Jana Zielonka, MD
InstructorAbout
Research
Publications
2026
Integrated molecular networks reveal latent components distinguishing type 2-high and type 2-low asthma
Ramirez M, Diaz M, Wang N, Liu Q, Li H, Kay S, Shuguli M, Zielonka J, Wilson G, Sauler M, Wang Z, Yan X, Chupp G, Gomez J. Integrated molecular networks reveal latent components distinguishing type 2-high and type 2-low asthma. BMJ Open Respiratory Research 2026, 13: e004003. PMID: 42150795, PMCID: PMC13185048, DOI: 10.1136/bmjresp-2025-004003.Peer-Reviewed Original ResearchConceptsT2-high endotypeT2-low asthmaT2-lowT2-highClinical managementAsthma endotypesClinical management of patientsT2-low endotypeFractional exhaled nitric oxideType 2 inflammationSmooth muscle contractionManagement of patientsEndotypes of asthmaExhaled Nitric OxideSmooth muscle pathwaysCohort of subjectsStudy populationTreatment optionsBlood eosinophilsEndotypesBenralizumabClinical relevancePatient samplesMuscle pathwaysAsthmaSkin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis
Zielonka J, Li N, Liu Y, Yan X, Wang Z, Ramirez M, Figueroa A, Korde A, Yin H, Britto C, Singh I, Sun H, Herzog E, Feghali‐Bostwick C, Hinchcliff M, Ryu C, Gomez J. Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis. Arthritis & Rheumatology 2026 PMID: 41930625, DOI: 10.1002/art.70163.Peer-Reviewed Original ResearchSSc-ILDSystemic sclerosisStromal cellsMultiorgan involvementSSc-related interstitial lung diseaseKRAS pathwaySevere multiorgan involvementSystemic sclerosis skinInterstitial lung diseaseCutaneous signaturesLung involvementDysregulated immunityCause of deathGene Set Enrichment AnalysisImmune cellsProgressive fibrosisSkin fibrosisLung fibrosisSingle-cell RNA sequencingLung diseaseMicrovascular damageLung impairmentLung functionGene correlation analysisKRAS
2025
Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation
Yu S, Hu B, Sun Y, Peng X, Lee C, Woo S, McGovern J, Zielonka J, Saber T, Ghincea A, Gandhi S, Walia A, Pivarnik T, Ishikawa G, Shao S, Sun H, Gunes B, Kujawski S, Perez S, Odell W, Hinchcliff M, Varga J, Feghali-Bostwick C, Sauler M, Gomez J, Ryu C, Herzog E. Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation. European Respiratory Journal 2025, 66: 2401564. PMID: 40374521, PMCID: PMC12332468, DOI: 10.1183/13993003.01564-2024.Peer-Reviewed Original ResearchPrecision cut lung slicesSSc-ILD lung tissuesType 1 interferonSSc-ILDProduction of cytokinesBronchoalveolar lavageHuman precision cut lung slicesLung tissueLung fibroblastsLungs of patientsInterstitial lung diseasePulmonary fibrosis modelBleomycin mouse modelIsolated lung fibroblastsCultured fibroblastsPerturbs innate immunityFibrotic stimuliSingle cell RNA sequencing datasetsSystemic sclerosisHuman lung fibroblastsLung diseaseMouse modelCyclic GMP-AMP synthaseFibrosis modelTherapeutic approaches
2024
Identification of Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Subgroups by Machine Learning Implementation in Electronic Health Records.
Li H, Huston J, Zielonka J, Kay S, Sauler M, Gomez J. Identification of Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Subgroups by Machine Learning Implementation in Electronic Health Records. Chronic Obstructive Pulmonary Diseases Journal Of The COPD Foundation 2024, 11: 611-623. PMID: 39423339, PMCID: PMC11703024, DOI: 10.15326/jcopdf.2024.0556.Peer-Reviewed Original ResearchElectronic health recordsMachine learningAcute exacerbation of COPDAdoption of electronic health recordsHealth recordsMachine learning implementationElectronic health record dataImplementation of MLEHR-derived dataML implementationChronic obstructive pulmonary disease subgroupCOVID-19 cohortSevere acute exacerbation of COPDClinical careExacerbation of COPDAcute exacerbationRetrospective cohort of patientsLearning implementationSeverity of acute exacerbations of COPDMachineRelevant subgroupsRetrospective cohortImplementationCohortCohort of patients