaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis.Chouairi F, McCarty TR, Hathorn KE, Sharma P, Aslanian HR, Jamidar PA, Thompson CC, Muniraj T. Surg Endosc. 2022 Jan; 2021 Jan 22. PMID: 33481109.

2021

Gallbladder Cryoablation: Other Endoscopic Options for High-Risk Patients with Cholecystitis.Jones J, Aslanian HR, Muniraj T. Am J Med. 2021 Nov. PMID: 34799010.
Factors associated with complete clip closure after endoscopic mucosal resection of large colorectal polyps.Ortiz O, Rex DK, Grimm IS, Moyer MT, Hasan MK, Pleskow D, Elmunzer BJ, Khashab MA, Sanaei O, Al-Kawas FH, Gordon SR, Mathew A, Levenick JM, Aslanian HR, Antaki F, von Renteln D, Crockett SD, Rastogi A, Gill JA, Law R, Wallace MB, Elias PA, MacKenzie TA, Pohl H, Pellisé M. Endoscopy. 2021 Nov; 2021 Apr 20. PMID: 33291159.
Education and gastroenterology fellow knowledge about endoscopic mucosal resection of colon adenomas: a survey-based study.Garg S, Inamdar S, Tharian B, Muniraj T, Aslanian HR. Endosc Int Open. 2021 Aug; 2021 Jul 16. PMID: 34447869.
Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies.Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. World J Gastroenterol. 2021 Apr 21. PMID: 33958848.
Enhanced EUS imaging (with videos).Krishnan K, Bhutani MS, Aslanian HR, Melson J, Navaneethan U, Pannala R, Parsi MA, Schulman AR, Sethi A, Sullivan S, Trikudanathan G, Trindade AJ, Watson RR, Maple JT, Lichtenstein DR. Gastrointest Endosc. 2021 Feb; 2020 Oct 28. PMID: 33129492.
Endoscopic ultrasound-guided fine needle aspiration cytology diagnosis of upper gastrointestinal tract mesenchymal tumors: Impact of rapid onsite evaluation and correlation with histopathologic follow-up.Gilani SM, Muniraj T, Aslanian HR, Cai G. Diagn Cytopathol. 2021 Feb; 2020 Oct 2. PMID: 33006819.
Musculoskeletal Pain Symptoms and Injuries Among Endoscopists Who Perform ERCP.Campbell EV 3rd, Muniraj T, Aslanian HR, Laine L, Jamidar P. Dig Dis Sci. 2021 Jan; 2020 Mar 6. PMID: 32144599.

2020

Endoscopic management of gastric outlet obstruction of remnant stomach in a patient with Roux-en-Y gastric bypass.Kesar V, Magulick J, Kesar V, Muniraj T, Aslanian HR. VideoGIE. 2020 Nov; 2020 Aug 20. PMID: 33204916.
Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction.Vyas M, Celli R, Singh M, Patel N, Aslanian HR, Boffa D, Deng Y, Ciarleglio MM, Laine L, Jain D. Hum Pathol. 2020 Nov; 2020 Sep 14. PMID: 32941964.
The Reply.Lam R, Jamidar PA, Aslanian HR, Muniraj T. Am J Med. 2020 Oct. PMID: 33004185.
Esophageal stent-assisted biliary access.Campbell EV 3rd, Magulick J, Aslanian HR, Jamidar P. Gastrointest Endosc. 2020 Oct; 2020 May 1. PMID: 32360903.
Fitz-Hugh-Curtis Syndrome Presenting as Acute Abdomen.Lam R, Jamidar PA, Aslanian HR, Muniraj T. Am J Med. 2020 Oct; 2020 Apr 9. PMID: 32277885.
Endoscopic Ultrasound-Guided, Percutaneous, and Transjugular Liver Biopsy: A Comparative Systematic Review and Meta-Analysis.McCarty TR, Bazarbashi AN, Njei B, Ryou M, Aslanian HR, Muniraj T. Clin Endosc. 2020 Sep; 2020 Sep 29. PMID: 33027584.
The New Virtual Reality: Advanced Endoscopy Education in the COVID-19 Era.Siddiqui UD, Aslanian HR. Dig Dis Sci. 2020 Jul. PMID: 32504351.
AGA Clinical Practice Update on Pancreas Cancer Screening in High-Risk Individuals: Expert Review.Aslanian HR, Lee JH, Canto MI. Gastroenterology. 2020 Jul; 2020 May 19. PMID: 32416142.
Endoscopic ultrasound-guided fine needle aspiration of accessory spleen: Cytomorphologic features and diagnostic considerations.Gilani SM, Muniraj T, Farrell JJ, Aslanian HR, Cai G. Diagn Cytopathol. 2020 Jul; 2020 Apr 21. PMID: 32315514.
Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial.Pohl H, Grimm IS, Moyer MT, Hasan MK, Pleskow D, Elmunzer BJ, Khashab MA, Sanaei O, Al-Kawas FH, Gordon SR, Mathew A, Levenick JM, Aslanian HR, Antaki F, von Renteln D, Crockett SD, Rastogi A, Gill JA, Law RJ, Elias PA, Pellise M, Mackenzie TA, Rex DK. Gastroenterology. 2020 Jul; 2020 Mar 12. PMID: 32173478.
Endoscopic rectal variceal ligation.Campbell EV 3rd, Aslanian HR, Muniraj T. VideoGIE. 2020 Jun; 2020 Jun 3. PMID: 32529163.
Endoscopic ultrasound (EUS) and the management of pancreatic cancer.Yousaf MN, Chaudhary FS, Ehsan A, Suarez AL, Muniraj T, Jamidar P, Aslanian HR, Farrell JJ. BMJ Open Gastroenterol. 2020 May. PMID: 32414753.
Fine needle aspiration cytology of peripancreatic myelolipoma.Huang Q, Parmer C, Muniraj T, Aslanian HR, Cai G. Diagn Cytopathol. 2020 May; 2020 Mar 9. PMID: 32150351.
Endoscopic Resection of a Giant Duodenal Lipoma.Gnanapandithan K, Aslanian HR, Jamidar PA, Muniraj T. ACG Case Rep J. 2020 Mar; 2020 Mar 17. PMID: 32337302.
Comparative effectiveness of pharmacologic and endoscopic interventions for prevention of post-ERCP pancreatitis: a network meta-analysis.Njei B, McCarty TR, Muniraj T, Sharma P, Jamidar PA, Aslanian HR, Varadarajulu S, Navaneethan U. Endosc Int Open. 2020 Jan; 2020 Jan 8. PMID: 31921982.
Combined versus single use 20 G fine-needle biopsy and 25 G fine-needle aspiration for endoscopic ultrasound-guided tissue sampling of solid gastrointestinal lesions.van Riet PA, Giorgio Arcidiacono P, Petrone M, Quoc Nguyen N, Kitano M, Chang K, Larghi A, Iglesias-Garcia J, Giovannini M, van der Merwe S, Santo E, Baldaque-Silva F, Bucobo JC, Bruno MJ, Aslanian HR, Cahen DL, Farrell J. Endoscopy. 2020 Jan; 2019 Jul 22. PMID: 31330556.

2019

Clip Closure Prevents Bleeding After Endoscopic Resection of Large Colon Polyps in a Randomized Trial.Pohl H, Grimm IS, Moyer MT, Hasan MK, Pleskow D, Elmunzer BJ, Khashab MA, Sanaei O, Al-Kawas FH, Gordon SR, Mathew A, Levenick JM, Aslanian HR, Antaki F, von Renteln D, Crockett SD, Rastogi A, Gill JA, Law RJ, Elias PA, Pellise M, Wallace MB, Mackenzie TA, Rex DK. Gastroenterology. 2019 Oct; 2019 Mar 15. PMID: 30885778.
Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing.Majumder S, Taylor WR, Yab TC, Berger CK, Dukek BA, Cao X, Foote PH, Wu CW, Mahoney DW, Aslanian HR, Fernández-Del Castillo C, Doyle LA, Farrell JJ, Fisher WE, Lee LS, Lee YN, Park W, Rodrigues C, Gould Rothberg BE, Salem RR, Simeone DM, Urs S, Van Buren G, Smyrk TC, Allawi HT, Lidgard GP, Raimondo M, Chari ST, Kendrick ML, Kisiel JB, Topazian MD, Ahlquist DA. Am J Gastroenterol. 2019 Sep. PMID: 31306149.
Advances in the diagnosis and surveillance of Barrett's esophagus (with videos).Trindade AJ, Navaneethan U, Aslanian HR, Bhutani MS, Krishnan K, Lichtenstein DR, Melson J, Pannala R, Parsi MA, Schulman AR, Sethi A, Trikudanathan G, Watson RR, Maple JT. Gastrointest Endosc. 2019 Sep; 2019 May 18. PMID: 31113535.
ASGE guideline for endoscopic full-thickness resection and submucosal tunnel endoscopic resection.Aslanian HR, Sethi A, Bhutani MS, Goodman AJ, Krishnan K, Lichtenstein DR, Melson J, Navaneethan U, Pannala R, Parsi MA, Schulman AR, Sullivan SA, Thosani N, Trikudanathan G, Trindade AJ, Watson RR, Maple JT. VideoGIE. 2019 Aug; 2019 Jun 29. PMID: 31388606.
Devices for endoscopic hemostasis of nonvariceal GI bleeding (with videos).Parsi MA, Schulman AR, Aslanian HR, Bhutani MS, Krishnan K, Lichtenstein DR, Melson J, Navaneethan U, Pannala R, Sethi A, Trikudanathan G, Trindade AJ, Watson RR, Maple JT. VideoGIE. 2019 Jul; 2019 Jun 27. PMID: 31334417.
Endoscopic simulators.Goodman AJ, Melson J, Aslanian HR, Bhutani MS, Krishnan K, Lichtenstein DR, Navaneethan U, Pannala R, Parsi MA, Schulman AR, Sethi A, Sullivan SA, Thosani N, Trikudanathan G, Trindade AJ, Watson RR, Maple JT. Gastrointest Endosc. 2019 Jul; 2019 May 20. PMID: 31122746.
Perforation of the duodenum 2 weeks after lumen-apposing metal stent placement for malignant pyloric stricture.Muniraj T, Salem R, Olave-Martinez M, Suarez A, Aslanian HR. Gastrointest Endosc. 2019 May; 2019 Jan 10. PMID: 30639540.
Endoscopic Ultrasound for the Diagnosis and Staging of Liver Tumors.Lange A, Muniraj T, Aslanian HR. Gastrointest Endosc Clin N Am. 2019 Apr. PMID: 30846157.

2018

Barrett's esophagus: A comprehensive review for the internist.Klavan H, Russell MB, Macklin J, Lee E, Aslanian HR, Muniraj T. Dis Mon. 2018 Nov; 2018 Jun 5. PMID: 29880269.
Long-Term Follow-Up of Low-Risk Branch Duct IPMNs of the Pancreas: Watch for Main Pancreatic Duct Dilatation, and for How Long?Muniraj T, Aslanian HR. Clin Transl Gastroenterol. 2018 Oct 24; 2018 Oct 24. PMID: 30353003.
Safety and rate of delayed adverse events with lumen-apposing metal stents (LAMS) for pancreatic fluid collections: a multicenter study.Yang D, Perbtani YB, Mramba LK, Kerdsirichairat T, Prabhu A, Manvar A, Ho S, Pannu D, Keswani RN, Strand DS, Wang AY, Quintero E, Buscaglia JM, Muniraj T, Aslanian HR, Draganov PV, Siddiqui AS. Endosc Int Open. 2018 Oct; 2018 Oct 8. PMID: 30302385.
Cannabis Use Is Associated With Increased Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: Analysis of the US Nationwide Inpatient Sample Database, 2004-2014.Njei B, Sharma P, McCarty TR, Singh M, Haque L, Aslanian HR, Jamidar P, Muniraj T. Pancreas. 2018 Oct. PMID: 30134357.
Endoscopic management of pancreatic duct disruption with large mediastinal pseudocyst.Ortiz V, Yousaf MN, Muniraj T, Jamidar P, Aslanian HR. VideoGIE. 2018 May; 2018 Mar 16. PMID: 29917026.
EUS diagnosis of cystic pancreatic neuroendocrine tumors.Li-Geng T, Cai G, Aslanian HR. VideoGIE. 2018 Mar; 2018 Feb 28. PMID: 29916484.
Endoscopic submucosal dissection for resection of submucosal tumors of the colon and rectum: Within reach, or the edge of tomorrow?Sahakian AB, Aslanian HR. Gastrointest Endosc. 2018 Feb. PMID: 29406933.
EUS evaluation of liver lesions.Yousaf MN, Cai G, Aslanian HR. VideoGIE. 2018 Jan; 2017 Nov 11. PMID: 29905169.

2017

Endoscopic diagnosis of paraesophageal hernia with gastric volvulus.Yousaf MN, Duffy AJ, Aslanian HR. VideoGIE. 2017 Nov; 2017 Oct 12. PMID: 30027133.
New Developments in Endoscopic Ultrasound Tissue Acquisition.Muniraj T, Aslanian HR. Gastrointest Endosc Clin N Am. 2017 Oct. PMID: 28918800.
Primary Care Physicians Could Play a Role in Improving Colonoscopy Quality Measures.Langberg KM, Solad Y, Ciarleglio M, Sukumar N, Teslya P, Chowdhury MM, Aslanian HR. Dig Dis Sci. 2017 May; 2017 Mar 27. PMID: 28349232.
Clinical utility of rapid on-site cytopathology.Oza VM, Cai G, Aslanian HR. Gastrointest Endosc. 2017 Jan; 2016 Aug 22. PMID: 27562939.
Endoscopic Management of Pancreatic Fluid Collections.Muniraj T, Jamidar PA, Nealon WH, Aslanian HR. J Clin Gastroenterol. 2017 Jan. PMID: 27548730.

2016

Endoscopic Management of Esophagopleural Fistula.McCarty TR, Bakhit M, Aslanian HR, Rustagi T. J Clin Gastroenterol. 2016 Nov/Dec. PMID: 27552330.
EUS Needle Identification Comparison and Evaluation study (with videos).Tang SJ, Vilmann AS, Saftoiu A, Wang W, Streba CT, Fink PP, Griswold M, Wu R, Dietrich CF, Jenssen C, Hocke M, Kantowski M, Pohl J, Fockens P, Annema JT, van der Heijden EH, Havre RF, Pham KD, Kunda R, Deprez PH, Mariana J, Vazquez-Sequeiros E, Larghi A, Buscarini E, Fusaroli P, Lahav M, Puri R, Garg PK, Sharma M, Maluf-Filho F, Sahai A, Brugge WR, Lee LS, Aslanian HR, Wang AY, Shami VM, Markowitz A, Siddiqui AA, Mishra G, Scheiman JM, Isenberg G, Siddiqui UD, Shah RJ, Buxbaum J, Watson RR, Willingham FF, Bhutani MS, Levy MJ, Harris C, Wallace MB, Nolsøe CP, Lorentzen T, Bang N, Sørensen SM, Gilja OH, D'Onofrio M, Piscaglia F, Gritzmann N, Radzina M, Sparchez ZA, Sidhu PS, Freeman S, McCowan TC, de Araujo CR Jr, Patel A, Ali MA, Campbell G, Chen E, Vilmann P. Gastrointest Endosc. 2016 Sep; 2016 Feb 10. PMID: 26873530.
Confocal laser endomicroscopy features of sessile serrated adenomas/polyps.Parikh ND, Gibson J, Nagar A, Ahmed AA, Aslanian HR. United European Gastroenterol J. 2016 Aug; 2015 Dec 15. PMID: 27536371.
Awash in a Multitude of Pancreas Cysts: Can We Stop Looking?Muniraj T, Aslanian HR. Clin Gastroenterol Hepatol. 2016 Jun; 2016 Feb 4. PMID: 26851707.
Digital chromoendoscopy utilization in clinical practice: A survey of gastroenterologists in Connecticut.Langberg KM, Parikh ND, Deng Y, Ciarlegio M, Laine L, Aslanian HR. World J Gastrointest Pharmacol Ther. 2016 May 6. PMID: 27158543.
Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP?Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR. Dig Dis Sci. 2016 Mar; 2015 Nov 14. PMID: 26572779.
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience.Alomari AK, Ustun B, Aslanian HR, Ge X, Chhieng D, Cai G. Cytojournal. 2016; 2016 Jan 28. PMID: 26955395.

2015

Endoscopic Treatment of Gastrointestinal Perforations, Leaks, and Fistulae.Rustagi T, McCarty TR, Aslanian HR. J Clin Gastroenterol. 2015 Nov-Dec. PMID: 26325190.
Treatment of Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review.Rustagi T, Aslanian HR, Laine L. J Clin Gastroenterol. 2015 Nov-Dec. PMID: 25626632.
Endoscopic ultrasound-guided fine-needle aspiration biopsy of autoimmune pancreatitis: diagnostic clues and pitfalls.Cai G, Bernstein J, Aslanian HR, Hui P, Chhieng D. J Am Soc Cytopathol. 2015 Jul-Aug; 2015 Jan 21. PMID: 31051756.
Is Advanced Endoscopy Training Worth it?Aslanian HR, Ahmed AM, Jamidar PA. Clin Gastroenterol Hepatol. 2015 Jul. PMID: 26091939.
Variation in Aptitude of Trainees in Endoscopic Ultrasonography, Based on Cumulative Sum Analysis.Wani S, Hall M, Keswani RN, Aslanian HR, Casey B, Burbridge R, Chak A, Chen AM, Cote G, Edmundowicz SA, Faulx AL, Hollander TG, Lee LS, Mullady D, Murad F, Muthusamy VR, Pfau PR, Scheiman JM, Tokar J, Wagh MS, Watson R, Early D. Clin Gastroenterol Hepatol. 2015 Jul; 2014 Nov 14. PMID: 25460557.
A double-blind, randomized, sham-controlled trial of the effect of a radiation-attenuating drape on radiation exposure to endoscopy staff during ERCP.Muniraj T, Aslanian HR, Laine L, Farrell J, Ciarleglio MM, Deng Y, Ho H, Jamidar PA. Am J Gastroenterol. 2015 May; 2015 Mar 31. PMID: 25823765.
Endoscopic strangulation techniques for treatment of upper GI mucosal and submucosal lesions.Rustagi T, Aslanian HR. Gastrointest Endosc. 2015 Apr; 2014 Jul 12. PMID: 25028275.
Influence of colonoscopy quality measures on patients' colonoscopist selection.Solad Y, Wang C, Laine L, Deng Y, Schwartz H, Ciarleglio MM, Aslanian HR. Am J Gastroenterol. 2015 Feb; 2014 Jul 29. PMID: 25070055.
Cold snare polypectomy for large sessile colonic polyps: a single-center experience.Muniraj T, Sahakian A, Ciarleglio MM, Deng Y, Aslanian HR. Gastroenterol Res Pract. 2015; 2015 Mar 23. PMID: 25878658.

2014

Endoscopic management of biliary leaks after laparoscopic cholecystectomy.Rustagi T, Aslanian HR. J Clin Gastroenterol. 2014 Sep. PMID: 24296422.
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of Merkel cell carcinoma metastatic to the pancreas.Bernstein J, Adeniran AJ, Cai G, Theoharis CG, Ustun B, Beckman D, Aslanian HR, Harigopal M. Diagn Cytopathol. 2014 Mar; 2012 Jun 25. PMID: 22730170.

2013

The utility of esophagogastroduodenoscopy before endoscopic ultrasonography in patients undergoing endoscopic ultrasonography for pancreatico-biliary and mediastinal indications.Sahakian AB, Aslanian HR, Mehra M, Rossi F, Laine L, Sanchez M, Ciarleglio MM, Adimoolam V, Siddiqui UD. J Clin Gastroenterol. 2013 Nov-Dec. PMID: 23632349.
Emphysematous Cholecystitis Resulting in Secondary Biliary Cirrhosis: A Rare Complication of Endoscopic Retrograde Cholangiopancreatography.Bari K, Aslanian HR, Pollak J, Reiner E, Salem RR, Taddei TH, Emre SH, Jamidar PA. ACG Case Rep J. 2013 Oct; 2013 Oct 8. PMID: 26157820.
Endosonographic and cyst fluid characteristics of cystic pancreatic neuroendocrine tumours: a multicentre case series.Ho HC, Eloubeidi MA, Siddiqui UD, Brugge WR, Rossi F, Bounds BW, Aslanian HR. Dig Liver Dis. 2013 Sep; 2013 Apr 9. PMID: 23582348.
Performance of endoscopic ultrasound-guided fine needle aspiration in diagnosing pancreatic neuroendocrine tumors.Bernstein J, Ustun B, Alomari A, Bao F, Aslanian HR, Siddiqui U, Chhieng D, Cai G. Cytojournal. 2013; 2013 May 29. PMID: 23858320.
Nurse observation during colonoscopy increases polyp detection: a randomized prospective study.Aslanian HR, Shieh FK, Chan FW, Ciarleglio MM, Deng Y, Rogart JN, Jamidar PA, Siddiqui UD. Am J Gastroenterol. 2013 Feb. PMID: 23381064.
Pancreatic neuroendocrine tumors.Muniraj T, Vignesh S, Shetty S, Thiruvengadam S, Aslanian HR. Dis Mon. 2013 Jan. PMID: 23312533.

2012

Hypertriglyceridemia independent propofol-induced pancreatitis.Muniraj T, Aslanian HR. JOP. 2012 Jul 10; 2012 Jul 10. PMID: 22797405.

2011

Endoscopic ultrasound identifies synchronous pancreas cystic lesions not seen on initial cross-sectional imaging.Adimoolam V, Sanchez MJ, Siddiqui UD, Yu S, Dzuira JD, Padda MS, Aslanian HR. Pancreas. 2011 Oct. PMID: 21705942.
Endoscopic ultrasound and endoscopic retrograde cholangiopancreatography for obstructing pancreas head masses: combined or separate procedures?Aslanian HR, Estrada JD, Rossi F, Dziura J, Jamidar PA, Siddiqui UD. J Clin Gastroenterol. 2011 Sep. PMID: 21301359.
Patient preferences after endoscopic ultrasound with fine needle aspiration (EUS-FNA) diagnosis of pancreas cancer: rapid communication valued over long-term relationships.Siddiqui UD, Rossi F, Padda MS, Rosenthal LS, Aslanian HR. Pancreas. 2011 Jul. PMID: 21602735.
Littoral cell angioma of the spleen diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy.Nagarajan P, Cai G, Padda MS, Selbst M, Kowalski D, Proctor DD, Chhieng D, Aslanian HR, Harigopal M. Diagn Cytopathol. 2011 May. PMID: 21488173.
Endoscopic ultrasound and gastric lesions.Nagler AK, Aslanian HR, Siddiqui UD. J Clin Gastroenterol. 2011 Mar. PMID: 21278579.
Narrow band imaging to detect residual or recurrent neoplastic tissue during surveillance endoscopy.Rogart JN, Aslanian HR, Siddiqui UD. Dig Dis Sci. 2011 Feb; 2010 Jun 9. PMID: 20532981.

2010

Gastric perforations associated with the use of crack cocaine.Chander B, Aslanian HR. Gastroenterol Hepatol (N Y). 2010 Nov. PMID: 21437024.

2009

EUS-guided FNA of solid pancreatic masses: a prospective, randomized trial comparing 22-gauge and 25-gauge needles.Siddiqui UD, Rossi F, Rosenthal LS, Padda MS, Murali-Dharan V, Aslanian HR. Gastrointest Endosc. 2009 Dec; 2009 Jul 28. PMID: 19640524.
Young female with pancreatic mass.Padda MS, Aslanian HR, Theoharis C. Gastroenterology. 2009 Sep; 2009 Jul 29. PMID: 19646403.

2008

Massive hemobilia after transjugular liver biopsy treated endoscopically and angiographically.Rogart JN, Aslanian HR. Clin Gastroenterol Hepatol. 2008 Dec. PMID: 19081523.
Altered DNA mismatch repair expression in synchronous and metachronous colorectal cancers.Aslanian HR, Burgart LJ, Harrington JJ, Mahoney DW, Zinsmeister AR, Thibodeau SN, Ahlquist DA. Clin Gastroenterol Hepatol. 2008 Dec; 2008 Jul 17. PMID: 18639494.
Screening colonoscopy and fecal occult blood testing practice patterns: a population-based survey of gastroenterologists.Rossi F, Sosa JA, Aslanian HR. J Clin Gastroenterol. 2008 Nov-Dec. PMID: 18936643.
Fellow involvement may increase adenoma detection rates during colonoscopy.Rogart JN, Siddiqui UD, Jamidar PA, Aslanian HR. Am J Gastroenterol. 2008 Nov; 2008 Aug 27. PMID: 18759826.

David Assis, MD

2023

Reply: Insurance should cover vancomycin for primary sclerosing cholangitis.Bowlus CL, Arrivé L, Bergquist A, Deneau M, Forman L, Ilyas SI, Lunsford KE, Martinez M, Sapisochin G, Shroff R, Tabibian JH, Assis DN. Hepatology. 2023 Jun 1; 2023 Jan 26. PMID: 36695291.
Reply: Living donor liver transplantation for people with PSC.Forman LM, Sapisochin G, Assis DN, Arrivé L, Bergquist A, Bowlus CL, Deneau M, Ilyas SI, Lunsford KE, Martinez M, Shroff R, Tabibian JH. Hepatology. 2023 May 1; 2023 Jan 3. PMID: 36732294.
Recent Advances in the Management of Primary Sclerosing Cholangitis.Assis DN, Bowlus CL. Clin Gastroenterol Hepatol. 2023 Apr 19; 2023 Apr 19. PMID: 37084929.
Research gaps and opportunities in autoimmune hepatitis-Results of the international autoimmune hepatitis group research workshop 2022.Snijders RJALM, Assis DN, Oo YH, Sebode M, Taubert R, Willemse J, Tomsin B, Lohse AW, Drenth JPH, Gevers TJG. Liver Int. 2023 Apr 10; 2023 Apr 10. PMID: 37035872.
Outcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-associated inflammatory bowel disease.Sayed A, Assis DN, Silveira MG, Deng Y, Ciarleglio M, Gaidos JKJ, Proctor DD, Al-Bawardy B. Eur J Gastroenterol Hepatol. 2023 Mar 1; 2023 Jan 17. PMID: 36708297.
Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis.Li X, Li Y, Xiao J, Wang H, Guo Y, Mao X, Shi P, Hou Y, Zhang X, Zhao N, Zheng M, He Y, Ding J, Tan Y, Liao M, Li L, Peng Y, Li X, Pan Q, Xie Q, Li Q, Li J, Li Y, Chen Z, Huang Y, Assis DN, Cai SY, Boyer JL, Huang X, Tang CE, Liu X, Peng S, Chai J. Nat Commun. 2023 Feb 9; 2023 Feb 9. PMID: 36759512.
AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma.Bowlus CL, Arrivé L, Bergquist A, Deneau M, Forman L, Ilyas SI, Lunsford KE, Martinez M, Sapisochin G, Shroff R, Tabibian JH, Assis DN. Hepatology. 2023 Feb 1; 2022 Oct 20. PMID: 36083140.

2022

Update in Advancing the Gastrointestinal Frontier in Cystic Fibrosis.Vélez C, Freedman SD, Assis DN. Clin Chest Med. 2022 Dec. PMID: 36344078.
Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis.Gallucci GM, Alsuwayt B, Auclair AM, Boyer JL, Assis DN, Ghonem NS. Inflammation. 2022 Dec; 2022 Jul 15. PMID: 35838934.
Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis.Alrabadi LS, Dutton A, Rabiee A, Roberts SJ, Deng Y, Cusack L, Silveira MG, Ciarleglio M, Bucala R, Sinha R, Boyer JL, Assis DN. JHEP Rep. 2022 May; 2022 Feb 18. PMID: 35434588.

2021

Adjunct Fenofibrate Up-regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis.Gallucci GM, Trottier J, Hemme C, Assis DN, Boyer JL, Barbier O, Ghonem NS. Hepatol Commun. 2021 Dec; 2021 Aug 27. PMID: 34558841.
Defining Primary Sclerosing Cholangitis: Results From an International Primary Sclerosing Cholangitis Study Group Consensus Process.Ponsioen CY, Assis DN, Boberg KM, Bowlus CL, Deneau M, Thorburn D, Aabakken L, Färkkilä M, Petersen B, Rupp C, Hübscher SG. Gastroenterology. 2021 Dec; 2021 Aug 10. PMID: 34384749.
Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study.Efe C, Dhanasekaran R, Lammert C, Ebik B, Higuera-de la Tijera F, Aloman C, Rıza Calışkan A, Peralta M, Gerussi A, Massoumi H, Catana AM, Torgutalp M, Purnak T, Rigamonti C, Gomez Aldana AJ, Khakoo N, Kacmaz H, Nazal L, Frager S, Demir N, Irak K, Ellik ZM, Balaban Y, Atay K, Eren F, Cristoferi L, Batıbay E, Urzua Á, Snijders R, Kıyıcı M, Akyıldız M, Ekin N, Carr RM, Harputluoğlu M, Hatemi I, Mendizabal M, Silva M, Idilman R, Silveira M, Drenth JPH, Assis DN, Björnsson E, Boyer JL, Invernizzi P, Levy C, Schiano TD, Ridruejo E, Wahlin S. Hepatology. 2021 Jun. PMID: 33713486.
Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine.Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Semin Liver Dis. 2021 May; 2021 May 6. PMID: 33957696.
Treatment of Metastatic Extramammary Paget Disease with Combination Ipilimumab and Nivolumab: A Case Report.Guercio BJ, Iyer G, Kidwai WZ, Lacouture ME, Ghafoor S, Rossi AM, Assis DN, Chen YB, Busam KJ, Janjigian YY, Jhaveri K, Feldman DR, Capozzi A, Figueroa V, Bajorin DF, Rosenberg JE, Hollmann TJ, Funt SA. Case Rep Oncol. 2021 Jan-Apr; 2021 Mar 12. PMID: 33790764.

2020

Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol.Ghonem NS, Auclair AM, Hemme CL, Gallucci GM, de la Rosa Rodriguez R, Boyer JL, Assis DN. Clin Pharmacol Ther. 2020 Dec; 2020 Jul 17. PMID: 32480421.
A Systematic Review of Patient-Reported Outcomes in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.Kim HP, Lieber SR, Rogers ME, Moon AM, Loiselle M, Walker J, Assis DN, Safer R, Gomel R, Evon DM. Hepatol Commun. 2020 Oct; 2020 Aug 1. PMID: 33024919.
Immunosuppressive Treatment Regimens in Autoimmune Hepatitis: Systematic Reviews and Meta-Analyses Supporting American Association for the Study of Liver Diseases Guidelines.Vierling JM, Kerkar N, Czaja AJ, Mack CL, Adams D, Assis DN, Manns MP, Mayo MJ, Nayfeh T, Majzoub AMM, Alzuabi MA, Ding J, Haffar S, Murad MH, Alsawas M. Hepatology. 2020 Aug. PMID: 32500593.
Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases.Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ. Hepatology. 2020 Aug; 2020 May 12. PMID: 31863477.
Immunopathogenesis of Autoimmune Hepatitis.Assis DN. Clin Liver Dis (Hoboken). 2020 Mar; 2020 Apr 4. PMID: 32257125.
Machine Learning in a Complex Disease: PREsTo Improves the Prognostication of Primary Sclerosing Cholangitis.Shung DL, Assis DN. Hepatology. 2020 Jan. PMID: 31850533.
Effects of Vedolizumab in Patients With Primary Sclerosing Cholangitis and Inflammatory Bowel Diseases.Lynch KD, Chapman RW, Keshav S, Montano-Loza AJ, Mason AL, Kremer AE, Vetter M, de Krijger M, Ponsioen CY, Trivedi P, Hirschfield G, Schramm C, Liu CH, Bowlus CL, Estes DJ, Pratt D, Hedin C, Bergquist A, de Vries AC, van der Woude CJ, Yu L, Assis DN, Boyer J, Ytting H, Hallibasic E, Trauner M, Marschall HU, Daretti LM, Marzioni M, Yimam KK, Perin N, Floreani A, Beretta-Piccoli BT, Rogers JK, Levy C. Clin Gastroenterol Hepatol. 2020 Jan; 2019 May 14. PMID: 31100458.

2019

The Contribution of B Cells in Autoimmune Liver Diseases.Taylor SA, Assis DN, Mack CL. Semin Liver Dis. 2019 Nov; 2019 Jun 21. PMID: 31226726.
Bile-Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile.Soroka CJ, Assis DN, Alrabadi LS, Roberts S, Cusack L, Jaffe AB, Boyer JL. Hepatology. 2019 Sep; 2019 Mar 13. PMID: 30561836.
Clinical utility of genomic analysis in adults with idiopathic liver disease.Hakim A, Zhang X, DeLisle A, Oral EA, Dykas D, Drzewiecki K, Assis DN, Silveira M, Batisti J, Jain D, Bale A, Mistry PK, Vilarinho S. J Hepatol. 2019 Jun; 2019 Apr 15. PMID: 31000363.
Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies.Soroka CJ, Assis DN, Boyer JL. Methods Mol Biol. 2019. PMID: 31016667.

2018

Histologic features of autoimmune hepatitis: a critical appraisal.Gurung A, Assis DN, McCarty TR, Mitchell KA, Boyer JL, Jain D. Hum Pathol. 2018 Dec; 2018 Jul 21. PMID: 30041025.
Chronic Complications of Cholestasis: Evaluation and Management.Assis DN. Clin Liver Dis. 2018 Aug; 2018 May 28. PMID: 30259851.

2017

Gallbladder and bile duct disease in Cystic Fibrosis.Assis DN, Debray D. J Cyst Fibros. 2017 Nov. PMID: 28986023.
Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. J Clin Gastroenterol. 2017 Feb. PMID: 27428727.

2016

A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients.Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R. Dig Dis Sci. 2016 Dec; 2016 Oct 1. PMID: 27696094.
Gastrointestinal Disorders in Cystic Fibrosis.Assis DN, Freedman SD. Clin Chest Med. 2016 Mar; 2015 Dec 24. PMID: 26857772.

2015

Fibrates and cholestasis.Ghonem NS, Assis DN, Boyer JL. Hepatology. 2015 Aug; 2015 Mar 23. PMID: 25678132.
Editorial: environmental risk factors for PSC with and without IBD--the story unfolds.Assis DN, Levy C. Aliment Pharmacol Ther. 2015 Jun. PMID: 25939466.

2014

The role of macrophage migration inhibitory factor in autoimmune liver disease.Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson DJ, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R. Hepatology. 2014 Feb; 2013 Dec 20. PMID: 23913513.

2012

New pharmacotherapy for hepatitis C.Assis DN, Lim JK. Clin Pharmacol Ther. 2012 Sep; 2012 Aug 1. PMID: 22850602.
Successful treatment of a bleeding umbilical varix by percutaneous umbilical vein embolization with sclerotherapy.Assis DN, Pollak J, Schilsky ML, Emre S. J Clin Gastroenterol. 2012 Feb. PMID: 21897280.

2010

Testing and management of thrombocytopenia and coagulopathy in the pre- and postliver transplant patient.Assis DN, Schilsky ML. Minerva Gastroenterol Dietol. 2010 Sep. PMID: 21037549.

James Lorenzen Boyer, MD, FACEP

2023

Runt-related transcription factor-1 ameliorates bile acid-induced hepatic inflammation in cholestasis through JAK/STAT3 signaling.Zhang L, Pan Q, Zhang L, Xia H, Liao J, Zhang X, Zhao N, Xie Q, Liao M, Tan Y, Li Q, Zhu J, Li L, Fan S, Li J, Zhang C, Cai SY, Boyer JL, Chai J. Hepatology. 2023 Jun 1; 2023 Jan 3. PMID: 36647589.
Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans.Pan Q, Zhu G, Xu Z, Zhu J, Ouyang J, Tong Y, Zhao N, Zhang X, Cheng Y, Zhang L, Tan Y, Li J, Zhang C, Chen W, Cai SY, Boyer JL, Chai J. Cell Mol Gastroenterol Hepatol. 2023 May 3; 2023 May 3. PMID: 37146714.
Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis.Li X, Li Y, Xiao J, Wang H, Guo Y, Mao X, Shi P, Hou Y, Zhang X, Zhao N, Zheng M, He Y, Ding J, Tan Y, Liao M, Li L, Peng Y, Li X, Pan Q, Xie Q, Li Q, Li J, Li Y, Chen Z, Huang Y, Assis DN, Cai SY, Boyer JL, Huang X, Tang CE, Liu X, Peng S, Chai J. Nat Commun. 2023 Feb 9; 2023 Feb 9. PMID: 36759512.

2022

Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis.Gallucci GM, Alsuwayt B, Auclair AM, Boyer JL, Assis DN, Ghonem NS. Inflammation. 2022 Dec; 2022 Jul 15. PMID: 35838934.
SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface.Zhao N, Zhang X, Ding J, Pan Q, Zheng MH, Liu WY, Luo G, Qu J, Li M, Li L, Cheng Y, Peng Y, Xie Q, Wei Q, Li Q, Zou L, Ouyang X, Cai SY, Boyer JL, Chai J. JCI Insight. 2022 Aug 8; 2022 Aug 8. PMID: 35938531.
Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis.Alrabadi LS, Dutton A, Rabiee A, Roberts SJ, Deng Y, Cusack L, Silveira MG, Ciarleglio M, Bucala R, Sinha R, Boyer JL, Assis DN. JHEP Rep. 2022 May; 2022 Feb 18. PMID: 35434588.
Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis.Efe C, Lammert C, Taşçılar K, Dhanasekaran R, Ebik B, Higuera-de la Tijera F, Calışkan AR, Peralta M, Gerussi A, Massoumi H, Catana AM, Purnak T, Rigamonti C, Aldana AJG, Khakoo N, Nazal L, Frager S, Demir N, Irak K, Melekoğlu-Ellik Z, Kacmaz H, Balaban Y, Atay K, Eren F, Alvares-da-Silva MR, Cristoferi L, Urzua Á, Eşkazan T, Magro B, Snijders R, Barutçu S, Lytvyak E, Zazueta GM, Demirezer-Bolat A, Aydın M, Heurgue-Berlot A, De Martin E, Ekin N, Yıldırım S, Yavuz A, Bıyık M, Narro GC, Kıyıcı M, Akyıldız M, Kahramanoğlu-Aksoy E, Vincent M, Carr RM, Günşar F, Reyes EC, Harputluoğlu M, Aloman C, Gatselis NK, Üstündağ Y, Brahm J, Vargas NCE, Güzelbulut F, Garcia SR, Aguirre J, Anders M, Ratusnu N, Hatemi I, Mendizabal M, Floreani A, Fagiuoli S, Silva M, Idilman R, Satapathy SK, Silveira M, Drenth JPH, Dalekos GN, N Assis D, Björnsson E, Boyer JL, Yoshida EM, Invernizzi P, Levy C, Montano-Loza AJ, Schiano TD, Ridruejo E, Wahlin S. Liver Int. 2022 Mar; 2021 Dec 13. PMID: 34846800.

2021

Adjunct Fenofibrate Up-regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis.Gallucci GM, Trottier J, Hemme C, Assis DN, Boyer JL, Barbier O, Ghonem NS. Hepatol Commun. 2021 Dec; 2021 Aug 27. PMID: 34558841.
A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.Pan Q, Luo G, Qu J, Chen S, Zhang X, Zhao N, Ding J, Yang H, Li M, Li L, Cheng Y, Li X, Xie Q, Li Q, Zhou X, Zou H, Fan S, Zou L, Liu W, Deng G, Cai SY, Boyer JL, Chai J. EMBO Mol Med. 2021 Nov 8; 2021 Sep 29. PMID: 34585848.
In Memoriam: Peter J. Meier (1947-2021).Stieger B, Boyer JL. J Hepatol. 2021 Jul 28; 2021 Jul 28. PMID: 34332756.
Bile formation and secretion: An update.Boyer JL, Soroka CJ. J Hepatol. 2021 Jul; 2021 Feb 20. PMID: 33617926.
Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study.Efe C, Dhanasekaran R, Lammert C, Ebik B, Higuera-de la Tijera F, Aloman C, Rıza Calışkan A, Peralta M, Gerussi A, Massoumi H, Catana AM, Torgutalp M, Purnak T, Rigamonti C, Gomez Aldana AJ, Khakoo N, Kacmaz H, Nazal L, Frager S, Demir N, Irak K, Ellik ZM, Balaban Y, Atay K, Eren F, Cristoferi L, Batıbay E, Urzua Á, Snijders R, Kıyıcı M, Akyıldız M, Ekin N, Carr RM, Harputluoğlu M, Hatemi I, Mendizabal M, Silva M, Idilman R, Silveira M, Drenth JPH, Assis DN, Björnsson E, Boyer JL, Invernizzi P, Levy C, Schiano TD, Ridruejo E, Wahlin S. Hepatology. 2021 Jun. PMID: 33713486.
Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine.Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Semin Liver Dis. 2021 May; 2021 May 6. PMID: 33957696.
The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology.Li B, Cai SY, Boyer JL. Biochim Biophys Acta Mol Basis Dis. 2021 May 1; 2021 Jan 24. PMID: 33497820.
The role of bile acids in cholestatic liver injury.Cai SY, Boyer JL. Ann Transl Med. 2021 Apr. PMID: 33987435.
Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis.Cai SY, Yu D, Soroka CJ, Wang J, Boyer JL. J Hepatol. 2021 Mar; 2020 Oct 9. PMID: 33039404.

2020

Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol.Ghonem NS, Auclair AM, Hemme CL, Gallucci GM, de la Rosa Rodriguez R, Boyer JL, Assis DN. Clin Pharmacol Ther. 2020 Dec; 2020 Jul 17. PMID: 32480421.
Organic Solute Transporter Alpha Deficiency: A Disorder With Cholestasis, Liver Fibrosis, and Congenital Diarrhea.Gao E, Cheema H, Waheed N, Mushtaq I, Erden N, Nelson-Williams C, Jain D, Soroka CJ, Boyer JL, Khalil Y, Clayton PT, Mistry PK, Lifton RP, Vilarinho S. Hepatology. 2020 May. PMID: 31863603.
A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis.Xu Y, Sun X, Zhang R, Cao T, Cai SY, Boyer JL, Zhang X, Li D, Huang Y. Cell Rep. 2020 Feb 4. PMID: 32023451.
Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse.Cai SY, Ge M, Mennone A, Hoque R, Ouyang X, Boyer JL. Cell Mol Gastroenterol Hepatol. 2020; 2019 Dec 27. PMID: 31887435.

2019

Bile acid metabolism and T cell responses in cholangiopathy: Not one-way traffic.Shetty S, Boyer JL. J Hepatol. 2019 Oct; 2019 Aug 22. PMID: 31447221.
Bile-Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile.Soroka CJ, Assis DN, Alrabadi LS, Roberts S, Cusack L, Jaffe AB, Boyer JL. Hepatology. 2019 Sep; 2019 Mar 13. PMID: 30561836.
Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis.Cai SY, Boyer JL. Hepatology. 2019 Feb; 2019 Jan 16. PMID: 30251326.
Liver Complications Following Treatment of Hematologic Malignancy With Anti-CD22-Calicheamicin (Inotuzumab Ozogamicin).McDonald GB, Freston JW, Boyer JL, DeLeve LD. Hepatology. 2019 Feb; 2019 Jan 18. PMID: 30120894.
Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies.Soroka CJ, Assis DN, Boyer JL. Methods Mol Biol. 2019. PMID: 31016667.

2018

Histologic features of autoimmune hepatitis: a critical appraisal.Gurung A, Assis DN, McCarty TR, Mitchell KA, Boyer JL, Jain D. Hum Pathol. 2018 Dec; 2018 Jul 21. PMID: 30041025.
H19 Is Expressed in Hybrid Hepatocyte Nuclear Factor 4α(+) Periportal Hepatocytes but Not Cytokeratin 19(+) Cholangiocytes in Cholestatic Livers.Jiang Y, Huang Y, Cai S, Song Y, Boyer JL, Zhang K, Gao L, Zhao J, Huang W, Liang G, Liangpunsakul S, Wang L. Hepatol Commun. 2018 Nov; 2018 Sep 24. PMID: 30411082.
Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis.Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, Zhou X, Chen S, Li J, Xu S, Huang D, Chen Y, Li L, Wang H, Chen W, Cai SY, Boyer JL, Chai J. Gastroenterology. 2018 Nov; 2018 Jul 29. PMID: 30063921.
Cenicriviroc, a cytokine receptor antagonist, potentiates all-trans retinoic acid in reducing liver injury in cholestatic rodents.Yu D, Cai SY, Mennone A, Vig P, Boyer JL. Liver Int. 2018 Jun; 2018 Feb 13. PMID: 29356312.
Primary Sclerosing Cholangitis Is Not Rare Among Blacks in a Multicenter North American Consortium.Goldberg DS, Levy C, Yimam K, Gordon SC, Forman L, Verna E, Yu L, Rahimi R, Schwarz K, Eksteen B, Pratt D, Boyer JL, Assis D, Bowlus C. Clin Gastroenterol Hepatol. 2018 Apr; 2017 Nov 2. PMID: 29102704.
OSTα-OSTβ Guards the Ileal Enterocyte From the Accumulation of Toxic Levels of Bile Acids.Boyer JL. Cell Mol Gastroenterol Hepatol. 2018; 2018 Feb 10. PMID: 29713669.

2017

Maintaining a Vibrant and Productive Laboratory as a Senior Investigator.Boyer JL. Cell Mol Gastroenterol Hepatol. 2017 Sep; 2017 Jun 7. PMID: 28840184.
Mechanisms of bile acid mediated inflammation in the liver.Li M, Cai SY, Boyer JL. Mol Aspects Med. 2017 Aug; 2017 Jul 1. PMID: 28606651.
Na(+)-taurocholate cotransporting polypeptide (NTCP/SLC10A1) ortholog in the marine skate Leucoraja erinacea is not a physiological bile salt transporter.Yu D, Zhang H, Lionarons DA, Boyer JL, Cai SY. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1; 2017 Jan 11. PMID: 28077388.
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714.
Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. J Clin Gastroenterol. 2017 Feb. PMID: 27428727.
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury.Cai SY, Boyer JL. Inflamm Cell Signal. 2017; 2017 Jun 19. PMID: 28804737.
The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage.Cai SY, Boyer JL. Dig Dis. 2017; 2017 Mar 1. PMID: 28249287.
CFTR-associated ligand is a negative regulator of Mrp2 expression.Li M, Soroka CJ, Harry K, Boyer JL. Am J Physiol Cell Physiol. 2017 Jan 1; 2016 Nov 9. PMID: 27834195.

2016

Treatment of chronic cholestasis: What we know and what we will know?Boyer JL. Clin Liver Dis (Hoboken). 2016 Dec; 2016 Dec 30. PMID: 31041082.
A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients.Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R. Dig Dis Sci. 2016 Dec; 2016 Oct 1. PMID: 27696094.
Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis.Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL. Hepatology. 2016 Dec; 2016 Oct 28. PMID: 27639250.
A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL. PLoS One. 2016; 2016 Jun 28. PMID: 27351185.

2015

Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis.Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He X, He Y, Chen L, Wang R, Wang H, Boyer JL, Chen W. J Hepatol. 2015 Dec; 2015 Jul 23. PMID: 26212029.
Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury.Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL. Hepatology. 2015 Oct; 2015 Aug 22. PMID: 26108984.
Fibrates and cholestasis.Ghonem NS, Assis DN, Boyer JL. Hepatology. 2015 Aug; 2015 Mar 23. PMID: 25678132.
The origins of hepatobiliary and gastrointestinal physiology.Boyer JL. Hepatology. 2015 May; 2015 Mar 18. PMID: 25677183.
A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress.Lee JW, Park HS, Park SA, Ryu SH, Meng W, Jürgensmeier JM, Kurie JM, Hong WK, Boyer JL, Herbst RS, Koo JS. PLoS One. 2015; 2015 Apr 21. PMID: 25897662.
Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.Perry RJ, Zhang D, Zhang XM, Boyer JL, Shulman GI. Science. 2015 Mar 13; 2015 Feb 26. PMID: 25721504.

2014

The hepatobiliary paracellular pathway: a paradigm revisited.Boyer JL. Gastroenterology. 2014 Nov; 2014 Sep 26. PMID: 25263297.
A RAS renaissance: emerging targeted therapies for KRAS-mutated non-small cell lung cancer.Vasan N, Boyer JL, Herbst RS. Clin Cancer Res. 2014 Aug 1; 2014 Jun 3. PMID: 24893629.
Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Soroka CJ, Boyer JL. Mol Aspects Med. 2014 Jun; 2013 May 15. PMID: 23685087.
Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice.Cai SY, Mennone A, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 2014 Jan 30. PMID: 24481602.
Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease.Mistry PK, Liu J, Sun L, Chuang WL, Yuen T, Yang R, Lu P, Zhang K, Li J, Keutzer J, Stachnik A, Mennone A, Boyer JL, Jain D, Brady RO, New MI, Zaidi M. Proc Natl Acad Sci U S A. 2014 Apr 1; 2014 Mar 17. PMID: 24639522.
All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice.Cai SY, Mennone A, Soroka CJ, Boyer JL. J Pharmacol Exp Ther. 2014 Apr; 2014 Feb 3. PMID: 24492652.
Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion.Ghonem NS, Ananthanarayanan M, Soroka CJ, Boyer JL. Hepatology. 2014 Mar; 2014 Jan 27. PMID: 24122873.
The role of macrophage migration inhibitory factor in autoimmune liver disease.Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson DJ, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R. Hepatology. 2014 Feb; 2013 Dec 20. PMID: 23913513.
"Quitting smoking will benefit your health": the evolution of clinician messaging to encourage tobacco cessation.Toll BA, Rojewski AM, Duncan LR, Latimer-Cheung AE, Fucito LM, Boyer JL, O'Malley SS, Salovey P, Herbst RS. Clin Cancer Res. 2014 Jan 15; 2014 Jan 16. PMID: 24436474.
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL. J Hepatol. 2014 Jan; 2013 Aug 23. PMID: 23978715.

2013

Bile formation and secretion.Boyer JL. Compr Physiol. 2013 Jul. PMID: 23897680.
Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion.Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Hepatology. 2013 Jun. PMID: 23175353.
A step towards treating KRAS-mutant NSCLC.Goldberg SB, Schlessinger J, Boyer JL, Herbst RS. Lancet Oncol. 2013 Jan; 2012 Nov 28. PMID: 23200176.

2012

Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2).Lionarons DA, Boyer JL, Cai SY. J Lipid Res. 2012 Aug; 2012 Jun 5. PMID: 22669917.
A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis.Lam P, Xu S, Soroka CJ, Boyer JL. Hepatology. 2012 Jun; 2012 Apr 25. PMID: 22161577.
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2012 May 1; 2012 Feb 16. PMID: 22345550.
Targeting vascular endothelial growth factor in patients with squamous cell lung cancer.Koo PJ, Morgensztern D, Boyer JL, Herbst RS. J Clin Oncol. 2012 Apr 1; 2012 Feb 21. PMID: 22355057.

2011

Ostα depletion protects liver from oral bile acid load.Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 2011 Jun 30. PMID: 21719738.
Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells.He H, Mennone A, Boyer JL, Cai SY. Hepatology. 2011 Feb; 2010 Dec 10. PMID: 21274875.
Small-duct sclerosing cholangitis associated with Schistosoma mansoni.McCrann CH, Boyer JL. Hepatology. 2011 Feb; 2010 Sep 29. PMID: 20882579.

2010

Psychological stress is associated with relapse in type 1 autoimmune hepatitis.Srivastava S, Boyer JL. Liver Int. 2010 Nov; 2010 Sep 16. PMID: 20849437.
Role of breast cancer resistance protein in the adaptive response to cholestasis.Mennone A, Soroka CJ, Harry KM, Boyer JL. Drug Metab Dispos. 2010 Oct; 2010 Jul 2. PMID: 20601550.
Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.Cai SY, He H, Nguyen T, Mennone A, Boyer JL. J Lipid Res. 2010 Aug; 2010 Mar 25. PMID: 20338915.
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535.
NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function.Li M, Wang W, Soroka CJ, Mennone A, Harry K, Weinman EJ, Boyer JL. J Biol Chem. 2010 Jun 18; 2010 Apr 19. PMID: 20404332.
Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.Soroka CJ, Ballatori N, Boyer JL. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422499.
The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease.Lam P, Soroka CJ, Boyer JL. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422495.
Cholestasis: genetic and acquired.Boyer JL. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422493.
Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL. Hepatology. 2010 Jan. PMID: 19902485.

2009

Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Hepatology. 2009 Nov. PMID: 19821532.
It's all about bile.Boyer JL. Hepatology. 2009 Mar. PMID: 19242972.
ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. Gastroenterology. 2009 Mar; 2008 Nov 1. PMID: 19027009.

2008

Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II.Wang L, Dong H, Soroka CJ, Wei N, Boyer JL, Hochstrasser M. Hepatology. 2008 Nov. PMID: 18798335.
N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.Soroka CJ, Xu S, Mennone A, Lam P, Boyer JL. BMC Cell Biol. 2008 Oct 10; 2008 Oct 10. PMID: 18847488.
Bile canalicular secretion - tales from Vienna and Yale.Boyer JL. Wien Med Wochenschr. 2008. PMID: 18998067.

2007

Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases.Lam P, Pearson CL, Soroka CJ, Xu S, Mennone A, Boyer JL. Am J Physiol Cell Physiol. 2007 Nov; 2007 Sep 13. PMID: 17855769.
The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.Cai SY, Xiong L, Wray CG, Ballatori N, Boyer JL. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 2007 Jun 13. PMID: 17567710.
Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Feb 1. PMID: 17272513.
New perspectives for the treatment of cholestasis: lessons from basic science applied clinically.Boyer JL. J Hepatol. 2007 Mar; 2006 Dec 18. PMID: 17223219.

2006

Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes.Wang W, Soroka CJ, Mennone A, Rahner C, Harry K, Pypaert M, Boyer JL. Gastroenterology. 2006 Sep. PMID: 16952556.
FXR: a target for cholestatic syndromes?Cai SY, Boyer JL. Expert Opin Ther Targets. 2006 Jun. PMID: 16706681.
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 2006 Jan 19. PMID: 16423920.
Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis.Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. Hepatology. 2006 May. PMID: 16628672.
A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology.Denk GU, Cai SY, Chen WS, Lin A, Soroka CJ, Boyer JL. World J Gastroenterol. 2006 Apr 28. PMID: 16688799.
Rat hepatocyte engraftment in severe combined immunodeficient x beige mice using mouse-specific anti-fas antibody.Wilson JH, Paturzo FX, Johnson LK, Carreiro MP, Hixson DC, Mennone A, Boyer JL, Pober JS, Harding MJ. Xenotransplantation. 2006 Jan. PMID: 16497212.

2005

Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease?Boyer JL. Gastroenterology. 2005 Aug. PMID: 16083726.
Liver biopsy: evolving role in the new millennium.Sheela H, Seela S, Caldwell C, Boyer JL, Jain D. J Clin Gastroenterol. 2005 Aug. PMID: 16000929.
Autoimmune hepatitis type 1: safety and efficacy of prolonged medical therapy.Seela S, Sheela H, Boyer JL. Liver Int. 2005 Aug. PMID: 15998423.

2004

Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis.Denk GU, Soroka CJ, Mennone A, Koepsell H, Beuers U, Boyer JL. Hepatology. 2004 May. PMID: 15122767.
The maintenance and generation of membrane polarity in hepatocytes.Wang L, Boyer JL. Hepatology. 2004 Apr. PMID: 15057889.
Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat.Denk GU, Soroka CJ, Takeyama Y, Chen WS, Schuetz JD, Boyer JL. J Hepatol. 2004 Apr. PMID: 15030973.

Shi-Ying Cai, DSc

2023

Runt-related transcription factor-1 ameliorates bile acid-induced hepatic inflammation in cholestasis through JAK/STAT3 signaling.Zhang L, Pan Q, Zhang L, Xia H, Liao J, Zhang X, Zhao N, Xie Q, Liao M, Tan Y, Li Q, Zhu J, Li L, Fan S, Li J, Zhang C, Cai SY, Boyer JL, Chai J. Hepatology. 2023 Jun 1; 2023 Jan 3. PMID: 36647589.
Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans.Pan Q, Zhu G, Xu Z, Zhu J, Ouyang J, Tong Y, Zhao N, Zhang X, Cheng Y, Zhang L, Tan Y, Li J, Zhang C, Chen W, Cai SY, Boyer JL, Chai J. Cell Mol Gastroenterol Hepatol. 2023 May 3; 2023 May 3. PMID: 37146714.
Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis.Li X, Li Y, Xiao J, Wang H, Guo Y, Mao X, Shi P, Hou Y, Zhang X, Zhao N, Zheng M, He Y, Ding J, Tan Y, Liao M, Li L, Peng Y, Li X, Pan Q, Xie Q, Li Q, Li J, Li Y, Chen Z, Huang Y, Assis DN, Cai SY, Boyer JL, Huang X, Tang CE, Liu X, Peng S, Chai J. Nat Commun. 2023 Feb 9; 2023 Feb 9. PMID: 36759512.
Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis.Liao M, Liao J, Qu J, Shi P, Cheng Y, Pan Q, Zhao N, Zhang X, Zhang L, Tan Y, Li Q, Zhu JF, Li J, Zhang C, Cai SY, Chai J. Cell Death Discov. 2023 Jan 23; 2023 Jan 23. PMID: 36690641.

2022

SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface.Zhao N, Zhang X, Ding J, Pan Q, Zheng MH, Liu WY, Luo G, Qu J, Li M, Li L, Cheng Y, Peng Y, Xie Q, Wei Q, Li Q, Zou L, Ouyang X, Cai SY, Boyer JL, Chai J. JCI Insight. 2022 Aug 8; 2022 Aug 8. PMID: 35938531.

2021

A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.Pan Q, Luo G, Qu J, Chen S, Zhang X, Zhao N, Ding J, Yang H, Li M, Li L, Cheng Y, Li X, Xie Q, Li Q, Zhou X, Zou H, Fan S, Zou L, Liu W, Deng G, Cai SY, Boyer JL, Chai J. EMBO Mol Med. 2021 Nov 8; 2021 Sep 29. PMID: 34585848.
The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology.Li B, Cai SY, Boyer JL. Biochim Biophys Acta Mol Basis Dis. 2021 May 1; 2021 Jan 24. PMID: 33497820.
The role of bile acids in cholestatic liver injury.Cai SY, Boyer JL. Ann Transl Med. 2021 Apr. PMID: 33987435.
Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis.Cai SY, Yu D, Soroka CJ, Wang J, Boyer JL. J Hepatol. 2021 Mar; 2020 Oct 9. PMID: 33039404.

2020

A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis.Xu Y, Sun X, Zhang R, Cao T, Cai SY, Boyer JL, Zhang X, Li D, Huang Y. Cell Rep. 2020 Feb 4. PMID: 32023451.
Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse.Cai SY, Ge M, Mennone A, Hoque R, Ouyang X, Boyer JL. Cell Mol Gastroenterol Hepatol. 2020; 2019 Dec 27. PMID: 31887435.

2019

A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters.Ge MX, Niu WX, Ren JF, Cai SY, Yu DK, Liu HT, Zhang N, Zhang YX, Wang YC, Shao RG, Wang JX, He HW. Acta Pharmacol Sin. 2019 Jul; 2018 Dec 20. PMID: 30573812.
Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis.Cai SY, Boyer JL. Hepatology. 2019 Feb; 2019 Jan 16. PMID: 30251326.

2018

Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis.Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, Zhou X, Chen S, Li J, Xu S, Huang D, Chen Y, Li L, Wang H, Chen W, Cai SY, Boyer JL, Chai J. Gastroenterology. 2018 Nov; 2018 Jul 29. PMID: 30063921.
Cenicriviroc, a cytokine receptor antagonist, potentiates all-trans retinoic acid in reducing liver injury in cholestatic rodents.Yu D, Cai SY, Mennone A, Vig P, Boyer JL. Liver Int. 2018 Jun; 2018 Feb 13. PMID: 29356312.
Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia.Zhang N, Geng T, Wang Z, Zhang R, Cao T, Camporez JP, Cai SY, Liu Y, Dandolo L, Shulman GI, Carmichael GG, Taylor HS, Huang Y. JCI Insight. 2018 May 17; 2018 May 17. PMID: 29769440.
Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, Pongratz RL, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ. Cell Metab. 2018 Feb 6. PMID: 29414684.

2017

Mechanisms of bile acid mediated inflammation in the liver.Li M, Cai SY, Boyer JL. Mol Aspects Med. 2017 Aug; 2017 Jul 1. PMID: 28606651.
Na(+)-taurocholate cotransporting polypeptide (NTCP/SLC10A1) ortholog in the marine skate Leucoraja erinacea is not a physiological bile salt transporter.Yu D, Zhang H, Lionarons DA, Boyer JL, Cai SY. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1; 2017 Jan 11. PMID: 28077388.
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714.
Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. J Clin Gastroenterol. 2017 Feb. PMID: 27428727.
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury.Cai SY, Boyer JL. Inflamm Cell Signal. 2017; 2017 Jun 19. PMID: 28804737.
The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage.Cai SY, Boyer JL. Dig Dis. 2017; 2017 Mar 1. PMID: 28249287.

2015

Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis.Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He X, He Y, Chen L, Wang R, Wang H, Boyer JL, Chen W. J Hepatol. 2015 Dec; 2015 Jul 23. PMID: 26212029.
The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway.Yu DK, Zhang CX, Zhao SS, Zhang SH, Zhang H, Cai SY, Shao RG, He HW. Acta Pharmacol Sin. 2015 Apr; 2015 Mar 16. PMID: 25832428.

2014

Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice.Cai SY, Mennone A, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 2014 Jan 30. PMID: 24481602.
All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice.Cai SY, Mennone A, Soroka CJ, Boyer JL. J Pharmacol Exp Ther. 2014 Apr; 2014 Feb 3. PMID: 24492652.

2013

Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion.Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Hepatology. 2013 Jun. PMID: 23175353.

2012

Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2).Lionarons DA, Boyer JL, Cai SY. J Lipid Res. 2012 Aug; 2012 Jun 5. PMID: 22669917.

2011

Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells.He H, Mennone A, Boyer JL, Cai SY. Hepatology. 2011 Feb; 2010 Dec 10. PMID: 21274875.

2010

Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.Cai SY, He H, Nguyen T, Mennone A, Boyer JL. J Lipid Res. 2010 Aug; 2010 Mar 25. PMID: 20338915.
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535.

2009

Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Hepatology. 2009 Nov. PMID: 19821532.
ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. Gastroenterology. 2009 Mar; 2008 Nov 1. PMID: 19027009.

2007

The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.Cai SY, Xiong L, Wray CG, Ballatori N, Boyer JL. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 2007 Jun 13. PMID: 17567710.
Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Feb 1. PMID: 17272513.

2006

FXR: a target for cholestatic syndromes?Cai SY, Boyer JL. Expert Opin Ther Targets. 2006 Jun. PMID: 16706681.
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 2006 Jan 19. PMID: 16423920.
Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis.Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. Hepatology. 2006 May. PMID: 16628672.
A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology.Denk GU, Cai SY, Chen WS, Lin A, Soroka CJ, Boyer JL. World J Gastroenterol. 2006 Apr 28. PMID: 16688799.

2003

Molecular characterization of a multidrug resistance-associated protein, Mrp2, from the little skate.Cai SY, Soroka CJ, Ballatori N, Boyer JL. Am J Physiol Regul Integr Comp Physiol. 2003 Jan; 2002 Oct 3. PMID: 12388433.

2002

An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins.Cai SY, Wang W, Soroka CJ, Ballatori N, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2002 Apr. PMID: 11897630.

2001

Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations.Cai SY, Wang L, Ballatori N, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2001 Aug. PMID: 11447010.

2000

A primitive ATP receptor from the little skate Raja erinacea.Dranoff JA, O'Neill AF, Franco AM, Cai SY, Connolly GC, Ballatori N, Boyer JL, Nathanson MH. J Biol Chem. 2000 Sep 29. PMID: 10900200.

1999

A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.Cai SY, Babbitt RW, Marchesi VT. Proc Natl Acad Sci U S A. 1999 Mar 16. PMID: 10077596.

Chuhan Chung, MD

2022

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Creasy KT, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA, Rader DJ, Voight BF, Chang KM. Nat Genet. 2022 Jun; 2022 Jun 2. PMID: 35654975.

2017

An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization.Park JK, Shao M, Kim MY, Baik SK, Cho MY, Utsumi T, Satoh A, Ouyang X, Chung C, Iwakiri Y. Hepatology. 2017 May; 2017 Mar 22. PMID: 28090670.

2016

Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a Protein-induced Autophagy in Pancreatic Intraepithelial Neoplasms.Gong J, Belinsky G, Sagheer U, Zhang X, Grippo PJ, Chung C. J Biol Chem. 2016 Oct 14; 2016 Aug 24. PMID: 27557659.
The liver throws the skeleton a bone (resorption factor).Chung C, Insogna KL. Hepatology. 2016 Sep; 2016 Jul 25. PMID: 27312397.
Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade.Belinsky GS, Sreekumar B, Andrejecsk JW, Saltzman WM, Gong J, Herzog RI, Lin S, Horsley V, Carpenter TO, Chung C. FASEB J. 2016 Aug; 2016 Apr 28. PMID: 27127101.
Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI.Belinsky GS, Ward L, Chung C. Rare Dis. 2016; 2016 Jul 19. PMID: 27579219.
Targeting αv Integrins in Pancreatic Fibrosis: Progress in Resolving the Scar.Chung C, Gorelick FS. Cell Mol Gastroenterol Hepatol. 2016 Jul; 2016 May 24. PMID: 28090563.
PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction.Principe DR, DeCant B, Diaz AM, Mangan RJ, Hwang R, Lowy A, Shetuni BB, Sreekumar BK, Chung C, Bentrem DJ, Munshi HG, Jung B, Grippo PJ, Bishehsari F. Oncotarget. 2016 May 10. PMID: 27058416.

2015

Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease.Sagheer U, Gong J, Chung C. J Dev Biol. 2015 Dec; 2015 Nov 20. PMID: 27239449.
Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver.Protiva P, Gong J, Sreekumar B, Torres R, Zhang X, Belinsky GS, Cornwell M, Crawford SE, Iwakiri Y, Chung C. Cell Mol Gastroenterol Hepatol. 2015 Sep 1; 2015 Jul 4. PMID: 26473164.

2014

Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions.Sreekumar BK, Belinsky GS, Einwachter H, Rhim AD, Schmid R, Chung C. Pancreas. 2014 Nov. PMID: 25072283.
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.Gattu AK, Birkenfeld AL, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel VT, Crawford SE, Chung C. Endocrinology. 2014 Apr; 2014 Jan 23. PMID: 24456163.

2013

Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content.Gattu AK, Swenson ES, Iwakiri Y, Samuel VT, Troiano N, Berry R, Church CD, Rodeheffer MS, Carpenter TO, Chung C. FASEB J. 2013 Nov; 2013 Jul 25. PMID: 23887690.
The lymphatic vascular system in liver diseases: its role in ascites formation.Chung C, Iwakiri Y. Clin Mol Hepatol. 2013 Jun; 2013 Jun 27. PMID: 23837133.
Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice.Tashiro K, Satoh A, Utsumi T, Chung C, Iwakiri Y. Am J Pathol. 2013 Mar; 2013 Jan 9. PMID: 23313137.

2012

Activated hepatic stellate cells: negative regulators of hepatocyte proliferation in liver diseases.Chung C, Iwakiri Y. Hepatology. 2012 Jul. PMID: 22876366.

2011

The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.Chung C, Mader CC, Schmitz JC, Atladottir J, Fitchev P, Cornwell ML, Koleske AJ, Crawford SE, Gorelick F. Lab Invest. 2011 May; 2011 Feb 21. PMID: 21339745.
Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis.Zhang D, Utsumi T, Huang HC, Gao L, Sangwung P, Chung C, Shibao K, Okamoto K, Yamaguchi K, Groszmann RJ, Jozsef L, Hao Z, Sessa WC, Iwakiri Y. Hepatology. 2011 Apr. PMID: 21480333.

2009

Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator.Chung C, Shugrue C, Nagar A, Doll JA, Cornwell M, Gattu A, Kolodecik T, Pandol SJ, Gorelick F. Gastroenterology. 2009 Jan; 2008 Oct 7. PMID: 18996124.

2008

Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL).Chung C, Doll JA, Gattu AK, Shugrue C, Cornwell M, Fitchev P, Crawford SE. J Hepatol. 2008 Mar; 2007 Dec 26. PMID: 18191271.
Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.Chung C, Doll JA, Stellmach VM, Gonzales J, Surapureddi S, Cornwell M, Reddy JK, Crawford SE. Adv Exp Med Biol. 2008. PMID: 18497086.

Luca Fabris, MD, PhD

2023

Intrahepatic Cholangiocarcinoma Developing in Patients with Metabolic Syndrome Is Characterized by Osteopontin Overexpression in the Tumor Stroma.Cadamuro M, Sarcognato S, Camerotto R, Girardi N, Lasagni A, Zanus G, Cillo U, Gringeri E, Morana G, Strazzabosco M, Campello E, Simioni P, Guido M, Fabris L. Int J Mol Sci. 2023 Mar 1; 2023 Mar 1. PMID: 36902188.
Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance.Calvisi DF, Boulter L, Vaquero J, Saborowski A, Fabris L, Rodrigues PM, Coulouarn C, Castro RE, Segatto O, Raggi C, van der Laan LJW, Carpino G, Goeppert B, Roessler S, Kendall TJ, Evert M, Gonzalez-Sanchez E, Valle JW, Vogel A, Bridgewater J, Borad MJ, Gores GJ, Roberts LR, Marin JJG, Andersen JB, Alvaro D, Forner A, Banales JM, Cardinale V, Macias RIR, Vicent S, Chen X, Braconi C, Verstegen MMA, Fouassier L. Nat Rev Gastroenterol Hepatol. 2023 Feb 8; 2023 Feb 8. PMID: 36755084.
The Landscape of HNF1B Deficiency: A Syndrome Not Yet Fully Explored.Gambella A, Kalantari S, Cadamuro M, Quaglia M, Delvecchio M, Fabris L, Pinon M. Cells. 2023 Jan 13; 2023 Jan 13. PMID: 36672242.
Rational development of combination therapies for biliary tract cancers.Harding JJ, Khalil DN, Fabris L, Abou-Alfa GK. J Hepatol. 2023 Jan; 2022 Sep 20. PMID: 36150578.

2022

New case of syncytial giant-cell variant of hepatocellular carcinoma in a pediatric patient with HNF1B deficiency: does it fit with the syndrome?Pinon M, Gambella A, Giugliano L, Chiadò C, Kalantari S, Bracciamà V, Deaglio S, Tinti D, Peruzzi L, Cotti R, Catalano S, Cadamuro M, Fabris L, Calvo PL, Romagnoli R. BMJ Open Gastroenterol. 2022 Dec. PMID: 36572455.
Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models.Olaizola P, Lee-Law PY, Fernandez-Barrena MG, Alvarez L, Cadamuro M, Azkargorta M, O'Rourke CJ, Caballero-Camino FJ, Olaizola I, Macias RIR, Marin JJG, Serrano-Maciá M, Martinez-Chantar ML, Avila MA, Aspichueta P, Calvisi DF, Evert M, Fabris L, Castro RE, Elortza F, Andersen JB, Bujanda L, Rodrigues PM, Perugorria MJ, Banales JM. J Hepatol. 2022 Jul; 2022 Feb 23. PMID: 35217064.
Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma.Cadamuro M, Romanzi A, Guido M, Sarcognato S, Cillo U, Gringeri E, Zanus G, Strazzabosco M, Simioni P, Villa E, Fabris L. J Pers Med. 2022 Jun 30; 2022 Jun 30. PMID: 35887583.
Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1(-/-) mouse model of congenital hepatic fibrosis.Fabris L, Milani C, Fiorotto R, Mariotti V, Kaffe E, Seller B, Sonzogni A, Strazzabosco M, Cadamuro M. FASEB J. 2022 Jun. PMID: 35593740.
Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry.Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł, Scripcariu V, Grazi GL, Landa-Magdalena A, Ijzermans JN, Evert K, Erdmann JI, López-López F, Saborowski A, Scheiter A, Santos-Laso A, Carpino G, Andersen JB, Marin JJ, Alvaro D, Bujanda L, Forner A, Valle JW, Koerkamp BG, Banales JM. J Hepatol. 2022 May; 2022 Feb 12. PMID: 35167909.
The Neglected Role of Bile Duct Epithelial Cells in NASH.Cadamuro M, Lasagni A, Sarcognato S, Guido M, Fabris R, Strazzabosco M, Strain AJ, Simioni P, Villa E, Fabris L. Semin Liver Dis. 2022 Feb; 2021 Nov 18. PMID: 34794182.
Mechanisms of Pharmacoresistance in Hepatocellular Carcinoma: New Drugs but Old Problems.Marin JJG, Romero MR, Herraez E, Asensio M, Ortiz-Rivero S, Sanchez-Martin A, Fabris L, Briz O. Semin Liver Dis. 2022 Feb; 2021 Sep 20. PMID: 34544160.

2021

New insights on the role of vascular endothelial growth factor in biliary pathophysiology.Mariotti V, Fiorotto R, Cadamuro M, Fabris L, Strazzabosco M. JHEP Rep. 2021 Jun; 2021 Feb 4. PMID: 34151244.
Fibrocystic liver disease: novel concepts and translational perspectives.Lasagni A, Cadamuro M, Morana G, Fabris L, Strazzabosco M. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824930.
Rare and undiagnosed liver diseases: challenges and opportunities.Fabris L, Strazzabosco M. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824922.
Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic.Cadamuro M, Lasagni A, Lamarca A, Fouassier L, Guido M, Sarcognato S, Gringeri E, Cillo U, Strazzabosco M, Marin JJ, Banales JM, Fabris L. Expert Opin Investig Drugs. 2021 Apr; 2021 Feb 23. PMID: 33622120.
Illuminate TWEAK/Fn14 pathway in intrahepatic cholangiocarcinoma: Another brick in the wall of tumor niche.Fabris L, Cadamuro M, Fouassier L. J Hepatol. 2021 Apr; 2021 Feb 12. PMID: 33583626.
The Tumor Microenvironment in Cholangiocarcinoma Progression.Fabris L, Sato K, Alpini G, Strazzabosco M. Hepatology. 2021 Jan; 2020 Nov 6. PMID: 32500550.

2020

Intrahepatic cholangiocarcinoma: A single-cell resolution unraveling the complexity of the tumor microenvironment.Fabris L, Andersen JB, Fouassier L. J Hepatol. 2020 Nov; 2020 Sep 6. PMID: 32900521.
Health related quality of life in chronic liver diseases.Cortesi PA, Conti S, Scalone L, Jaffe A, Ciaccio A, Okolicsanyi S, Rota M, Fabris L, Colledan M, Fagiuoli S, Belli LS, Cesana G, Strazzabosco M, Mantovani LG. Liver Int. 2020 Nov. PMID: 32851764.
Obeticholic acid reduces biliary and hepatic matrix metalloproteinases activity in rat hepatic ischemia/reperfusion injury.Ferrigno A, Palladini G, Di Pasqua LG, Berardo C, Richelmi P, Cadamuro M, Fabris L, Perlini S, Adorini L, Vairetti M. PLoS One. 2020; 2020 Sep 10. PMID: 32911524.
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Rizvi S, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ. Nat Rev Gastroenterol Hepatol. 2020 Sep; 2020 Jun 30. PMID: 32606456.
Liver Matrix in Benign and Malignant Biliary Tract Disease.Fabris L, Cadamuro M, Cagnin S, Strazzabosco M, Gores GJ. Semin Liver Dis. 2020 Aug; 2020 Mar 11. PMID: 32162285.
HCV infection and the risk of head and neck cancer: A meta-analysis.Borsetto D, Fussey J, Fabris L, Bandolin L, Gaudioso P, Phillips V, Polesel J, Boscolo-Rizzo P. Oral Oncol. 2020 Jun 26; 2020 Jun 26. PMID: 32599500.
The Emerging Role of Macrophages in Chronic Cholangiopathies Featuring Biliary Fibrosis: An Attractive Therapeutic Target for Orphan Diseases.Cadamuro M, Girardi N, Gores GJ, Strazzabosco M, Fabris L. Front Med (Lausanne). 2020; 2020 Apr 21. PMID: 32373615.
Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.Kyritsi K, Chen L, O'Brien A, Francis H, Hein TW, Venter J, Wu N, Ceci L, Zhou T, Zawieja D, Gashev AA, Meng F, Invernizzi P, Fabris L, Wu C, Skill NJ, Saxena R, Liangpunsakul S, Alpini G, Glaser SS. Hepatology. 2020 Mar; 2019 Oct 18. PMID: 31344280.
Clinical outcome indicators in chronic hepatitis B and C: A primer for value-based medicine in hepatology.Strazzabosco M, Cortesi PA, Conti S, Okolicsanyi S, Rota M, Ciaccio A, Cozzolino P, Fornari C, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Zavaglia C, Perricone G, Munari LM, Mantovani LG, Belli LS. Liver Int. 2020 Jan; 2019 Nov 12. PMID: 31654608.

2019

Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.Kennedy L, Francis H, Invernizzi P, Venter J, Wu N, Carbone M, Gershwin ME, Bernuzzi F, Franchitto A, Alvaro D, Marzioni M, Onori P, Gaudio E, Sybenga A, Fabris L, Meng F, Glaser S, Alpini G. FASEB J. 2019 Sep; 2019 Jun 28. PMID: 31251081.
Cell Interactions in Biliary Diseases: Clues from Pathophysiology and Repair Mechanisms to Foster Early Assessment.Fabris L, Spirli C, Mertens J. Int J Mol Sci. 2019 Aug 14; 2019 Aug 14. PMID: 31416247.
Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases.Fabris L, Fiorotto R, Spirli C, Cadamuro M, Mariotti V, Perugorria MJ, Banales JM, Strazzabosco M. Nat Rev Gastroenterol Hepatol. 2019 Aug. PMID: 31165788.
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.Chen L, Zhou T, Wu N, O'Brien A, Venter J, Ceci L, Kyritsi K, Onori P, Gaudio E, Sybenga A, Xie L, Wu C, Fabris L, Invernizzi P, Zawieja D, Liangpunsakul S, Meng F, Francis H, Alpini G, Huang Q, Glaser S. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1; 2019 Mar 16. PMID: 30890428.
Incretin-based treatment in type 2 diabetes mellitus and risk of cholangiocarcinoma: Is it only adverse drug effect?Barbato GM, Cadamuro M, Fabris L. Clin Res Hepatol Gastroenterol. 2019 Jun; 2019 Mar 1. PMID: 30833185.
The tumour microenvironment and immune milieu of cholangiocarcinoma.Fabris L, Perugorria MJ, Mertens J, Björkström NK, Cramer T, Lleo A, Solinas A, Sänger H, Lukacs-Kornek V, Moncsek A, Siebenhüner A, Strazzabosco M. Liver Int. 2019 May. PMID: 30907492.
Animal models of cholestasis: An update on inflammatory cholangiopathies.Mariotti V, Cadamuro M, Spirli C, Fiorotto R, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Aug 11. PMID: 30398152.
Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Sep 5. PMID: 30264693.
Animal models for cystic fibrosis liver disease (CFLD).Fiorotto R, Amenduni M, Mariotti V, Cadamuro M, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Jul 30. PMID: 30071276.
Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma.Cadamuro M, Brivio S, Mertens J, Vismara M, Moncsek A, Milani C, Fingas C, Cristina Malerba M, Nardo G, Dall'Olmo L, Milani E, Mariotti V, Stecca T, Massani M, Spirli C, Fiorotto R, Indraccolo S, Strazzabosco M, Fabris L. J Hepatol. 2019 Apr; 2018 Dec 14. PMID: 30553841.

2018

Animal models of cholangiocarcinoma: What they teach us about the human disease.Cadamuro M, Brivio S, Stecca T, Kaffe E, Mariotti V, Milani C, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Clin Res Hepatol Gastroenterol. 2018 Oct; 2018 May 9. PMID: 29753731.
Precision medicine in cholangiocarcinoma.Pellino A, Loupakis F, Cadamuro M, Dadduzio V, Fassan M, Guido M, Cillo U, Indraccolo S, Fabris L. Transl Gastroenterol Hepatol. 2018; 2018 Jul 12. PMID: 30148225.
β-Catenin and interleukin-1β-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis.Kaffe E, Fiorotto R, Pellegrino F, Mariotti V, Amenduni M, Cadamuro M, Fabris L, Strazzabosco M, Spirli C. Hepatology. 2018 May; 2018 Mar 25. PMID: 29140564.
Optimising the clinical strategy for autoimmune liver diseases: Principles of value-based medicine.Carbone M, Cristoferi L, Cortesi PA, Rota M, Ciaccio A, Okolicsanyi S, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Belli LS, Munari LM, Mantovani L, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Aug 24. PMID: 28844954.
The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma.Cadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 27. PMID: 28757170.
Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium.Strazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 25. PMID: 28754453.
Animal models of biliary injury and altered bile acid metabolism.Mariotti V, Strazzabosco M, Fabris L, Calvisi DF. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 11. PMID: 28709963.
Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Hepatology. 2018 Mar; 2018 Jan 26. PMID: 28836688.

2017

Emerging concepts in biliary repair and fibrosis.Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 2017 May 19. PMID: 28526690.
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M. J Hepatol. 2017 Mar; 2016 Nov 5. PMID: 27826057.
Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma.Cadamuro M, Brivio S, Spirli C, Joplin RE, Strazzabosco M, Fabris L. Int J Mol Sci. 2017 Jan 13; 2017 Jan 13. PMID: 28098760.

2016

Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma.Cadamuro M, Spagnuolo G, Sambado L, Indraccolo S, Nardo G, Rosato A, Brivio S, Caslini C, Stecca T, Massani M, Bassi N, Novelli E, Spirli C, Fabris L, Strazzabosco M. Cancer Res. 2016 Aug 15; 2016 Jun 21. PMID: 27328733.
Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Hepatology. 2016 Mar; 2016 Jan 16. PMID: 26645994.
Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the "Reactive" Biliary Epithelial Phenotype.Fabris L, Brivio S, Cadamuro M, Strazzabosco M. Stem Cells Int. 2016; 2016 Jan 6. PMID: 26880950.

2015

Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma?Brivio S, Cadamuro M, Fabris L, Strazzabosco M. J Clin Med. 2015 Dec 19; 2015 Dec 19. PMID: 26703747.
Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage.Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2015 Dec; 2015 Oct 10. PMID: 26313562.
Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation.Morton SD, Cadamuro M, Brivio S, Vismara M, Stecca T, Massani M, Bassi N, Furlanetto A, Joplin RE, Floreani A, Fabris L, Strazzabosco M. Oncotarget. 2015 Sep 22. PMID: 26296968.

2014

Osteopontin: a new player in regulating hepatic ductular reaction and hepatic progenitor cell responses during chronic liver injury.Strazzabosco M, Fabris L, Albano E. Gut. 2014 Nov; 2014 Jul 23. PMID: 25056656.
Neural cell adhesion molecule and polysialic acid in ductular reaction: the puzzle is far from completed, but the picture is becoming more clear.Strazzabosco M, Fabris L. Hepatology. 2014 Nov; 2014 Oct 1. PMID: 24995463.

2013

Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis.Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M. Hepatology. 2013 Nov; 2013 Sep 30. PMID: 23744610.
Unveiling the role of tumor reactive stroma in cholangiocarcinoma: an opportunity for new therapeutic strategies.Cadamuro M, Morton SD, Strazzabosco M, Fabris L. Transl Gastrointest Cancer. 2013 Jul. PMID: 28989865.
Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice.Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M. J Hepatol. 2013 Jul; 2013 Mar 7. PMID: 23500150.
The balance between Notch/Wnt signaling regulates progenitor cells' commitment during liver repair: mystery solved?Strazzabosco M, Fabris L. J Hepatol. 2013 Jan; 2012 Aug 15. PMID: 22902547.

2012

Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib.Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2012 Dec; 2012 Aug 27. PMID: 22653837.
Development of the bile ducts: essentials for the clinical hepatologist.Strazzabosco M, Fabris L. J Hepatol. 2012 May; 2012 Jan 13. PMID: 22245898.
Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes.Spirli C, Locatelli L, Fiorotto R, Morell CM, Fabris L, Pozzan T, Strazzabosco M. Hepatology. 2012 Mar. PMID: 21987453.

2011

Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice.Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M. Gastroenterology. 2011 Oct; 2011 Jun 26. PMID: 21712022.

2010

Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Hepatology. 2010 May. PMID: 20131403.
ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Gastroenterology. 2010 Jan; 2009 Sep 18. PMID: 19766642.

2008

Functional anatomy of normal bile ducts.Strazzabosco M, Fabris L. Anat Rec (Hoboken). 2008 Jun. PMID: 18484611.

2007

Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion.Fiorotto R, Spirlì C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M. Gastroenterology. 2007 Nov; 2007 Sep 2. PMID: 17983806.

James J Farrell, MBChB

2023

Surveillance of Pancreatic Cystic Neoplasms.Chhoda A, Schmidt J, Farrell JJ. Gastrointest Endosc Clin N Am. 2023 Jul; 2023 Apr 24. PMID: 37245939.
Racial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance.Katona BW, Klute K, Brand RE, Everett JN, Farrell JJ, Hawthorne K, Kaul V, Kupfer SS, Paiella S, Simeone DM, Sussman DA, Zogopoulos G, Lucas AL, Kastrinos F. Cancer Prev Res (Phila). 2023 Jun 1. PMID: 37259800.
Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis.Chhoda A, Singh S, Sheth AH, Grimshaw AA, Gunderson CG, Sharma P, Kunstman JW, Sharma A, Ahuja N, Gonda TA, Farrell JJ. Clin Gastroenterol Hepatol. 2023 Jun; 2022 May 11. PMID: 35568304.
Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms.Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan WY, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood LD, Iacobuzio-Donahue C, Wolfgang CL, Kunstman JW, Salem RR, Farrell JJ, Ahuja N. Clin Epigenetics. 2023 Feb 20; 2023 Feb 20. PMID: 36803844.
Reply to S. Raoof.Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Canto MI, Goggins M. J Clin Oncol. 2023 Feb 10; 2022 Oct 31. PMID: 36315911.
Precision Medicine for Pancreas Cancer Treatment: A Multidisciplinary Challenge or Opportunity?Farrell JJ, Robert ME, Lacy J. Clin Gastroenterol Hepatol. 2023 Jan 12; 2023 Jan 12. PMID: 36640803.

2022

A Rare Cause of Gastrointestinal Bleeding After Pancreaticoduodenectomy.Block PD, Farrell JJ, Li DK. Gastroenterology. 2022 Dec 30; 2022 Dec 30. PMID: 36592728.
The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival.Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Blackford AL, Rustgi AK, Dudley B, Lee LS, Chhoda A, Kwon R, Ginsberg GG, Klein AP, Kamel I, Hruban RH, He J, Shin EJ, Lennon AM, Canto MI, Goggins M. J Clin Oncol. 2022 Oct 1; 2022 Jun 15. PMID: 35704792.
International external validation of a stratification tool to identify branch-duct intraductal papillary mucinous neoplasms at lowest risk of progression.Overbeek KA, van Leeuwen N, Tacelli M, Anwar MS, Yousaf MN, Chhoda A, Arcidiacono PG, Gonda TA, Wallace MB, Capurso G, Farrell JJ, Cahen DL, Bruno MJ. United European Gastroenterol J. 2022 Mar; 2022 Feb 24. PMID: 35199484.
Late-Stage Pancreatic Cancer Detected During High-Risk Individual Surveillance: A Systematic Review and Meta-Analysis.Chhoda A, Vodusek Z, Wattamwar K, Mukherjee E, Gunderson C, Grimshaw A, Sharma A, Ahuja N, Kastrinos F, Farrell JJ. Gastroenterology. 2022 Mar; 2021 Nov 20. PMID: 34813861.
Comorbidities Drive the Majority of Overall Mortality in Low-Risk Mucinous Pancreatic Cysts Under Surveillance.Chhoda A, Yousaf MN, Madhani K, Aslanian H, Jamidar PA, Suarez AL, Salem RR, Muniraj T, Kunstman JW, Farrell JJ. Clin Gastroenterol Hepatol. 2022 Mar; 2020 Dec 10. PMID: 33309984.

2021

Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer.Ying L, Sharma A, Chhoda A, Ruzgar N, Hasan N, Kwak R, Wolfgang CL, Wang TH, Kunstman JW, Salem RR, Wood LD, Iacobuzio-Donahue C, Schneider EB, Farrell JJ, Ahuja N. Pancreas. 2021 Oct 1. PMID: 34860810.
Screening for Pancreatic Ductal Adenocarcinoma: Are We Asking the Impossible?-Letter.Katona BW, Brand RE, Canto MI, Chak A, Farrell JJ, Kastrinos F, Rustgi AK, Stoffel EM, Syngal S, Goggins M. Cancer Prev Res (Phila). 2021 Oct. PMID: 34607877.
COVID-19 related pancreatic cancer surveillance disruptions amongst high-risk individuals.Katona BW, Mahmud N, Dbouk M, Ahmad N, Chhoda A, Dudley B, Hayat U, Kwon RS, Lee LS, Rustgi AK, Ukaegbu C, Vasquez L, Volk S, Brand RE, Canto MI, Chak A, Farrell JJ, Kastrinos F, Stoffel EM, Syngal S, Goggins M. Pancreatology. 2021 Apr 20; 2021 Apr 20. PMID: 33926820.
Gastrointestinal mucosal damage in patients with COVID-19 undergoing endoscopy: an international multicentre study.Vanella G, Capurso G, Burti C, Fanti L, Ricciardiello L, Souza Lino A, Boskoski I, Bronswijk M, Tyberg A, Krishna Kumar Nair G, Angeletti S, Mauro A, Zingone F, Oppong KW, de la Iglesia-Garcia D, Pouillon L, Papanikolaou IS, Fracasso P, Ciceri F, Rovere-Querini P, Tomba C, Viale E, Eusebi LH, Riccioni ME, van der Merwe S, Shahid H, Sarkar A, Yoo JWG, Dilaghi E, Speight RA, Azzolini F, Buttitta F, Porcari S, Petrone MC, Iglesias-Garcia J, Savarino EV, Di Sabatino A, Di Giulio E, Farrell JJ, Kahaleh M, Roelandt P, Costamagna G, Artifon ELA, Bazzoli F, Testoni PA, Greco S, Arcidiacono PG. BMJ Open Gastroenterol. 2021 Feb. PMID: 33627313.

2020

Relationship between papilla-related variables and post endoscopic retrograde cholangiopancreatography pancreatitis: A multicenter, prospective study.Wang X, Zhao J, Wang L, Ning B, Zeng W, Tao Q, Ren G, Liang S, Luo H, Wang B, Farrell JJ, Pan Y, Guo X, Wu K. J Gastroenterol Hepatol. 2020 Dec; 2020 Jun 29. PMID: 32511794.
Learning curve of double-guidewire technique by trainees during hands-on endoscopic retrograde cholangiopancreatography training.Wang X, Ren G, Xi Y, Luo H, Liang S, Wang B, Tao Q, Luo B, Qin Q, Farrell JJ, Guo X, Wu K, Pan Y. J Gastroenterol Hepatol. 2020 Dec; 2020 Jun 23. PMID: 32473040.
Reviews on Current Liquid Biopsy for Detection and Management of Pancreatic Cancers.Kaczor-Urbanowicz KE, Cheng J, King JC, Sedarat A, Pandol SJ, Farrell JJ, Wong DTW, Kim Y. Pancreas. 2020 Oct. PMID: 33003085.
Endoscopic ultrasound-guided fine needle aspiration of accessory spleen: Cytomorphologic features and diagnostic considerations.Gilani SM, Muniraj T, Farrell JJ, Aslanian HR, Cai G. Diagn Cytopathol. 2020 Jul; 2020 Apr 21. PMID: 32315514.
Endoscopic ultrasound (EUS) and the management of pancreatic cancer.Yousaf MN, Chaudhary FS, Ehsan A, Suarez AL, Muniraj T, Jamidar P, Aslanian HR, Farrell JJ. BMJ Open Gastroenterol. 2020 May. PMID: 32414753.
Does Pancreatic Cyst Stability Justify Stopping Intraductal Papillary Mucinous Neoplasm Surveillance?Farrell JJ. Gastroenterology. 2020 Jan; 2019 Nov 15. PMID: 31738923.

2019

Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing.Majumder S, Taylor WR, Yab TC, Berger CK, Dukek BA, Cao X, Foote PH, Wu CW, Mahoney DW, Aslanian HR, Fernández-Del Castillo C, Doyle LA, Farrell JJ, Fisher WE, Lee LS, Lee YN, Park W, Rodrigues C, Gould Rothberg BE, Salem RR, Simeone DM, Urs S, Van Buren G, Smyrk TC, Allawi HT, Lidgard GP, Raimondo M, Chari ST, Kendrick ML, Kisiel JB, Topazian MD, Ahlquist DA. Am J Gastroenterol. 2019 Sep. PMID: 31306149.
Overview and comparison of guidelines for management of pancreatic cystic neoplasms.Hasan A, Visrodia K, Farrell JJ, Gonda TA. World J Gastroenterol. 2019 Aug 21. PMID: 31496620.
Incidence of pancreatitis with the use of immune checkpoint inhibitors (ICI) in advanced cancers: A systematic review and meta-analysis.George J, Bajaj D, Sankaramangalam K, Yoo JW, Joshi NS, Gettinger S, Price C, Farrell JJ. Pancreatology. 2019 Jun; 2019 May 2. PMID: 31076344.
Pancreatic Cancer Prediction Through an Artificial Neural Network.Muhammad W, Hart GR, Nartowt B, Farrell JJ, Johung K, Liang Y, Deng J. Front Artif Intell. 2019; 2019 May 3. PMID: 33733091.
Impact of endoscopic ultrasound on diagnosis and management of presumed mucinous neoplasms when done for pancreatic cyst morphology change on non-invasive surveillance imaging.Madhani K, Yousaf M, Aamar A, Ooka K, Muniraj T, Aslanian H, Salem R, Farrell JJ. Endosc Int Open. 2019 Apr; 2019 Mar 15. PMID: 30931368.
Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors.Farrell JJ, Al-Haddad MA, Jackson SA, Gonda TA. Gastrointest Endosc. 2019 Apr; 2018 Nov 14. PMID: 30447214.
Current Approaches to Pancreatic Cancer Screening.Chhoda A, Lu L, Clerkin BM, Risch H, Farrell JJ. Am J Pathol. 2019 Jan. PMID: 30558719.

2018

Management of Autoimmune Pancreatitis.Madhani K, Farrell JJ. Gastrointest Endosc Clin N Am. 2018 Oct; 2018 Aug 1. PMID: 30241640.
Intraductal papillary mucinous neoplasm to pancreas ductal adenocarcinoma sequence and pancreas cancer screening.Farrell JJ. Endosc Ultrasound. 2018 Sep-Oct. PMID: 30323160.
A variant Sp1 (R218Q) transcription factor might enhance HbF expression in β(0) -thalassaemia homozygotes.Jiang Z, Luo HY, Farrell JJ, Zhang Z, Schulz VP, Albarawi D, Steinberg MH, Al-Allawi NAS, Gallagher PG, Forget BG, Chui DHK. Br J Haematol. 2018 Mar; 2017 Feb 27. PMID: 28240767.

2017

Cryoablation of a duodenal adenoma with intramucosal carcinoma.Ooka K, Celli R, Farrell JJ. VideoGIE. 2017 Sep; 2017 May 20. PMID: 29905297.
Comparison of the diagnostic accuracy of three current guidelines for the evaluation of asymptomatic pancreatic cystic neoplasms.Xu MM, Yin S, Siddiqui AA, Salem RR, Schrope B, Sethi A, Poneros JM, Gress FG, Genkinger JM, Do C, Brooks CA, Chabot JA, Kluger MD, Kowalski T, Loren DE, Aslanian H, Farrell JJ, Gonda TA. Medicine (Baltimore). 2017 Sep. PMID: 28858107.
Surveillance and Outcomes of Nonresected Presumed Branch-Duct Intraductal Papillary Mucinous Neoplasms: A Meta-analysis.Ooka K, Rustagi T, Evans A, Farrell JJ. Pancreas. 2017 Aug. PMID: 28697134.
Editorial: Stopping Pancreatic Cyst Surveillance?Farrell JJ. Am J Gastroenterol. 2017 Jul. PMID: 28725064.
Pancreatic Cysts and Guidelines.Farrell JJ. Dig Dis Sci. 2017 Jul; 2017 May 20. PMID: 28528374.
Response to Del Chiaro et al.Farrell JJ. Am J Gastroenterol. 2017 May. PMID: 28469214.

2016

Precision Medicine and Pancreatic Cancer: A Gemcitabine Pathway Approach.Farrell JJ, Moughan J, Wong JL, Regine WF, Schaefer P, Benson AB 3rd, Macdonald JS, Liu X, Yen Y, Lai R, Zheng Z, Bepler G, Guha C, Elsaleh H. Pancreas. 2016 Nov. PMID: 27748721.
Poking the Pancreas: When to Needle that Incidental Cyst.Farrell JJ. Am J Gastroenterol. 2016 Oct; 2016 Sep 13. PMID: 27619834.
Autoimmune Pancreatitis: An Update on Diagnosis and Management.Madhani K, Farrell JJ. Gastroenterol Clin North Am. 2016 Mar. PMID: 26895679.
The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) β(0) -thalassaemia homozygotes.Jiang Z, Luo HY, Huang S, Farrell JJ, Davis L, Théberge R, Benson KA, Riolueang S, Viprakasit V, Al-Allawi NA, Ünal S, Gümrük F, Akar N, Başak AN, Osorio L, Badens C, Pissard S, Joly P, Campbell AD, Gallagher PG, Steinberg MH, Forget BG, Chui DH. Br J Haematol. 2016 Mar; 2016 Jan 13. PMID: 26771086.

2015

Linear-array EUS improves detection of pancreatic lesions in high-risk individuals: a randomized tandem study.Shin EJ, Topazian M, Goggins MG, Syngal S, Saltzman JR, Lee JH, Farrell JJ, Canto MI. Gastrointest Endosc. 2015 Nov; 2015 Apr 27. PMID: 25930097.
Prevalence, Diagnosis and Management of Pancreatic Cystic Neoplasms: Current Status and Future Directions.Farrell JJ. Gut Liver. 2015 Sep 23. PMID: 26343068.

2014

Endoscopic diagnosis and treatment of pancreatic neuroendocrine tumors.Rustagi T, Farrell JJ. J Clin Gastroenterol. 2014 Nov-Dec. PMID: 24828360.

2013

Endoscopically acquired pancreatic cyst fluid microRNA 21 and 221 are associated with invasive cancer.Farrell JJ, Toste P, Wu N, Li L, Wong J, Malkhassian D, Tran LM, Wu X, Li X, Dawson D, Wu H, Donahue TR. Am J Gastroenterol. 2013 Aug; 2013 Jun 11. PMID: 23752880.
Pancreatic cystic neoplasms: management and unanswered questions.Farrell JJ, Fernández-del Castillo C. Gastroenterology. 2013 Jun. PMID: 23622140.

Romina Fiorotto, PhD

2023

Fibroblasts to hepatocytes: A nonstop flight into cell therapy for liver diseases?Gouon-Evans V, Fiorotto R. Hepatology. 2023 May 1; 2023 Apr 17. PMID: 35957526.
Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation.Fiorotto R, Mariotti V, Taleb SA, Zehra SA, Nguyen M, Amenduni M, Strazzabosco M. Hepatol Commun. 2023 Apr 1; 2023 Mar 24. PMID: 36972396.

2022

Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes.Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.
Bile acids and their receptors: modulators and therapeutic targets in liver inflammation.Bertolini A, Fiorotto R, Strazzabosco M. Semin Immunopathol. 2022 Jul; 2022 Apr 12. PMID: 35415765.
Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1(-/-) mouse model of congenital hepatic fibrosis.Fabris L, Milani C, Fiorotto R, Mariotti V, Kaffe E, Seller B, Sonzogni A, Strazzabosco M, Cadamuro M. FASEB J. 2022 Jun. PMID: 35593740.

2021

New insights on the role of vascular endothelial growth factor in biliary pathophysiology.Mariotti V, Fiorotto R, Cadamuro M, Fabris L, Strazzabosco M. JHEP Rep. 2021 Jun; 2021 Feb 4. PMID: 34151244.
Novel approaches to liver disease diagnosis and modeling.Oliveira AG, Fiorotto R. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824923.
IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression.Stein S, Henze L, Poch T, Carambia A, Krech T, Preti M, Schuran FA, Reich M, Keitel V, Fiorotto R, Strazzabosco M, Fischer L, Li J, Müller LM, Wagner J, Gagliani N, Herkel J, Schwinge D, Schramm C. J Hepatol. 2021 Apr; 2020 Nov 13. PMID: 33197512.

2020

Abnormal Liver Function Tests in Patients With COVID-19: Relevance and Potential Pathogenesis.Bertolini A, van de Peppel IP, Bodewes FAJA, Moshage H, Fantin A, Farinati F, Fiorotto R, Jonker JW, Strazzabosco M, Verkade HJ, Peserico G. Hepatology. 2020 Nov; 2020 Oct 20. PMID: 32702162.
Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview.Torres S, Abdullah Z, Brol MJ, Hellerbrand C, Fernandez M, Fiorotto R, Klein S, Königshofer P, Liedtke C, Lotersztajn S, Nevzorova YA, Schierwagen R, Reiberger T, Uschner FE, Tacke F, Weiskirchen R, Trebicka J. Int J Mol Sci. 2020 Mar 16; 2020 Mar 16. PMID: 32188134.

2019

Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases.Fabris L, Fiorotto R, Spirli C, Cadamuro M, Mariotti V, Perugorria MJ, Banales JM, Strazzabosco M. Nat Rev Gastroenterol Hepatol. 2019 Aug. PMID: 31165788.
Animal models of cholestasis: An update on inflammatory cholangiopathies.Mariotti V, Cadamuro M, Spirli C, Fiorotto R, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Aug 11. PMID: 30398152.
Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Sep 5. PMID: 30264693.
Animal models for cystic fibrosis liver disease (CFLD).Fiorotto R, Amenduni M, Mariotti V, Cadamuro M, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Jul 30. PMID: 30071276.
Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma.Cadamuro M, Brivio S, Mertens J, Vismara M, Moncsek A, Milani C, Fingas C, Cristina Malerba M, Nardo G, Dall'Olmo L, Milani E, Mariotti V, Stecca T, Massani M, Spirli C, Fiorotto R, Indraccolo S, Strazzabosco M, Fabris L. J Hepatol. 2019 Apr; 2018 Dec 14. PMID: 30553841.
Pathophysiology of Cystic Fibrosis Liver Disease: A Channelopathy Leading to Alterations in Innate Immunity and in Microbiota.Fiorotto R, Strazzabosco M. Cell Mol Gastroenterol Hepatol. 2019; 2019 May 7. PMID: 31075352.

2018

Animal models of cholangiocarcinoma: What they teach us about the human disease.Cadamuro M, Brivio S, Stecca T, Kaffe E, Mariotti V, Milani C, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Clin Res Hepatol Gastroenterol. 2018 Oct; 2018 May 9. PMID: 29753731.
β-Catenin and interleukin-1β-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis.Kaffe E, Fiorotto R, Pellegrino F, Mariotti V, Amenduni M, Cadamuro M, Fabris L, Strazzabosco M, Spirli C. Hepatology. 2018 May; 2018 Mar 25. PMID: 29140564.
The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma.Cadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 27. PMID: 28757170.
Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium.Strazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 25. PMID: 28754453.
Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Hepatology. 2018 Mar; 2018 Jan 26. PMID: 28836688.

2017

Notch signaling and progenitor/ductular reaction in steatohepatitis.Morell CM, Fiorotto R, Meroni M, Raizner A, Torsello B, Cadamuro M, Spagnuolo G, Kaffe E, Sutti S, Albano E, Strazzabosco M. PLoS One. 2017; 2017 Nov 15. PMID: 29140985.
Emerging concepts in biliary repair and fibrosis.Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 2017 May 19. PMID: 28526690.
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M. J Hepatol. 2017 Mar; 2016 Nov 5. PMID: 27826057.

2016

The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity.Fiorotto R, Villani A, Kourtidis A, Scirpo R, Amenduni M, Geibel PJ, Cadamuro M, Spirli C, Anastasiadis PZ, Strazzabosco M. Hepatology. 2016 Dec; 2016 Oct 27. PMID: 27629435.
Cystic Fibrosis-Related Liver Diseases: New Paradigm for Treatment Based on Pathophysiology.Fiorotto R, Strazzabosco M. Clin Liver Dis (Hoboken). 2016 Nov; 2016 Nov 30. PMID: 31041076.
Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Hepatology. 2016 Mar; 2016 Jan 16. PMID: 26645994.

2015

Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage.Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2015 Dec; 2015 Oct 10. PMID: 26313562.
Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium.Scirpo R, Fiorotto R, Villani A, Amenduni M, Spirli C, Strazzabosco M. Hepatology. 2015 Nov; 2015 Aug 28. PMID: 26199136.

2013

Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis.Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M. Hepatology. 2013 Nov; 2013 Sep 30. PMID: 23744610.
Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice.Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M. J Hepatol. 2013 Jul; 2013 Mar 7. PMID: 23500150.

2012

Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib.Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2012 Dec; 2012 Aug 27. PMID: 22653837.
Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes.Spirli C, Locatelli L, Fiorotto R, Morell CM, Fabris L, Pozzan T, Strazzabosco M. Hepatology. 2012 Mar. PMID: 21987453.

2011

Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice.Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M. Gastroenterology. 2011 Oct; 2011 Jun 26. PMID: 21712022.

2010

Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Hepatology. 2010 May. PMID: 20131403.
ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Gastroenterology. 2010 Jan; 2009 Sep 18. PMID: 19766642.

2009

Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation.Strazzabosco M, Fiorotto R, Melero S, Glaser S, Francis H, Spirli C, Alpini G. Hepatology. 2009 Jul. PMID: 19444869.

2007

Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion.Fiorotto R, Spirlì C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M. Gastroenterology. 2007 Nov; 2007 Sep 2. PMID: 17983806.

Guadalupe Garcia-Tsao, MD

2023

Emerging concepts in the care of patients with cirrhosis and septic shock.Jimenez JV, Garcia-Tsao G, Saffo S. World J Hepatol. 2023 Apr 27. PMID: 37206653.
Medications for alcohol use disorder improve survival in patients with hazardous drinking and alcohol-associated cirrhosis.Rabiee A, Mahmud N, Falker C, Garcia-Tsao G, Taddei T, Kaplan DE. Hepatol Commun. 2023 Apr 1; 2023 Mar 24. PMID: 36972386.
Admission Serum Metabolites and Thyroxine Predict Advanced Hepatic Encephalopathy in a Multicenter Inpatient Cirrhosis Cohort.Bajaj JS, Tandon P, O'Leary JG, Reddy KR, Garcia-Tsao G, Thuluvath P, Lai JC, Subramanian RM, Vargas HE, Wong F, Fagan A, McGeorge S, Thacker LR, Kamath PS. Clin Gastroenterol Hepatol. 2023 Apr; 2022 Apr 15. PMID: 35436625.
Update in the Treatment of the Complications of Cirrhosis.Abraldes JG, Caraceni P, Ghabril M, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2023 Mar 25; 2023 Mar 25. PMID: 36972759.
Endovascular Assessment of Liver Hemodynamics in Patients with Cirrhosis Complicated by Portal Hypertension.Ferral H, Schepis F, Gaba RC, Garcia-Tsao G, Zanetto A, Perez-Campuzano V, Haskal ZJ, Garcia-Pagan JC. J Vasc Interv Radiol. 2023 Mar; 2022 Dec 11. PMID: 36516940.
Thromboelastography-Guided Therapy Enhances Patient Blood Management in Cirrhotic Patients: A Meta-analysis Based on Randomized Controlled Trials.Hartmann J, Dias JD, Pivalizza EG, Garcia-Tsao G. Semin Thromb Hemost. 2023 Mar; 2022 Sep 2. PMID: 36055266.
Acute Kidney Injury in Patients with Cirrhosis.Nadim MK, Garcia-Tsao G. N Engl J Med. 2023 Feb 23. PMID: 36812435.
Machine learning liver histology scores correlate with portal hypertension assessments in nonalcoholic steatohepatitis cirrhosis.Noureddin M, Goodman Z, Tai D, Chng ELK, Ren Y, Boudes P, Shlevin H, Garcia-Tsao G, Harrison SA, Chalasani NP. Aliment Pharmacol Ther. 2023 Feb; 2023 Jan 17. PMID: 36647687.

2022

Noninvasive predictors of clinically significant portal hypertension in NASH cirrhosis: Validation of ANTICIPATE models and development of a lab-based model.Rabiee A, Deng Y, Ciarleglio M, Chan JL, Pons M, Genesca J, Garcia-Tsao G. Hepatol Commun. 2022 Dec; 2022 Oct 10. PMID: 36214066.
"Periprocedural management of abnormal coagulation parameters and thrombocytopenia in patients with cirrhosis: Guidance from the SSC of the ISTH": Comment from Hartmann et al.Hartmann J, Dias JD, Garcia-Tsao G, Pivalizza EG. J Thromb Haemost. 2022 Nov. PMID: 36271460.
Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.Ventura-Cots M, Argemi J, Jones PD, Lackner C, El Hag M, Abraldes JG, Alvarado E, Clemente A, Ravi S, Alves A, Alboraie M, Altamirano J, Barace S, Bosques F, Brown R, Caballeria J, Cabezas J, Carvalhana S, Cortez-Pinto H, Costa A, Degré D, Fernandez-Carrillo C, Ganne-Carrie N, Garcia-Tsao G, Genesca J, Koskinas J, Lanthier N, Louvet A, Lozano JJ, Lucey MR, Masson S, Mathurin P, Mendez-Sanchez N, Miquel R, Moreno C, Mounajjed T, Odena G, Kim W, Sancho-Bru P, Warren Sands R, Szafranska J, Verset L, Schnabl B, Sempoux C, Shah V, Shawcross DL, Stauber RE, Straub BK, Verna E, Tiniakos D, Trépo E, Vargas V, Villanueva C, Woosley JT, Ziol M, Mueller S, Stärkel P, Bataller R. Gut. 2022 Sep; 2022 Jan 6. PMID: 34992134.
Early mechanical ventilation for grade IV hepatic encephalopathy is associated with increased mortality among patients with cirrhosis: an exploratory study.Saffo S, Garcia-Tsao G. Acute Crit Care. 2022 Aug; 2022 Aug 18. PMID: 35977889.
Reply to: 'Management of portal hypertension in patients treated with atezolizumab and bevacizumab for hepatocellular carcinoma'.de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C. J Hepatol. 2022 Aug; 2022 May 5. PMID: 35526788.
North American Practice-Based Recommendations for Transjugular Intrahepatic Portosystemic Shunts in Portal Hypertension.Boike JR, Thornburg BG, Asrani SK, Fallon MB, Fortune BE, Izzy MJ, Verna EC, Abraldes JG, Allegretti AS, Bajaj JS, Biggins SW, Darcy MD, Farr MA, Farsad K, Garcia-Tsao G, Hall SA, Jadlowiec CC, Krowka MJ, Laberge J, Lee EW, Mulligan DC, Nadim MK, Northup PG, Salem R, Shatzel JJ, Shaw CJ, Simonetto DA, Susman J, Kolli KP, VanWagner LB. Clin Gastroenterol Hepatol. 2022 Aug; 2021 Jul 15. PMID: 34274511.
Portal pressure reductions induced by nonselective beta-blockers improve outcomes and decrease mortality in patients with cirrhosis with and without ascites.Turco L, García-Tsao G. Clin Liver Dis (Hoboken). 2022 Jul; 2022 Jun 3. PMID: 35899241.
Corrigendum to 'Baveno VII - Renewing consensus in portal hypertension' [J Hepatol (2022) 959-974].de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C. J Hepatol. 2022 Jul; 2022 Apr 14. PMID: 35431106.
Reply.Saffo S, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2022 Jul; 2021 Aug 28. PMID: 34464719.
Management of varices and variceal hemorrhage in liver cirrhosis: a recent update.Diaz-Soto MP, Garcia-Tsao G. Therap Adv Gastroenterol. 2022; 2022 Jun 20. PMID: 35757384.
Correction to: The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study.Morales-Arráez D, Ventura-Cots M, Altamirano J, Abraldes JG, Cruz-Lemini M, Thursz MR, Atkinson SR, Sarin SK, Kim W, Chavez-Araujo R, Higuera-de la Tijera MF, Singal AK, Shah VH, Kamath PS, Duarte-Rojo A, Charles EA, Vargas V, Jager M, Rautou PE, Rincon D, Zamarripa F, Restrepo-Gutiérrez JC, Torre A, Lucey MR, Arab JP, Mathurin P, Louvet A, García-Tsao G, González JA, Verna EC, Brown RS Jr, Argemi J, Fernández-Carrillo C, Clemente A, Alvarado-Tapias E, Forrest E, Allison M, Bataller R. Am J Gastroenterol. 2022 May 1. PMID: 35501978.
Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: A pilot study (RIFA-AH).Jiménez C, Ventura-Cots M, Sala M, Calafat M, Garcia-Retortillo M, Cirera I, Cañete N, Soriano G, Poca M, Simón-Talero M, Altamirano J, Lucey M, Garcia-Tsao G, Brown RS Jr, Schwabe RF, Verna EC, Schnabl B, Bosques-Padilla F, Mathurin P, Caballería J, Louvet A, Shawcross DL, Abraldes JG, Genescà J, Bataller R, Vargas V. Liver Int. 2022 May; 2022 Mar 7. PMID: 35220659.
Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward.Belcher JM, Parada XV, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Sharma P, Regner KR, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Allegretti AS. Am J Kidney Dis. 2022 May; 2021 Oct 2. PMID: 34606933.
Changes in Ascitic Fluid Polymorphonuclear Cell Count After Antibiotics Are Associated With Mortality in Spontaneous Bacterial Peritonitis.Saffo S, To UK, Santoiemma PP, Laurito M, Haque L, Rabiee A, Verna EC, Angarone MP, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2022 May; 2021 Jul 14. PMID: 34273564.
Baveno VII - Renewing consensus in portal hypertension.de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C. J Hepatol. 2022 Apr; 2021 Dec 30. PMID: 35120736.
Prognosis of hospitalized patients with cirrhosis and acute kidney disease.Wong F, Garcia-Tsao G, Reddy KR, O'Leary JG, Kamath PS, Tandon P, Lai JC, Vargas HE, Biggins SW, Fallon MB, Thuluvath PJ, Maliakkal BJ, Subramanian R, Thacker L, Bajaj JS. Liver Int. 2022 Apr; 2022 Jan 28. PMID: 35023264.
Nonselective Beta-Blockers in Portal Hypertension: Why, When, and How?Rabiee A, Garcia-Tsao G, Tapper EB. Clin Liver Dis (Hoboken). 2022 Mar; 2022 Mar 8. PMID: 35355838.
The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study.Morales-Arráez D, Ventura-Cots M, Altamirano J, Abraldes JG, Cruz-Lemini M, Thursz MR, Atkinson SR, Sarin SK, Kim W, Chavez-Araujo R, Higuera-de la Tijera MF, Singal AK, Shah VH, Kamath PS, Duarte-Rojo A, Charles EA, Vargas V, Jager M, Rautou PE, Rincon D, Zamarripa F, Restrepo-Gutiérrez JC, Torre A, Lucey MR, Arab JP, Mathurin P, Louvet A, García-Tsao G, González JA, Verna EC, Brown RS Jr, Argemi J, Fernández-Carrillo C, Clemente A, Alvarado-Tapias E, Forrest E, Allison M, Bataller R. Am J Gastroenterol. 2022 Feb 1. PMID: 34962498.
Trajectory of Serum Bilirubin Predicts Spontaneous Recovery in a Real-World Cohort of Patients With Alcoholic Hepatitis.Parker R, Cabezas J, Altamirano J, Arab JP, Ventura-Cots M, Sinha A, Dhanda A, Arrese M, McCune CA, Rowe IA, Schnabl B, Mathurin P, Shawcross D, Abraldes JG, Lucey MR, Garcia-Tsao G, Verna E, Brown RS Jr, Bosques-Padilla F, Vargas V, Louvet A, Holt AP, Bataller R. Clin Gastroenterol Hepatol. 2022 Feb; 2021 Jan 28. PMID: 33516950.
Invasive Fungal Infections Are Underdiagnosed in Hospitalized Patients With Decompensated Cirrhosis: An Autopsy Study.Saffo S, Jain D, Sanchez H, Garcia-Tsao G. Gastro Hep Adv. 2022; 2022 Jun 2. PMID: 36160304.

2021

Can We Rely on Changes in HVPG in Patients with Cirrhosis?Garcia-Tsao G. Hepatology. 2021 Dec; 2021 Oct 28. PMID: 34569630.
Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study.Arab JP, Díaz LA, Baeza N, Idalsoaga F, Fuentes-López E, Arnold J, Ramírez CA, Morales-Arraez D, Ventura-Cots M, Alvarado-Tapias E, Zhang W, Clark V, Simonetto D, Ahn JC, Buryska S, Mehta TI, Stefanescu H, Horhat A, Bumbu A, Dunn W, Attar B, Agrawal R, Haque ZS, Majeed M, Cabezas J, García-Carrera I, Parker R, Cuyàs B, Poca M, Soriano G, Sarin SK, Maiwall R, Jalal PK, Abdulsada S, Higuera-de la Tijera MF, Kulkarni AV, Rao PN, Guerra Salazar P, Skladaný L, Bystrianska N, Prado V, Clemente-Sanchez A, Rincón D, Haider T, Chacko KR, Cairo F, de Sousa Coelho M, Romero GA, Pollarsky FD, Restrepo JC, Castro-Sanchez S, Toro LG, Yaquich P, Mendizabal M, Garrido ML, Narvaez A, Bessone F, Marcelo JS, Piombino D, Dirchwolf M, Arancibia JP, Altamirano J, Kim W, Araujo RC, Duarte-Rojo A, Vargas V, Rautou PE, Issoufaly T, Zamarripa F, Torre A, Lucey MR, Mathurin P, Louvet A, García-Tsao G, González JA, Verna E, Brown RS, Roblero JP, Abraldes JG, Arrese M, Shah VH, Kamath PS, Singal AK, Bataller R. J Hepatol. 2021 Nov; 2021 Jun 21. PMID: 34166722.
REPLY.Bajaj JS, Garcia-Tsao G, Kamath PS, O'Leary JG, Reddy KR, Wong F. Hepatology. 2021 Nov; 2021 Jul 2. PMID: 34110034.
Admission Urinary and Serum Metabolites Predict Renal Outcomes in Hospitalized Patients With Cirrhosis.Bajaj JS, Garcia-Tsao G, Reddy KR, O'Leary JG, Vargas HE, Lai JC, Kamath PS, Tandon P, Subramanian RM, Thuluvath P, Fagan A, Sehrawat T, de la Rosa Rodriguez R, Thacker LR, Wong F. Hepatology. 2021 Nov; 2021 Jul 8. PMID: 34002868.
A Historical Overview of Spontaneous Bacterial Peritonitis: From Rare to Resistant.Haque LY, Garcia-Tsao G. Clin Liver Dis (Hoboken). 2021 Oct; 2021 Oct 29. PMID: 34745584.
Nonalcoholic Steatohepatitis - Opportunities and Challenges.Garcia-Tsao G. N Engl J Med. 2021 Oct 21. PMID: 34670048.
Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis.Jain D, Sreenivasan P, Inayat I, Deng Y, Ciarleglio MM, Garcia-Tsao G. Am J Clin Pathol. 2021 Oct 13. PMID: 33940622.
Reply.Chew M, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2021 Oct; 2021 Jun 18. PMID: 34147681.
The Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol-Associated Hepatitis.Musto JA, Eickhoff J, Ventura-Cots M, Abraldes JG, Bosques-Padilla F, Verna EC, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Mathurin P, Garcia-Tsao G, Schnabl B, Bataller R, Lucey MR. Liver Transpl. 2021 Oct; 2021 Jul 31. PMID: 34109723.
Significant Liver Injury During Hospitalization for COVID-19 Is Not Associated With Liver Insufficiency or Death.Chew M, Tang Z, Radcliffe C, Caruana D, Doilicho N, Ciarleglio MM, Deng Y, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2021 Oct; 2021 May 15. PMID: 34004326.
Increased Risk of ACLF and Inpatient Mortality in Hospitalized Patients with Cirrhosis and Hepatic Hydrothorax.O'Leary JG, Rajender Reddy K, Tandon P, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai JC, Fallon M, Vargas HE, Thuluvath P, Subramanian R, Thacker LR, Bajaj JS. Dig Dis Sci. 2021 Oct; 2020 Nov 13. PMID: 33185787.
Nonselective Beta-Blockers in Compensated Cirrhosis: Preventing Variceal Hemorrhage or Preventing Decompensation?Garcia-Tsao G, Abraldes JG. Gastroenterology. 2021 Sep; 2021 May 11. PMID: 33989660.
Reply to "Acute kidney injury in patients with decompensated cirrhosis".Campello E, Zanetto A, Garcia-Tsao G, Simioni P. Dig Liver Dis. 2021 Sep; 2021 Apr 27. PMID: 33926815.
Cirrhosis Is Associated With High Mortality and Readmissions Over 90 Days Regardless of COVID-19: A Multicenter Cohort.Bajaj JS, Garcia-Tsao G, Wong F, Biggins SW, Kamath PS, McGeorge S, Chew M, Pearson M, Shaw J, Kalluri A, Fagan A, Olofson A, Moini M, de la Rosa Rodriguez R, Reddy KR. Liver Transpl. 2021 Sep; 2021 Mar 15. PMID: 33427401.
Current knowledge and management of portal vein thrombosis in cirrhosis.Senzolo M, Garcia-Tsao G, García-Pagán JC. J Hepatol. 2021 Aug; 2021 Apr 27. PMID: 33930474.
Progression of Stage 2 and 3 Acute Kidney Injury in Patients With Decompensated Cirrhosis and Ascites.Wong F, Reddy KR, Tandon P, O'Leary JG, Garcia-Tsao G, Vargas HE, Lai JC, Biggins SW, Maliakkal B, Fallon M, Subramanian R, Thuluvath P, Kamath PS, Thacker L, Bajaj JS. Clin Gastroenterol Hepatol. 2021 Aug; 2020 Aug 13. PMID: 32798707.
Determinants of increased thrombotic tendency in NASH cirrhosis: not there yet!Zanetto A, Senzolo M, Campello E, Bulato C, Gavasso S, Saggiorato G, Feltracco P, Farinati F, Russo FP, Burra P, Garcia-Tsao G, Simioni P. Transpl Int. 2021 Jul; 2021 May 21. PMID: 33932057.
Acute kidney injury is associated with increased levels of circulating microvesicles in patients with decompensated cirrhosis.Campello E, Zanetto A, Radu CM, Bulato C, Truma A, Spiezia L, Senzolo M, Garcia-Tsao G, Simioni P. Dig Liver Dis. 2021 Jul; 2021 Jan 8. PMID: 33431230.
Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study.Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT. Clin Transl Gastroenterol. 2021 May 11; 2021 May 11. PMID: 33979307.
Terlipressin and Intravenous Albumin in Advanced Cirrhosis - Friend and Foe.Garcia-Tsao G. N Engl J Med. 2021 Mar 4. PMID: 33657300.
Sleep Disturbance Is Associated With the Presence of Portosystemic Collaterals in Patients With Compensated Cirrhosis.Balakrishnan M, Falker C, Conley S, Ciarleglio M, Deng Y, Redeker NS, Garcia-Tsao G. Hepatol Commun. 2021 Mar; 2021 Feb 3. PMID: 33681681.
SGLT2 inhibitors in patients with cirrhosis and diabetes mellitus: A tertiary center cohort study and insights about a potential therapeutic target for portal hypertension.Saffo S, Garcia-Tsao G, Taddei T. J Diabetes. 2021 Mar; 2020 Dec 6. PMID: 33210815.
Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort.Bajaj JS, Garcia-Tsao G, Biggins SW, Kamath PS, Wong F, McGeorge S, Shaw J, Pearson M, Chew M, Fagan A, de la Rosa Rodriguez R, Worthington J, Olofson A, Weir V, Trisolini C, Dwyer S, Reddy KR. Gut. 2021 Mar; 2020 Jul 13. PMID: 32660964.
Insurance Status But Not Race and Ethnicity Are Associated With Outcomes in a Large Hospitalized Cohort of Patients With Cirrhosis.Bajaj JS, O'Leary JG, Tandon P, Wong F, Kamath PS, Biggins SW, Garcia-Tsao G, Lai J, Fallon MB, Thuluvath PJ, Vargas HE, Maliakkal B, Subramanian RM, Thacker LR, Reddy KR. Clin Gastroenterol Hepatol. 2021 Mar; 2020 May 8. PMID: 32389884.
Low Predictability of Readmissions and Death Using Machine Learning in Cirrhosis.Hu C, Anjur V, Saboo K, Reddy KR, O'Leary J, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Lai JC, Biggins SW, Fallon MB, Thuluvath P, Subramanian RM, Maliakkal B, Vargas H, Thacker LR, Iyer RK, Bajaj JS. Am J Gastroenterol. 2021 Feb 1. PMID: 33038139.
Overview of Current Management of Portal Hypertension.Garcia-Tsao G. Gastroenterol Hepatol (N Y). 2021 Jan. PMID: 34035762.
Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases.Northup PG, Garcia-Pagan JC, Garcia-Tsao G, Intagliata NM, Superina RA, Roberts LN, Lisman T, Valla DC. Hepatology. 2021 Jan; 2021 Jan 20. PMID: 33219529.
Factors associated with health-related quality of life in patients with cirrhosis: a systematic review.Rabiee A, Ximenes RO, Nikayin S, Hickner A, Juthani P, Rosen RH, Garcia-Tsao G. Liver Int. 2021 Jan; 2020 Nov 2. PMID: 32998172.

2020

Intestinal Virome in Patients With Alcoholic Hepatitis.Jiang L, Lang S, Duan Y, Zhang X, Gao B, Chopyk J, Schwanemann LK, Ventura-Cots M, Bataller R, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Kisseleva T, Brenner DA, Tu XM, Stärkel P, Pride D, Fouts DE, Schnabl B. Hepatology. 2020 Dec; 2020 Oct 10. PMID: 32654263.
Clinical Research in Hepatology in the COVID-19 Pandemic and Post-Pandemic Era: Challenges and the Need for Innovation.Verna EC, Serper M, Chu J, Corey K, Fix OK, Hoyt K, Page KA, Loomba R, Li M, Everson GT, Fried MW, Garcia-Tsao G, Terrault N, Lok AS, Chung RT, Reddy KR. Hepatology. 2020 Nov. PMID: 32740969.
Sodium-Glucose Cotransporter 2 Inhibitors Ameliorate Ascites and Peripheral Edema in Patients With Cirrhosis and Diabetes.Montalvo-Gordon I, Chi-Cervera LA, García-Tsao G. Hepatology. 2020 Nov. PMID: 32294260.
Getting to implementation: a protocol for a Hybrid III stepped wedge cluster randomized evaluation of using data-driven implementation strategies to improve cirrhosis care for Veterans.Rogal SS, Yakovchenko V, Morgan T, Bajaj JS, Gonzalez R, Park A, Beste L, Miech EJ, Lamorte C, Neely B, Gibson S, Malone PS, Chartier M, Taddei T, Garcia-Tsao G, Powell BJ, Dominitz JA, Ross D, Chinman MJ. Implement Sci. 2020 Oct 21; 2020 Oct 21. PMID: 33087156.
Subaortic Membranes in Patients With Hereditary Hemorrhagic Telangiectasia and Liver Vascular Malformations.Kim AS, Henderson KJ, Pawar S, Kim MJ, Punjani S, Pollak JS, Fahey JT, Garcia-Tsao G, Sugeng L, Young LH. J Am Heart Assoc. 2020 Oct 20; 2020 Oct 15. PMID: 33054561.
Acute Kidney Injury in Decompensated Cirrhosis Is Associated With Both Hypo-coagulable and Hyper-coagulable Features.Zanetto A, Rinder HM, Campello E, Saggiorato G, Deng Y, Ciarleglio M, Wilson FP, Senzolo M, Gavasso S, Bulato C, Simioni P, Garcia-Tsao G. Hepatology. 2020 Oct. PMID: 32614088.
Some Answers and More Questions About Portal Vein Thrombosis in Patients With Decompensated Cirrhosis.Zanetto A, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2020 Oct; 2020 Apr 14. PMID: 32302710.
Underutilization of Hospice in Inpatients with Cirrhosis: The NACSELD Experience.O'Leary JG, Tandon P, Reddy KR, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai J, Fallon M, Vargas HE, Thuluvath P, Subramanian R, Thacker LR, Bajaj JS. Dig Dis Sci. 2020 Sep; 2020 Mar 7. PMID: 32146602.
Ordinal Outcomes Are Superior to Binary Outcomes for Designing and Evaluating Clinical Trials in Compensated Cirrhosis.D'Amico G, Abraldes JG, Rebora P, Valsecchi MG, Garcia-Tsao G. Hepatology. 2020 Sep; 2020 Jul 6. PMID: 31837238.
#LiverTwitter: An Emerging Tool for Liver Education and Research.Mikolajczyk AE, Ufere N, Breu AC, Parikh ND, Garcia-Tsao G, Tapper EB. Hepatol Commun. 2020 Aug; 2020 Jul 5. PMID: 32766481.
Where does TIPS fit in the management of patients with cirrhosis?García-Pagán JC, Saffo S, Mandorfer M, Garcia-Tsao G. JHEP Rep. 2020 Aug; 2020 May 23. PMID: 32671331.
Evaluation and Management of Esophageal and Gastric Varices in Patients with Cirrhosis.Jakab SS, Garcia-Tsao G. Clin Liver Dis. 2020 Aug; 2020 May 31. PMID: 32620275.
Update to the Society of Radiologists in Ultrasound Liver Elastography Consensus Statement.Barr RG, Wilson SR, Rubens D, Garcia-Tsao G, Ferraioli G. Radiology. 2020 Aug; 2020 Jun 9. PMID: 32515681.
Response to Mancuso et al.Simonetto DA, Singal AK, Garcia-Tsao G, Caldwell SH, Ahn J, Kamath PS. Am J Gastroenterol. 2020 Jun. PMID: 32427682.
Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension.Garcia-Tsao G, Bosch J, Kayali Z, Harrison SA, Abdelmalek MF, Lawitz E, Satapathy SK, Ghabril M, Shiffman ML, Younes ZH, Thuluvath PJ, Berzigotti A, Albillos A, Robinson JM, Hagerty DT, Chan JL, Sanyal AJ. J Hepatol. 2020 May; 2019 Dec 21. PMID: 31870950.
Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension.Chalasani N, Abdelmalek MF, Garcia-Tsao G, Vuppalanchi R, Alkhouri N, Rinella M, Noureddin M, Pyko M, Shiffman M, Sanyal A, Allgood A, Shlevin H, Horton R, Zomer E, Irish W, Goodman Z, Harrison SA, Traber PG. Gastroenterology. 2020 Apr; 2019 Dec 5. PMID: 31812510.
Author response to Letter to the Editor: 'Dynamics of platelet count after sustained virologic response do not mirror those of hepatic venous pressure gradient'.Ortiz GA, Sayyar M, Garcia-Tsao G. Liver Int. 2020 Apr; 2019 Dec 3. PMID: 31749290.
Reply to: "Lack of evidence for a continuum between hepatorenal syndrome and acute tubular necrosis".Garcia-Tsao G, Angeli P, Nadim MK, Parikh CR. J Hepatol. 2020 Mar; 2019 Dec 4. PMID: 31810532.
Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis.Lang S, Duan Y, Liu J, Torralba MG, Kuelbs C, Ventura-Cots M, Abraldes JG, Bosques-Padilla F, Verna EC, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross D, Lucey MR, Louvet A, Mathurin P, Garcia-Tsao G, Ho SB, Tu XM, Bataller R, Stärkel P, Fouts DE, Schnabl B. Hepatology. 2020 Feb; 2019 Aug 20. PMID: 31228214.
Lowering Portal Pressure Improves Outcomes of Patients With Cirrhosis, With or Without Ascites: A Meta-Analysis.Turco L, Villanueva C, La Mura V, García-Pagán JC, Reiberger T, Genescà J, Groszmann RJ, Sharma BC, Merkel C, Bureau C, Alvarado E, Abraldes JG, Albillos A, Bañares R, Peck-Radosavljevic M, Augustin S, Sarin SK, Bosch J, García-Tsao G. Clin Gastroenterol Hepatol. 2020 Feb; 2019 Jun 5. PMID: 31176013.
ACG Clinical Guideline: Disorders of the Hepatic and Mesenteric Circulation.Simonetto DA, Singal AK, Garcia-Tsao G, Caldwell SH, Ahn J, Kamath PS. Am J Gastroenterol. 2020 Jan. PMID: 31895720.

2019

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease.Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White RC, Clarke TH, Nguyen K, Torralba M, Shao Y, Liu J, Hernandez-Morales A, Lessor L, Rahman IR, Miyamoto Y, Ly M, Gao B, Sun W, Kiesel R, Hutmacher F, Lee S, Ventura-Cots M, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Tu XM, Eckmann L, van der Donk WA, Young R, Lawley TD, Stärkel P, Pride D, Fouts DE, Schnabl B. Nature. 2019 Nov; 2019 Nov 13. PMID: 31723265.
Venous Thromboembolism in Patients with Liver Cirrhosis: Findings from the RIETE (Registro Informatizado de la Enfermedad TromboEmbolica) Registry.Bikdeli B, Jiménez D, Garcia-Tsao G, Barba R, Font C, Díaz-Pedroche MDC, Mazzolai L, Little DHW, Tufano A, Tafur AJ, Siegal D, Lip GYH, Monreal M. Semin Thromb Hemost. 2019 Nov; 2019 Oct 15. PMID: 31614388.
Portal Hypertension: Pathogenesis and Diagnosis.Turco L, Garcia-Tsao G. Clin Liver Dis. 2019 Nov. PMID: 31563212.
Platelet count increases after viral elimination in chronic HCV, independent of the presence or absence of cirrhosis.Sayyar M, Saidi M, Zapatka S, Deng Y, Ciarleglio M, Garcia-Tsao G. Liver Int. 2019 Nov; 2019 Aug 21. PMID: 31365178.
Prophylactic Antibiotics in Cirrhosis: Are They Promoting or Preventing Infections?Garcia-Tsao G. Clin Liver Dis (Hoboken). 2019 Sep; 2019 Oct 9. PMID: 31632658.
Reply.Wong F, Reddy KR, O'Leary JG, Garcia-Tsao G, Kamath PS, Bajaj JS. Liver Transpl. 2019 Oct; 2019 Aug 14. PMID: 31344749.
News in pathophysiology, definition and classification of hepatorenal syndrome: A step beyond the International Club of Ascites (ICA) consensus document.Angeli P, Garcia-Tsao G, Nadim MK, Parikh CR. J Hepatol. 2019 Oct; 2019 Jul 11. PMID: 31302175.
Simple Clinical Tools to Predict Decompensation in Patients With Compensated Cirrhosis: An Unmet Need.Abraldes JG, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2019 Oct; 2019 Apr 17. PMID: 31004761.
Reply.Hagerty D, Garcia-Tsao G, Bosch J. Hepatology. 2019 Sep. PMID: 31034095.
Nosocomial Infections Are Frequent and Negatively Impact Outcomes in Hospitalized Patients With Cirrhosis.Bajaj JS, OʼLeary JG, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Biggins SW, Lai JC, Vargas HE, Maliakkal B, Fallon MB, Thuluvath PJ, Subramanian RM, Thacker LR, Reddy KR. Am J Gastroenterol. 2019 Jul. PMID: 31180922.
Management of acute variceal hemorrhage.Zanetto A, Garcia-Tsao G. F1000Res. 2019; 2019 Jun 25. PMID: 31281637.
Impact of Chronic Kidney Disease on Outcomes in Cirrhosis.Wong F, Reddy KR, O'Leary JG, Tandon P, Biggins SW, Garcia-Tsao G, Maliakkal BJ, Lai JC, Fallon MB, Vargas HE, Subramanian R, Thuluvath PJ, Kamath PS, Thacker L, Bajaj JS. Liver Transpl. 2019 Jun; 2019 Apr 25. PMID: 30908855.
Outcomes After Listing for Liver Transplant in Patients With Acute-on-Chronic Liver Failure: The Multicenter North American Consortium for the Study of End-Stage Liver Disease Experience.O'Leary JG, Bajaj JS, Tandon P, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai J, Fallon M, Vargas HE, Thuluvath P, Subramanian R, Thacker LR, Reddy KR. Liver Transpl. 2019 Apr; 2019 Mar 24. PMID: 30724010.
Outcomes in Patients With Cirrhosis on Primary Compared to Secondary Prophylaxis for Spontaneous Bacterial Peritonitis.Bajaj JS, Tandon P, OʼLeary JG, Wong F, Biggins SW, Garcia-Tsao G, Kamath PS, Maliakkal B, Fallon MB, Lai JC, Thuluvath PJ, Vargas HE, Subramanian RM, Thacker LR, Reddy KR. Am J Gastroenterol. 2019 Apr. PMID: 30694868.
Reply to: "It takes two "eyes" to see in depth".Turco L, Garcia-Tsao G, Rossi R, Villa E, Schepis F. J Hepatol. 2019 Apr; 2018 Dec 24. PMID: 30591265.
Reply to Risk Stratification in Acute Variceal Bleeding: Child-Pugh Versus Model for End-stage Liver Disease.Fortune BE, Ciarleglio M, Deng Y, Garcia-Tsao G. J Clin Gastroenterol. 2019 Apr. PMID: 28375866.
Future Pharmacological Therapies of Portal Hypertension.Ortiz GA, Garcia-Tsao G. Curr Hepatol Rep. 2019 Mar; 2019 Feb 19. PMID: 35722634.
Prioritization of Therapeutic Targets and Trial Design in Cirrhotic Portal Hypertension.Abraldes JG, Trebicka J, Chalasani N, D'Amico G, Rockey DC, Shah VH, Bosch J, Garcia-Tsao G. Hepatology. 2019 Mar; 2019 Feb 9. PMID: 30318607.
Emricasan (IDN-6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension.Garcia-Tsao G, Fuchs M, Shiffman M, Borg BB, Pyrsopoulos N, Shetty K, Gallegos-Orozco JF, Reddy KR, Feyssa E, Chan JL, Yamashita M, Robinson JM, Spada AP, Hagerty DT, Bosch J. Hepatology. 2019 Feb; 2018 Nov 26. PMID: 30063802.
Screening and Surveillance of Varices in Patients With Cirrhosis.Jakab SS, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2019 Jan; 2018 Mar 15. PMID: 29551741.

2018

Acute-on-Chronic Liver Failure: An Old Entity in Search of Clarity.Garcia-Tsao G. Hepatol Commun. 2018 Dec; 2018 Dec 10. PMID: 30556031.
Reply.O'Leary JG, Rajender Reddy K, Wong F, Garcia-Tsao G, Kamath PS, Thacker LR, Bajaj JS. Hepatology. 2018 Nov. PMID: 30199577.
PRO: Patients With Advanced Cirrhosis and Portal Vein Thrombosis Should Receive Anticoagulation.To UK, Garcia-Tsao G. Clin Liver Dis (Hoboken). 2018 Sep; 2018 Oct 2. PMID: 30988915.

Fred Gorelick, MD

2023

Plasma renalase levels are associated with the development of acute pancreatitis.Wang M, Weiss FU, Guo X, Kolodecik T, Bewersdorf JP, Laine L, Lerch MM, Desir G, Gorelick FS. Pancreatology. 2023 Mar; 2023 Jan 3. PMID: 36697349.

2021

Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma.Gao Y, Wang M, Guo X, Hu J, Chen TM, Finn SMB, Lacy J, Kunstman JW, Cha CH, Bellin MD, Robert ME, Desir GV, Gorelick FS. PLoS One. 2021; 2021 Sep 29. PMID: 34587190.
Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease.Pointer TC, Gorelick FS, Desir GV. Cells. 2021 Aug 6; 2021 Aug 6. PMID: 34440775.
Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis.Mareninova OA, Vegh ET, Shalbueva N, Wightman CJ, Dillon DL, Malla S, Xie Y, Takahashi T, Rakonczay Z Jr, French SW, Gaisano HY, Gorelick FS, Pandol SJ, Bensinger SJ, Davidson NO, Dawson DW, Gukovsky I, Gukovskaya AS. J Clin Invest. 2021 Aug 2. PMID: 34128834.
Ketamine and xylazine effects in murine model of acute pancreatitis.Wang M, Gorelick FS. Am J Physiol Gastrointest Liver Physiol. 2021 Jun 1; 2021 Apr 21. PMID: 33881355.
Protein Lysine Acetylation: An Unexpected Mediator in Pancreatitis.Gorelick FS. Cell Mol Gastroenterol Hepatol. 2021; 2020 Dec 3. PMID: 33279460.

2020

American Pancreatic Association Frank Brooks Symposium: Fifty Years of Pancreatic Cell Biology.Williams JA, Groblewski GE, Gorelick FS, Mayerle J, Apte M, Gukovskaya AS. Pancreas. 2020 May/Jun. PMID: 32433396.
Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice.Malla SR, Krueger B, Wartmann T, Sendler M, Mahajan UM, Weiss FU, Thiel FG, De Boni C, Gorelick FS, Halangk W, Aghdassi AA, Reinheckel T, Gukovskaya AS, Lerch MM, Mayerle J. Cell Mol Life Sci. 2020 May; 2019 Jul 30. PMID: 31363815.

2019

Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.Lowe ME, Andersen DK, Caprioli RM, Choudhary J, Cruz-Monserrate Z, Dasyam AK, Forsmark CE, Gorelick FS, Gray JW, Haupt M, Kelly KA, Olive KP, Plevritis SK, Rappaport N, Roth HR, Steen H, Swamidass SJ, Tirkes T, Uc A, Veselkov K, Whitcomb DC, Habtezion A. Pancreas. 2019 Nov/Dec. PMID: 31688587.
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. Nat Genet. 2019 Aug; 2019 Jul 29. PMID: 31358993.

2018

Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice.Alahmari AA, Sreekumar B, Patel V, Ashat M, Alexandre M, Uduman AK, Akinbiyi EO, Ceplenski A, Shugrue CA, Kolodecik TR, Tashkandi N, Messenger SW, Groblewski GE, Gorelick FS, Thrower EC. PLoS One. 2018; 2018 Jun 5. PMID: 29870540.
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models.Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z Jr, Gukovsky I, Gukovskaya AS. Gastroenterology. 2018 Feb; 2017 Oct 23. PMID: 29074451.

2017

The serum protein renalase reduces injury in experimental pancreatitis.Kolodecik TR, Reed AM, Date K, Shugrue CA, Patel V, Chung SL, Desir GV, Gorelick FS. J Biol Chem. 2017 Dec 22; 2017 Oct 17. PMID: 29042438.
Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis.Lugea A, Waldron RT, Mareninova OA, Shalbueva N, Deng N, Su HY, Thomas DD, Jones EK, Messenger SW, Yang J, Hu C, Gukovsky I, Liu Z, Groblewski GE, Gukovskaya AS, Gorelick FS, Pandol SJ. Am J Pathol. 2017 Dec; 2017 Sep 19. PMID: 28935577.
Do Animal Models of Acute Pancreatitis Reproduce Human Disease?Gorelick FS, Lerch MM. Cell Mol Gastroenterol Hepatol. 2017 Sep; 2017 Jun 10. PMID: 28752114.
Bidirectional regulation of Aβ levels by Presenilin 1.Bustos V, Pulina MV, Kelahmetoglu Y, Sinha SC, Gorelick FS, Flajolet M, Greengard P. Proc Natl Acad Sci U S A. 2017 Jul 3; 2017 May 22. PMID: 28533411.
Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion.Bustos V, Pulina MV, Bispo A, Lam A, Flajolet M, Gorelick FS, Greengard P. Proc Natl Acad Sci U S A. 2017 Jul 3; 2017 May 22. PMID: 28533369.

2016

Advances in pancreatology: 2016.Gorelick FS. Curr Opin Gastroenterol. 2016 Sep. PMID: 27454030.
Targeting αv Integrins in Pancreatic Fibrosis: Progress in Resolving the Scar.Chung C, Gorelick FS. Cell Mol Gastroenterol Hepatol. 2016 Jul; 2016 May 24. PMID: 28090563.
Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.Srinivasan P, Thrower EC, Gorelick FS, Said HM. Am J Physiol Gastrointest Liver Physiol. 2016 May 15; 2016 Mar 17. PMID: 26999808.

2015

Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells.Srinivasan P, Thrower EC, Loganathan G, Balamurugan AN, Subramanian VS, Gorelick FS, Said HM. PLoS One. 2015; 2015 Dec 3. PMID: 26633299.
Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells.Messenger SW, Thomas DD, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS, Groblewski GE. Cell Mol Gastroenterol Hepatol. 2015 Nov 1. PMID: 26618189.

2014

Low pH enhances connexin32 degradation in the pancreatic acinar cell.Reed AM, Kolodecik T, Husain SZ, Gorelick FS. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1; 2014 May 8. PMID: 24812055.

2012

Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses.Alexandre M, Uduman AK, Minervini S, Raoof A, Shugrue CA, Akinbiyi EO, Patel V, Shitia M, Kolodecik TR, Patton R, Gorelick FS, Thrower EC. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 2012 Jul 26. PMID: 22837343.
Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.Shugrue CA, Alexandre M, Diaz de Villalvilla A, Kolodecik TR, Young LH, Gorelick FS, Thrower EC. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 2012 Jul 19. PMID: 22821946.
Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells.Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS. PLoS One. 2012; 2012 Jul 23. PMID: 22844459.

2011

Low extracellular pH induces damage in the pancreatic acinar cell by enhancing calcium signaling.Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH. J Biol Chem. 2011 Jan 21; 2010 Nov 17. PMID: 21084290.
The emerging role of smoking in the development of pancreatitis.Alexandre M, Pandol SJ, Gorelick FS, Thrower EC. Pancreatology. 2011; 2011 Oct 5. PMID: 21986098.

2010

Molecular and cellular mechanisms of pancreatic injury.Thrower EC, Gorelick FS, Husain SZ. Curr Opin Gastroenterol. 2010 Sep. PMID: 20651589.

2009

The acinar cell and early pancreatitis responses.Gorelick FS, Thrower E. Clin Gastroenterol Hepatol. 2009 Nov. PMID: 19896090.
Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini.Thrower EC, Wang J, Cheriyan S, Lugea A, Kolodecik TR, Yuan J, Reeve JR Jr, Gorelick FS, Pandol SJ. Pancreas. 2009 Nov. PMID: 19752773.
Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats.Bhoomagoud M, Jung T, Atladottir J, Kolodecik TR, Shugrue C, Chaudhuri A, Thrower EC, Gorelick FS. Gastroenterology. 2009 Sep; 2009 May 18. PMID: 19454288.

2008

The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells.Thrower EC, Osgood S, Shugrue CA, Kolodecik TR, Chaudhuri AM, Reeve JR Jr, Pandol SJ, Gorelick FS. Am J Physiol Gastrointest Liver Physiol. 2008 Jun; 2008 Apr 3. PMID: 18388183.

2007

Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin.Husain SZ, Grant WM, Gorelick FS, Nathanson MH, Shah AU. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 2007 Mar 1. PMID: 17332472.
Cyclic AMP-dependent protein kinase and Epac mediate cyclic AMP responses in pancreatic acini.Chaudhuri A, Husain SZ, Kolodecik TR, Grant WM, Gorelick FS. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Jan 18. PMID: 17234888.

2006

Vacuolar adenosine triphosphatase and pancreatic acinar cell function.Gorelick FS, Shugrue CA, Kolodecik TR, Thrower EC. J Gastroenterol Hepatol. 2006 Oct. PMID: 16958663.
The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle.Siddiqi SA, Siddiqi S, Mahan J, Peggs K, Gorelick FS, Mansbach CM 2nd. J Biol Chem. 2006 Jul 28; 2006 May 30. PMID: 16735505.
Zymogen activation in a reconstituted pancreatic acinar cell system.Thrower EC, Diaz de Villalvilla AP, Kolodecik TR, Gorelick FS. Am J Physiol Gastrointest Liver Physiol. 2006 May; 2005 Dec 8. PMID: 16339296.

2005

The ryanodine receptor mediates early zymogen activation in pancreatitis.Husain SZ, Prasad P, Grant WM, Kolodecik TR, Nathanson MH, Gorelick FS. Proc Natl Acad Sci U S A. 2005 Oct 4; 2005 Sep 26. PMID: 16186498.

2004

Acute pancreatitis.Nagar AB, Gorelick FS. Curr Opin Gastroenterol. 2004 Sep. PMID: 15689676.

2003

Alcohol and zymogen activation in the pancreatic acinar cell.Gorelick FS. Pancreas. 2003 Nov. PMID: 14576492.
Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice.Chakrabarti S, Kobayashi KS, Flavell RA, Marks CB, Miyake K, Liston DR, Fowler KT, Gorelick FS, Andrews NW. J Cell Biol. 2003 Aug 18. PMID: 12925704.
Pancreas cell physiology and pancreatitis cell biology. Summary of a symposium held at the joint meeting of the EPC and the IAP, Heidelberg 2002.Gorelick FS. Pancreatology. 2003. PMID: 12771516.

2002

Acute pancreatitis.Nagar AB, Gorelick FS. Curr Opin Gastroenterol. 2002 Sep. PMID: 17033332.

2001

Exiting the endoplasmic reticulum.Gorelick FS, Shugrue C. Mol Cell Endocrinol. 2001 May 25. PMID: 11377815.

1999

Etiopathogenesis of acute pancreatitis.Karne S, Gorelick FS. Surg Clin North Am. 1999 Aug. PMID: 10470320.
Mechanisms of intracellular zymogen activation.Gorelick FS, Otani T. Baillieres Best Pract Res Clin Gastroenterol. 1999 Jul. PMID: 11030603.

1996

Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells.Matovcik LM, Maranto AR, Soroka CJ, Gorelick FS, Smith J, Goldenring JR. J Histochem Cytochem. 1996 Nov. PMID: 8918899.

1995

Effect of cerulein hyperstimulation on the paracellular barrier of rat exocrine pancreas.Fallon MB, Gorelick FS, Anderson JM, Mennone A, Saluja A, Steer ML. Gastroenterology. 1995 Jun. PMID: 7539388.

1994

Antibodies to an epitope on synapsin I detect a protein associated with the endocytic compartment in non-neuronal cells.Matovcik LM, Karapetian O, Czernik AJ, Marino CR, Kinder BK, Gorelick FS. Eur J Cell Biol. 1994 Dec. PMID: 7536673.
Calcium/calmodulin-dependent protein kinase-II activation in rat pituitary cells in the presence of thyrotropin-releasing hormone and dopamine.Cui ZJ, Gorelick FS, Dannies PS. Endocrinology. 1994 May. PMID: 8156928.
Cell cycle-dependent and kinase-specific regulation of the apical Na/H exchanger and the Na,K-ATPase in the kidney cell line LLC-PK1 by calcitonin.Chakraborty M, Chatterjee D, Gorelick FS, Baron R. Proc Natl Acad Sci U S A. 1994 Mar 15. PMID: 8134357.

1993

Characterization of cAMP-dependent protein kinase activation by CCK in rat pancreas.Marino CR, Leach SD, Schaefer JF, Miller LJ, Gorelick FS. FEBS Lett. 1993 Jan 18. PMID: 7678554.

1992

Scientific advances in cystic fibrosis.Marino CR, Gorelick FS. Gastroenterology. 1992 Aug. PMID: 1378805.
New perspectives on acute pancreatitis.Leach SD, Gorelick FS, Modlin IM. Scand J Gastroenterol Suppl. 1992. PMID: 1439566.

1990

Acute pancreatitis at its centenary. The contribution of Reginald Fitz.Leach SD, Gorelick FS, Modlin IM. Ann Surg. 1990 Jul. PMID: 2194439.
Regulated phosphorylation of secretory granule membrane proteins of the rat parotid gland.Marino CR, Castle JD, Gorelick FS. Am J Physiol. 1990 Jul. PMID: 1695488.

1988

Development of secretagogue responsiveness in the pancreas.Jamieson JD, Gorelick FS, Chang A. Scand J Gastroenterol Suppl. 1988. PMID: 2852401.

1987

Calcium-calmodulin-stimulated protein kinase in developing pancreas.Gorelick FS, Chang A, Jamieson JD. Am J Physiol. 1987 Oct. PMID: 3116856.
Second messenger systems and adaptation.Gorelick FS. Gut. 1987. PMID: 2826313.

Mateus Tavares Guerra, PhD

2023

Above the legal limit: Alcohol brings ER and mitochondria too close together.Guerra MT, Nathanson MH. Cell Calcium. 2023 May 22; 2023 May 22. PMID: 37235972.

2022

Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes.Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.
Correlation Between Clinical and Pathological Findings of Liver Injury in 27 Patients With Lethal COVID-19 Infections in Brazil.Santana MF, Guerra MT, Hundt MA, Ciarleglio MM, Pinto RAA, Dutra BG, Xavier MS, Lacerda MVG, Ferreira AJ, Wanderley DC, Borges do Nascimento IJ, Araújo RFA, Pinheiro SVB, Araújo SA, Leite MF, Ferreira LCL, Nathanson MH, Vieira Teixeira Vidigal P. Hepatol Commun. 2022 Feb; 2021 Sep 14. PMID: 34520633.

2021

Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis.Takeuchi M, Vidigal PT, Guerra MT, Hundt MA, Robert ME, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, de la Rosa Rodriguez R, Banales JM, Nathanson MH, Weerachayaphorn J. Gut. 2021 Feb; 2020 Nov 19. PMID: 33214166.

2020

Inositol 1,4,5-trisphosphate receptor type 3 plays a protective role in hepatocytes during hepatic ischemia-reperfusion injury.Lima Filho ACM, França A, Florentino RM, Dos Santos ML, de Oliveira Lemos F, Missiaggia DG, Fonseca RC, Gustavo Oliveira A, Ananthanarayanan M, Guerra MT, de Castro Fonseca M, Vidigal PVT, Lima CX, Nathanson MH, Fatima Leite M. Cell Calcium. 2020 Nov; 2020 Aug 11. PMID: 32957029.
Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis.Perry RJ, Zhang D, Guerra MT, Brill AL, Goedeke L, Nasiri AR, Rabin-Court A, Wang Y, Peng L, Dufour S, Zhang Y, Zhang XM, Butrico GM, Toussaint K, Nozaki Y, Cline GW, Petersen KF, Nathanson MH, Ehrlich BE, Shulman GI. Nature. 2020 Mar; 2020 Mar 4. PMID: 32132708.
Type 3 Inositol 1,4,5-Trisphosphate Receptor Is Increased and Enhances Malignant Properties in Cholangiocarcinoma.Ueasilamongkol P, Khamphaya T, Guerra MT, Rodrigues MA, Gomes DA, Kong Y, Wei W, Jain D, Trampert DC, Ananthanarayanan M, Banales JM, Roberts LR, Farshidfar F, Nathanson MH, Weerachayaphorn J. Hepatology. 2020 Feb; 2019 Aug 19. PMID: 31251815.
Type 3 inositol 1,4,5-trisphosphate receptor: A calcium channel for all seasons.Mangla A, Guerra MT, Nathanson MH. Cell Calcium. 2020 Jan; 2019 Nov 25. PMID: 31790953.

2019

Expression of the type 3 InsP(3) receptor is a final common event in the development of hepatocellular carcinoma.Guerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF. Gut. 2019 Sep; 2019 Jul 17. PMID: 31315892.
Effects of Endotoxin on Type 3 Inositol 1,4,5-Trisphosphate Receptor in Human Cholangiocytes.Franca A, Carlos Melo Lima Filho A, Guerra MT, Weerachayaphorn J, Loiola Dos Santos M, Njei B, Robert M, Xavier Lima C, Vieira Teixeira Vidigal P, Banales JM, Ananthanarayanam M, Leite MF, Nathanson MH. Hepatology. 2019 Feb; 2018 Dec 31. PMID: 30141207.

2017

Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP.Kruglov E, Ananthanarayanan M, Sousa P, Weerachayaphorn J, Guerra MT, Nathanson MH. Biochem Biophys Res Commun. 2017 May 6; 2017 Mar 19. PMID: 28327356.
Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver.Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE. Hepatol Commun. 2017 Feb; 2016 Nov 11. PMID: 28966992.

2016

Mitochondrial MIsCUes in liver regeneration.Guerra MT. Hepatology. 2016 Nov; 2016 Sep 30. PMID: 27629287.

2015

Calcium signaling and secretion in cholangiocytes.Guerra MT, Nathanson MH. Pancreatology. 2015 Jul; 2015 Jun 12. PMID: 26100660.
Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506.Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH. J Biol Chem. 2015 Jan 2; 2014 Nov 5. PMID: 25378392.

2011

Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes.Kruglov EA, Gautam S, Guerra MT, Nathanson MH. Hepatology. 2011 Nov; 2011 Aug 30. PMID: 21748767.

2010

Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver.Cruz LN, Guerra MT, Kruglov E, Mennone A, Garcia CR, Chen J, Nathanson MH. Hepatology. 2010 Jul. PMID: 20578149.

2007

Lipid rafts establish calcium waves in hepatocytes.Nagata J, Guerra MT, Shugrue CA, Gomes DA, Nagata N, Nathanson MH. Gastroenterology. 2007 Jul; 2007 Apr 11. PMID: 17631147.
The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves.Hernandez E, Leite MF, Guerra MT, Kruglov EA, Bruna-Romero O, Rodrigues MA, Gomes DA, Giordano FJ, Dranoff JA, Nathanson MH. J Biol Chem. 2007 Mar 30; 2007 Feb 6. PMID: 17284437.

2006

Calcium release from ryanodine receptors in the nucleoplasmic reticulum.Marius P, Guerra MT, Nathanson MH, Ehrlich BE, Leite MF. Cell Calcium. 2006 Jan; 2005 Nov 9. PMID: 16289270.

2005

Protein 4.1N does not interact with the inositol 1,4,5-trisphosphate receptor in an epithelial cell line.Sehgal S, Guerra MT, Kruglov EA, Wang J, Nathanson MH. Cell Calcium. 2005 Nov. PMID: 16122796.

2004

Endotoxin unmasks the role of gap junctions in the liver.Correa PR, Guerra MT, Leite MF, Spray DC, Nathanson MH. Biochem Biophys Res Commun. 2004 Sep 24. PMID: 15336523.

2003

Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum.Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. Nat Cell Biol. 2003 May. PMID: 12717445.

Matija Hedl, PhD

2021

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.Ranjan K, Hedl M, Sinha S, Zhang X, Abraham C. J Clin Invest. 2021 Sep 1. PMID: 34623328.
The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate innate receptor-induced outcomes.Ranjan K, Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2021 Aug 10. PMID: 34353900.
TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants.Sun R, Hedl M, Abraham C. Cell Mol Gastroenterol Hepatol. 2021; 2020 Aug 19. PMID: 32827707.

2020

Disease Risk-Associated Genetic Variants in STAT1 and STAT4 Function in a Complementary Manner to Increase Pattern-Recognition Receptor-Induced Outcomes in Human Macrophages.Hedl M, Sun R, Abraham C. J Immunol. 2020 Sep 1; 2020 Jul 13. PMID: 32661180.
Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions.Yan J, Hedl M, Abraham C. J Immunol. 2020 Aug 15; 2020 Jul 20. PMID: 32690658.
IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes.Sun R, Hedl M, Abraham C. Gut. 2020 Feb; 2019 May 16. PMID: 31097538.

2019

LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.Huang C, Hedl M, Ranjan K, Abraham C. Cell Rep. 2019 Dec 24. PMID: 31875558.
STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes.Hedl M, Sun R, Huang C, Abraham C. J Immunol. 2019 Dec 15; 2019 Nov 15. PMID: 31732533.
Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters.Sun R, Hedl M, Abraham C. J Immunol. 2019 Jun 1; 2019 Apr 26. PMID: 31028123.
IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome.Hedl M, Yan J, Witt H, Abraham C. J Immunol. 2019 Feb 1; 2018 Dec 28. PMID: 30593537.

2018

INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. Elife. 2018 Oct 25; 2018 Oct 25. PMID: 30355448.

2017

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B. Nat Commun. 2017 Jun 28; 2017 Jun 28. PMID: 28656966.
Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes.Lahiri A, Hedl M, Yan J, Abraham C. Nat Commun. 2017 Jun 8; 2017 Jun 8. PMID: 28593945.
ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. Cell Death Dis. 2017 Feb 23; 2017 Feb 23. PMID: 28230865.

2016

JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages.Hedl M, Proctor DD, Abraham C. J Immunol. 2016 Nov 1; 2016 Sep 23. PMID: 27664279.
A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion.Hedl M, Abraham C. Gut. 2016 Nov; 2015 Jul 27. PMID: 26215868.
IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation.Hedl M, Yan J, Abraham C. Cell Rep. 2016 Aug 30; 2016 Aug 18. PMID: 27545875.

2015

MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.Lahiri A, Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2015 Aug 18; 2015 Aug 3. PMID: 26240347.
Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators.Zheng S, Hedl M, Abraham C. J Immunol. 2015 Jul 1; 2015 May 27. PMID: 26019273.
TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages.Zheng S, Hedl M, Abraham C. J Immunol. 2015 Feb 15; 2015 Jan 7. PMID: 25567680.

2014

A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2014 Sep 16; 2014 Sep 2. PMID: 25197060.
The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.Hedl M, Zheng S, Abraham C. J Immunol. 2014 Jun 15; 2014 May 19. PMID: 24842757.
Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.Hedl M, Lahiri A, Ning K, Cho JH, Abraham C. Immunity. 2014 May 15. PMID: 24837102.

2013

NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation.Hedl M, Abraham C. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15; 2013 Jan 3. PMID: 23287275.
Negative regulation of human mononuclear phagocyte function.Hedl M, Abraham C. Mucosal Immunol. 2013 Mar; 2013 Jan 23. PMID: 23340822.

2012

Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines.Hedl M, Abraham C. Gastroenterology. 2012 Dec; 2012 Sep 8. PMID: 22967725.
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA. Nature. 2012 Nov 8; 2012 Oct 17. PMID: 23075849.
IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells.Hedl M, Abraham C. J Immunol. 2012 Jun 1; 2012 Apr 27. PMID: 22544929.

2011

Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages.Hedl M, Abraham C. J Biol Chem. 2011 Jul 29; 2011 Jun 9. PMID: 21659536.
Secretory mediators regulate Nod2-induced tolerance in human macrophages.Hedl M, Abraham C. Gastroenterology. 2011 Jan; 2010 Sep 18. PMID: 20854823.

Avlin Barlow Imaeda, MD, PhD

2017

Preclinical endoscopic training using a part-task simulator: learning curve assessment and determination of threshold score for advancement to clinical endoscopy.Jirapinyo P, Abidi WM, Aihara H, Zaki T, Tsay C, Imaeda AB, Thompson CC. Surg Endosc. 2017 Oct; 2017 Feb 22. PMID: 28229238.
Unsuspected Colonic Hemorrhage Found on Screening Colonoscopy.Jangouk P, Chang JJ, Imaeda AB. Gastroenterology. 2017 May; 2017 Apr 4. PMID: 28384453.

2016

Small Intestinal Angioectasias Are Not Randomly Distributed in the Small Bowel and Most May Be Reached by Push Enteroscopy.Plotkin E, Imaeda A. J Clin Gastroenterol. 2016 Aug. PMID: 26485105.
Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men.Clark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L. Gastroenterology. 2016 Feb; 2015 Oct 9. PMID: 26439436.

2015

Endoscopic training in gastroenterology fellowship: adherence to core curriculum guidelines.Jirapinyo P, Imaeda AB, Thompson CC. Surg Endosc. 2015 Dec; 2015 Mar 24. PMID: 25801105.
Confocal laser endomicroscopy for the detection of atrophic gastritis: a new application for confocal endomicroscopy?Imaeda A. J Clin Gastroenterol. 2015 May-Jun. PMID: 25811115.

2010

Cell death and fibrogenesis.Mehal W, Imaeda A. Semin Liver Dis. 2010 Aug; 2010 Jul 21. PMID: 20665375.
What is most important to patients when deciding about colorectal screening?Imaeda A, Bender D, Fraenkel L. J Gen Intern Med. 2010 Jul; 2010 Mar 23. PMID: 20309740.

2009

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ. J Clin Invest. 2009 Feb; 2009 Jan 26. PMID: 19164858.

2008

A pilot project examining the predicted preferences of patients and physicians in the primary prophylaxis of variceal hemorrhage.Longacre AV, Imaeda A, Garcia-Tsao G, Fraenkel L. Hepatology. 2008 Jan. PMID: 17935182.

Yasuko Iwakiri, PhD

2023

What is in a name? toward culturally sensitive nomenclature for liver disease in the east and west.Kim WR, Iwakiri Y, Lok AS. Hepatology. 2023 Apr 19; 2023 Apr 19. PMID: 37070237.
Overexpression of NgBR inhibits high-fat diet-induced atherosclerosis in ApoE-deficiency mice.Gong K, Wang M, Wang D, Gao Y, Ma L, Yang X, Zhu X, Chen S, Zhang M, Li H, Chen Y, Hu W, Miao QR, Iwakiri Y, Liao C, Duan Y, Han J. Hepatol Commun. 2023 Apr 1; 2023 Mar 30. PMID: 36996002.
The evolving role of liver sinusoidal endothelial cells in liver health and disease.McConnell MJ, Kostallari E, Ibrahim SH, Iwakiri Y. Hepatology. 2023 Jan 3; 2023 Jan 3. PMID: 36626620.
Portal Hypertension in Alcohol-Associated Hepatitis.McConnell MJ, Iwakiri Y. Curr Hepatol Rep. 2023; 2023 Apr 5. PMID: 37214274.

2022

Hepatic lymphatic vascular system in health and disease.Jeong J, Tanaka M, Iwakiri Y. J Hepatol. 2022 Jul; 2022 Feb 11. PMID: 35157960.
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X. J Biol Chem. 2022 Feb; 2022 Jan 5. PMID: 34998825.
Covid-19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis.McConnell MJ, Kondo R, Kawaguchi N, Iwakiri Y. Hepatol Commun. 2022 Feb; 2021 Nov 10. PMID: 34658172.
Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH.Maeda H, Ishima Y, Saruwatari J, Mizuta Y, Minayoshi Y, Ichimizu S, Yanagisawa H, Nagasaki T, Yasuda K, Oshiro S, Taura M, McConnell MJ, Oniki K, Sonoda K, Wakayama T, Kinoshita M, Shuto T, Kai H, Tanaka M, Sasaki Y, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T. J Control Release. 2022 Jan; 2021 Nov 29. PMID: 34856227.

2021

Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: A series of 43 cases.Kondo R, Kawaguchi N, McConnell MJ, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Sun Z, Utsumi T, Strazzabosco M, Iwakiri Y. Hepatol Res. 2021 Sep; 2021 Aug 2. PMID: 34260803.
Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy.McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee AI, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. J Hepatol. 2021 Sep; 2021 May 13. PMID: 33991637.
Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy.Iwakiri Y, Trebicka J. JHEP Rep. 2021 Aug; 2021 Jun 4. PMID: 34337369.
Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease.Yang Y, Sangwung P, Kondo R, Jung Y, McConnell MJ, Jeong J, Utsumi T, Sessa WC, Iwakiri Y. J Hepatol. 2021 Aug; 2021 Mar 3. PMID: 33675874.
Enhanced Meningeal Lymphatic Drainage Ameliorates Neuroinflammation and Hepatic Encephalopathy in Cirrhotic Rats.Hsu SJ, Zhang C, Jeong J, Lee SI, McConnell M, Utsumi T, Iwakiri Y. Gastroenterology. 2021 Mar; 2020 Nov 20. PMID: 33227282.
Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis.Su T, Yang Y, Lai S, Jeong J, Jung Y, McConnell M, Utsumi T, Iwakiri Y. Cell Mol Gastroenterol Hepatol. 2021; 2020 Dec 16. PMID: 33340713.
Lymphatic Dysfunction as a Novel Therapeutic Target in Nonalcoholic Steatohepatitis.Jeong J, Iwakiri Y. Cell Mol Gastroenterol Hepatol. 2021; 2020 Nov 18. PMID: 33220266.

2020

Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity.Zhang S, Guo F, Yu M, Yang X, Yao Z, Li Q, Wei Z, Feng K, Zeng P, Zhao D, Li X, Zhu Y, Miao QR, Iwakiri Y, Chen Y, Han J, Duan Y. J Hepatol. 2020 Dec; 2020 Jul 29. PMID: 32738448.
The lymphatic system in alcohol-associated liver disease.Kondo R, Iwakiri Y. Clin Mol Hepatol. 2020 Oct; 2020 Sep 21. PMID: 32951411.
Endothelial Leukocyte Cell-Derived Chemotaxin 2/Tyrosine Kinase With Immunoglobulin-Like and Epidermal Growth Factor-Like Domains 1 Signaling in Liver Fibrosis.Su T, Iwakiri Y. Hepatology. 2020 Jul. PMID: 32060947.

2019

O-GlcNAc transferase suppresses necroptosis and liver fibrosis.Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Iwakiri Y, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. JCI Insight. 2019 Nov 1; 2019 Nov 1. PMID: 31672932.
Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation.Zhao P, Han SN, Arumugam S, Yousaf MN, Qin Y, Jiang JX, Torok NJ, Chen Y, Mankash MS, Liu J, Li J, Iwakiri Y, Ouyang X. Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1; 2019 Aug 14. PMID: 31411894.
Poly(amine-co-ester) nanoparticles for effective Nogo-B knockdown in the liver.Cui J, Piotrowski-Daspit AS, Zhang J, Shao M, Bracaglia LG, Utsumi T, Seo YE, DiRito J, Song E, Wu C, Inada A, Tietjen GT, Pober JS, Iwakiri Y, Saltzman WM. J Control Release. 2019 Jun 28; 2019 May 1. PMID: 31054286.

2018

Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats.Saruwatari J, Dong C, Utsumi T, Tanaka M, McConnell M, Iwakiri Y. Sci Rep. 2018 Dec 20; 2018 Dec 20. PMID: 30573742.
Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions.Minayoshi Y, Maeda H, Yanagisawa H, Hamasaki K, Mizuta Y, Nishida K, Kinoshita R, Enoki Y, Imafuku T, Chuang VTG, Koga T, Fujiwara Y, Takeya M, Sonoda K, Wakayama T, Taguchi K, Ishima Y, Ishida T, Iwakiri Y, Tanaka M, Sasaki Y, Watanabe H, Otagiri M, Maruyama T. Drug Deliv. 2018 Nov. PMID: 29688069.
Lymphatics in the liver.Tanaka M, Iwakiri Y. Curr Opin Immunol. 2018 Aug; 2018 May 14. PMID: 29772409.
Is miR-21 a potent target for liver fibrosis?Lai S, Iwakiri Y. Hepatology. 2018 Jun; 2018 Apr 19. PMID: 29315674.
Biology of portal hypertension.McConnell M, Iwakiri Y. Hepatol Int. 2018 Feb; 2017 Oct 26. PMID: 29075990.
The portal hypertension syndrome: etiology, classification, relevance, and animal models.Bosch J, Iwakiri Y. Hepatol Int. 2018 Feb; 2017 Oct 24. PMID: 29064029.

2017

Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model.Maxfield MW, Stacy MR, Kurobe H, Tara S, Yi T, Cleary MA, Zhuang ZW, Rodriguez-Davalos MI, Emre SH, Iwakiri Y, Shinoka T, Breuer CK. Regen Med. 2017 Dec; 2017 Dec 7. PMID: 29215317.
Corrigendum to "Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension" [J Hepatol 62 (2015) 325-331].Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed FEZ, Davies N, Sharma V, Iwakiri Y, Jalan R. J Hepatol. 2017 Nov. PMID: 28893453.
Reply.Park JK, Iwakiri Y. Hepatology. 2017 Nov; 2017 Sep 29. PMID: 28745830.
Comparative efficacy and safety of antibody induction therapy for the treatment of kidney: a network meta-analysis.Shao M, Tian T, Zhu X, Ming Y, Iwakiri Y, Ye S, Ye Q. Oncotarget. 2017 Sep 12; 2017 Aug 2. PMID: 29029524.
Reply.Iwakiri Y. Hepatology. 2017 Jun; 2017 Apr 28. PMID: 28195342.
Alcohol and calcium make a potent cocktail.Iwakiri Y, Nathanson MH. J Physiol. 2017 May 15; 2017 Apr 18. PMID: 28295353.
An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization.Park JK, Shao M, Kim MY, Baik SK, Cho MY, Utsumi T, Satoh A, Ouyang X, Chung C, Iwakiri Y. Hepatology. 2017 May; 2017 Mar 22. PMID: 28090670.

2016

The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis.Tanaka M, Iwakiri Y. Cell Mol Gastroenterol Hepatol. 2016 Nov; 2016 Sep 14. PMID: 28105461.
The lymphatic system: A new frontier in hepatology.Iwakiri Y. Hepatology. 2016 Sep; 2016 Jun 23. PMID: 27228259.
Cellular distribution of injected PLGA-nanoparticles in the liver.Park JK, Utsumi T, Seo YE, Deng Y, Satoh A, Saltzman WM, Iwakiri Y. Nanomedicine. 2016 Jul; 2016 Mar 4. PMID: 26961463.

2015

Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase.Iwakiri Y. Clin Mol Hepatol. 2015 Dec; 2015 Dec 24. PMID: 26770919.
Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver.Protiva P, Gong J, Sreekumar B, Torres R, Zhang X, Belinsky GS, Cornwell M, Crawford SE, Iwakiri Y, Chung C. Cell Mol Gastroenterol Hepatol. 2015 Sep 1; 2015 Jul 4. PMID: 26473164.
Nitric oxide in liver diseases.Iwakiri Y, Kim MY. Trends Pharmacol Sci. 2015 Aug; 2015 May 28. PMID: 26027855.
Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a.Wang S, Song K, Srivastava R, Dong C, Go GW, Li N, Iwakiri Y, Mani A. FASEB J. 2015 Aug; 2015 Apr 27. PMID: 25917329.
Can hypersplenism secondary to portal hypertension be treated by non-selective beta blockers?Kim MY, Iwakiri Y. Hepatol Int. 2015 Jul; 2015 Jan 25. PMID: 25788189.
Development of small diameter nanofiber tissue engineered arterial grafts.Kurobe H, Maxfield MW, Tara S, Rocco KA, Bagi PS, Yi T, Udelsman B, Zhuang ZW, Cleary M, Iwakiri Y, Breuer CK, Shinoka T. PLoS One. 2015; 2015 Apr 1. PMID: 25830942.
Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension.Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed Fel Z, Davies N, Sharma V, Iwakiri Y, Jalan R. J Hepatol. 2015 Feb; 2014 Aug 23. PMID: 25152204.

2014

Vascular pathobiology in chronic liver disease and cirrhosis - current status and future directions.Iwakiri Y, Shah V, Rockey DC. J Hepatol. 2014 Oct; 2014 Jun 6. PMID: 24911462.
Pathophysiology of portal hypertension.Iwakiri Y. Clin Liver Dis. 2014 May; 2014 Feb 25. PMID: 24679494.
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.Gattu AK, Birkenfeld AL, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel VT, Crawford SE, Chung C. Endocrinology. 2014 Apr; 2014 Jan 23. PMID: 24456163.

2013

eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases.Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC. J Cell Sci. 2013 Dec 15; 2013 Sep 17. PMID: 24046447.
Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content.Gattu AK, Swenson ES, Iwakiri Y, Samuel VT, Troiano N, Berry R, Church CD, Rodeheffer MS, Carpenter TO, Chung C. FASEB J. 2013 Nov; 2013 Jul 25. PMID: 23887690.
The lymphatic vascular system in liver diseases: its role in ascites formation.Chung C, Iwakiri Y. Clin Mol Hepatol. 2013 Jun; 2013 Jun 27. PMID: 23837133.
Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice.Gao L, Utsumi T, Tashiro K, Liu B, Zhang D, Swenson ES, Iwakiri Y. Hepatology. 2013 May; 2013 Mar 19. PMID: 23299899.
Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice.Tashiro K, Satoh A, Utsumi T, Chung C, Iwakiri Y. Am J Pathol. 2013 Mar; 2013 Jan 9. PMID: 23313137.

2012

Activated hepatic stellate cells: negative regulators of hepatocyte proliferation in liver diseases.Chung C, Iwakiri Y. Hepatology. 2012 Jul. PMID: 22876366.
Intestinal and plasma VEGF levels in cirrhosis: the role of portal pressure.Huang HC, Haq O, Utsumi T, Sethasine S, Abraldes JG, Groszmann RJ, Iwakiri Y. J Cell Mol Med. 2012 May. PMID: 21801303.
A role of miR-33 for cell cycle progression and cell proliferation.Iwakiri Y. Cell Cycle. 2012 Mar 15; 2012 Mar 15. PMID: 22395363.
Endothelial dysfunction in the regulation of cirrhosis and portal hypertension.Iwakiri Y. Liver Int. 2012 Feb; 2011 Jul 5. PMID: 21745318.
Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO.Sangwung P, Greco TM, Wang Y, Ischiropoulos H, Sessa WC, Iwakiri Y. PLoS One. 2012; 2012 Feb 21. PMID: 22363674.

2011

S-nitrosylation of proteins: a new insight into endothelial cell function regulated by eNOS-derived NO.Iwakiri Y. Nitric Oxide. 2011 Aug 1; 2011 Apr 30. PMID: 21554971.
Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis.Zhang D, Utsumi T, Huang HC, Gao L, Sangwung P, Chung C, Shibao K, Okamoto K, Yamaguchi K, Groszmann RJ, Jozsef L, Hao Z, Sessa WC, Iwakiri Y. Hepatology. 2011 Apr. PMID: 21480333.

2008

Vascular biology and pathobiology of the liver: Report of a single-topic symposium.Iwakiri Y, Grisham M, Shah V. Hepatology. 2008 May. PMID: 18393322.

2007

Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease.Fernández-Hernando C, Ackah E, Yu J, Suárez Y, Murata T, Iwakiri Y, Prendergast J, Miao RQ, Birnbaum MJ, Sessa WC. Cell Metab. 2007 Dec. PMID: 18054314.
The molecules: mechanisms of arterial vasodilatation observed in the splanchnic and systemic circulation in portal hypertension.Iwakiri Y. J Clin Gastroenterol. 2007 Nov-Dec. PMID: 17975478.

2006

Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking.Iwakiri Y, Satoh A, Chatterjee S, Toomre DK, Chalouni CM, Fulton D, Groszmann RJ, Shah VH, Sessa WC. Proc Natl Acad Sci U S A. 2006 Dec 26; 2006 Dec 14. PMID: 17170139.

2005

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis.Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC. J Clin Invest. 2005 Aug. PMID: 16075056.

2004

Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release.Fulton D, Babbitt R, Zoellner S, Fontana J, Acevedo L, McCabe TJ, Iwakiri Y, Sessa WC. J Biol Chem. 2004 Jul 16; 2004 May 10. PMID: 15136572.

2003

Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice.Gratton JP, Lin MI, Yu J, Weiss ED, Jiang ZL, Fairchild TA, Iwakiri Y, Groszmann R, Claffey KP, Cheng YC, Sessa WC. Cancer Cell. 2003 Jul. PMID: 12892711.

2002

Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension.Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Am J Physiol Gastrointest Liver Physiol. 2002 Nov. PMID: 12381520.
Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension.Iwakiri Y, Tsai MH, McCabe TJ, Gratton JP, Fulton D, Groszmann RJ, Sessa WC. Am J Physiol Heart Circ Physiol. 2002 Jun. PMID: 12003815.

Priya Arvind Jamidar, FACG, FASGE, MBChB

2022

GIE Editorial Board Top 10: advances in GI endoscopy in 2021.Qayed E, Chua TY, Mulki R, Yang D, Jamidar PA, Singh A, Leung FW, Yu JX, Lightdale JR. Gastrointest Endosc. 2022 Dec; 2022 Aug 7. PMID: 35948180.
Comorbidities Drive the Majority of Overall Mortality in Low-Risk Mucinous Pancreatic Cysts Under Surveillance.Chhoda A, Yousaf MN, Madhani K, Aslanian H, Jamidar PA, Suarez AL, Salem RR, Muniraj T, Kunstman JW, Farrell JJ. Clin Gastroenterol Hepatol. 2022 Mar; 2020 Dec 10. PMID: 33309984.
Juxta-papillary duodenal diverticula are associated with pyogenic liver abscesses: a case control study.Shankar U, Bhandari P, Panchal A, Weeks D, Wu H, Chen F, Maheshwari N, Bansal R, Walfish A, Baum J, Jamidar PA, Aron J. BMC Gastroenterol. 2022 Feb 7; 2022 Feb 7. PMID: 35130860.
Digital single-operator cholangioscopy interobserver study using a new classification: the Mendoza Classification (with video).Kahaleh M, Gaidhane M, Shahid HM, Tyberg A, Sarkar A, Ardengh JC, Kedia P, Andalib I, Gress F, Sethi A, Gan SI, Suresh S, Makar M, Bareket R, Slivka A, Widmer JL, Jamidar PA, Alkhiari R, Oleas R, Kim D, Robles-Medranda CA, Raijman I. Gastrointest Endosc. 2022 Feb; 2021 Aug 31. PMID: 34478737.
Evaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis.Chouairi F, McCarty TR, Hathorn KE, Sharma P, Aslanian HR, Jamidar PA, Thompson CC, Muniraj T. Surg Endosc. 2022 Jan; 2021 Jan 22. PMID: 33481109.

2021

GIE Editorial Board top 10 topics: advances in GI endoscopy in 2020.Chua TY, Kyanam Kabir Baig KR, Leung FW, Ashat M, Jamidar PA, Mulki R, Singh A, Yu JX, Lightdale JR. Gastrointest Endosc. 2021 Sep; 2021 Jun 17. PMID: 34147512.
Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies.Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. World J Gastroenterol. 2021 Apr 21. PMID: 33958848.

2020

The Reply.Lam R, Jamidar PA, Aslanian HR, Muniraj T. Am J Med. 2020 Oct. PMID: 33004185.
Fitz-Hugh-Curtis Syndrome Presenting as Acute Abdomen.Lam R, Jamidar PA, Aslanian HR, Muniraj T. Am J Med. 2020 Oct; 2020 Apr 9. PMID: 32277885.
Endoscopic Resection of a Giant Duodenal Lipoma.Gnanapandithan K, Aslanian HR, Jamidar PA, Muniraj T. ACG Case Rep J. 2020 Mar; 2020 Mar 17. PMID: 32337302.
Comparative effectiveness of pharmacologic and endoscopic interventions for prevention of post-ERCP pancreatitis: a network meta-analysis.Njei B, McCarty TR, Muniraj T, Sharma P, Jamidar PA, Aslanian HR, Varadarajulu S, Navaneethan U. Endosc Int Open. 2020 Jan; 2020 Jan 8. PMID: 31921982.

2019

Barium in the Bronchi: A Tracheoesophageal Fistula.Gnanapandithan K, Bramley K, Jamidar PA. ACG Case Rep J. 2019 Aug; 2019 Aug 21. PMID: 31737720.

2017

Endoscopic Management of Pancreatic Fluid Collections.Muniraj T, Jamidar PA, Nealon WH, Aslanian HR. J Clin Gastroenterol. 2017 Jan. PMID: 27548730.

2016

Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP?Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR. Dig Dis Sci. 2016 Mar; 2015 Nov 14. PMID: 26572779.

2015

Incidence and predictors of post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction undergoing biliary or dual sphincterotomy: results from the EPISOD prospective multicenter randomized sham-controlled study.Yaghoobi M, Pauls Q, Durkalski V, Romagnuolo J, Fogel EL, Tarnasky PR, Aliperti G, Freeman ML, Kozarek RA, Jamidar PA, Wilcox CM, Elta GH, Hawes RH, Wood-Williams A, Cotton PB. Endoscopy. 2015 Oct; 2015 Jul 10. PMID: 26165739.
Is Advanced Endoscopy Training Worth it?Aslanian HR, Ahmed AM, Jamidar PA. Clin Gastroenterol Hepatol. 2015 Jul. PMID: 26091939.
A double-blind, randomized, sham-controlled trial of the effect of a radiation-attenuating drape on radiation exposure to endoscopy staff during ERCP.Muniraj T, Aslanian HR, Laine L, Farrell J, Ciarleglio MM, Deng Y, Ho H, Jamidar PA. Am J Gastroenterol. 2015 May; 2015 Mar 31. PMID: 25823765.
Endoscopic treatment of malignant biliary strictures.Rustagi T, Jamidar PA. Curr Gastroenterol Rep. 2015 Jan. PMID: 25613178.
Endoscopic management of benign biliary strictures.Rustagi T, Jamidar PA. Curr Gastroenterol Rep. 2015 Jan. PMID: 25613176.
Endoscopic retrograde cholangiopancreatography (ERCP)-related adverse events: post-ERCP pancreatitis.Rustagi T, Jamidar PA. Gastrointest Endosc Clin N Am. 2015 Jan. PMID: 25442962.
Endoscopic retrograde cholangiopancreatography-related adverse events: general overview.Rustagi T, Jamidar PA. Gastrointest Endosc Clin N Am. 2015 Jan. PMID: 25442961.

2014

Intraductal radiofrequency ablation for management of malignant biliary obstruction.Rustagi T, Jamidar PA. Dig Dis Sci. 2014 Nov; 2014 Jun 7. PMID: 24906696.
Single-port pancreatectomy: ready for prime time.Rustagi T, Jamidar PA. J Clin Gastroenterol. 2014 Jul. PMID: 24781386.
Can patient and pain characteristics predict manometric sphincter of Oddi dysfunction in patients with clinically suspected sphincter of Oddi dysfunction?Romagnuolo J, Cotton PB, Durkalski V, Pauls Q, Brawman-Mintzer O, Drossman DA, Mauldin P, Orrell K, Williams AW, Fogel EL, Tarnasky PR, Aliperti G, Freeman ML, Kozarek RA, Jamidar PA, Wilcox CM, Serrano J, Elta GH. Gastrointest Endosc. 2014 May; 2014 Jan 25. PMID: 24472759.

2013

Emphysematous Cholecystitis Resulting in Secondary Biliary Cirrhosis: A Rare Complication of Endoscopic Retrograde Cholangiopancreatography.Bari K, Aslanian HR, Pollak J, Reiner E, Salem RR, Taddei TH, Emre SH, Jamidar PA. ACG Case Rep J. 2013 Oct; 2013 Oct 8. PMID: 26157820.
Nurse observation during colonoscopy increases polyp detection: a randomized prospective study.Aslanian HR, Shieh FK, Chan FW, Ciarleglio MM, Deng Y, Rogart JN, Jamidar PA, Siddiqui UD. Am J Gastroenterol. 2013 Feb. PMID: 23381064.

2012

High-definition confocal endomicroscopy of the common bile duct.Shieh FK, Drumm H, Nathanson MH, Jamidar PA. J Clin Gastroenterol. 2012 May-Jun. PMID: 22011583.

2011

Endoscopic ultrasound and endoscopic retrograde cholangiopancreatography for obstructing pancreas head masses: combined or separate procedures?Aslanian HR, Estrada JD, Rossi F, Dziura J, Jamidar PA, Siddiqui UD. J Clin Gastroenterol. 2011 Sep. PMID: 21301359.

2008

Fellow involvement may increase adenoma detection rates during colonoscopy.Rogart JN, Siddiqui UD, Jamidar PA, Aslanian HR. Am J Gastroenterol. 2008 Nov; 2008 Aug 27. PMID: 18759826.
Laparoscopic-assisted transgastric endoscopy: current indications and future implications.Roberts KE, Panait L, Duffy AJ, Jamidar PA, Bell RL. JSLS. 2008 Jan-Mar. PMID: 18402736.

Loren Laine, MD

2023

Letter: factors influencing discontinuation of aspirin in patients after gastrointestinal bleeding - authors' reply.Li DK, Laine L. Aliment Pharmacol Ther. 2023 Jun. PMID: 37161633.
Presentation of the Julius M. Friedenwald Medal to Sheila E. Crowe, MD.Laine L, Hecht G. Gastroenterology. 2023 Jun; 2023 Apr 16. PMID: 37061896.
Disparities in Access to Endoscopy for Patients With Upper Gastrointestinal Bleeding Presenting to Emergency Departments.Rodriguez NJ, Zheng NS, Mezzacappa C, Canavan M, Laine L, Shung DL. Gastroenterology. 2023 Jun; 2022 Oct 10. PMID: 36228735.
The Reply.Kurlander JE, Laine L. Am J Med. 2023 Apr. PMID: 36958908.
Plasma renalase levels are associated with the development of acute pancreatitis.Wang M, Weiss FU, Guo X, Kolodecik T, Bewersdorf JP, Laine L, Lerch MM, Desir G, Gorelick FS. Pancreatology. 2023 Mar; 2023 Jan 3. PMID: 36697349.
Over-the-scope clips versus standard treatment.Barkun AN, Laine L, Leontiadis GI, Saltzman JR. Gut. 2023 Mar; 2022 May 9. PMID: 35534090.
Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding.Li DK, Ong SY, Hughes ML, Hung KW, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Aliment Pharmacol Ther. 2023 Jan; 2022 Nov 16. PMID: 36394111.
Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial.Laine L, DeVault K, Katz P, Mitev S, Lowe J, Hunt B, Spechler S. Gastroenterology. 2023 Jan; 2022 Oct 10. PMID: 36228734.

2022

Trends in characteristics, management, and outcomes of patients presenting with gastrointestinal bleeding to emergency departments in the United States from 2006 to 2019.Zheng NS, Tsay C, Laine L, Shung DL. Aliment Pharmacol Ther. 2022 Dec; 2022 Sep 29. PMID: 36173090.
Rebleeding in peptic ulcer bleeding - a nationwide cohort study of 19,537 patients.Laursen SB, Stanley AJ, Laine L, Schaffalitzky de Muckadell OB. Scand J Gastroenterol. 2022 Dec; 2022 Jul 19. PMID: 35853234.
Response to Graham.Laine L, Sharma P, Mulford DJ, Hunt B, Leifke E, Smith N, Howden CW. Am J Gastroenterol. 2022 Nov 1. PMID: 36327440.
Association of Antisecretory Drugs with Upper Gastrointestinal Bleeding in Patients Using Oral Anticoagulants: A Systematic Review and Meta-Analysis.Kurlander JE, Barnes GD, Fisher A, Gonzalez JJ, Helminski D, Saini SD, Sengupta N, Yang YX, Scheiman J, Laine L. Am J Med. 2022 Oct; 2022 Jun 7. PMID: 35679879.
Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial.Chey WD, Mégraud F, Laine L, López LJ, Hunt BJ, Howden CW. Gastroenterology. 2022 Sep; 2022 Jun 6. PMID: 35679950.
Antiplatelet Monotherapy Is Associated with an Increased Risk of Bleeding After Endoscopic Sphincterotomy.Zakko A, Zakko L, Grimshaw AA, Laine L. Dig Dis Sci. 2022 Aug; 2021 Nov 18. PMID: 34796411.