2022
Reducing asthma exacerbations in vulnerable children through a medical–legal partnership
Mainardi AS, Harris D, Rosenthal A, Redlich CA, Hu B, Fenick AM. Reducing asthma exacerbations in vulnerable children through a medical–legal partnership. Journal Of Asthma 2022, 60: 262-269. PMID: 35188437, DOI: 10.1080/02770903.2022.2045307.Peer-Reviewed Original ResearchConceptsMedical-legal partnershipsAsthma exacerbationsEmergency departmentHealth disparitiesAsthma exacerbation ratePrimary care officesAcademic children's hospitalAsthma health disparitiesExacerbation rateHealthcare utilizationPediatric populationChildren's HospitalCare officesPrimary careWorse outcomesChronic illnessInpatient settingStudy populationAsthmaTotal encountersSocial determinantsHospitalizationExacerbationStatistical significanceIntervention
2017
Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry
Collins JJ, Anteau S, Conner PR, Cassidy LD, Doney B, Wang ML, Kurth L, Carson M, Molenaar D, Redlich CA, Storey E. Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry. Journal Of Occupational And Environmental Medicine 2017, 59: s22-s27. PMID: 29200135, PMCID: PMC5763544, DOI: 10.1097/jom.0000000000000890.Peer-Reviewed Original ResearchMedical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States
Cassidy LD, Doney B, Wang ML, Kurth L, Conner PR, Collins JJ, Carson M, Molenaar D, Redlich CA, Storey E. Medical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States. Journal Of Occupational And Environmental Medicine 2017, 59: s13-s21. PMID: 29200134, PMCID: PMC5728423, DOI: 10.1097/jom.0000000000001197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAsthma, OccupationalChemical IndustryEnvironmental MonitoringFemaleForced Expiratory VolumeHumansMaleMiddle AgedOccupational ExposurePopulation SurveillanceProgram EvaluationReferral and ConsultationSpirometrySurveys and QuestionnairesSymptom AssessmentToluene 2,4-DiisocyanateUnited StatesYoung AdultConceptsLung function criteriaOccupational health programWeb-based data collection systemTDI workersOccupational asthmaPossible asthmaStudy protocolHealth outcomesMultidisciplinary teamHealth programsMedical monitoringAsthmaFurther evaluationEligible workersFurther assessmentResearch protocolPotential casesSubsequent evaluationProduction workersSymptomsToluene diisocyanateWorkersEvaluationRecommendations for a Clinical Decision Support System for Work-Related Asthma in Primary Care Settings
Harber P, Redlich CA, Hines S, Filios MS, Storey E. Recommendations for a Clinical Decision Support System for Work-Related Asthma in Primary Care Settings. Journal Of Occupational And Environmental Medicine 2017, 59: e231-e235. PMID: 29023337, PMCID: PMC6282164, DOI: 10.1097/jom.0000000000001182.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsWork-related asthmaElectronic health recordsPossible work-related asthmaPrimary care health care providersMortality of asthmaPrimary care settingSpecific clinical conditionsAmerican Thoracic SocietyHealth care providersClinical decision support systemAsthma symptomsAsthma diagnosisThoracic SocietyPossible referralCare settingsClinical conditionsCare providersAsthmaAvailable guidelinesFurther evaluationHealth recordsClinical decision support approachEHR systemsPositive responseSpecific recommendationsImproving the asthma disparity gap with legal advocacy? A qualitative study of patient-identified challenges to improve social and environmental factors that contribute to poorly controlled asthma
Harris DA, Mainardi A, Iyamu O, Rosenthal MS, Bruce RD, Pisani MA, Redlich CA. Improving the asthma disparity gap with legal advocacy? A qualitative study of patient-identified challenges to improve social and environmental factors that contribute to poorly controlled asthma. Journal Of Asthma 2017, 55: 924-932. PMID: 28872933, DOI: 10.1080/02770903.2017.1373393.Peer-Reviewed Original ResearchConceptsPoor symptom controlSymptom controlAsthma Control Test scoresCommon barriersCommunity health centersWork-related symptomsEnvironmental risk factorsPercent of participantsCommunity-engaged approachAsthmatic adultsAsthma controlRisk factorsAsthma triggersHealth centersImproved outcomesMedical careDisparity gapStudy participantsPerson interviewsLack of awarenessAsthmaPatientsConstant comparative methodEnvironmental factorsAdults
2014
Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up
Gui W, Wisnewski AV, Neamtiu I, Gurzau E, Sparer JA, Stowe MH, Liu J, Slade MD, Rusu OA, Redlich CA. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up. American Journal Of Industrial Medicine 2014, 57: 1207-1215. PMID: 25266741, PMCID: PMC4198484, DOI: 10.1002/ajim.22385.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAirway ObstructionAsthma, OccupationalFemaleFollow-Up StudiesForced Expiratory VolumeHumansImmunoglobulin EImmunoglobulin GLost to Follow-UpMaleMiddle AgedOccupational ExposurePolyurethanesPrevalenceProspective StudiesTime FactorsToluene 2,4-DiisocyanateVital CapacityYoung AdultConceptsAsthma symptomsIsocyanate asthmaInception cohort studyHealth effectsCurrent asthma symptomsTDI levelsFirst yearFurther longitudinal evaluationAirflow obstructionCohort studyInception cohortOccupational asthmaTDI exposureRespiratory healthSkin exposureLongitudinal evaluationAsthmaOne-yearPersonal samplingSymptomsRiskExposureFindingsFEV1Spirometry
2012
Transferability of Aliphatic Isocyanates from Recently Applied Paints to the Skin of Auto Body Shop Workers
De Vries TT, Bello D, Stowe MH, Harari H, Slade MD, Redlich CA. Transferability of Aliphatic Isocyanates from Recently Applied Paints to the Skin of Auto Body Shop Workers. Journal Of Occupational And Environmental Hygiene 2012, 9: 699-711. PMID: 23067057, DOI: 10.1080/15459624.2012.728893.Peer-Reviewed Original ResearchConceptsSkin exposureSkin samplesAuto body shop workersOccupational asthmaIsocyanate asthmaCommon causeSkin wipesGreater riskSkin contactPotent sensitizerInitial sampling timeShop workersPositive samplesAsthmaAuto body shopsHigh-performance liquid chromatographyExposureCross-linking chemicalsRiskGeometric meanLiquid chromatographyPrimary prevention: exposure reduction, skin exposure and respiratory protection
Heederik D, Henneberger PK, Redlich CA. Primary prevention: exposure reduction, skin exposure and respiratory protection. European Respiratory Review 2012, 21: 112-124. PMID: 22654083, PMCID: PMC9487304, DOI: 10.1183/09059180.00005111.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOccupational asthmaPrimary preventionSkin exposureLiterature searchExposure reductionSystematic literature searchNatural rubber latex glovesEffectiveness of respiratorsOccupational exposurePrimary preventive approachAsthmaExposure eliminationWork exposureWorkplace exposuresMedical literatureLatex glovesFuture interventionsPreventive approachPreventionRespiratory protectionExposureInterventionWeak evidenceEvidenceBest option
2011
An Official American Thoracic Society Statement: Work-Exacerbated Asthma
Henneberger PK, Redlich CA, Callahan DB, Harber P, Lemière C, Martin J, Tarlo SM, Vandenplas O, Torén K. An Official American Thoracic Society Statement: Work-Exacerbated Asthma. American Journal Of Respiratory And Critical Care Medicine 2011, 184: 368-378. PMID: 21804122, DOI: 10.1164/rccm.812011st.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsWork-exacerbated asthmaWork-related symptomsClinical characteristicsOccupational asthmaOfficial American Thoracic Society StatementAmerican Thoracic Society StatementWorsening of asthmaOnset of asthmaStandard medical managementMedical managementAdverse outcomesDescriptive epidemiologyOA casesRisk factorsAdverse socioeconomic outcomesCase definitionOccupational exposureSociety statementMedian prevalenceAsthmaWork exposurePreventive interventionsMedical careMedical literatureSystematic search
2010
Automobile Maintenance, Repair and Refinishing
Stowe M, Redlich C. Automobile Maintenance, Repair and Refinishing. 2010, 203-210. DOI: 10.1002/9780470710425.ch15.ChaptersWork-exacerbated asthma
Henneberger P, Redlich C. Work-exacerbated asthma. Progress In Inflammation Research 2010, 89-100. DOI: 10.1007/978-3-7643-8556-9_6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsWork-exacerbated asthmaExacerbation of asthmaStandard medical managementSubstantial adverse outcomesNon-industrial workplacesConcurrent asthmaOccupational asthmaMedical managementAdverse outcomesCommon conditionAsthmaWork exposureMultiple factorsExposureExacerbationAllergensCliniciansPrevalenceIrritants
2008
Diagnosis and Management of Work-Related Asthma American College of Chest Physicians Consensus Statement
Tarlo SM, Balmes J, Balkissoon R, Beach J, Beckett W, Bernstein D, Blanc PD, Brooks SM, Cowl CT, Daroowalla F, Harber P, Lemiere C, Liss GM, Pacheco KA, Redlich CA, Rowe B, Heitzer J. Diagnosis and Management of Work-Related Asthma American College of Chest Physicians Consensus Statement. CHEST Journal 2008, 134: 1s-41s. PMID: 18779187, DOI: 10.1378/chest.08-0201.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsWork-related asthmaWork-exacerbated asthmaChest Physicians consensus statementConsensus statementConsensus documentAmerican CollegeManagement of WRAChallenge testSpecific inhalation challenge testInhalation challenge testPreventive measuresMethacholine challenge testPeak flow recordingsCurrent consensus statementsOccupational medicine physiciansCareful occupational historyEffective preventive measuresOccupational asthmaImmunologic testsAppropriate investigationsSubstantial prevalenceEarly diagnosisMedicine physiciansOccupational historyAsthmaSkin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: II. A Quantitative Assessment
Bello D, Redlich CA, Stowe MH, Sparer J, Woskie SR, Streicher RP, Hosgood HD, Liu Y. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: II. A Quantitative Assessment. Annals Of Work Exposures And Health 2008, 52: 117-124. PMID: 18209009, DOI: 10.1093/annhyg/mem066.Peer-Reviewed Original ResearchConceptsSkin exposureUnprotected skinAuto body shop workersAuto Body RepairRespiratory exposureSkin areasExposure dataShop workersSkin samplingSkinExposureWipe samplesUnpaired samplesHigh concentrationsPPEGm loadYale studyHigh levelsBody repairAsthmaMajor contributorLevelsQuantitative assessmentForearmSensitization
2006
Skin Exposure to Isocyanates: Reasons for Concern
Bello D, Herrick CA, Smith TJ, Woskie SR, Streicher RP, Cullen MR, Liu Y, Redlich CA. Skin Exposure to Isocyanates: Reasons for Concern. Environmental Health Perspectives 2006, 115: 328-335. PMID: 17431479, PMCID: PMC1849909, DOI: 10.1289/ehp.9557.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSkin exposureIsocyanate asthmaSuch exposureAsthma-like responsesSubsequent inhalation challengeOccupational SafetyPersonal protective equipmentInhalation challengeOccupational asthmaSystemic sensitizationAsthmaInhalation exposureHealth AdministrationComputerized searchRespiratory exposureRelevant articlesProtective equipmentHuman literatureSkin absorptionSensitizationGoogle databasesNational InstituteLines of evidencePotential roleSufficient evidenceBiophysical determinants of toluene diisocyanate antigenicity associated with exposure and asthma
Ye YM, Kim CW, Kim HR, Kim HM, Suh CH, Nahm DH, Park HS, Redlich CA, Wisnewski AV. Biophysical determinants of toluene diisocyanate antigenicity associated with exposure and asthma. Journal Of Allergy And Clinical Immunology 2006, 118: 885-891. PMID: 17030242, DOI: 10.1016/j.jaci.2006.06.026.Peer-Reviewed Original ResearchImmunologic Changes in Human Albumin Exposed to Toluene Diisocyanate (TDI) Vapor: Differences Compared with Liquid TDI Exposure and Association with IgE/IgG Binding and TDI Asthma
Ye Y, Kim S, Lee S, Park H, Redlich C, Wisnewski A. Immunologic Changes in Human Albumin Exposed to Toluene Diisocyanate (TDI) Vapor: Differences Compared with Liquid TDI Exposure and Association with IgE/IgG Binding and TDI Asthma. Journal Of Allergy And Clinical Immunology 2006, 117: s267. DOI: 10.1016/j.jaci.2005.12.1057.Peer-Reviewed Original ResearchREACTIVE AIRWAYS DYSFUNCTION SYNDROME
Tarlo S, Redlich C. REACTIVE AIRWAYS DYSFUNCTION SYNDROME. 2006, 614-618. DOI: 10.1016/b0-12-370879-6/00343-4.ChaptersReactive airways dysfunction syndromeAirways dysfunction syndromeAsthma symptomsDysfunction syndromeDiagnosis of RADSIrritant-induced asthmaPulmonary function changesType of asthmaHistory of exposureAirway diseaseIrritant exposureAirway pathologyLung diseaseAsthmaWorkplace exposuresRespiratory irritantsDelayed onsetObjective documentationSymptomsSyndromeObjective evidenceSuch exposureShort durationDiseaseExposure
2004
Isocyanate Exposures in Autobody Shop Work: The SPRAY Study
Sparer J, Stowe MH, Bello D, Liu Y, Gore RJ, Youngs F, Cullen MR, Redlich CA, Woskie SR. Isocyanate Exposures in Autobody Shop Work: The SPRAY Study. Journal Of Occupational And Environmental Hygiene 2004, 1: 570-581. PMID: 15559329, DOI: 10.1080/15459620490485909.Peer-Reviewed Original ResearchConceptsIsocyanate exposurePersonal air samplesTypes of glovesRespiratory sensitizationEpidemiologic studiesTypes of respiratorsU.K. guidelinesSkin contactAutobody shopsSubstantial exposureAir respiratorsNational InstituteOccupational SafetyRespiratorsCartridge respiratorsPersonal samplesExposure limitsMedian concentrationsExposureUnited Kingdom HealthSealerHealthGuidelinesPercentAsthmaIsocyanate vapor-induced antigenicity of human albumin
Wisnewski AV, Stowe MH, Cartier A, Liu Q, Liu J, Chen L, Redlich CA. Isocyanate vapor-induced antigenicity of human albumin. Journal Of Allergy And Clinical Immunology 2004, 113: 1178-1184. PMID: 15208602, DOI: 10.1016/j.jaci.2004.03.009.Peer-Reviewed Original ResearchConceptsHDI exposureHuman albuminAuto body shop workersHDI vaporHuman immune systemOccupational asthmaHumoral armSpecific IgEIgG titersHealthy workersImmune responseSerology studiesHuman airwaysImmune systemSignificant associationAntigenic formsShop workersAlbumin conjugatesAsthmaticsAsthmaIgEAntigenicityParallel studyAlbuminSignificant changes
2002
Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up
Redlich CA, Stowe MH, Coren BA, Wisnewski AV, Holm CT, Cullen MR. Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up. American Journal Of Industrial Medicine 2002, 42: 511-518. PMID: 12439874, DOI: 10.1002/ajim.10143.Peer-Reviewed Original ResearchConceptsHealthy worker effectAuto body shop workersWorker effectHexamethylene diisocyanate exposureHistory of asthmaLower asthma prevalenceCross-sectional studyDiisocyanate exposureOccupational asthmaAsthma prevalenceImmunologic responseLow prevalenceAsthmaOne-yearHigh job turnover ratesShop workersEpisodic exposureSignificant differencesAuto body shopsPrevalenceEffect of HDISignificant changesExposureSymptomsIgG