Professor of Surgery (Cardiac); Division Chief, Cardiac Surgery, Surgery
Advanced Heart Failure and Transplant
Directed by Tariq Ahmad MD, MPH, FACC, in collaboration with surgical director Arnar Geirsson, MD, the Advanced Heart Failure Program provides a comprehensive, multidisciplinary approach to caring for patients with end-stage heart failure.
Heart Transplantation
Since 2018, the cardiac transplant program has performed on par with any other top program in the country. More patients are receiving their heart transplants at Yale than at any time in the past, and we are as busy, if not busier, than any other cardiac transplant program in New England. In addition to performing a large number of heart transplants, our program has worked to expand access to donations through methods such as “donation after cardiovascular death,” the use of Hepatitis C NAT+ donors, and through desensitization efforts of patients highly sensitized to potential donor antigens. Our group is active in outcomes research in this population as well.
Left Ventricular Assist Device Implantation
Fellowship Training Program
Comprehensive Heart Failure Program
Led by the interim director Tariq Ahmad MD, MPH, FACC, the Comprehensive Heart Failure Program comprises of a number of out-patient and in-patient initiatives dedicated to producing high quality outcomes for all types of heart failure patients.
The Heart Failure Population Health Program is a clinical care network which extends across the Connecticut shoreline, from Greenwich in the west to New London in the east. Our group utilizes a variety of technologies for monitoring the health of our heart failure patients in the community, and we have several Heart Failure Disease Management clinics open to drive the medical care of patients with newly diagnosed heart failure or recent hospital admissions.
Directed by Daniel Jacoby, MD, the Inherited Cardiomyopathy Program includes clinics staffed with clinicians whom are experts in diseases such as hypertrophic cardiomyopathy and arrhythmogenic cardiomyopathy. Cardiomyopathy clinics which focus on acquired disease such as cardiac sarcoidosis and cardiac amyloidosis also exist. Finally, directed by Robert Elder, MD, the Adult Congenital Heart Disease Program acts as a clinical care bridge for the pediatric patient with heart disease as they age and mature into adulthood.
Heart Failure Research
Directed by Jeffrey Testani, MD, MTR, members of our group are active in many forms investigational scientific and clinical research. Areas of interest include diuretic therapies - not only loop diuretics but also SGLT-2 inhibitors, digital tools to assess heart failure population risk and predicted patient outcomes, new medical therapies for hypertrophic cardiomyopathy and TTR cardiac amyloidosis, as well as endeavors to expand the heart transplant donor pool. Our investigators also have the opportunity to partner with the immense talent available through the Yale School of Medicine’s Center for Outcomes Research and Evaluation (CORE) and the Yale Cardiovascular Research Group.
Publications
2022
- Sarcomere protein modulation: The new frontier in cardiovascular medicine and beyond.Morelli C, Ingrasciotta G, Jacoby D, Masri A, Olivotto I. Eur J Intern Med. 2022 May 6; 2022 May 6. PMID: 35534374.
- Sleep Characteristics, Mood, Somatic Symptoms, and Self-Care Among People With Heart Failure and Insomnia.Breazeale S, Jeon S, Hwang Y, O'Connell M, Nwanaji-Enwerem U, Linsky S, Yaggi HK, Jacoby DL, Conley S, Redeker NS. Nurs Res. 2022 May-Jun 01. PMID: 35149627.
- Rates of In-hospital Decongestion and Association with Mortality and Cardiovascular Outcomes among Patients admitted for Acute Heart Failure.McCallum W, Tighiouart H, Testani JM, Griffin M, Konstam MA, Udelson JE, Sarnak MJ. Am J Med. 2022 Apr 23; 2022 Apr 23. PMID: 35472391.
- Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy.Riaz M, Park J, Sewanan LR, Ren Y, Schwan J, Das SK, Pomianowski PT, Huang Y, Ellis MW, Luo J, Liu J, Song L, Chen IP, Qiu C, Yazawa M, Tellides G, Hwa J, Young LH, Yang L, Marboe CC, Jacoby DL, Campbell SG, Qyang Y. Circulation. 2022 Apr 19; 2022 Apr 6. PMID: 35384713.
- Symptom Cluster Profiles Among Adults with Insomnia and Heart Failure.Conley S, Jeon S, Breazeale S, O'Connell M, Hollenbeak CS, Jacoby D, Linsky S, Yaggi HK, Redeker NS. Behav Sleep Med. 2022 Apr 7; 2022 Apr 7. PMID: 35388730.
- Risk and predictors of mortality after implantable cardioverter-defibrillator implantation in patients with sarcoid cardiomyopathy.Higgins AY, Annapureddy AR, Wang Y, Minges KE, Bellumkonda L, Lampert R, Rosenfeld LE, Jacoby DL, Curtis JP, Miller EJ, Freeman JV. Am Heart J. 2022 Apr; 2021 Dec 27. PMID: 34968442.
- Renal effects of guideline-directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology.Mullens W, Martens P, Testani JM, Tang WHW, Skouri H, Verbrugge FH, Fudim M, Iacoviello M, Franke J, Flammer AJ, Palazzuoli A, Barragan PM, Thum T, Marcos MC, Miró Ò, Rossignol P, Metra M, Lassus J, Orso F, Jankowska EA, Chioncel O, Milicic D, Hill L, Seferovic P, Rosano G, Coats A, Damman K. Eur J Heart Fail. 2022 Apr; 2022 Mar 27. PMID: 35239201.
- The impact of induction therapy on mortality and treated rejection in cardiac transplantation: A retrospective study.Bellumkonda L, Oikonomou EK, Hsueh C, Maulion C, Testani J, Patel J. J Heart Lung Transplant. 2022 Apr; 2022 Jan 19. PMID: 35094919.
- Automated multilabel diagnosis on electrocardiographic images and signals.Sangha V, Mortazavi BJ, Haimovich AD, Ribeiro AH, Brandt CA, Jacoby DL, Schulz WL, Krumholz HM, Ribeiro ALP, Khera R. Nat Commun. 2022 Mar 24; 2022 Mar 24. PMID: 35332137.
- Inferior Vena Cava Diameter Measurement Provides Distinct and Complementary Information to Right Atrial Pressure in Acute Decompensated Heart Failure.Griffin M, Ivey-Miranda J, McCallum W, Sarnak M, Eder M, Bellumkonda L, Maulion C, Wilson FP, Rao VS, Testani J. J Card Fail. 2022 Mar 14; 2022 Mar 14. PMID: 35301109.
- Variability in Blood Pressure Assessment in Patients Supported with the HeartMate 3TM.Cowger JA, Estep JD, Rinde-Hoffman DA, Givertz MM, Anderson AS, Jacoby D, Chen L, Brieke A, Mahr C, Hall S, Ewald GA, Dirckx N, Baker AT, Pinney SP. ASAIO J. 2022 Mar 1. PMID: 34172641.
- Evidence-Based Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease.Beldhuis IE, Lam CSP, Testani JM, Voors AA, Van Spall HGC, Ter Maaten JM, Damman K. Circulation. 2022 Mar; 2022 Feb 28. PMID: 35226558.
- Changes in inferior vena cava area represent a more sensitive metric than changes in filling pressures during experimental manipulation of intravascular volume and tone.Ivey-Miranda JB, Wetterling F, Gaul R, Sheridan S, Asher JL, Rao VS, Maulion C, Mahoney D, Mebazaa A, Gray AP, Burkhoff D, Cowie MR, Cox ZL, Butler J, Fudim M, McDonald K, Damman K, Borlaug BA, Testani JM. Eur J Heart Fail. 2022 Mar; 2022 Jan 11. PMID: 34837447.
- Renal Hemodynamics and Renin-Angiotensin-Aldosterone System Profiles in Patients With Heart Failure.Lytvyn Y, Burns KD, Testani JM, Lytvyn A, Ambinathan JPN, Osuntokun O, Godoy LC, Cherney DZI, Parker JD. J Card Fail. 2022 Mar; 2021 Sep 4. PMID: 34487814.
- Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy.Baker ML, Yamamoto Y, Perazella MA, Dizman N, Shirali AC, Hafez N, Weinstein J, Simonov M, Testani JM, Kluger HM, Cantley LG, Parikh CR, Wilson FP, Moledina DG. J Immunother Cancer. 2022 Mar. PMID: 35354588.
- The Yale Roadmap for Health Psychology and Integrated Cardiovascular Care.Gaffey AE, Harris KM, Mena-Hurtado C, Sinha R, Jacoby DL, Smolderen KG. Health Psychol. 2022 Feb 24; 2022 Feb 24. PMID: 35201804.
- Arabidopsis EARLY FLOWERING 3 controls temperature responsiveness of the circadian clock independently of the evening complex.Zhu Z, Quint M, Anwer MU. J Exp Bot. 2022 Jan 27. PMID: 34698833.
- Noonan syndrome and pregnancy outcomes.Chow CA, Campbell KH, Chou JC, Elder RW. Cardiol Young. 2022 Jan 17; 2022 Jan 17. PMID: 35034678.
- Cognitive behavioral therapy for insomnia has sustained effects on insomnia, fatigue, and function among people with chronic heart failure and insomnia: the HeartSleep Study.Redeker NS, Yaggi HK, Jacoby D, Hollenbeak CS, Breazeale S, Conley S, Hwang Y, Iennaco J, Linsky S, Nwanaji-Enwerem U, O'Connell M, Jeon S. Sleep. 2022 Jan 11. PMID: 34657160.
- Does foreign direct investment asymmetrically affect the mitigation of environmental degradation in Malaysia?Faheem M, Hussain S, ArsalanTanveer, Safdar N, Anwer MA. Environ Sci Pollut Res Int. 2022 Jan; 2021 Sep 2. PMID: 34476703.
Faculty
Associate Professor of Medicine; Medical Director of Advanced Heart Failure, Cardiovascular Medicine; Chief, Heart Failure Program
Assistant Professor of Surgery (Cardiac); Director Mechanical circulatory support and ECMO, Cardiac Surgery; Associate Director Heart Transplant, Cardiac Surgery
Assistant Professor; Program Director, Advanced Heart Failure Fellowship Program; Director, Cardio-Obstetrics; Co-Director, Maternal Cardiology
Assistant Professor of Clinical Medicine; Physician Advisor, Yale-New Haven Hospital; Associate Director, Cardiac Catheterization Laboratory; Associate Clinical Professor of Medicine, Yale School of Medicine
Associate Professor of Medicine; Director of Heart Failure Research, Cardiovascular Medicine; Co-Director Heart & Vascular Center Clinical Research, Heart & Vascular Center