2025
A ventilated perfused lung model platform to dissect the response of the lungs to viral infection
Derman I, Alioglu M, Moses J, Chroneos Z, Yilmaz Y, Banerjee D, Koff J, Rizvi S, Klunk D, Celik N, Pochareddy S, Umstead T, Namli I, Holton S, Mikacenic C, Thompson J, Castaneda D, Hickey D, Nagamine M, Warang P, Schotsaert M, Chen P, Peeples M, Palucka K, Ozbolat I. A ventilated perfused lung model platform to dissect the response of the lungs to viral infection. Trends In Biotechnology 2025 PMID: 40280814, DOI: 10.1016/j.tibtech.2025.03.012.Peer-Reviewed Original ResearchRespiratory syncytial virusViral infectionEpithelial barrier functionAir-liquid interfaceResponse to ventilationResponse to viral infectionTight-junction formationResponse to infectionViral responseProinflammatory chemokinesSyncytial virusRespiratory infectionsPulmonary physiologyViral recognitionLung physiologyEpithelial layerRespiratory cyclePerfusion modelBarrier functionAlveolar epithelial layerVascular componentInfectionViral spreadLung modelVentilation
2024
Phage Therapy for Respiratory Infections: Opportunities and Challenges
Khosravi A, Chen Q, Echterhof A, Koff J, Bollyky P. Phage Therapy for Respiratory Infections: Opportunities and Challenges. Lung 2024, 202: 223-232. PMID: 38772946, PMCID: PMC11570333, DOI: 10.1007/s00408-024-00700-7.Peer-Reviewed Original ResearchChronic lung infectionLung infectionRespiratory infectionsAntimicrobial resistancePhage therapyClinical trialsPhage therapy clinical trialsProgressive respiratory failureChronic respiratory infectionsPersonalized phage therapyAntimicrobial resistant infectionsPost-antibiotic eraPotential of phagesSalvage therapyAdjuvant therapyRespiratory failureDisease resolutionChronic respiratory diseasesTreatment efficacyTherapyTherapeutic potentialIncreased mortalityInfectionNovel antibioticsPhage
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