2012
Transferability of Aliphatic Isocyanates from Recently Applied Paints to the Skin of Auto Body Shop Workers
De Vries TT, Bello D, Stowe MH, Harari H, Slade MD, Redlich CA. Transferability of Aliphatic Isocyanates from Recently Applied Paints to the Skin of Auto Body Shop Workers. Journal Of Occupational And Environmental Hygiene 2012, 9: 699-711. PMID: 23067057, DOI: 10.1080/15459624.2012.728893.Peer-Reviewed Original ResearchConceptsSkin exposureSkin samplesAuto body shop workersOccupational asthmaIsocyanate asthmaCommon causeSkin wipesGreater riskSkin contactPotent sensitizerInitial sampling timeShop workersPositive samplesAsthmaAuto body shopsHigh-performance liquid chromatographyExposureCross-linking chemicalsRiskGeometric meanLiquid chromatographySkin symptoms in bakery and auto body shop workers: associations with exposure and respiratory symptoms
Arrandale V, Meijster T, Pronk A, Doekes G, Redlich CA, Holness DL, Heederik D. Skin symptoms in bakery and auto body shop workers: associations with exposure and respiratory symptoms. International Archives Of Occupational And Environmental Health 2012, 86: 167-175. PMID: 22411214, PMCID: PMC3555349, DOI: 10.1007/s00420-012-0760-x.Peer-Reviewed Original ResearchConceptsAuto body shop workersExposure-response relationshipRespiratory symptomsSkin symptomsItchy skinShop workersBakery workersPossible exposure-response relationshipSignificant exposure-response associationsExposure-response associationsRespiratory outcomesMean ageDry skinSkin exposureSymptomsAverage exposureStatistical significanceWheat allergensSkinExposureAssociationPrevious studiesResultsDataMethodsDataWorkers
2010
The 24-bp CHIT1 Exon 10 Polymorphism Is Associated With Airway Hyperresponsiveness In A Population Of Autobody Shop Workers
Ong P, Wisnewski A, Stowe M, Holm C, He X, Zheng W, Zhang C, Zhao H, Redlich C, Chupp G. The 24-bp CHIT1 Exon 10 Polymorphism Is Associated With Airway Hyperresponsiveness In A Population Of Autobody Shop Workers. 2010, a4002-a4002. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4002.Peer-Reviewed Original Research
2009
IgG Responses to Isocyanate in Auto Body Shop Workers: Associations with Skin and Respiratory Exposures.
Redlich C, Stowe M, Wang S, Liu J, Gore R, Liu Y, Woskie, Wisnewski A. IgG Responses to Isocyanate in Auto Body Shop Workers: Associations with Skin and Respiratory Exposures. 2009, a3670. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3670.Peer-Reviewed Original Research
2008
Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: III. A Personal Exposure Algorithm
Liu Y, Stowe MH, Bello D, Sparer J, Gore RJ, Cullen MR, Redlich CA, Woskie SR. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: III. A Personal Exposure Algorithm. Annals Of Work Exposures And Health 2008, 53: 33-40. PMID: 19011126, PMCID: PMC2638551, DOI: 10.1093/annhyg/men070.Peer-Reviewed Original ResearchConceptsPersonal protective equipmentSkin exposureExposure metricsAuto body shop workersExposure indexUse of PPEExposure-response relationshipJob title categoriesAuto Body RepairIsocyanate asthmaExposure algorithmSemiquantitative algorithmSkin areasProtective equipmentSuch exposureExposure dataSpearman correlationShop workersExposure indicatorsOffice workersPositive Spearman correlationAuto body shopsExposureTask-based dataWork diariesComparison of Task-Based Exposure Metrics for an Epidemiologic Study of Isocyanate Inhalation Exposures Among Autobody Shop Workers
Woskie SR, Bello D, Gore RJ, Stowe MH, Eisen EA, Liu Y, Sparer JA, Redlich CA, Cullen MR. Comparison of Task-Based Exposure Metrics for an Epidemiologic Study of Isocyanate Inhalation Exposures Among Autobody Shop Workers. Journal Of Occupational And Environmental Hygiene 2008, 5: 588-598. PMID: 18615291, DOI: 10.1080/15459620802275429.Peer-Reviewed Original ResearchConceptsQuantitative exposure metricsOccupational exposure limitsEpidemiologic studiesExposure metricsRespirator useCross-week changesExposure-response analysisTime-weighted average exposureShop workersExposure assessmentPersonal daily exposureMagnitude of associationOccupational epidemiologic studiesWorkplace protection factorsQuantitative exposure assessmentTask-based exposure assessmentRespiratory functionInhalation exposureDaily exposureAverage exposureRisk estimatesExposure misclassificationQuantitative exposureSpearman correlationComparison of tasksSkin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: II. A Quantitative Assessment
Bello D, Redlich CA, Stowe MH, Sparer J, Woskie SR, Streicher RP, Hosgood HD, Liu Y. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: II. A Quantitative Assessment. Annals Of Work Exposures And Health 2008, 52: 117-124. PMID: 18209009, DOI: 10.1093/annhyg/mem066.Peer-Reviewed Original ResearchConceptsSkin exposureUnprotected skinAuto body shop workersAuto Body RepairRespiratory exposureSkin areasExposure dataShop workersSkin samplingSkinExposureWipe samplesUnpaired samplesHigh concentrationsPPEGm loadYale studyHigh levelsBody repairAsthmaMajor contributorLevelsQuantitative assessmentForearmSensitization
2007
Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: A Qualitative Assessment
LIU Y, BELLO D, SPARER JA, STOWE MH, GORE RJ, WOSKIE SR, CULLEN MR, REDLICH CA. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: A Qualitative Assessment. Annals Of Work Exposures And Health 2007, 51: 429-439. PMID: 17602207, DOI: 10.1093/annhyg/mem021.Peer-Reviewed Original ResearchConceptsAuto body shop workersSkin exposureHigh-performance liquid chromatographyShop workersHigher positive rateAuto Body RepairPositive surface samplesPositive sample rateEpidemiologic studiesUnprotected skinRespiratory exposurePercent of samplesSensitive high-performance liquid chromatographyLatex glovesScale 0Exposure dataExposure determinantsSkin samplesQuantitative high-performance liquid chromatographyNational InstituteOccupational SafetyAuto body shopsExposureMajor determinantPositive rate
2004
Urinary Hexane Diamine to Assess Respiratory Exposure to Hexamethylene Diisocyanate Aerosol: A Human Inhalation Study
Liu Y, Berode M, Stowe MH, Holm CT, Walsh FX, Slade MD, Boeniger MF, Redlich CA. Urinary Hexane Diamine to Assess Respiratory Exposure to Hexamethylene Diisocyanate Aerosol: A Human Inhalation Study. International Journal Of Occupational And Environmental Health 2004, 10: 262-271. PMID: 15473079, DOI: 10.1179/oeh.2004.10.3.262.Peer-Reviewed Original ResearchConceptsRespiratory exposureAuto body shop workersAcute respiratory exposureHours post exposureHuman respiratory exposureBiomarkers of exposureHuman inhalation studiesHDI exposureInhalation studiesBaseline valuesConsiderable individual variabilityPost exposureUrine samplesShop workersExposureBiomarkersIndividual variabilityHoursBaselineIsocyanate vapor-induced antigenicity of human albumin
Wisnewski AV, Stowe MH, Cartier A, Liu Q, Liu J, Chen L, Redlich CA. Isocyanate vapor-induced antigenicity of human albumin. Journal Of Allergy And Clinical Immunology 2004, 113: 1178-1184. PMID: 15208602, DOI: 10.1016/j.jaci.2004.03.009.Peer-Reviewed Original ResearchConceptsHDI exposureHuman albuminAuto body shop workersHDI vaporHuman immune systemOccupational asthmaHumoral armSpecific IgEIgG titersHealthy workersImmune responseSerology studiesHuman airwaysImmune systemSignificant associationAntigenic formsShop workersAlbumin conjugatesAsthmaticsAsthmaIgEAntigenicityParallel studyAlbuminSignificant changes
2003
Truncating the Dose Range for Methacholine Challenge Tests: Three Occupational Studies
Agalliu I, Eisen EA, Hauser R, Redlich CA, Stowe MH, Cullen MR, Wegman DH, Christiani DC, Kennedy SM. Truncating the Dose Range for Methacholine Challenge Tests: Three Occupational Studies. Journal Of Occupational And Environmental Medicine 2003, 45: 841-847. PMID: 12915785, DOI: 10.1097/01.jom.0000083031.56116.53.Peer-Reviewed Original Research226. Workplace Performance Assessment of Half-Facepiece Respirators in Isocyanate-exposed Body Shop Workers: The Spray Study
Liu Y, Sparer J, Stowe M, Walsh F, Holm C, Redlich C, Cullen M, Bello D, Young F, Woskie S, Streicher R. 226. Workplace Performance Assessment of Half-Facepiece Respirators in Isocyanate-exposed Body Shop Workers: The Spray Study. 2003, 226-226. DOI: 10.3320/1.2757904.Peer-Reviewed Original Research
2002
Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up
Redlich CA, Stowe MH, Coren BA, Wisnewski AV, Holm CT, Cullen MR. Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up. American Journal Of Industrial Medicine 2002, 42: 511-518. PMID: 12439874, DOI: 10.1002/ajim.10143.Peer-Reviewed Original ResearchConceptsHealthy worker effectAuto body shop workersWorker effectHexamethylene diisocyanate exposureHistory of asthmaLower asthma prevalenceCross-sectional studyDiisocyanate exposureOccupational asthmaAsthma prevalenceImmunologic responseLow prevalenceAsthmaOne-yearHigh job turnover ratesShop workersEpisodic exposureSignificant differencesAuto body shopsPrevalenceEffect of HDISignificant changesExposureSymptomsIgG
2001
Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers
Redlich C, Stowe M, Wisnewski A, Eisen E, Karol M, Lemus R, Holm C, Chung J, Sparer J, Liu Y, Woskie S, Appiah‐Pippim J, Gore R, Cullen M. Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers. American Journal Of Industrial Medicine 2001, 39: 587-597. PMID: 11385643, DOI: 10.1002/ajim.1058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAir Pollutants, OccupationalAnalysis of VarianceAsthmaAutomobilesChi-Square DistributionCross-Sectional StudiesCyanatesEpidemiologic StudiesFemaleHumansIsocyanatesMaleMiddle AgedOccupational DiseasesOccupational ExposurePaintStatistics, NonparametricSurveys and QuestionnairesConceptsAuto body shop workersDiisocyanate asthmaLymphocyte proliferationHost risk factorsShortness of breathShop workersMethacholine responsivenessMethacholine challengeChest tightnessDiisocyanate exposureOccupational asthmaImmunologic responseRisk factorsPhysiologic changesImmune responseEpidemiologic studiesSurveillance studyPhysiologic responsesAsthmaOvert casesSymptomsExposure dataEpisodic exposureAuto body shopsExposure
1996
Feasibility Study of Respiratory Questionnaire and Peak Flow Recordings in Autobody Shop Workers Exposed to Isocyanate-containing Spray Paint: Observations and Limitations
Cullen M, Redlich C, Beckett W, Weltmann B, Sparer J, Jackson G, Ruff T, Rubinstein E, Holden W. Feasibility Study of Respiratory Questionnaire and Peak Flow Recordings in Autobody Shop Workers Exposed to Isocyanate-containing Spray Paint: Observations and Limitations. Occupational Medicine 1996, 46: 197-204. PMID: 8695771, DOI: 10.1093/occmed/46.3.197.Peer-Reviewed Original ResearchConceptsOccupational asthmaAirway symptomsWork-related asthmaAutobody shopsPeak flow recordingsClinical epidemiological studiesNew Haven areaCross-sectional surveyRespiratory QuestionnaireIncidence rateHigh prevalenceSpray paintersEpidemiological studiesLower riskAsthmaFlow recordingsSymptomsExposure classificationSubject complianceClear associationQuestionnaire responsesRecord dataRegular useShop workersOffice workers