Digestive Diseases Publications

Clara Abraham, MD

Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI: INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Elife. 2018 Oct 25; 2018 Oct 25. PMID: 30355448

Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA: Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29; 2017 Jun 21. PMID: 28636595

Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP. Nat Commun. 2017 Jun 28; 2017 Jun 28. PMID: 28656966

Lahiri A, Hedl M, Yan J, Abraham C: Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes. Nat Commun. 2017 Jun 8; 2017 Jun 8. PMID: 28593945

Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR: ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017 Feb 23; 2017 Feb 23. PMID: 28230865

Abraham C, Dulai PS, Vermeire S, Sandborn WJ: Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. Gastroenterology. 2017 Feb; 2016 Oct 22. PMID: 27780712

Hedl M, Abraham C: A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion. Gut. 2016 Nov; 2015 Jul 27. PMID: 26215868

Hedl M, Proctor DD, Abraham C: JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages. J Immunol. 2016 Nov 1; 2016 Sep 23. PMID: 27664279

Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Evelyn Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D, Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R, Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S, Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K, Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe'er I, Kugathasan S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH: A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF. Gastroenterology. 2016 Oct; 2016 Jul 1. PMID: 27377463

Hedl M, Yan J, Abraham C: IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation. Cell Rep. 2016 Aug 30; 2016 Aug 18. PMID: 27545875

Zheng S, Abraham C: NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms. Mol Cell Biol. 2013 Dec; 2013 Oct 7. PMID: 24100018

Zhang CK, Hewett J, Hemming J, Grant T, Zhao H, Abraham C, Oikonomou I, Kanakia M, Cho JH, Proctor DD: The influence of depression on quality of life in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013 Jul. PMID: 23669400

Hedl M, Abraham C: NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15; 2013 Jan 3. PMID: 23287275

Shen H, Zhang W, Abraham C, Cho JH: Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells. PLoS One. 2013; 2013 Mar 1. PMID: 23469228

Hedl M, Abraham C: Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines. Gastroenterology. 2012 Dec; 2012 Sep 8. PMID: 22967725

Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA: IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012 Nov 8; 2012 Oct 17. PMID: 23075849

Sarin R, Abraham C: CD18 is required for optimal lymphopenia-induced proliferation of mouse T cells. Am J Physiol Gastrointest Liver Physiol. 2012 Oct; 2012 Jul 19. PMID: 22821945

Hedl M, Abraham C: IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells. J Immunol. 2012 Jun 1; 2012 Apr 27. PMID: 22544929

Zhang W, Ferguson J, Ng SM, Hui K, Goh G, Lin A, Esplugues E, Flavell RA, Abraham C, Zhao H, Cho JH: Effector CD4+ T cell expression signatures and immune-mediated disease associated genes. PLoS One. 2012; 2012 Jun 8. PMID: 22715389

Menard L, Saadoun D, Isnardi I, Ng YS, Meyers G, Massad C, Price C, Abraham C, Motaghedi R, Buckner JH, Gregersen PK, Meffre E: The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J Clin Invest. 2011 Sep; 2011 Aug 1. PMID: 21804190

Hedl M, Abraham C: Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages. J Biol Chem. 2011 Jul 29; 2011 Jun 9. PMID: 21659536

Sarin R, Wu X, Abraham C: Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses. Proc Natl Acad Sci U S A. 2011 Jun 7; 2011 May 23. PMID: 21606346

Abraham C, Medzhitov R: Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology. 2011 May. PMID: 21530739

Hedl M, Abraham C: Secretory mediators regulate Nod2-induced tolerance in human macrophages. Gastroenterology. 2011 Jan; 2010 Sep 18. PMID: 20854823

Capurso NA, Look M, Jeanbart L, Nowyhed H, Abraham C, Craft J, Fahmy TM: Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells. Self Nonself. 2010 Oct. PMID: 21487509

Zenewicz LA, Abraham C, Flavell RA, Cho JH: Unraveling the genetics of autoimmunity. Cell. 2010 Mar 19. PMID: 20303870

Abraham C, Cho JH: Inflammatory bowel disease. N Engl J Med. 2009 Nov 19. PMID: 19923578

Abraham C, Cho J: Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflamm Bowel Dis. 2009 Jul. PMID: 19253307

Abraham C, Cho JH: IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease. Annu Rev Med. 2009. PMID: 18976050

Abraham C, Hart J, Locke SM, Baker AL: A case of indometacin-induced acute hepatitis developing into chronic autoimmune hepatitis. Nat Clin Pract Gastroenterol Hepatol. 2008 Mar; 2008 Jan 29. PMID: 18227818

Cho JH, Abraham C: Inflammatory bowel disease genetics: Nod2. Annu Rev Med. 2007. PMID: 16987083

Harry Aslanian, MD

James Lorenzen Boyer, MD, FACEP

Luca Fabris, MD, PhD

James J Farrell, MBChB

Romina Fiorotto, PhD

Guadalupe Garcia-Tsao, MD

O'Leary JG, Rajender Reddy K, Wong F, Garcia-Tsao G, Kamath PS, Thacker LR, Bajaj JS: Reply. Hepatology. 2018 Nov. PMID: 30199577

Abraldes JG, Trebicka J, Chalasani N, D'Amico G, Rockey D, Shah V, Bosch J, Garcia-Tsao G: Prioritization of Therapeutic Targets and Trial Design in Cirrhotic Portal Hypertension. Hepatology. 2018 Oct 15; 2018 Oct 15. PMID: 30318607

Haghighat L, Brandt EJ, Proctor DD, Garcia-Tsao G, Pollak J, Young LH: Evolution of Intrahepatic Shunts in a Patient With Hereditary Hemorrhagic Telangiectasia. Ann Intern Med. 2018 Oct 2; 2018 Jun 5. PMID: 29868721

Bajaj JS, Tandon P, O'Leary JG, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai JC, Fallon M, Thuluvath P, Vargas HE, Subramanian RM, Thacker LR, Reddy KR: The Impact of Albumin Use on Resolution of Hyponatremia in Hospitalized Patients With Cirrhosis. Am J Gastroenterol. 2018 Sep; 2018 Jun 8. PMID: 29880972

Turco L, Garcia-Tsao G, Rossi R, Villa E, Schepis F: Reply to: "Relationship of hyperdynamic circulation and cardiodynamic states in cirrhosis". J Hepatol. 2018 Sep; 2018 Jun 2. PMID: 29870763

Hung A, Garcia-Tsao G: Author response to Letter to the Editor "Post-paracentesis hemoperitoneum - time to become more careful!" Liver Int. 2018 Sep. PMID: 30145847

O'Leary JG, Rajender Reddy K, Wong F, Garcia-Tsao G, Kamath PS, Bajaj JS: Reply. Hepatology. 2018 Aug. PMID: 29663463

Brandl K, Hartmann P, Jih LJ, Pizzo DP, Argemi J, Ventura-Cots M, Coulter S, Liddle C, Ling L, Rossi SJ, DePaoli AM, Loomba R, Mehal WZ, Fouts DE, Lucey MR, Bosques-Padilla F, Mathurin P, Louvet A, Garcia-Tsao G, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross D, Stärkel P, Ho SB, Bataller R, Schnabl B: Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis. J Hepatol. 2018 Aug; 2018 Apr 12. PMID: 29654817

Hung A, Garcia-Tsao G: Acute kidney injury, but not sepsis, is associated with higher procedure-related bleeding in patients with decompensated cirrhosis. Liver Int. 2018 Aug; 2018 Feb 24. PMID: 29393567

Garcia-Tsao G, Fuchs M, Shiffman M, Borg BB, Pyrsopoulos N, Shetty K, Gallegos-Orozco JF, Reddy KR, Feyssa E, Chan JL, Yamashita M, Robinson JM, Spada AP, Hagerty DT, Bosch J: Emricasan (IDN-6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension. Hepatology. 2018 Jul 31; 2018 Jul 31. PMID: 30063802

Schepis F, Vizzutti F, Garcia-Tsao G, Marzocchi G, Rega L, De Maria N, Di Maira T, Gitto S, Caporali C, Colopi S, De Santis M, Arena U, Rampoldi A, Airoldi A, Cannavale A, Fanelli F, Mosconi C, Renzulli M, Agazzi R, Nani R, Quaretti P, Fiorina I, Moramarco L, Miraglia R, Luca A, Bruno R, Fagiuoli S, Golfieri R, Torricelli P, Di Benedetto F, Belli LS, Banchelli F, Laffi G, Marra F, Villa E: Under-dilated TIPS Associate With Efficacy and Reduced Encephalopathy in a Prospective, Non-randomized Study of Patients With Cirrhosis. Clin Gastroenterol Hepatol. 2018 Jul; 2018 Mar 3. PMID: 29378312

Garcia-Tsao G: Long-term albumin in cirrhosis: is it the ANSWER? Lancet. 2018 Jun 16; 2018 Jun 1. PMID: 29861077

O'Leary JG, Reddy KR, Garcia-Tsao G, Biggins SW, Wong F, Fallon MB, Subramanian RM, Kamath PS, Thuluvath P, Vargas HE, Maliakkal B, Tandon P, Lai J, Thacker LR, Bajaj JS: NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis. Hepatology. 2018 Jun; 2018 Apr 19. PMID: 29315693

Garcia-Tsao G: Regression of HCV cirrhosis: Time will tell. Hepatology. 2018 May; 2018 Mar 26. PMID: 29222930

Turco L, Garcia-Tsao G, Magnani I, Bianchini M, Costetti M, Caporali C, Colopi S, Simonini E, De Maria N, Banchelli F, Rossi R, Villa E, Schepis F: Cardiopulmonary hemodynamics and C-reactive protein as prognostic indicators in compensated and decompensated cirrhosis. J Hepatol. 2018 May; 2018 Jan 10. PMID: 29331339

Bajaj JS, Rajender Reddy K, Tandon P, Wong F, Kamath PS, Biggins SW, Garcia-Tsao G, Fallon M, Maliakkal B, Lai J, Vargas HE, Subramanian RM, Thuluvath P, Thacker LR, O'Leary JG: Prediction of Fungal Infection Development and Their Impact on Survival Using the NACSELD Cohort. Am J Gastroenterol. 2018 Apr; 2017 Dec 19. PMID: 29257141

Jakab SS, Garcia-Tsao G: Screening and Surveillance of Varices in Patients With Cirrhosis. Clin Gastroenterol Hepatol. 2018 Mar 15; 2018 Mar 15. PMID: 29551741

Bhutta AQ, Garcia-Tsao G, Reddy KR, Tandon P, Wong F, O'Leary JG, Acharya C, Banerjee D, Abraldes JG, Jones TM, Shaw J, Deng Y, Ciarleglio M, Bajaj JS: Beta-blockers in hospitalised patients with cirrhosis and ascites: mortality and factors determining discontinuation and reinitiation. Aliment Pharmacol Ther. 2018 Jan; 2017 Oct 9. PMID: 28994122

Garcia-Tsao G: Management of Acute Variceal Hemorrhage as a Model of Individualized Care for Patients With Cirrhosis. Clin Gastroenterol Hepatol. 2018 Jan; 2017 Sep 1. PMID: 28865767

Chizinga M, Rudkovskaia AA, Henderson K, Pollak J, Garcia-Tsao G, Young LH, Fares WH: Pulmonary Hypertension Prevalence and Prognosis in a Cohort of Patients with Hereditary Hemorrhagic Telangiectasia Undergoing Embolization of Pulmonary Arteriovenous Malformations. Am J Respir Crit Care Med. 2017 Nov 15. PMID: 28375020

Garcia-Tsao G: The Use of Nonselective Beta Blockers for Treatment of Portal Hypertension. Gastroenterol Hepatol (N Y). 2017 Oct. PMID: 29230139

Albillos A, Zamora J, Martínez J, Arroyo D, Ahmad I, De-la-Peña J, Garcia-Pagán JC, Lo GH, Sarin S, Sharma B, Abraldes JG, Bosch J, Garcia-Tsao G, Baveno Cooperation.: Stratifying risk in the prevention of recurrent variceal hemorrhage: Results of an individual patient meta-analysis. Hepatology. 2017 Oct; 2017 Aug 26. PMID: 28543862

Jangouk P, Turco L, De Oliveira A, Schepis F, Villa E, Garcia-Tsao G: Validating, deconstructing and refining Baveno criteria for ruling out high-risk varices in patients with compensated cirrhosis. Liver Int. 2017 Aug; 2017 Mar 7. PMID: 28160373

Wong F, O'Leary JG, Reddy KR, Garcia-Tsao G, Fallon MB, Biggins SW, Subramanian RM, Thuluvath PJ, Kamath PS, Patton H, Maliakkal B, Tandon P, Vargas H, Thacker L, Bajaj JS: Acute Kidney Injury in Cirrhosis: Baseline Serum Creatinine Predicts Patient Outcomes. Am J Gastroenterol. 2017 Jul; 2017 Apr 25. PMID: 28440305

Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J: Reply. Hepatology. 2017 Jul; 2017 May 27. PMID: 28342181

Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B: Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017 Jun 30; 2017 May 22. PMID: 28530644

Fortune BE, Garcia-Tsao G, Ciarleglio M, Deng Y, Fallon MB, Sigal S, Chalasani NP, Lim JK, Reuben A, Vargas HE, Abrams G, Lewis MD, Hassanein T, Trotter JF, Sanyal AJ, Beavers KL, Ganger D, Thuluvath PJ, Grace ND, Groszmann RJ, Vapreotide Study Group.: Child-Turcotte-Pugh Class is Best at Stratifying Risk in Variceal Hemorrhage: Analysis of a US Multicenter Prospective Study. J Clin Gastroenterol. 2017 May/Jun. PMID: 27779613

Fortune BE, Ciarleglio M, Deng Y, Garcia-Tsao G: Reply to Risk Stratification in Acute Variceal Bleeding: Child-Pugh Versus Model for End-stage Liver Disease. J Clin Gastroenterol. 2017 Apr 3; 2017 Apr 3. PMID: 28375866

Bajaj JS, O'Leary JG, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Maliakkal B, Biggins SW, Thuluvath PJ, Fallon MB, Subramanian RM, Vargas HE, Lai J, Thacker LR, Reddy KR: Hepatic Encephalopathy Is Associated With Mortality in Patients With Cirrhosis Independent of Other Extrahepatic Organ Failures. Clin Gastroenterol Hepatol. 2017 Apr; 2016 Oct 5. PMID: 27720916

O'Leary JG, Wong F, Reddy KR, Garcia-Tsao G, Kamath PS, Biggins SW, Fallon MB, Subramanian RM, Maliakkal B, Thacker L, Bajaj JS: Gender-Specific Differences in Baseline, Peak, and Delta Serum Creatinine: The NACSELD Experience. Dig Dis Sci. 2017 Mar; 2016 Dec 26. PMID: 28025746

Shung DL, Garcia-Tsao G: Liver Capsule: Portal Hypertension and Varices: Pathogenesis, Stages, and Management. Hepatology. 2017 Mar; 2017 Feb 8. PMID: 28032650

Bianchini M, Pietri L, Garcia-Tsao G, Villa E: Reply. Hepatology. 2017 Feb; 2016 Nov 25. PMID: 27639187

Abraldes JG, Garcia-Tsao G: The Design of Clinical Trials in Portal Hypertension. Semin Liver Dis. 2017 Feb; 2017 Feb 15. PMID: 28201851

Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J: Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases. Hepatology. 2017 Jan; 2016 Dec 1. PMID: 27786365

Tandon P, Reddy KR, O'Leary JG, Garcia-Tsao G, Abraldes JG, Wong F, Biggins SW, Maliakkal B, Fallon MB, Subramanian RM, Thuluvath P, Kamath PS, Thacker LR, Bajaj JS, North American Consortium for the Study of End-Stage Liver Disease.: A Karnofsky performance status-based score predicts death after hospital discharge in patients with cirrhosis. Hepatology. 2017 Jan; 2016 Nov 29. PMID: 27775842

Garcia-Tsao G: Empowering women: Perspective from a hepatologist. Hepatology. 2016 Dec. PMID: 27770471

Garcia-Tsao G: The Child-Turcotte Classification: From Gestalt to Sophisticated Statistics and Back. Dig Dis Sci. 2016 Nov. PMID: 27696097

Garcia-Tsao G, Sack J: Reply. Hepatology. 2016 Nov; 2016 May 17. PMID: 27112971

Balakrishnan M, Souza F, Muñoz C, Augustin S, Loo N, Deng Y, Ciarleglio M, Garcia-Tsao G: Liver and Spleen Stiffness Measurements by Point Shear Wave Elastography via Acoustic Radiation Force Impulse: Intraobserver and Interobserver Variability and Predictors of Variability in a US Population. J Ultrasound Med. 2016 Nov; 2016 Sep 23. PMID: 27663656

De Pietri L, Bianchini M, Garcia-Tsao G, Villa E: Reply. Hepatology. 2016 Sep; 2016 Feb 19. PMID: 26705089

Tate JP, Mohanty A, Garcia-Tsao G: Reply. Gastroenterology. 2016 Aug; 2016 Jul 1. PMID: 27376519

Njei B, McCarty TR, Garcia-Tsao G: Beta-blockers in patients with cirrhosis and ascites: type of beta-blocker matters. Gut. 2016 Aug; 2016 May 20. PMID: 27207973

De Pietri L, Bianchini M, Garcia-Tsao G, Villa E: Reply. Hepatology. 2016 Aug; 2016 Jan 8. PMID: 26547626

Tandon P, Ripoll C, Assis D, Wongcharatrawee S, Groszmann RJ, Garcia-Tsao G: The interpretation of hepatic venous pressure gradient tracings - excellent interobserver agreement unrelated to experience. Liver Int. 2016 Aug; 2016 Feb 8. PMID: 26763558

Bajaj JS, Reddy KR, Tandon P, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Biggins SW, Thuluvath PJ, Fallon MB, Subramanian RM, Vargas H, Thacker LR, O'Leary JG, North American Consortium for the Study of End-Stage Liver Disease.: The 3-month readmission rate remains unacceptably high in a large North American cohort of patients with cirrhosis. Hepatology. 2016 Jul; 2016 Feb 19. PMID: 26690389

Arroyo V, Moreau R, Kamath PS, Jalan R, Ginès P, Nevens F, Fernández J, To U, García-Tsao G, Schnabl B: Acute-on-chronic liver failure in cirrhosis. Nat Rev Dis Primers. 2016 Jun 9; 2016 Jun 9. PMID: 27277335

Fernández J, Tandon P, Mensa J, Garcia-Tsao G: Antibiotic prophylaxis in cirrhosis: Good and bad. Hepatology. 2016 Jun; 2016 Jan 11. PMID: 26528864

Fraenkel L, Lim J, Garcia-Tsao G, Reyna V, Monto A, Bridges JF: Variation in Treatment Priorities for Chronic Hepatitis C: A Latent Class Analysis. Patient. 2016 Jun. PMID: 26518200

Barr RG, Ferraioli G, Palmeri ML, Goodman ZD, Garcia-Tsao G, Rubin J, Garra B, Myers RP, Wilson SR, Rubens D, Levine D: Elastography Assessment of Liver Fibrosis: Society of Radiologists in Ultrasound Consensus Conference Statement. Ultrasound Q. 2016 Jun. PMID: 27233069

Nadim MK, Durand F, Kellum JA, Levitsky J, O'Leary JG, Karvellas CJ, Bajaj JS, Davenport A, Jalan R, Angeli P, Caldwell SH, Fernández J, Francoz C, Garcia-Tsao G, Ginès P, Ison MG, Kramer DJ, Mehta RL, Moreau R, Mulligan D, Olson JC, Pomfret EA, Senzolo M, Steadman RH, Subramanian RM, Vincent JL, Genyk YS: Corrigendum to "Management of the critically ill patients with cirrhosis: A multidisciplinary perspective". J Hepatol. 2016 May 27; 2016 May 27. PMID: 27241199

Sack J, Garcia-Tsao G: Variceal Hemorrhage in a Patient With Hepatitis C Virus Cirrhosis in Whom Liver Synthetic Function had Normalized After Viral Elimination. Hepatology. 2016 May; 2016 Mar 10. PMID: 26806550

Fraenkel L, Lim J, Garcia-Tsao G, Reyna V, Monto A: Examining Hepatitis C Virus Treatment Preference Heterogeneity Using Segmentation Analysis: Treat Now or Defer? J Clin Gastroenterol. 2016 Mar. PMID: 26166145

Garcia-Tsao G: Beta blockers in cirrhosis: The window re-opens. J Hepatol. 2016 Mar; 2015 Dec 24. PMID: 26724557

Nadim MK, Durand F, Kellum JA, Levitsky J, O'Leary JG, Karvellas CJ, Bajaj JS, Davenport A, Jalan R, Angeli P, Caldwell SH, Fernández J, Francoz C, Garcia-Tsao G, Ginès P, Ison MG, Kramer DJ, Mehta RL, Moreau R, Mulligan D, Olson JC, Pomfret EA, Senzolo M, Steadman RH, Subramanian RM, Vincent JL, Genyk YS: Management of the critically ill patient with cirrhosis: A multidisciplinary perspective. J Hepatol. 2016 Mar; 2015 Oct 28. PMID: 26519602

Mohanty A, Tate JP, Garcia-Tsao G: Statins Are Associated With a Decreased Risk of Decompensation and Death in Veterans With Hepatitis C-Related Compensated Cirrhosis. Gastroenterology. 2016 Feb; 2015 Oct 17. PMID: 26484707

De Pietri L, Bianchini M, Montalti R, De Maria N, Di Maira T, Begliomini B, Gerunda GE, di Benedetto F, Garcia-Tsao G, Villa E: Thrombelastography-guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: A randomized, controlled trial. Hepatology. 2016 Feb; 2015 Dec 9. PMID: 26340411

Garcia-Tsao G: Current Management of the Complications of Cirrhosis and Portal Hypertension: Variceal Hemorrhage, Ascites, and Spontaneous Bacterial Peritonitis. Dig Dis. 2016; 2016 May 11. PMID: 27170392

Yan K, Garcia-Tsao G: Novel prevention strategies for bacterial infections in cirrhosis. Expert Opin Pharmacother. 2016; 2016 Feb 23. PMID: 26799197

Garcia-Tsao G, Bosch J: Varices and Variceal Hemorrhage in Cirrhosis: A New View of an Old Problem. Clin Gastroenterol Hepatol. 2015 Nov; 2015 Jul 17. PMID: 26192141

Barr RG, Ferraioli G, Palmeri ML, Goodman ZD, Garcia-Tsao G, Rubin J, Garra B, Myers RP, Wilson SR, Rubens D, Levine D: Elastography Assessment of Liver Fibrosis: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology. 2015 Sep; 2015 Jun 16. PMID: 26079489

Ripoll C, Bari K, Garcia-Tsao G: Serum Albumin Can Identify Patients With Compensated Cirrhosis With a Good Prognosis. J Clin Gastroenterol. 2015 Aug. PMID: 25203362

Balakrishnan M, Garcia-Tsao G, Deng Y, Ciarleglio M, Jain D: Hepatic arteriolosclerosis: a small-vessel complication of diabetes and hypertension. Am J Surg Pathol. 2015 Jul. PMID: 25786083

Bhutta AQ, Garcia-Tsao G: The Role of Medical Therapy for Variceal Bleeding. Gastrointest Endosc Clin N Am. 2015 Jul; 2015 Apr 20. PMID: 26142033

Reddy KR, O'Leary JG, Kamath PS, Fallon MB, Biggins SW, Wong F, Patton HM, Garcia-Tsao G, Subramanian RM, Thacker LR, Bajaj JS, North American Consortium for the Study of End-Stage Liver Disease.: High risk of delisting or death in liver transplant candidates following infections: Results from the North American Consortium for the Study of End-Stage Liver Disease. Liver Transpl. 2015 Jul. PMID: 25845966

Yan K, Bridges JF, Augustin S, Laine L, Garcia-Tsao G, Fraenkel L: Factors impacting physicians' decisions to prevent variceal hemorrhage. BMC Gastroenterol. 2015 May 2; 2015 May 2. PMID: 25934271

O'Leary JG, Reddy KR, Wong F, Kamath PS, Patton HM, Biggins SW, Fallon MB, Garcia-Tsao G, Subramanian RM, Malik R, Thacker LR, Bajaj JS, North American Consortium for the Study of End-Stage Liver Disease.: Long-term use of antibiotics and proton pump inhibitors predict development of infections in patients with cirrhosis. Clin Gastroenterol Hepatol. 2015 Apr; 2014 Aug 12. PMID: 25130937

Mohanty A, Garcia-Tsao G: Hyponatremia and Hepatorenal Syndrome. Gastroenterol Hepatol (N Y). 2015 Apr. PMID: 27099594

Angeli P, Gines P, Wong F, Bernardi M, Boyer TD, Gerbes A, Moreau R, Jalan R, Sarin SK, Piano S, Moore K, Lee SS, Durand F, Salerno F, Caraceni P, Kim WR, Arroyo V, Garcia-Tsao G, International Club of Ascites.: Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites. Gut. 2015 Apr; 2015 Jan 28. PMID: 25631669

Angeli P, Ginès P, Wong F, Bernardi M, Boyer TD, Gerbes A, Moreau R, Jalan R, Sarin SK, Piano S, Moore K, Lee SS, Durand F, Salerno F, Caraceni P, Kim WR, Arroyo V, Garcia-Tsao G: Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites. J Hepatol. 2015 Apr; 2015 Jan 28. PMID: 25638527

Wong F, O'Leary JG, Reddy KR, Kamath PS, Garcia-Tsao G, Maliakkal B, Subramanian R, Thacker L, Bajaj J, North American Consortium for the Study of End-Stage Liver Disease.: A cut-off serum creatinine value of 1.5 mg/dl for AKI--to be or not to be. J Hepatol. 2015 Mar; 2014 Dec 5. PMID: 25485798

Belcher JM, Garcia-Tsao G, Sanyal AJ, Thiessen-Philbrook H, Peixoto AJ, Perazella MA, Ansari N, Lim J, Coca SG, Parikh CR, TRIBE-AKI Consortium.: Urinary biomarkers and progression of AKI in patients with cirrhosis. Clin J Am Soc Nephrol. 2014 Nov 7; 2014 Sep 2. PMID: 25183658

Belcher JM, Sanyal AJ, Peixoto AJ, Perazella MA, Lim J, Thiessen-Philbrook H, Ansari N, Coca SG, Garcia-Tsao G, Parikh CR, TRIBE-AKI Consortium.: Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology. 2014 Aug; 2014 Jun 26. PMID: 24375576

Jalan R, Fernandez J, Wiest R, Schnabl B, Moreau R, Angeli P, Stadlbauer V, Gustot T, Bernardi M, Canton R, Albillos A, Lammert F, Wilmer A, Mookerjee R, Vila J, Garcia-Martinez R, Wendon J, Such J, Cordoba J, Sanyal A, Garcia-Tsao G, Arroyo V, Burroughs A, Ginès P: Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. J Hepatol. 2014 Jun; 2014 Feb 12. PMID: 24530646

Fortune B, Garcia-Tsao G: Current Management Strategies for Acute Esophageal Variceal Hemorrhage. Curr Hepatol Rep. 2014 Mar 1. PMID: 24955303

Belcher JM, Sanyal AJ, Garcia-Tsao G, Ansari N, Coca SG, Shlipak MG, Parikh CR: Early trends in cystatin C and outcomes in patients with cirrhosis and acute kidney injury. Int J Nephrol. 2014; 2014 Mar 18. PMID: 24757564

Belcher JM, Parikh CR, Garcia-Tsao G: Acute kidney injury in patients with cirrhosis: perils and promise. Clin Gastroenterol Hepatol. 2013 Dec; 2013 Apr 10. PMID: 23583467

Chander Roland B, Garcia-Tsao G, Ciarleglio MM, Deng Y, Sheth A: Decompensated cirrhotics have slower intestinal transit times as compared with compensated cirrhotics and healthy controls. J Clin Gastroenterol. 2013 Nov-Dec. PMID: 23632359

Loo NM, Souza FF, Garcia-Tsao G: Non-hemorrhagic acute complications associated with cirrhosis and portal hypertension. Best Pract Res Clin Gastroenterol. 2013 Oct; 2013 Sep 5. PMID: 24160926

Young LH, Henderson KJ, White RI, Garcia-Tsao G: Bevacizumab: finding its niche in the treatment of heart failure secondary to liver vascular malformations in hereditary hemorrhagic telangiectasia. Hepatology. 2013 Jul; 2013 May 31. PMID: 23686865

Bedossa P, Garcia-Tsao G, Jain D: Cirrhosis Regression and Subclassification. Surg Pathol Clin. 2013 Jun; 2013 Apr 26. PMID: 26838976

Belcher JM, Garcia-Tsao G, Sanyal AJ, Bhogal H, Lim JK, Ansari N, Coca SG, Parikh CR, TRIBE-AKI Consortium.: Association of AKI with mortality and complications in hospitalized patients with cirrhosis. Hepatology. 2013 Feb; 2012 Dec 6. PMID: 22454364

Bari K, Miñano C, Shea M, Inayat IB, Hashem HJ, Gilles H, Heuman D, Garcia-Tsao G: The combination of octreotide and midodrine is not superior to albumin in preventing recurrence of ascites after large-volume paracentesis. Clin Gastroenterol Hepatol. 2012 Oct; 2012 Jul 16. PMID: 22801062

Sethasine S, Jain D, Groszmann RJ, Garcia-Tsao G: Quantitative histological-hemodynamic correlations in cirrhosis. Hepatology. 2012 Apr. PMID: 22109744

Bari K, Garcia-Tsao G: Treatment of portal hypertension. World J Gastroenterol. 2012 Mar 21. PMID: 22468079

Opio CK, Garcia-Tsao G: Managing varices: drugs, bands, and shunts. Gastroenterol Clin North Am. 2011 Sep. PMID: 21893274

Tandon P, Garcia-Tsao G: Renal dysfunction is the most important independent predictor of mortality in cirrhotic patients with spontaneous bacterial peritonitis. Clin Gastroenterol Hepatol. 2011 Mar; 2010 Dec 8. PMID: 21145427

Miñano C, Garcia-Tsao G: Clinical pharmacology of portal hypertension. Gastroenterol Clin North Am. 2010 Sep. PMID: 20951924

Tandon P, Inayat I, Tal M, Spector M, Shea M, Groszmann RJ, Garcia-Tsao G: Sildenafil has no effect on portal pressure but lowers arterial pressure in patients with compensated cirrhosis. Clin Gastroenterol Hepatol. 2010 Jun; 2010 Feb 6. PMID: 20144739

Garcia-Tsao G, Friedman S, Iredale J, Pinzani M: Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis. Hepatology. 2010 Apr. PMID: 20077563

Garcia-Tsao G, Bosch J: Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med. 2010 Mar 4. PMID: 20200386

Fraenkel L, Chodkowski D, Lim J, Garcia-Tsao G: Patients' preferences for treatment of hepatitis C. Med Decis Making. 2010 Jan-Feb; 2009 Jul 27. PMID: 19636065

Khalid SK, Lane J, Navarro V, Garcia-Tsao G: Use of over-the-counter analgesics is not associated with acute decompensation in patients with cirrhosis. Clin Gastroenterol Hepatol. 2009 Sep; 2009 Apr 24. PMID: 19394441

Garcia-Tsao G, Lim JK, Members of Veterans Affairs Hepatitis C Resource Center Program.: Management and treatment of patients with cirrhosis and portal hypertension: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program. Am J Gastroenterol. 2009 Jul; 2009 May 19. PMID: 19455106

Tandon P, Garcia-Tsao G: Prognostic indicators in hepatocellular carcinoma: a systematic review of 72 studies. Liver Int. 2009 Apr; 2008 Dec 24. PMID: 19141028

Garcia-Tsao G, Parikh CR, Viola A: Acute kidney injury in cirrhosis. Hepatology. 2008 Dec. PMID: 19003880

Khalid SK, Garcia-Tsao G: Hepatic vascular malformations in hereditary hemorrhagic telangiectasia. Semin Liver Dis. 2008 Aug; 2008 Sep 23. PMID: 18814078

Sheth AA, Garcia-Tsao G: Probiotics and liver disease. J Clin Gastroenterol. 2008 Jul. PMID: 18542037

Floch MH, Walker WA, Guandalini S, Hibberd P, Gorbach S, Surawicz C, Sanders ME, Garcia-Tsao G, Quigley EM, Isolauri E, Fedorak RN, Dieleman LA: Recommendations for probiotic use--2008. J Clin Gastroenterol. 2008 Jul. PMID: 18542033

Garcia-Tsao G, Bosch J, Groszmann RJ: Portal hypertension and variceal bleeding--unresolved issues. Summary of an American Association for the study of liver diseases and European Association for the study of the liver single-topic conference. Hepatology. 2008 May. PMID: 18435460

Longacre AV, Imaeda A, Garcia-Tsao G, Fraenkel L: A pilot project examining the predicted preferences of patients and physicians in the primary prophylaxis of variceal hemorrhage. Hepatology. 2008 Jan. PMID: 17935182

Ripoll C, Garcia-Tsao G: Treatment of gastropathy and gastric antral vascular ectasia in patients with portal hypertension. Curr Treat Options Gastroenterol. 2007 Dec. PMID: 18221609

Garcia-Tsao G: Preventing the development of varices in cirrhosis. J Clin Gastroenterol. 2007 Nov-Dec. PMID: 17975480

Garcia-Tsao G, Nathanson MH: Portal hypertension: from the patient to the molecule and back: a symposium honoring Roberto J. Groszmann, MD. J Clin Gastroenterol. 2007 Nov-Dec. PMID: 17975470

Garcia-Tsao G, Sanyal AJ, Grace ND, Carey WD, Practice Guidelines Committee of American Association for Study of Liver Diseases., Practice Parameters Committee of American College of Gastroenterology.: Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Am J Gastroenterol. 2007 Sep. PMID: 17727436

Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W, Practice Guidelines Committee of the American Association for the Study of Liver Diseases., Practice Parameters Committee of the American College of Gastroenterology.: Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 2007 Sep. PMID: 17879356

Ripoll C, Groszmann R, Garcia-Tsao G, Grace N, Burroughs A, Planas R, Escorsell A, Garcia-Pagan JC, Makuch R, Patch D, Matloff DS, Bosch J, Portal Hypertension Collaborative Group.: Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis. Gastroenterology. 2007 Aug; 2007 May 21. PMID: 17681169

Garcia-Tsao G: Liver involvement in hereditary hemorrhagic telangiectasia (HHT). J Hepatol. 2007 Mar; 2007 Jan 2. PMID: 17239481

Ghassemi S, Garcia-Tsao G: Prevention and treatment of infections in patients with cirrhosis. Best Pract Res Clin Gastroenterol. 2007. PMID: 17223498

Garcia-Tsao G, Gish RG, Punch J: Model for end-stage liver disease (MELD) exception for hereditary hemorrhagic telangiectasia. Liver Transpl. 2006 Dec. PMID: 17123286

Wu JS, Saluja S, Garcia-Tsao G, Chong A, Henderson KJ, White RI Jr: Liver involvement in hereditary hemorrhagic telangiectasia: CT and clinical findings do not correlate in symptomatic patients. AJR Am J Roentgenol. 2006 Oct. PMID: 16985112

Longacre AV, Garcia-Tsao G: A commonsense approach to esophageal varices. Clin Liver Dis. 2006 Aug. PMID: 17162231

Garcia-Tsao G: The transjugular intrahepatic portosystemic shunt for the management of cirrhotic refractory ascites. Nat Clin Pract Gastroenterol Hepatol. 2006 Jul. PMID: 16819501

Fraenkel L, McGraw S, Wongcharatrawee S, Garcia-Tsao G: Patients' experiences related to anti-viral treatment for hepatitis C. Patient Educ Couns. 2006 Jul; 2005 Aug 10. PMID: 16098705

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2006 May. PMID: 16550040

Chainuvati S, Khalid SK, Kancir S, Shea M, Edwards J, Sernyak M, Wongcharatrawee S, Garcia-Tsao G: Comparison of hepatitis C treatment patterns in patients with and without psychiatric and/or substance use disorders. J Viral Hepat. 2006 Apr. PMID: 16611189

Nagula S, Jain D, Groszmann RJ, Garcia-Tsao G: Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis. J Hepatol. 2006 Jan; 2005 Sep 23. PMID: 16274836

Fraenkel L, McGraw S, Wongcharatrawee S, Garcia-Tsao G: What do patients consider when making decisions about treatment for hepatitis C? Am J Med. 2005 Dec. PMID: 16378783

Garcia-Tsao G: Transjugular intrahepatic portosystemic shunt in the management of refractory ascites. Semin Intervent Radiol. 2005 Dec. PMID: 21326706

Groszmann RJ, Garcia-Tsao G, Bosch J, Grace ND, Burroughs AK, Planas R, Escorsell A, Garcia-Pagan JC, Patch D, Matloff DS, Gao H, Makuch R, Portal Hypertension Collaborative Group.: Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med. 2005 Nov 24. PMID: 16306522

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2005 May. PMID: 15818152

Garcia-Tsao G: Bacterial infections in cirrhosis: treatment and prophylaxis. J Hepatol. 2005; 2005 Jan 18. PMID: 15777576

Garcia-Tsao G: Refractory ascites and hepatorenal syndrome. Rev Gastroenterol Mex. 2004 Nov. PMID: 16881221

Garcia-Tsao G: Spontaneous bacterial peritonitis: a historical perspective. J Hepatol. 2004 Oct. PMID: 15464231

Garcia-Tsao G: Bacterial infections in cirrhosis. Can J Gastroenterol. 2004 Jun. PMID: 15190398

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2004 May. PMID: 15703650

Garcia-Tsao G, Wiest R: Gut microflora in the pathogenesis of the complications of cirrhosis. Best Pract Res Clin Gastroenterol. 2004 Apr. PMID: 15123075

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2003 May. PMID: 15703565

Garcia-Tsao G, Bassin L: Difficult management decision. J Clin Gastroenterol. 2002 Nov-Dec. PMID: 12394218

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2002 May. PMID: 17033306

Tang LH, Hui P, Garcia-Tsao G, Salem RR, Jain D: Multiple angiomyolipomata of the liver: a case report. Mod Pathol. 2002 Feb. PMID: 11850546

Wongcharatrawee S, Garcia-Tsao G: Clinical management of ascites and its complications. Clin Liver Dis. 2001 Aug. PMID: 11565143

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2001 May. PMID: 17031170

Garcia-Tsao G: Current management of the complications of cirrhosis and portal hypertension: variceal hemorrhage, ascites, and spontaneous bacterial peritonitis. Gastroenterology. 2001 Feb. PMID: 11179247

Garcia-Tsao G: Treatment of refractory ascites: tips or taps? Hepatology. 2001 Feb. PMID: 11172354

Garcia-Tsao G, Korzenik JR, Young L, Henderson KJ, Jain D, Byrd B, Pollak JS, White RI Jr: Liver disease in patients with hereditary hemorrhagic telangiectasia. N Engl J Med. 2000 Sep 28. PMID: 11006369

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2000 May. PMID: 17023887

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 1999 May. PMID: 17023954

Steinlauf AF, Garcia-Tsao G, Zakko MF, Dickey K, Gupta T, Groszmann RJ: Low-dose midazolam sedation: an option for patients undergoing serial hepatic venous pressure measurements. Hepatology. 1999 Apr. PMID: 10094948

Kuan SF, Garcia-Tsao G, Cartun RW, Emanuel JR, West AB: Viral RNA in duodenal bile of cirrhotic patients with chronic hepatitis C. Arch Pathol Lab Med. 1997 Aug. PMID: 9278613

Taylor CR, Garcia-Tsao G, Henson B, Case CQ, Taylor KJ: Doppler ultrasound in the evaluation of cirrhotic patients: the prevalence of intrahepatic arteriovenous shunting, and implications for diagnosis of hepatocellular carcinoma. Ultrasound Med Biol. 1997. PMID: 9372563

García-Tsao G: [Gastroesophageal varices hemorrhage: non-surgical treatment]. Rev Gastroenterol Mex. 1996 Oct-Dec. PMID: 9102789

García-Tsao G: Treatment of chronic hepatitis C. Rev Gastroenterol Mex. 1995 Oct-Dec. PMID: 8948779

Navarro VJ, Garcia-Tsao G: Variceal hemorrhage. Crit Care Clin. 1995 Apr. PMID: 7788538

Garcia-Tsao G: Cirrhotic ascites: pathogenesis and management. Gastroenterologist. 1995 Mar. PMID: 7743121

Garcia-Tsao G: Spontaneous bacterial peritonitis. Gastroenterol Clin North Am. 1992 Mar. PMID: 1568776

Garcia-Tsao G, Panzini L, Yoselevitz M, West AB: Bacillary peliosis hepatis as a cause of acute anemia in a patient with the acquired immunodeficiency syndrome. Gastroenterology. 1992 Mar. PMID: 1537498

Conn HO, Grace ND, Bosch J, Groszmann RJ, Rodés J, Wright SC, Matloff DS, Garcia-Tsao G, Fisher RL, Navasa M: Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial. The Boston-New Haven-Barcelona Portal Hypertension Study Group. Hepatology. 1991 May. PMID: 2029994

Garcia-Tsao G: Treatment of ascites with a single total paracentesis. Hepatology. 1991 May. PMID: 2029984

Mateus Tavares Guerra, PhD

Avlin Barlow Imaeda, MD, PhD

Yasuko Iwakiri, PhD

Priya Arvind Jamidar, FACG, FASGE, MBChB

Annmarie Huysman Liapakis, MD

Xavier Llor, MD, PhD

Wajahat Zafar Mehal, PhD, MD

Thiruvengadam Muniraj, MD, MRCP

Michael Harris Nathanson, MD, PhD

Michael Schilsky, MD

Marina Silveira, MD

Carol J Soroka, PhD

Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL: Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714

Li M, Soroka CJ, Harry K, Boyer JL: CFTR-associated ligand is a negative regulator of Mrp2 expression. Am J Physiol Cell Physiol. 2017 Jan 1; 2016 Nov 9. PMID: 27834195

Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL: Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis. Hepatology. 2016 Dec; 2016 Oct 28. PMID: 27639250

Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL: A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. PLoS One. 2016; 2016 Jun 28. PMID: 27351185

Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL: Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology. 2015 Oct; 2015 Aug 22. PMID: 26108984

Soroka CJ, Boyer JL: Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations. Mol Aspects Med. 2014 Jun; 2013 May 15. PMID: 23685087

Cai SY, Mennone A, Soroka CJ, Boyer JL: Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 2014 Jan 30. PMID: 24481602

Cai SY, Mennone A, Soroka CJ, Boyer JL: All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice. J Pharmacol Exp Ther. 2014 Apr; 2014 Feb 3. PMID: 24492652

Ghonem NS, Ananthanarayanan M, Soroka CJ, Boyer JL: Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion. Hepatology. 2014 Mar; 2014 Jan 27. PMID: 24122873

Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL: Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. J Hepatol. 2014 Jan; 2013 Aug 23. PMID: 23978715

Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL: Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology. 2013 Jun. PMID: 23175353

Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM: Identification of functionally distinct Na-HCO3 co-transporters in colon. PLoS One. 2013; 2013 May 14. PMID: 23690961

Lam P, Xu S, Soroka CJ, Boyer JL: A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis. Hepatology. 2012 Jun; 2012 Apr 25. PMID: 22161577

Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL: Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Am J Physiol Gastrointest Liver Physiol. 2012 May 1; 2012 Feb 16. PMID: 22345550

Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL: Ostα depletion protects liver from oral bile acid load. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 2011 Jun 30. PMID: 21719738

Mennone A, Soroka CJ, Harry KM, Boyer JL: Role of breast cancer resistance protein in the adaptive response to cholestasis. Drug Metab Dispos. 2010 Oct; 2010 Jul 2. PMID: 20601550

Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL: Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535

Li M, Wang W, Soroka CJ, Mennone A, Harry K, Weinman EJ, Boyer JL: NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. J Biol Chem. 2010 Jun 18; 2010 Apr 19. PMID: 20404332

Soroka CJ, Ballatori N, Boyer JL: Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422499

Lam P, Soroka CJ, Boyer JL: The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422495

Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL: Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology. 2010 Jan. PMID: 19902485

Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL: Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression. Hepatology. 2009 Nov. PMID: 19821532

Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL: ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology. 2009 Mar; 2008 Nov 1. PMID: 19027009

Wang L, Dong H, Soroka CJ, Wei N, Boyer JL, Hochstrasser M: Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II. Hepatology. 2008 Nov. PMID: 18798335

Soroka CJ, Xu S, Mennone A, Lam P, Boyer JL: N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta. BMC Cell Biol. 2008 Oct 10; 2008 Oct 10. PMID: 18847488

Lam P, Pearson CL, Soroka CJ, Xu S, Mennone A, Boyer JL: Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases. Am J Physiol Cell Physiol. 2007 Nov; 2007 Sep 13. PMID: 17855769

Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL: Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Feb 1. PMID: 17272513

Wang W, Soroka CJ, Mennone A, Rahner C, Harry K, Pypaert M, Boyer JL: Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes. Gastroenterology. 2006 Sep. PMID: 16952556

Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N: Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 2006 Jan 19. PMID: 16423920

Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL: Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology. 2006 May. PMID: 16628672

Denk GU, Cai SY, Chen WS, Lin A, Soroka CJ, Boyer JL: A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology. World J Gastroenterol. 2006 Apr 28. PMID: 16688799

Denk GU, Soroka CJ, Mennone A, Koepsell H, Beuers U, Boyer JL: Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis. Hepatology. 2004 May. PMID: 15122767

Denk GU, Soroka CJ, Takeyama Y, Chen WS, Schuetz JD, Boyer JL: Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J Hepatol. 2004 Apr. PMID: 15030973

Cai SY, Soroka CJ, Ballatori N, Boyer JL: Molecular characterization of a multidrug resistance-associated protein, Mrp2, from the little skate. Am J Physiol Regul Integr Comp Physiol. 2003 Jan; 2002 Oct 3. PMID: 12388433

Wang L, Soroka CJ, Boyer JL: The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II. J Clin Invest. 2002 Oct. PMID: 12370274

Azzaroli F, Mehal W, Soroka CJ, Wang L, Lee J, Crispe IN, Boyer JL: Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. Hepatology. 2002 Jul. PMID: 12085348

Cai SY, Wang W, Soroka CJ, Ballatori N, Boyer JL: An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins. Am J Physiol Gastrointest Liver Physiol. 2002 Apr. PMID: 11897630

Mario Strazzabosco, MD, PhD

Tamar Hamosh Taddei, MD

Jittima Weerachayaphorn, PhD

Xinshou Ouyang, PhD