Key areas of our research are the molecular & cellular mechanisms regulating heart (metabolism in cv disease), autocrine-paracrine pathways (modulating cardiac cell signaling and function), and metabolic signaling pathways in atrial fibrillation. Processes under investigation include: regulation of heart metabolism/function; AMPK protection against solid organ ischemia; JNK pathway in reperfusion injury; cardiac autocrine/paracrine factors; MIF CD74 signaling; novel myocyte autocrine proteins; atrial fibrillation; and LKB1 role in cardiac growth and remodeling.
Pioglitazone after Ischemic Stroke or Transient Ischemic Attack.Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, Brass LM, Schwartz GG, Adams HP Jr, Berger L, Carolei A, Clark W, Coull B, Ford GA, Kleindorfer D, O'Leary JR, Parsons MW, Ringleb P, Sen S, Spence JD, Tanne D, Wang D, Winder TR. N Engl J Med. 2016 Apr 7; 2016 Feb 17. PMID: 26886418.