Associate Professor of Medicine (Cardiology) and of Pathology; Section of Cardiovascular Medicine
Research Interests
Cardiology; Cardiovascular Diseases; Heart; Physiology; Stem Cells; Tissue Engineering
Yibing Qyang
Qyang Lab
My laboratory seeks to understand the basic biology of a novel population of cardiovascular progenitor cells (CPC) derived from heart tissues and embryonic stem (ES) and induced pluripotent stem (iPS) cells. These CPC are capable of making nearly an entire heart during heart formation and are marked by Isl1, a LIM-Homeo domain transcription factor. Using a high-throughput small molecule screen coupled with murine ES cell and embryonic heart developmental studies, we have discovered several small molecules modulating these CPC.
Publications
- Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes.Sewanan LR, Schwan J, Kluger J, Park J, Jacoby DL, Qyang Y, Campbell SG. JACC Basic Transl Sci. 2019 Aug; 2019 Jul 24. PMID: 31468004.
- Patient mutations linked to arrhythmogenic cardiomyopathy enhance calpain-mediated desmoplakin degradation.Ng R, Manring H, Papoutsidakis N, Albertelli T, Tsai N, See CJ, Li X, Park J, Stevens TL, Bobbili PJ, Riaz M, Ren Y, Stoddard CE, Janssen PM, Bunch TJ, Hall SP, Lo YC, Jacoby DL, Qyang Y, Wright N, Ackermann MA, Campbell SG. JCI Insight. 2019 Jun 13; 2019 Jun 13. PMID: 31194698.
- Sarcomere-Directed Calcium Reporters in Cardiomyocytes.Campbell SG, Qyang Y, Hinson JT. Circ Res. 2019 Apr 12. PMID: 30973804.
- The potential and limitations of induced pluripotent stem cells to achieve wound healing.Gorecka J, Kostiuk V, Fereydooni A, Gonzalez L, Luo J, Dash B, Isaji T, Ono S, Liu S, Lee SR, Xu J, Liu J, Taniguchi R, Yastula B, Hsia HC, Qyang Y, Dardik A. Stem Cell Res Ther. 2019 Mar 12; 2019 Mar 12. PMID: 30867069.
- Modeling elastin-associated vasculopathy with patient induced pluripotent stem cells and tissue engineering.Ellis MW, Luo J, Qyang Y. Cell Mol Life Sci. 2019 Mar; 2018 Nov 20. PMID: 30460472.
- Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture.Sharma D, Jia W, Long F, Pati S, Chen Q, Qyang Y, Lee B, Choi CK, Zhao F. Bioact Mater. 2019 Dec; 2019 Feb 21. PMID: 30873506.
- Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y. Biomaterials. 2017 Dec; 2017 Sep 19. PMID: 28942128.
- mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice.Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G. Arterioscler Thromb Vasc Biol. 2017 Sep; 2017 Jul 27. PMID: 28751568.
- Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE. Cell Transplant. 2017 Aug. PMID: 28901188.
- Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis.Lee HW, Chong DC, Ola R, Dunworth WP, Meadows S, Ka J, Kaartinen VM, Qyang Y, Cleaver O, Bautch VL, Eichmann A, Jin SW. Arterioscler Thromb Vasc Biol. 2017 Apr; 2017 Feb 23. PMID: 28232325.
- Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies.Anderson CW, Boardman N, Luo J, Park J, Qyang Y. Curr Cardiol Rep. 2017 Apr. PMID: 28324469.
- Implantable tissue-engineered blood vessels from human induced pluripotent stem cells.Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y. Biomaterials. 2016 Sep; 2016 Jun 14. PMID: 27336184.
- Anisotropic engineered heart tissue made from laser-cut decellularized myocardium.Schwan J, Kwaczala AT, Ryan TJ, Bartulos O, Ren Y, Sewanan LR, Morris AH, Jacoby DL, Qyang Y, Campbell SG. Sci Rep. 2016 Aug 30; 2016 Aug 30. PMID: 27572147.
- Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells.Dash BC, Levi K, Schwan J, Luo J, Bartulos O, Wu H, Qiu C, Yi T, Ren Y, Campbell S, Rolle MW, Qyang Y. Stem Cell Reports. 2016 Jul 12. PMID: 27411102.
- ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction.Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. JCI Insight. 2016 Jul 7. PMID: 27525311.
- Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis.Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. J Exp Med. 2016 Mar 7; 2016 Feb 8. PMID: 26858344.
- Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9.Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS. Circ Res. 2015 Jul 3; 2015 May 4. PMID: 25940550.
- Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application.Dash BC, Jiang Z, Suh C, Qyang Y. Biochem J. 2015 Jan 15. PMID: 25559088.
- Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor.Sivarapatna A, Ghaedi M, Le AV, Mendez JJ, Qyang Y, Niklason LE. Biomaterials. 2015; 2015 Mar 24. PMID: 25890758.
- Functional cardiomyocytes derived from Isl1 cardiac progenitors via Bmp4 stimulation.Cagavi E, Bartulos O, Suh CY, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y. PLoS One. 2014; 2014 Dec 18. PMID: 25522363.
- Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine.Suh CY, Wang Z, Bártulos O, Qyang Y. J Cardiovasc Pharmacol Ther. 2014 Jul; 2014 Mar 19. PMID: 24651517.
- Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos.Dunworth WP, Cardona-Costa J, Bozkulak EC, Kim JD, Meadows S, Fischer JC, Wang Y, Cleaver O, Qyang Y, Ober EA, Jin SW. Circ Res. 2014 Jan 3; 2013 Oct 11. PMID: 24122719.
- Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency.Li W, Li Q, Qin L, Ali R, Qyang Y, Tassabehji M, Pober BR, Sessa WC, Giordano FJ, Tellides G. Arterioscler Thromb Vasc Biol. 2013 May; 2013 Mar 14. PMID: 23493289.
- Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells.Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y. Circulation. 2012 Oct 2; 2012 Aug 22. PMID: 22914687.
- Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW. Dev Cell. 2012 Aug 14. PMID: 22898784.
- Regenerating functional heart tissue for myocardial repair.Alcon A, Cagavi Bozkulak E, Qyang Y. Cell Mol Life Sci. 2012 Aug; 2012 Mar 3. PMID: 22388688.
- Evaluation of the use of an induced puripotent stem cell sheet for the construction of tissue-engineered vascular grafts.Hibino N, Duncan DR, Nalbandian A, Yi T, Qyang Y, Shinoka T, Breuer CK. J Thorac Cardiovasc Surg. 2012 Mar; 2012 Jan 12. PMID: 22244569.
- Methods of cell purification: a critical juncture for laboratory research and translational science.Amos PJ, Cagavi Bozkulak E, Qyang Y. Cells Tissues Organs. 2012; 2011 Oct 12. PMID: 21996576.
- Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells.Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y. Stem Cell Res. 2012 Jan; 2011 Aug 22. PMID: 22099020.
- High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells.Lee MY, Cagavi Bozkulak E, Schliffke S, Amos PJ, Ren Y, Ge X, Ehrlich BE, Qyang Y. Biochem Biophys Res Commun. 2011 Dec 9; 2011 Nov 6. PMID: 22079290.
- Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells.Ren Y, Lee MY, Schliffke S, Paavola J, Amos PJ, Ge X, Ye M, Zhu S, Senyei G, Lum L, Ehrlich BE, Qyang Y. J Mol Cell Cardiol. 2011 Sep; 2011 May 4. PMID: 21569778.
- Regeneration of a heart cell.Qyang Y, Senyei G. Yale J Biol Med. 2009 Sep. PMID: 19774125.
- The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway.Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans SM, Ding S, Chien KR. Cell Stem Cell. 2007 Aug 16; 2007 Jun 14. PMID: 18371348.
- Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification.Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. Cell. 2006 Dec 15; 2006 Nov 22. PMID: 17123592.
- Isl1Cre reveals a common Bmp pathway in heart and limb development.Yang L, Cai CL, Lin L, Qyang Y, Chung C, Monteiro RM, Mummery CL, Fishman GI, Cogen A, Evans S. Development. 2006 Apr. PMID: 16556916.
- T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S. Development. 2005 May; 2005 Apr 20. PMID: 15843407.
- Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage.Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H. Biochemistry. 2004 May 11. PMID: 15122901.
- The novel Rho GTPase-activating protein family protein, Rga8, provides a potential link between Cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe.Yang P, Qyang Y, Bartholomeusz G, Zhou X, Marcus S. J Biol Chem. 2003 Dec 5; 2003 Sep 23. PMID: 14506270.
- The p21-activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe.Qyang Y, Yang P, Du H, Lai H, Kim H, Marcus S. Mol Microbiol. 2002 Apr. PMID: 11972773.