Suk-Won Jin

Jin Lab

My laboratory is interested in understanding molecular and cellular mechanisms that regulate developmental and pathological angiogenesis, using zebrafish as a model system. Currently our major efforts are directed at analyzing the function of Bone Morphogenetic Protein (BMP) signaling during vascular patterning, investigating interaction between endothelial and hematopoietic lineages during development, and analyzing molecular and cellular defects of vascular specific mutations.


Karthik S, Djukic T, Kim JD, Zuber B, Makanya A, Odriozola A, Hlushchuk R, Filipovic N, Jin SW, Djonov V: Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development. Sci Rep. 2018 Jun 29; 2018 Jun 29. PMID: 29959335

Reischauer S, Stone OA, Villasenor A, Chi N, Jin SW, Martin M, Lee MT, Fukuda N, Marass M, Witty A, Fiddes I, Kuo T, Chung WS, Salek S, Lerrigo R, Alsiö J, Luo S, Tworus D, Augustine SM, Mucenieks S, Nystedt B, Giraldez AJ, Schroth GP, Andersson O, Stainier DYR: Corrigendum: Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 2018 Mar 21. PMID: 29565360

Lee HW, Jin SW: VEGFR3 as a novel modulator for PAH. Oncotarget. 2017 Oct 17; 2017 Sep 28. PMID: 29156656

Hwangbo C, Lee HW, Kang H, Ju H, Wiley DS, Papangeli I, Han J, Kim JD, Dunworth WP, Hu X, Lee S, El-Hely O, Sofer A, Pak B, Peterson L, Comhair S, Hwang EM, Park JY, Thomas JL, Bautch VL, Erzurum SC, Chun HJ, Jin SW: Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension. Circulation. 2017 Jun 6; 2017 Mar 29. PMID: 28356442

Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M: FGF-dependent metabolic control of vascular development. Nature. 2017 May 11; 2017 May 3. PMID: 28467822

Lee HW, Chong DC, Ola R, Dunworth WP, Meadows S, Ka J, Kaartinen VM, Qyang Y, Cleaver O, Bautch VL, Eichmann A, Jin SW: Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis. Arterioscler Thromb Vasc Biol. 2017 Apr; 2017 Feb 23. PMID: 28232325

Mouillesseaux KP, Wiley DS, Saunders LM, Wylie LA, Kushner EJ, Chong DC, Citrin KM, Barber AT, Park Y, Kim JD, Samsa LA, Kim J, Liu J, Jin SW, Bautch VL: Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6. Nat Commun. 2016 Nov 11; 2016 Nov 11. PMID: 27834400

Kim YS, Jeong HY, Kim AR, Kim WH, Cho H, Um J, Seo Y, Kang WS, Jin SW, Kim MC, Kim YC, Jung DW, Williams DR, Ahn Y: Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment. Sci Rep. 2016 Aug 11; 2016 Aug 11. PMID: 27510556

Reischauer S, Stone OA, Villasenor A, Chi N, Jin SW, Martin M, Lee MT, Fukuda N, Marass M, Witty A, Fiddes I, Kuo T, Chung WS, Salek S, Lerrigo R, Alsiö J, Luo S, Tworus D, Augustine SM, Mucenieks S, Nystedt B, Giraldez AJ, Schroth GP, Andersson O, Stainier DY: Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 2016 Jul 14. PMID: 27411634

Cha JJ, Park Y, Yun J, Kim HW, Park CJ, Kang G, Jung M, Pak B, Jin SW, Lee JH: Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers. Biomed Res Int. 2016; 2016 Oct 12. PMID: 27812531

So JH, Kim JD, Yoo KW, Kim HT, Jung SH, Choi JH, Lee MS, Jin SW, Kim CH: FIH-1, a novel interactor of mindbomb, functions as an essential anti-angiogenic factor during zebrafish vascular development. PLoS One. 2014; 2014 Oct 27. PMID: 25347788

Kim JD, Lee HW, Jin SW: Diversity is in my veins: role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells. Arterioscler Thromb Vasc Biol. 2014 Sep; 2014 Jul 24. PMID: 25060789

Kim JD, Jin SW: A tale of two models: mouse and zebrafish as complementary models for lymphatic studies. Mol Cells. 2014 Jul; 2014 May 23. PMID: 24854860

Sakurai T, Woolls MJ, Jin SW, Murakami M, Simons M: Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PLoS One. 2014; 2014 Mar 6. PMID: 24603875

Kim JD, Kang Y, Kim J, Papangeli I, Kang H, Wu J, Park H, Nadelmann E, Rockson SG, Chun HJ, Jin SW: Essential role of Apelin signaling during lymphatic development in zebrafish. Arterioscler Thromb Vasc Biol. 2014 Feb; 2013 Dec 5. PMID: 24311379

Dunworth WP, Cardona-Costa J, Bozkulak EC, Kim JD, Meadows S, Fischer JC, Wang Y, Cleaver O, Qyang Y, Ober EA, Jin SW: Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos. Circ Res. 2014 Jan 3; 2013 Oct 11. PMID: 24122719

Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM: Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J Clin Invest. 2013 Dec; 2013 Nov 1. PMID: 24177422

Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ: Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res. 2013 Jun 21; 2013 Apr 19. PMID: 23603510

Schmitt CE, Woolls MJ, Jin SW: Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish. Mol Cells. 2013 Feb; 2013 Feb 21. PMID: 23456338

Kim SH, Schmitt CE, Woolls MJ, Holland MB, Kim JD, Jin SW: Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development. Biochem Biophys Res Commun. 2013 Jan 25; 2012 Dec 22. PMID: 23266606

Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn EJ 3rd, Jin SW, Patterson C: LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. Circ Res. 2012 Aug 17; 2012 Jul 9. PMID: 22777006

Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW: Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell. 2012 Aug 14. PMID: 22898784

Schmitt CE, Holland MB, Jin SW: Visualizing vascular networks in zebrafish: an introduction to microangiography. Methods Mol Biol. 2012. PMID: 22222521

Wiley DM, Jin SW: Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates. Semin Cell Dev Biol. 2011 Dec; 2011 Oct 12. PMID: 22008724

Tao Y, Neppl RL, Huang ZP, Chen J, Tang RH, Cao R, Zhang Y, Jin SW, Wang DZ: The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol. 2011 Aug 22. PMID: 21859860

Wiley DM, Kim JD, Hao J, Hong CC, Bautch VL, Jin SW: Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nat Cell Biol. 2011 Jun; 2011 May 15. PMID: 21572418

Lee CY, Vogeli KM, Kim SH, Chong SW, Jiang YJ, Stainier DY, Jin SW: Notch signaling functions as a cell-fate switch between the endothelial and hematopoietic lineages. Curr Biol. 2009 Oct 13; 2009 Sep 10. PMID: 19747827

Jin SW, Patterson C: The opening act: vasculogenesis and the origins of circulation. Arterioscler Thromb Vasc Biol. 2009 May; 2008 Nov 13. PMID: 19008532

Osborne N, Brand-Arzamendi K, Ober EA, Jin SW, Verkade H, Holtzman NG, Yelon D, Stainier DY: The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Curr Biol. 2008 Dec 9. PMID: 19062281

Jin SW, Patterson C: Partners in crime: how two Sox proteins cooperate to specify arterial fate. Circ Res. 2008 Jan 4. PMID: 18174468

Jin SW, Herzog W, Santoro MM, Mitchell TS, Frantsve J, Jungblut B, Beis D, Scott IC, D'Amico LA, Ober EA, Verkade H, Field HA, Chi NC, Wehman AM, Baier H, Stainier DY: A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Dev Biol. 2007 Jul 1; 2007 Apr 5. PMID: 17531218

Scott IC, Masri B, D'Amico LA, Jin SW, Jungblut B, Wehman AM, Baier H, Audigier Y, Stainier DY: The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Dev Cell. 2007 Mar. PMID: 17336906

Vogeli KM, Jin SW, Martin GR, Stainier DY: A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula. Nature. 2006 Sep 21. PMID: 16988712

Jin SW, Beis D, Mitchell T, Chen JN, Stainier DY: Cellular and molecular analyses of vascular tube and lumen formation in zebrafish. Development. 2005 Dec; 2005 Oct 26. PMID: 16251212

Beis D, Bartman T, Jin SW, Scott IC, D'Amico LA, Ober EA, Verkade H, Frantsve J, Field HA, Wehman A, Baier H, Tallafuss A, Bally-Cuif L, Chen JN, Stainier DY, Jungblut B: Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development. 2005 Sep; 2005 Aug 17. PMID: 16107477

Bree RT, McLoughlin S, Jin SW, McMeel OM, Stainier DY, Grealy M, Byrnes L: nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafish. Biochem Biophys Res Commun. 2005 Aug 5. PMID: 15961062

Qian F, Zhen F, Ong C, Jin SW, Meng Soo H, Stainier DY, Lin S, Peng J, Wen Z: Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Dev Dyn. 2005 Jul. PMID: 15937927

Cho S, Jin SW, Cohen A, Ellis RE: A phylogeny of caenorhabditis reveals frequent loss of introns during nematode evolution. Genome Res. 2004 Jul. PMID: 15231741

Parker LH, Schmidt M, Jin SW, Gray AM, Beis D, Pham T, Frantz G, Palmieri S, Hillan K, Stainier DY, De Sauvage FJ, Ye W: The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature. 2004 Apr 15. PMID: 15085134

Ober EA, Olofsson B, Mäkinen T, Jin SW, Shoji W, Koh GY, Alitalo K, Stainier DY: Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. EMBO Rep. 2004 Jan. PMID: 14710191