The goals of the Hwa Laboratory are to decipher the roles played by the prostacyclin and thromboxane receptors (both G-protein coupled receptors) in the development of atherothrombosis. Both prostacyclin and thromboxane are arachidonic acid derivatives generated through the actions of cyclooxygenase (COX-1 and COX-2) enzymes.
A neutrophil activation signature predicts critical illness and mortality in COVID-19.Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun H. medRxiv. 2020 Sep 2; 2020 Sep 2. PMID: 32908988.