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Joseph Brennan, MD, BS

Professor of Clinical Medicine (Cardiovascular Medicine); Firm Chief- Coronary Intensive Care Unit (CICU), Internal Medicine; Director, Interventional Cardiology Fellowship Program, Internal Medicine; Medical Director, Coronary Intensive Care Unit, Yale-New Haven Hospital, Yale Medicine; Director, Inpatient Cardiology Services, Yale Medicine

Contact Information

Joseph Brennan, MD, BS

Patient Care Locations

Mailing Address

  • Cardiovascular Medicine

    PO Box 208056

    New Haven, CT 06520-8056

    United States



I have been a member of the Section of Cardiovascular Medicine since completion of Cardiology fellowship in 1989. My primary interest has been clinical cardiology particularly in the areas of both Intensive Care Cardiology (serving as Medical Director of the CICU) as well as Interventional cardiology (serving as the Fellowship Director of the Interventional Cardiology Fellowship for the past 20 yrs). I have been the recipient of innumerable teaching awards both within the Yale Medical School as well as the Department of Medicine/Section of Cardiology.

Education & Training

  • Fellow
    Yale New Haven Hospital (1990)
  • Chief Resident
    Yale New Haven Hospital (1987)
  • Resident
    Yale New Haven Hospital (1986)
  • MD
    Medical College of Virginia (1983)
  • BS
    College of William and Mary, Biology (1978)


  • CRT
    Washington, United States 2019
    Speaker- Fellowship Directors Symposium
  • Physician Education
    Havana, Cuba; Saint Petersburg, Russia; Dalian, China; Moschi, Tanzania; Dechapelle, Haiti (1985-2016)
    Have served in multiple areas around the world both during medical residency as well as a faculty member

Honors & Recognition

AwardAwarding OrganizationDate
Fred Kantor Internal Medicine Residency Teaching AwardYale University2020
Leonard Tow Humanism in Medicine Award2017
Teacher of the Year Yale Primary Care Residency2015
Master Clinician Yale Primary Care Residency2015
Consultant of the Year Given by ED Residents2013
Teacher of the Year Cardiology Section2012
Nurses Choice Award2012
Teacher of the Year Yale Traditional Internal Medicine Residency2011
"Top Docs"Connecticut Magazine2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019
Fellow, Society of Coronary Angiography and Interventions (SCAI)2005
Connecticut State Medical Society (CSMS)2005
Inaugaral Faculty Award for Clinical Care- Dept. of Internal Medicine2004
Society of Distinguished Teachers- Yale University School of MedicineYale University2000
Outstanding House Staff Award- Given by Graduating Medical School Class (YSM)1987
Alpha Omega Alpha- Medical Honor SocietyVCU/MCV1982
Phi Beta KappaThe College of William and Mary1976

Professional Service

Department of Internal MedicineFacilitator/participant in Department of Internal Medicine's Medical Error Disclosure and Critical Conversations Panel.2019 - Present
Department of Internal Medicine-Section of Cardiovascular DiseaseServed as member of a clinical redesign committee within the Section of Cardiovascular Disease which had been tasked to redesign the large inpatient cardiac service.2018 - 2019
Department of Internal Medicine-RISE (Resilience,Innovation and Sustainable Excellence) FacultyDiscussant/Presenter/Facilitator at Workshops for new "hires" in Department of Internal Medicine at New Faculty Orientation.2018 - Present
Clinical Events Committee- LAAO Registry. Identifier: NCT02699957Chair of committee to adjudicate events The Left Atrial Appendage Occlusion Registry (LAAO Registry™) is designed to assess the prevalence, demographics, management, and outcomes of patients undergoing percutaneous and epicardial based left atrial appendage occlusion procedures to reduce the risk of stroke. Patient-level data will be submitted by participating hospitals on a quarterly basis to the American College of Cardiology Foundation's National Cardiovascular Data Registry (NCDR). The primary aims of the LAAO Registry are to optimize the outcomes and management of patients through the implementation of evidence-based guideline recommendations in clinical practice, facilitate efforts to improve the quality and safety for patients undergoing percutaneous and epicardial based left atrial appendage procedures, investigate novel quality improvement methods and provide risk-adjusted assessment of patients for comparison with nationwide NCDR data.2018 - Present
Clinical Event Committee-REFLECT Trial. Identifier: NCT02536196Serving as member of Clinical Event Committee (CEC) for REFLECT Trial, adjudicating all outcome events for this large trial.The Keystone Heart TriGuard™ HDH is an aortic embolism deflection device intended to reduce the amount of embolic material that may enter the carotid, subclavian, and vertebral arteries during transcatheter heart valve implantation. The objective of the study is to assess the safety and efficacy of the TriGuard™ HDH embolic deflection device in patients undergoing transcatheter aortic valve implantation (TAVI), in comparison with an active control group of patients undergoing unprotected TAVI.2018 - 2019
Clinical Events Committee-YALE NeuroTAVR - Neurological Complications of Contemporary Unprotected TAVR (Yale Neuro TAVR). Sponsor: Keystone Heart. Identifier: NCT02073864. A prospective, multi-center study enrolling a minimum of 20 up to a maximum of 80 patients at up to six (6) investigational sites in the United States and European Union.Member, Clinical Events Committee to adjudicate neurologic and other clinical events associated with TAVR.2017 - Present
Clinical Events Committee-BIOHELIX I. Bare Metal Stent Study. Sponsor: Biotronik. Identifier: NCT01612767Adjudicated end point and clinical events for the investigational BIOTRONIK PRO-Kinetic Energy stent in subjects with atherosclerotic disease of native coronary arteries2017 - 2018
Clinical Events Committee-Disrupt CAD I - Prospective Multi-Center, Single Arm Study of the Shockwave Coronary Rx Lithoplasty® System in Coronary Arteries Lithoplasty Study. Sponsor: Shockwave Medical Inc, Identifier: NCT02650128.Member, Clinical Events Committee to adjudicate events related to Lithoplasty device in coronary arteries.2017 - 2018
Hearts Around the WorldServed as physician liaison in Havana, Cuba2016
Clinical Events Committee-RESTORE II Trial-ReZolve2™ Sirolimus-Eluting Bioresorbable Coronary Scaffold. Sponsor: REVA Medical. Clinical Identifier: NCT01845311. A prospective, multi-center, safety and performance study with a study population consisting of patients with clinical evidence of myocardial ischemia or a positive functional study. A maximum of 125 patients were to be enrolled into the studyMember, Clinical Events Committee to adjudicate clinical events in study invoving a bioabsorbable coronary scaffold.2016 - Present
WTNH New Haven Channel 8Presenter/Speaker2016
Clinical Events Committee-SHOCKWAVE Coronary Rx Lithoplasty Study. Sponsor: Shockwave Medical Inc, Identifier: NCT02650128Adjudicated end point and clinical events for Prospective, multi-center, single arm study designed to evaluate the safety and performance of the Shockwave Coronary Rx Lithoplasty® System to treat calcified lesions in the coronary arteries for the purpose of enhancing the placement of stents and reducing the ultimate residual stenosis.2016 - 2018
Clinical Events Committee-FANTOM II Trial: FANTOM Sirolimus-Eluting Bioresorbable Coronary Scaffold. Sponsor: REVA Medical. Identifier: NCT02539966Adjudicated end point and clinical events for Fantom Bioresorbable Coronary Scaffold in native coronary arteries2015 - 2017
Yale University School of Medicine, Department of Internal MedicineMember of Department of Medicine's Clinical Chiefs/Directors Committee- met quarterly.2015 - 2019
Yale New Haven Hospital-ICU Leadership CommitteeICU leadership Committee2015 - Present
Yale University School of Medicine- Department of Internal Medicine/Section of Cardiovascular Disease.Member of the Section of Cardiovascular Medicine' s Clinical Competency Committee (CCC).2015 - Present
Clinical Event Committee-ABLATE Trial (Atherectomy by Laser Ablation With Turbo-Elite (ABLATE) Sponsor: Spectranetics Corporation. Identifier: NCT02307370Chair of Clinical events Committee for trial employing Spectranetics Laser treatment of PAD of infra-inguinal arteries.2014 - 2017
Hearts Around the WorldServed as physician liasion in Dalian, China2014
Clinical Events Committee- DEFLECT III Trial. A prospective, randomized, multicenter, non-powered, safety, efficacy, and performance trial will enroll up to 86 evaluable subjects and up to 15 roll-in subjects at up to 15 investigational sites in Europe and Israel. Sponsor: Keystone Heart. Clinical Identifier: NCT02070731.Served as member of committee to adjudicate clinical events related to a neuro-protective device for TAVRs.2014 - 2015
Clinical Events Committee-SALUS. Transcatheter Aortic Valve Replacement System Pivotal trial. Sponsor: Direct Flow. Identifier: NCT02163850.Adjudicated clinical events for a new Transcatheter Aortic valve (Direct Flow)2013 - 2016
Clinical Events Committee-DEFLECT I Trial. SMT Embolic DEFLECTion CE Mark Trial. A Study to Evaluate the Safety and Performance of the TriGuard™HDH in Patients Undergoing TAVR. Sponsor: Keystone Heart. Clinical Identifier:. NCT01448421. A prospective, multi-center, single arm feasibility study designed to assess the safety and performance of the SMT device among patients undergoing TAVR procedures.Adjudicated adverse events in feasibility study of cerebral embolic protection device for patients undergoing TAVR.2013 - 2014
Yale New Haven Hospital-YNHH Hospitalist Advisory CommitteeMember of YNHH Hospitalist Advisory Committee2013 - Present
Yale New Haven Hospital-YNHH Medical Directors Leadership CommitteeMember of YNHH Medical Directors Leadership Committee2013 - Present
YNHH-HVC Patient Experience ForumCo-Chair HVC Paytient Experience Forum2013 - Present
YNHH-HVC Operations CommitteeHVC Operations Council2013 - Present
Yale University School of Medicine-YSM Cardiology ElectivesServed as Director of YSM Student Electives in Section of Cardiovascular Medicine2011 - Present
YNHH-Therapeutic Hypothermia CommitteeMember, Therapeutic Hypothermia Committee-YNHH2010 - Present
YNHH-Chest Pain Reaccreditation CommitteeMember, Chest Pain Center Reaccreditaion Committee2010 - Present
YNHH-D2B CommitteeMember, YNHH D2B Committee2008 - Present
Hearts Around the WorldServed as Physician liasion in St. Petersburg, Russia2005

Departments & Organizations