Digestive Diseases Publications

Clara Abraham, MD

Hedl M, Yan J, Witt H, Abraham C: IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome. J Immunol. 2019 Feb 1; 2018 Dec 28. PMID: 30593537

Gettler K, Giri M, Kenigsberg E, Martin J, Chuang LS, Hsu NY, Denson LA, Hyams JS, Griffiths A, Noe JD, Crandall WV, Mack DR, Kellermayer R, Abraham C, Hoffman G, Kugathasan S, Cho JH: Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets. Genes Immun. 2019 Jan 29; 2019 Jan 29. PMID: 30692607

Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI: INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Elife. 2018 Oct 25; 2018 Oct 25. PMID: 30355448

Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA: Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29; 2017 Jun 21. PMID: 28636595

Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP. Nat Commun. 2017 Jun 28; 2017 Jun 28. PMID: 28656966

Lahiri A, Hedl M, Yan J, Abraham C: Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes. Nat Commun. 2017 Jun 8; 2017 Jun 8. PMID: 28593945

Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR: ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017 Feb 23; 2017 Feb 23. PMID: 28230865

Abraham C, Dulai PS, Vermeire S, Sandborn WJ: Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. Gastroenterology. 2017 Feb; 2016 Oct 22. PMID: 27780712

Hedl M, Abraham C: A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion. Gut. 2016 Nov; 2015 Jul 27. PMID: 26215868

Hedl M, Proctor DD, Abraham C: JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages. J Immunol. 2016 Nov 1; 2016 Sep 23. PMID: 27664279

Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Evelyn Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D, Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R, Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S, Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K, Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe'er I, Kugathasan S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH: A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF. Gastroenterology. 2016 Oct; 2016 Jul 1. PMID: 27377463

Hedl M, Yan J, Abraham C: IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation. Cell Rep. 2016 Aug 30; 2016 Aug 18. PMID: 27545875

Zheng S, Abraham C: NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms. Mol Cell Biol. 2013 Dec; 2013 Oct 7. PMID: 24100018

Zhang CK, Hewett J, Hemming J, Grant T, Zhao H, Abraham C, Oikonomou I, Kanakia M, Cho JH, Proctor DD: The influence of depression on quality of life in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013 Jul. PMID: 23669400

Hedl M, Abraham C: NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15; 2013 Jan 3. PMID: 23287275

Shen H, Zhang W, Abraham C, Cho JH: Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells. PLoS One. 2013; 2013 Mar 1. PMID: 23469228

Hedl M, Abraham C: Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines. Gastroenterology. 2012 Dec; 2012 Sep 8. PMID: 22967725

Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA: IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012 Nov 8; 2012 Oct 17. PMID: 23075849

Sarin R, Abraham C: CD18 is required for optimal lymphopenia-induced proliferation of mouse T cells. Am J Physiol Gastrointest Liver Physiol. 2012 Oct; 2012 Jul 19. PMID: 22821945

Hedl M, Abraham C: IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells. J Immunol. 2012 Jun 1; 2012 Apr 27. PMID: 22544929

Zhang W, Ferguson J, Ng SM, Hui K, Goh G, Lin A, Esplugues E, Flavell RA, Abraham C, Zhao H, Cho JH: Effector CD4+ T cell expression signatures and immune-mediated disease associated genes. PLoS One. 2012; 2012 Jun 8. PMID: 22715389

Menard L, Saadoun D, Isnardi I, Ng YS, Meyers G, Massad C, Price C, Abraham C, Motaghedi R, Buckner JH, Gregersen PK, Meffre E: The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J Clin Invest. 2011 Sep; 2011 Aug 1. PMID: 21804190

Hedl M, Abraham C: Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages. J Biol Chem. 2011 Jul 29; 2011 Jun 9. PMID: 21659536

Sarin R, Wu X, Abraham C: Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses. Proc Natl Acad Sci U S A. 2011 Jun 7; 2011 May 23. PMID: 21606346

Abraham C, Medzhitov R: Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology. 2011 May. PMID: 21530739

Hedl M, Abraham C: Secretory mediators regulate Nod2-induced tolerance in human macrophages. Gastroenterology. 2011 Jan; 2010 Sep 18. PMID: 20854823

Capurso NA, Look M, Jeanbart L, Nowyhed H, Abraham C, Craft J, Fahmy TM: Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells. Self Nonself. 2010 Oct. PMID: 21487509

Zenewicz LA, Abraham C, Flavell RA, Cho JH: Unraveling the genetics of autoimmunity. Cell. 2010 Mar 19. PMID: 20303870

Abraham C, Cho JH: Inflammatory bowel disease. N Engl J Med. 2009 Nov 19. PMID: 19923578

Abraham C, Cho J: Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflamm Bowel Dis. 2009 Jul. PMID: 19253307

Abraham C, Cho JH: IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease. Annu Rev Med. 2009. PMID: 18976050

Abraham C, Hart J, Locke SM, Baker AL: A case of indometacin-induced acute hepatitis developing into chronic autoimmune hepatitis. Nat Clin Pract Gastroenterol Hepatol. 2008 Mar; 2008 Jan 29. PMID: 18227818

Cho JH, Abraham C: Inflammatory bowel disease genetics: Nod2. Annu Rev Med. 2007. PMID: 16987083

Harry Aslanian, MD

James Lorenzen Boyer, MD, FACEP

Luca Fabris, MD, PhD

James J Farrell, MBChB

Romina Fiorotto, PhD

Guadalupe Garcia-Tsao, MD

Mateus Tavares Guerra, PhD

Avlin Barlow Imaeda, MD, PhD

Yasuko Iwakiri, PhD

Priya Arvind Jamidar, FACG, FASGE, MBChB

Annmarie Huysman Liapakis, MD

Xavier Llor, MD, PhD

Wajahat Zafar Mehal, PhD, MD

Thiruvengadam Muniraj, MD, MRCP

Michael Harris Nathanson, MD, PhD

Michael Schilsky, MD

Marina Silveira, MD

Carol J Soroka, PhD

Mario Strazzabosco, MD, PhD

Tamar Hamosh Taddei, MD

Jittima Weerachayaphorn, PhD

Xinshou Ouyang, PhD