2012
Transferability of Aliphatic Isocyanates from Recently Applied Paints to the Skin of Auto Body Shop Workers
De Vries TT, Bello D, Stowe MH, Harari H, Slade MD, Redlich CA. Transferability of Aliphatic Isocyanates from Recently Applied Paints to the Skin of Auto Body Shop Workers. Journal Of Occupational And Environmental Hygiene 2012, 9: 699-711. PMID: 23067057, DOI: 10.1080/15459624.2012.728893.Peer-Reviewed Original ResearchConceptsSkin exposureSkin samplesAuto body shop workersOccupational asthmaIsocyanate asthmaCommon causeSkin wipesGreater riskSkin contactPotent sensitizerInitial sampling timeShop workersPositive samplesAsthmaAuto body shopsHigh-performance liquid chromatographyExposureCross-linking chemicalsRiskGeometric meanLiquid chromatographyBiomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG
Wisnewski AV, Stowe MH, Nerlinger A, Opare-addo P, Decamp D, Kleinsmith CR, Redlich CA. Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG. Annals Of Work Exposures And Health 2012, 56: 901-910. PMID: 22449630, PMCID: PMC3471419, DOI: 10.1093/annhyg/mes024.Peer-Reviewed Original ResearchConceptsPersonal protective equipmentSkin exposureExposure surveillanceSpecific serum immunoglobulin GHexamethylene diisocyanate exposureSerum IgG levelsSerum immunoglobulin GNight shift workEnzyme-linked immunosorbentAdverse health effectsAsthma historyDiisocyanate exposureIgG levelsSerum levelsIgG titersChemical allergensPPE useImmune responseRespirator useIsocyanate exposureExposure biomarkersPractical biomarkersBasic demographicsHigh titersHygiene efforts
2008
Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: II. A Quantitative Assessment
Bello D, Redlich CA, Stowe MH, Sparer J, Woskie SR, Streicher RP, Hosgood HD, Liu Y. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: II. A Quantitative Assessment. Annals Of Work Exposures And Health 2008, 52: 117-124. PMID: 18209009, DOI: 10.1093/annhyg/mem066.Peer-Reviewed Original ResearchConceptsSkin exposureUnprotected skinAuto body shop workersAuto Body RepairRespiratory exposureSkin areasExposure dataShop workersSkin samplingSkinExposureWipe samplesUnpaired samplesHigh concentrationsPPEGm loadYale studyHigh levelsBody repairAsthmaMajor contributorLevelsQuantitative assessmentForearmSensitization
2007
Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: A Qualitative Assessment
LIU Y, BELLO D, SPARER JA, STOWE MH, GORE RJ, WOSKIE SR, CULLEN MR, REDLICH CA. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: A Qualitative Assessment. Annals Of Work Exposures And Health 2007, 51: 429-439. PMID: 17602207, DOI: 10.1093/annhyg/mem021.Peer-Reviewed Original ResearchConceptsAuto body shop workersSkin exposureHigh-performance liquid chromatographyShop workersHigher positive rateAuto Body RepairPositive surface samplesPositive sample rateEpidemiologic studiesUnprotected skinRespiratory exposurePercent of samplesSensitive high-performance liquid chromatographyLatex glovesScale 0Exposure dataExposure determinantsSkin samplesQuantitative high-performance liquid chromatographyNational InstituteOccupational SafetyAuto body shopsExposureMajor determinantPositive rateSlow Curing of Aliphatic Polyisocyanate Paints in Automotive Refinishing: A Potential Source for Skin Exposure
Bello D, Sparer J, Redlich CA, Ibrahim K, Stowe MH, Liu Y. Slow Curing of Aliphatic Polyisocyanate Paints in Automotive Refinishing: A Potential Source for Skin Exposure. Journal Of Occupational And Environmental Hygiene 2007, 4: 406-411. PMID: 17474030, DOI: 10.1080/15459620701341199.Peer-Reviewed Original Research
2006
Respiratory Protection from Isocyanate Exposure in the Autobody Repair and Refinishing Industry
Liu Y, Stowe MH, Bello D, Woskie SR, Sparer J, Gore R, Youngs F, Cullen MR, Redlich CA. Respiratory Protection from Isocyanate Exposure in the Autobody Repair and Refinishing Industry. Journal Of Occupational And Environmental Hygiene 2006, 3: 234-249. PMID: 16574607, DOI: 10.1080/15459620600628704.Peer-Reviewed Original ResearchConceptsWorkplace protection factorsIsocyanate exposureHalf-facepiece respiratorsRespiratory protectionFit factorsRespiratory protection programTotal isocyanate groupRespirator Fit FactorsOrganic vapor cartridgesShort-term exposure limitNegative pressureGM concentrationsPriming activitySignificant differencesExposure limitsUse trainingExposureRespiratorsProtection factorSecond testWorkersPortaCount
2004
Isocyanate Exposures in Autobody Shop Work: The SPRAY Study
Sparer J, Stowe MH, Bello D, Liu Y, Gore RJ, Youngs F, Cullen MR, Redlich CA, Woskie SR. Isocyanate Exposures in Autobody Shop Work: The SPRAY Study. Journal Of Occupational And Environmental Hygiene 2004, 1: 570-581. PMID: 15559329, DOI: 10.1080/15459620490485909.Peer-Reviewed Original ResearchConceptsIsocyanate exposurePersonal air samplesTypes of glovesRespiratory sensitizationEpidemiologic studiesTypes of respiratorsU.K. guidelinesSkin contactAutobody shopsSubstantial exposureAir respiratorsNational InstituteOccupational SafetyRespiratorsCartridge respiratorsPersonal samplesExposure limitsMedian concentrationsExposureUnited Kingdom HealthSealerHealthGuidelinesPercentAsthmaDeterminants of Isocyanate Exposures in Auto Body Repair and Refinishing Shops
Woskie S, Sparer J, Gore R, Stowe M, Bello D, Liu Y, Youngs F, Redlich C, Eisen E, Cullen M. Determinants of Isocyanate Exposures in Auto Body Repair and Refinishing Shops. Annals Of Work Exposures And Health 2004, 48: 393-403. PMID: 15148052, DOI: 10.1093/annhyg/meh021.Peer-Reviewed Original Research
2002
Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up
Redlich CA, Stowe MH, Coren BA, Wisnewski AV, Holm CT, Cullen MR. Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up. American Journal Of Industrial Medicine 2002, 42: 511-518. PMID: 12439874, DOI: 10.1002/ajim.10143.Peer-Reviewed Original ResearchConceptsHealthy worker effectAuto body shop workersWorker effectHexamethylene diisocyanate exposureHistory of asthmaLower asthma prevalenceCross-sectional studyDiisocyanate exposureOccupational asthmaAsthma prevalenceImmunologic responseLow prevalenceAsthmaOne-yearHigh job turnover ratesShop workersEpisodic exposureSignificant differencesAuto body shopsPrevalenceEffect of HDISignificant changesExposureSymptomsIgG
2001
Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers
Redlich C, Stowe M, Wisnewski A, Eisen E, Karol M, Lemus R, Holm C, Chung J, Sparer J, Liu Y, Woskie S, Appiah‐Pippim J, Gore R, Cullen M. Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers. American Journal Of Industrial Medicine 2001, 39: 587-597. PMID: 11385643, DOI: 10.1002/ajim.1058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAir Pollutants, OccupationalAnalysis of VarianceAsthmaAutomobilesChi-Square DistributionCross-Sectional StudiesCyanatesEpidemiologic StudiesFemaleHumansIsocyanatesMaleMiddle AgedOccupational DiseasesOccupational ExposurePaintStatistics, NonparametricSurveys and QuestionnairesConceptsAuto body shop workersDiisocyanate asthmaLymphocyte proliferationHost risk factorsShortness of breathShop workersMethacholine responsivenessMethacholine challengeChest tightnessDiisocyanate exposureOccupational asthmaImmunologic responseRisk factorsPhysiologic changesImmune responseEpidemiologic studiesSurveillance studyPhysiologic responsesAsthmaOvert casesSymptomsExposure dataEpisodic exposureAuto body shopsExposure
1996
Feasibility Study of Respiratory Questionnaire and Peak Flow Recordings in Autobody Shop Workers Exposed to Isocyanate-containing Spray Paint: Observations and Limitations
Cullen M, Redlich C, Beckett W, Weltmann B, Sparer J, Jackson G, Ruff T, Rubinstein E, Holden W. Feasibility Study of Respiratory Questionnaire and Peak Flow Recordings in Autobody Shop Workers Exposed to Isocyanate-containing Spray Paint: Observations and Limitations. Occupational Medicine 1996, 46: 197-204. PMID: 8695771, DOI: 10.1093/occmed/46.3.197.Peer-Reviewed Original ResearchConceptsOccupational asthmaAirway symptomsWork-related asthmaAutobody shopsPeak flow recordingsClinical epidemiological studiesNew Haven areaCross-sectional surveyRespiratory QuestionnaireIncidence rateHigh prevalenceSpray paintersEpidemiological studiesLower riskAsthmaFlow recordingsSymptomsExposure classificationSubject complianceClear associationQuestionnaire responsesRecord dataRegular useShop workersOffice workers
1992
Morphologic, biochemical, and cytogenetic studies of bone marrow and circulating blood cells in painters exposed to ethylene glycol ethers
Cullen M, Solomon L, Pace P, Buckley P, Duffy T, McPhedran P, Kelsey K, Redlich C. Morphologic, biochemical, and cytogenetic studies of bone marrow and circulating blood cells in painters exposed to ethylene glycol ethers. Environmental Research 1992, 59: 250-264. PMID: 1425515, DOI: 10.1016/s0013-9351(05)80244-0.Peer-Reviewed Original ResearchConceptsBone marrowPrevious cross-sectional surveySubclinical disease markersPossible etiologic rolePotential risk factorsBone marrow injuryGroup of controlsReduced glutathione levelsCross-sectional surveyCytogenetic studiesPeripheral red cellsRed cell studiesShipyard paintersMetabolic abnormalitiesClinical statusAbnormal countsHematologic abnormalitiesHistopathologic examinationEtiologic roleMarrow histologyMarrow morphologyRisk factorsMild anemiaPeripheral lymphocytesMarrow injury
1990
Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide
Redlich C, West A, Fleming L, True L, Cullen M, Riely C. Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide. Gastroenterology 1990, 99: 748-757. PMID: 2379779, DOI: 10.1016/0016-5085(90)90964-3.Peer-Reviewed Original ResearchConceptsToxic liver injuryLiver injuryDisulfiram-type reactionsFocal hepatocellular necrosisSmooth endoplasmic reticulumProminent smooth endoplasmic reticulumAbnormal aminotransferasesAbdominal painBiopsy findingsClinical characteristicsEnzyme elevationLiver biopsyPleomorphic mitochondriaAcute injuryHepatocellular necrosisMicrovesicular steatosisBiopsy histologyMacrovesicular steatosisPathological characteristicsOccupational exposureAlanine aminotransferaseOccupational historyLonger exposureInjuryAminotransferase