Yibing Qyang

Bio Profile

Yibing Qyang, PhD

Associate Professor of Medicine (Cardiology) and of Pathology

Section of Cardiovascular Medicine

Research Interests

Cardiology; Cardiovascular Diseases; Heart; Physiology; Stem Cells; Tissue Engineering

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Qyang Lab

My laboratory seeks to understand the basic biology of a novel population of cardiovascular progenitor cells (CPC) derived from heart tissues and embryonic stem (ES) and induced pluripotent stem (iPS) cells. These CPC are capable of making nearly an entire heart during heart formation and are marked by Isl1, a LIM-Homeo domain transcription factor. Using a high-throughput small molecule screen coupled with murine ES cell and embryonic heart developmental studies, we have discovered several small molecules modulating these CPC.


Ng R, Manring HR, Papoutsidakis N, Albertelli T, Tsai N, See C, Li X, Park J, Stevens TL, Bobbili PJ, Riaz M, Ren Y, Stoddard CE, Janssen PM, Bunch TJ, Hall SP, Lo YC, Jacoby DL, Qyang Y, Wright N, Ackermann MA, Campbell SG: Patient mutations linked to arrhythmogenic cardiomyopathy enhance calpain-mediated desmoplakin degradation. JCI Insight. 2019 Jun 13; 2019 Jun 13. PMID: 31194698

Campbell SG, Qyang Y, Hinson JT: Sarcomere-Directed Calcium Reporters in Cardiomyocytes. Circ Res. 2019 Apr 12. PMID: 30973804

Gorecka J, Kostiuk V, Fereydooni A, Gonzalez L, Luo J, Dash B, Isaji T, Ono S, Liu S, Lee SR, Xu J, Liu J, Taniguchi R, Yastula B, Hsia HC, Qyang Y, Dardik A: The potential and limitations of induced pluripotent stem cells to achieve wound healing. Stem Cell Res Ther. 2019 Mar 12; 2019 Mar 12. PMID: 30867069

Ellis MW, Luo J, Qyang Y: Modeling elastin-associated vasculopathy with patient induced pluripotent stem cells and tissue engineering. Cell Mol Life Sci. 2019 Mar; 2018 Nov 20. PMID: 30460472

Sharma D, Jia W, Long F, Pati S, Chen Q, Qyang Y, Lee B, Choi CK, Zhao F: Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture. Bioact Mater. 2019 Dec; 2019 Feb 21. PMID: 30873506

Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y: Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering. Biomaterials. 2017 Dec; 2017 Sep 19. PMID: 28942128

Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G: mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice. Arterioscler Thromb Vasc Biol. 2017 Sep; 2017 Jul 27. PMID: 28751568

Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE: Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. Cell Transplant. 2017 Aug. PMID: 28901188

Lee HW, Chong DC, Ola R, Dunworth WP, Meadows S, Ka J, Kaartinen VM, Qyang Y, Cleaver O, Bautch VL, Eichmann A, Jin SW: Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis. Arterioscler Thromb Vasc Biol. 2017 Apr; 2017 Feb 23. PMID: 28232325

Anderson CW, Boardman N, Luo J, Park J, Qyang Y: Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies. Curr Cardiol Rep. 2017 Apr. PMID: 28324469

Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y: Implantable tissue-engineered blood vessels from human induced pluripotent stem cells. Biomaterials. 2016 Sep; 2016 Jun 14. PMID: 27336184

Schwan J, Kwaczala AT, Ryan TJ, Bartulos O, Ren Y, Sewanan LR, Morris AH, Jacoby DL, Qyang Y, Campbell SG: Anisotropic engineered heart tissue made from laser-cut decellularized myocardium. Sci Rep. 2016 Aug 30; 2016 Aug 30. PMID: 27572147

Dash BC, Levi K, Schwan J, Luo J, Bartulos O, Wu H, Qiu C, Yi T, Ren Y, Campbell S, Rolle MW, Qyang Y: Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells. Stem Cell Reports. 2016 Jul 12. PMID: 27411102

Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y: ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. JCI Insight. 2016 Jul 7. PMID: 27525311

Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM: Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. J Exp Med. 2016 Mar 7; 2016 Feb 8. PMID: 26858344

Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS: Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9. Circ Res. 2015 Jul 3; 2015 May 4. PMID: 25940550

Dash BC, Jiang Z, Suh C, Qyang Y: Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application. Biochem J. 2015 Jan 15. PMID: 25559088

Sivarapatna A, Ghaedi M, Le AV, Mendez JJ, Qyang Y, Niklason LE: Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor. Biomaterials. 2015; 2015 Mar 24. PMID: 25890758

Cagavi E, Bartulos O, Suh CY, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y: Functional cardiomyocytes derived from Isl1 cardiac progenitors via Bmp4 stimulation. PLoS One. 2014; 2014 Dec 18. PMID: 25522363

Suh CY, Wang Z, Bártulos O, Qyang Y: Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine. J Cardiovasc Pharmacol Ther. 2014 Jul; 2014 Mar 19. PMID: 24651517

Dunworth WP, Cardona-Costa J, Bozkulak EC, Kim JD, Meadows S, Fischer JC, Wang Y, Cleaver O, Qyang Y, Ober EA, Jin SW: Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos. Circ Res. 2014 Jan 3; 2013 Oct 11. PMID: 24122719

Li W, Li Q, Qin L, Ali R, Qyang Y, Tassabehji M, Pober BR, Sessa WC, Giordano FJ, Tellides G: Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency. Arterioscler Thromb Vasc Biol. 2013 May; 2013 Mar 14. PMID: 23493289

Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y: Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells. Circulation. 2012 Oct 2; 2012 Aug 22. PMID: 22914687

Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW: Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell. 2012 Aug 14. PMID: 22898784

Alcon A, Cagavi Bozkulak E, Qyang Y: Regenerating functional heart tissue for myocardial repair. Cell Mol Life Sci. 2012 Aug; 2012 Mar 3. PMID: 22388688

Hibino N, Duncan DR, Nalbandian A, Yi T, Qyang Y, Shinoka T, Breuer CK: Evaluation of the use of an induced puripotent stem cell sheet for the construction of tissue-engineered vascular grafts. J Thorac Cardiovasc Surg. 2012 Mar; 2012 Jan 12. PMID: 22244569

Amos PJ, Cagavi Bozkulak E, Qyang Y: Methods of cell purification: a critical juncture for laboratory research and translational science. Cells Tissues Organs. 2012; 2011 Oct 12. PMID: 21996576

Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y: Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells. Stem Cell Res. 2012 Jan; 2011 Aug 22. PMID: 22099020

Lee MY, Cagavi Bozkulak E, Schliffke S, Amos PJ, Ren Y, Ge X, Ehrlich BE, Qyang Y: High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells. Biochem Biophys Res Commun. 2011 Dec 9; 2011 Nov 6. PMID: 22079290

Ren Y, Lee MY, Schliffke S, Paavola J, Amos PJ, Ge X, Ye M, Zhu S, Senyei G, Lum L, Ehrlich BE, Qyang Y: Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. J Mol Cell Cardiol. 2011 Sep; 2011 May 4. PMID: 21569778

Qyang Y, Senyei G: Regeneration of a heart cell. Yale J Biol Med. 2009 Sep. PMID: 19774125

Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans SM, Ding S, Chien KR: The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 2007 Aug 16; 2007 Jun 14. PMID: 18371348

Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR: Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006 Dec 15; 2006 Nov 22. PMID: 17123592

Yang L, Cai CL, Lin L, Qyang Y, Chung C, Monteiro RM, Mummery CL, Fishman GI, Cogen A, Evans S: Isl1Cre reveals a common Bmp pathway in heart and limb development. Development. 2006 Apr. PMID: 16556916

Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S: T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development. 2005 May; 2005 Apr 20. PMID: 15843407

Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H: Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry. 2004 May 11. PMID: 15122901