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Daniel Greif

  • Daniel Greif

    Associate Professor Tenure

    Research Interests
    • Aorta
    • Aortic Stenosis, Subvalvular
    • Cardiology
    • Cerebral Hemorrhage
    • Hypertension, Pulmonary
    • Pulmonary Fibrosis
    • Vascular Diseases
    • Developmental Biology
    • Atherosclerosis
    • Myofibroblasts

Greif Lab

My laboratory investigates blood vessel morphogenesis, the maintenance of the adult blood vessel and diseases of the vasculature. To this end, we utilize fundamental biochemical, genetic and developmental biological approaches, including lineage and clonal analyses. We initially investigated the origins of the smooth muscle and adventitial cells of the pulmonary artery and have delineated with cellular resolution the patterns of cell differentiation, proliferation, recruitment and migration in the developing pulmonary arterial wall. Furthermore, we have initiated a genetic dissection of the molecular processes and signals that underlie blood vessel formation and have demonstrated a role of the platelet derived growth factor pathway in this process.