2024
Early Warning Scores With and Without Artificial Intelligence
Edelson D, Churpek M, Carey K, Lin Z, Huang C, Siner J, Johnson J, Krumholz H, Rhodes D. Early Warning Scores With and Without Artificial Intelligence. JAMA Network Open 2024, 7: e2438986. PMID: 39405061, PMCID: PMC11544488, DOI: 10.1001/jamanetworkopen.2024.38986.Peer-Reviewed Original ResearchConceptsEarly Warning ScoreWarning ScoreCohort studyYale New Haven Health SystemClinical deterioration eventsHigh-risk thresholdHealth systemRetrospective cohort studyPatient encountersDeteriorating patientsOverall PPVMain OutcomesInpatient encountersEDI scoresHospital encountersDeterioration eventsClinical deteriorationIntensive care unitEarly warning toolCare unitDecision support toolArtificial intelligenceScoresReceiver operating characteristic curveNEWS2
2020
Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients
Sheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients. JAMA Neurology 2020, 78: 41-47. PMID: 32897296, PMCID: PMC7489395, DOI: 10.1001/jamaneurol.2020.3263.Peer-Reviewed Original ResearchIntensive care unit roomsIntensive care settingBrain injuryCare settingsIll patientsNeurological injuryT2 fluid-attenuated inversion recoveryCOVID-19Intensive care unit admissionSingle-center cohort studyIntensive care unit settingUnit roomsYale-New Haven HospitalNasopharyngeal swab resultsCare unit admissionSingle-center seriesBrain imaging findingsIntensive care unitFluid-attenuated inversion recoveryDiffusion-weighted imaging sequencesTraumatic brain injuryClinical care settingsNew Haven HospitalMagnetic resonance imagingConventional magnetic resonance imaging (MRI) systemEndotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study
Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/s2352-3026(20)30216-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBetacoronavirusBiomarkersBlood Coagulation DisordersCoronavirus InfectionsCOVID-19Critical IllnessCross-Sectional StudiesEndothelium, VascularFemaleFollow-Up StudiesHumansIntensive Care UnitsMaleMiddle AgedPandemicsPneumonia, ViralPrognosisSARS-CoV-2Vascular DiseasesYoung AdultConceptsCOVID-19-associated coagulopathyNon-ICU patientsIntensive care unitKaplan-Meier analysisSoluble P-selectinCross-sectional studyPlatelet activationHospital dischargeICU patientsSoluble thrombomodulinEndothelial cellsVWF antigenCOVID-19P-selectinSingle-center cross-sectional studyLaboratory-confirmed COVID-19Medical intensive care unitSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesisVon Willebrand factor antigenSoluble thrombomodulin concentrationsVWF antigen concentrationEndothelial cell injurySoluble CD40 ligandMicrovascular complicationsAdult patients
2019
Evaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours?
Leder SB, Warner HL, Suiter DM, Young NO, Bhattacharya B, Siner JM, Davis KA, Maerz LL, Rosenbaum SH, Marshall PS, Pisani MA, Siegel MD, Brennan JJ, Schuster KM. Evaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours? Annals Of Otology Rhinology & Laryngology 2019, 128: 619-624. PMID: 30841709, DOI: 10.1177/0003489419836115.Peer-Reviewed Original ResearchConceptsIntensive care unitSwallow evaluationDifferent intensive care unitsRe-intubation rateYale Swallow ProtocolMajority of patientsPost-extubation dysphagiaIntubation durationNosocomial pneumoniaPost extubationLonger hospitalizationCare unitProspective InvestigationSwallow ProtocolSwallowingHoursDysphagiaHospitalizationIntubationPneumoniaPatientsIncidenceEvaluation
2016
“Deterioration to Door Time”: An Exploratory Analysis of Delays in Escalation of Care for Hospitalized Patients
Sankey CB, McAvay G, Siner JM, Barsky CL, Chaudhry SI. “Deterioration to Door Time”: An Exploratory Analysis of Delays in Escalation of Care for Hospitalized Patients. Journal Of General Internal Medicine 2016, 31: 895-900. PMID: 26969311, PMCID: PMC4945556, DOI: 10.1007/s11606-016-3654-x.Peer-Reviewed Original ResearchConceptsMedical intensive care unitEscalation of careIntensive care unitClinical deteriorationCare escalationHospitalized patientsCare unitDoor timeInpatient medicineRetrospective cohort studySeverity of illnessRisk of deathAcademic medical centerHospital mortalityICU transferCohort studyInpatient floorInpatient settingMedical CenterGeneral floorPatientsCareMortalityCurrent eraPrevious studies
2015
Protocol-Based Care versus Individualized Management of Patients in the Intensive Care Unit
Siner JM, Connors GR. Protocol-Based Care versus Individualized Management of Patients in the Intensive Care Unit. Seminars In Respiratory And Critical Care Medicine 2015, 36: 870-877. PMID: 26595047, DOI: 10.1055/s-0035-1566157.BooksConceptsIntensive care unitCare unitGeneral practiceEvidence-based careStandard of careHealth care deliveryIndividualized managementPhysicians' concernsHigh-acuity environmentCare deliveryMedical careCareLoss of autonomyCare placesCorrect interventionCorrect careComplete penetranceMedical traineesUniform practiceConsistent practiceDeliveryPatientsHospitalAimBest protocolClinical Reasoning and Risk in the Intensive Care Unit
Connors GR, Siner JM. Clinical Reasoning and Risk in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 449-459. PMID: 26304282, DOI: 10.1016/j.ccm.2015.05.016.BooksAdverse Event Reporting and Quality Improvement in the Intensive Care Unit
Heavner JJ, Siner JM. Adverse Event Reporting and Quality Improvement in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 461-467. PMID: 26304283, DOI: 10.1016/j.ccm.2015.05.005.Books
2009
ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS
Siner JM, Bhandari V, Engle KM, Elias JA, Siegel MD. ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS. Shock 2009, 31: 348-353. PMID: 18791490, DOI: 10.1097/shk.0b013e318188bd06.Peer-Reviewed Original ResearchConceptsAng-2 levelsIntensive care unitAng-2Tertiary care medical intensive care unitProspective observational cohort studySerum Ang-2 levelsSerum angiopoietin-2 levelsMedical intensive care unitSerum Ang-2Observational cohort studyAngiopoietin-2 levelsIL-6 levelsHospital mortalityHuman sepsisICU admissionSevere sepsisCohort studyEndothelial dysfunctionHospital dischargeICU patientsIllness scoresSeptic shockCare unitIL-6Increased Mortality
2007
Mechanical Ventilation and Acute Respiratory Distress Syndrome in Older Patients
Siner JM, Pisani MA. Mechanical Ventilation and Acute Respiratory Distress Syndrome in Older Patients. Clinics In Chest Medicine 2007, 28: 783-791. PMID: 17967294, DOI: 10.1016/j.ccm.2007.08.008.BooksConceptsAcute respiratory distress syndromeRespiratory distress syndromeDistress syndromeMechanical ventilationAcute respiratory failureAcute lung injuryIntensive care unitUnited States agesRespiratory failureLung injuryOlder patientsCare unitFunctional outcomeIncidence rateRespiratory functionAge-specific changesElderly adultsPatient careRespiratory systemSyndromeStates agesAgeVentilationARDSPatients